Title: Synthesis and Biological Activity of Cyclic Peptide Inhibitors of Ribonucleotide Reductase
Abstract: A series of lactam-bridged peptide inhibitors (2−6) of mammalian ribonucleotide reductase (mRR) has been designed and synthesized on the basis of the heptapeptide N-AcFTLDADF (1), corresponding to the C-terminus of the R2 subunit of mRR. Inhibition studies revealed a direct relation between ring size and activity, with peptide 5 being 2.5 times more potent than peptide 1.
Publication Year: 1999
Publication Date: 1999-09-29
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 18
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