Publication Information

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374, 442, 446, 459], 'structural': [4, 26, 59, 375], 'joint': [5, 27, 60, 149, 179, 376], 'damage': [6, 28, 61, 150, 377], 'is': [7], 'a': [8, 19], 'key': [9], 'treatment': [10, 222], 'goal': [11], 'in': [12, 34, 41, 45, 66, 79, 88, 173, 207, 242, 291, 297, 308, 316, 351, 363, 370, 381], 'the': [13, 23, 56, 190, 256, 300, 338, 347, 372, 427, 443, 447], 'management': [14], 'RA<sup>1</sup>.': [16], 'Upadacitinib': [17], '(UPA),': [18], 'JAK1-selective': [20], 'inhibitor,': [21], 'inhibited': [22, 248], 'progression': [24, 57, 85, 147, 197, 250, 263, 278, 330, 373], 'at': [29, 143, 200], '6': [30], 'months': [31], 'as': [32, 96, 187, 189, 225, 239, 360], 'monotherapy': [33, 77, 111, 240], 'methotrexate': [35], '(MTX)–naïve': [36], 'RA': [37, 73], 'patients': [38], '(pts)<sup>2</sup>': [39], 'and': [40, 161, 183, 203, 221, 224, 241, 255, 266, 270, 289, 293, 349, 355, 362, 383, 440, 548, 559, 587, 600, 623, 654], 'combination': [42, 80, 243, 364], 'with': [43, 47, 68, 75, 81, 132, 194, 244, 260, 279, 365], 'MTX': [44, 110, 135, 246, 265, 287], 'pts': [46, 67, 100, 116, 142, 193, 259, 305], 'inadequate': [48], 'response': [49], '(IR)': [50], 'to': [51, 70, 103, 119, 306, 431], 'MTX<sup>3</sup>.': [52], '<h3>Objectives</h3>': [53], 'To': [54], 'evaluate': [55], '(radiographic)': [62], 'through': [63, 283, 321, 378], 'Week': [64, 284, 311, 322, 379], '48': [65, 204, 285, 323, 380], 'moderately': [69], 'severely': [71], 'active': [72], 'treated': [74], 'UPA': [76, 104, 120, 238, 280, 307, 358], 'or': [78, 106, 109, 123, 129], 'MTX.': [82], '<h3>Methods</h3>': [83], 'Radiographic': [84], 'was': [86, 281, 319, 333, 368, 426], 'assessed': [87], '2': [89], 'phase': [90], '3': [91], 'randomized': [92, 102, 118], 'controlled': [93], 'trials': [94], '(RCTs),': [95], 'previously': [97], 'described<sup>2,3</sup>.': [98], 'MTX–naïve': [99], 'were': [101, 117, 205, 211], '15': [105], '30mg': [107], 'QD': [108, 122], '[SELECT–EARLY,': [112], 'N=945],': [113], 'while': [114], 'MTX-IR': [115, 384], '15mg': [121], 'adalimumab': [124], '(ADA)': [125], '40': [126], 'mg': [127], 'eow': [128], 'placebo': [130], '(PBO),': [131], 'continuous': [133], 'background': [134, 245, 366], '[SELECT–COMPARE,': [136], 'N=1629].': [137], 'Both': [138], 'RCTs': [139, 353], 'specifically': [140], 'enrolled': [141], 'high': [144], 'risk': [145], 'for': [146, 217, 337], '(high': [151], 'disease': [152], 'activity': [153], 'including': [154], 'elevated': [155], 'hsCRP,': [156], 'presence': [157], 'baseline': [159, 171], 'erosions': [160], 'ACPA': [162], 'and/or': [163], 'RF': [164], 'positivity<sup>2,3</sup>).': [165], 'The': [166, 273, 326], 'mean': [167, 253, 317], 'changes': [168], '(Δ)': [169], 'from': [170, 455], '(BL)': [172], 'modified': [174], 'Total': [175], 'Sharp': [176, 662], 'Score': [177], '(mTSS),': [178], 'space': [180], 'narrowing': [181], '(JSN),': [182], 'erosion': [184], 'scores': [185, 341], '(ES)': [186], 'well': [188], 'proportion': [191, 257], 'no': [195, 261, 313], 'radiographic': [196, 249, 262, 277, 329], '(ΔmTSS': [198], '≤0)': [199], 'Weeks': [201, 236], '24/26': [202], 'determined': [206], 'both': [208, 352, 359], 'RCTs.': [209], 'Data': [210], 'analyzed': [212], 'by': [213, 252, 310], 'linear': [214], 'extrapolation': [215], '(LE)': [216, 296], 'missing': [218], 'data': [219, 434], 'imputation': [220], 'switching,': [223], 'observed': [226, 320, 336], '(AO).': [227], '<h3>Results</h3>': [228], 'BL': [229], 'demographics': [230], 'have': [231], 'been': [232], 'reported': [233], 'previously<sup>2,3</sup>.': [234], 'At': [235], '24/26,': [237], 'significantly': [247], 'measured': [251], 'ΔmTSS': [254], 'vs': [264, 286, 294, 331], 'PBO,': [267], 'respectively': [268], '(LE': [269, 288, 354], 'AO,': [271], '<b>Table</b>).': [272], 'significant': [274], 'inhibition': [275, 327], 'maintained': [282], 'AO)': [290], 'EARLY': [292], 'PBO': [295, 304], 'COMPARE.': [298], 'Following': [299], 'switch': [301], 'all': [303], 'COMPARE': [309], '26,': [312], 'further': [314], 'change': [315], 'mTSS': [318, 340], '(AO,<b>': [324], 'Table</b>).': [325], 'comparators': [332], 'not': [334], 'only': [335], 'overall': [339], 'but': [342], 'also': [343], 'its': [344], 'components': [345], '–': [346], 'JSN': [348], 'ES': [350], 'AO).': [356], '<h3>Conclusion</h3>': [357], 'monotherapy,': [361], 'MTX,': [367], 'effective': [369], 'inhibiting': [371], 'MTX-naïve,': [382], 'patients,': [385], 'respectively.': [386], '<h3>References</h3>': [387], '[1]': [388], 'Smolen': [389], 'JS': [390], 'et': [391, 402, 414], 'al.': [392, 403, 415], 'Ann': [393], 'Rheum': [394], 'Dis': [395], '2017;0:': [396], '1–18.&#xD;': [397], '[2]': [398], 'van': [399], 'Vollenhoven': [400], 'R,': [401, 413], 'Arthritis': [404, 416], 'Rheumatol.': [405, 417], '2018;': [406, 418], '70(suppl': [407], '10)': [408, 421], '[ACR': [409], '2018abstract].': [410], '[3]': [411], 'Fleischmann': [412], '70': [419], '(suppl': [420], '[ACR2018abstract].': [422], '<h3>Acknowledgement</h3>': [423], 'AbbVie,': [424, 470, 532, 535, 567, 578, 591, 604, 614, 640, 659, 670, 686, 718, 721, 736], 'Inc': [425], 'study': [428, 432], 'sponsor,': [429], 'contributed': [430], 'design,': [433], 'collection,': [435], 'analysis,': [436], 'interpretation,': [437], 'writing,': [438], 'reviewing,': [439], 'approval': [441], 'final': [444], 'version': [445], 'abstract.': [448], 'Medical': [449], 'writing': [450], 'support:': [451], 'Siddharth': [452], 'Mukherjee,': [453], 'PhD,': [454], 'Abbvie,': [456], 'Inc.': [457], '<h3>Disclosure': [458], 'Interests</h3>': [460], 'Charles': [461], 'Peterfy': [462], 'Shareholder': [463, 520, 530, 696, 706, 716, 724], 'of:': [464, 497, 521, 525, 531, 534, 697, 701, 707, 711, 717, 720, 725, 729], 'Spire': [465, 498], 'Sciences,': [466, 499], 'Inc,': [467, 500, 523, 527, 542, 553, 586, 599, 622, 652, 699, 703, 709, 713, 727, 731], 'Consultant': [468, 513, 550, 589, 668, 734], 'for:': [469, 514, 551, 590, 669, 735], 'Acerta,': [471], 'Amgen,': [472, 503, 737], 'AstraZeneca,': [473], 'Bristol-Myers': [474, 568, 579, 592, 605, 615, 629, 643, 671], 'Squibb,': [475, 569, 580, 593, 606, 616, 630, 644, 672], 'Centrexion,': [476], 'Daiichi': [477], 'Sankyu,': [478], 'Five': [479], 'Prime': [480], 'Therapeutics,': [481], 'Genentech,': [482], 'Hoffmann-La': [483], 'Roche,': [484, 588, 601, 624], 'Janssen,': [485, 545, 556, 574, 583, 596, 611, 619, 648, 688, 752], 'Lilly': [486], 'USA,': [487], 'MedImmune,': [488], 'Merck,': [489, 755], 'Novartis,': [490, 549, 573, 610, 650, 667, 679, 689, 756], 'Plexxikon,': [491], 'Pfizer,': [492, 546, 557, 572, 609, 660, 680, 690, 757], 'Sanofi,': [493, 633, 761], 'Salix-Santarus,': [494], 'Samsung,': [495, 759], 'Employee': [496, 524, 533, 700, 710, 719, 728], 'Speakers': [501, 602, 612, 627, 684], 'bureau:': [502, 603, 613, 628, 685], 'Mark': [504], 'C.': [505], 'Genovese': [506], 'Grant/research': [507, 538, 564, 575, 637, 656], 'support': [508, 539, 565, 576, 638, 657], 'from:': [509, 540, 566, 577, 639, 658], 'Sanofi/Genzyme,': [510, 515], 'Genentech/Roche,': [511, 516, 748], 'RPharm,': [512, 517], 'In-Ho': [518], 'Song': [519], 'AbbVie': [522, 526, 541, 552, 698, 702, 708, 712, 726, 730], 'Alan': [528], 'Friedman': [529], 'Stephen': [536], 'Hall': [537], 'BMS,': [543, 554, 739], 'Lilly,': [544, 555, 571, 608, 632, 754], 'UCB,': [547, 558, 655], 'Novartis': [560], ',': [561], 'Eduardo': [562], 'Mysler': [563], 'Eli': [570, 581, 594, 607, 617, 631], 'Lily,': [582, 595, 618], 'Medimmune,': [584, 597, 620], 'Pfizer': [585, 598, 621, 651], 'Patrick': [625], 'Durez': [626], 'Celltrion,': [634, 743], 'Xenofon': [635], 'Baraliakos': [636], 'Boehringer': [641, 673, 740], 'Ingelheim,': [642, 674, 741], 'Celgene,': [645, 675, 742], 'Centocor,': [646], 'Chugai,': [647, 676, 687], 'MSD,': [649], 'Roche': [653], 'Merck': [661], '&amp;': [663], 'Dohme,': [664], 'UCB': [665, 681, 691], 'Pharma,': [666, 682, 692], 'Janssen': [677], 'Biologics,': [678], 'Galapagos,': [683], 'Jose': [693], 'Jeffrey': [694], 'Enejosa': [695], 'Tim': [704], 'Shaw': [705], 'Yihan': [714], 'Li': [715], 'Su': [722], 'Chen': [723], 'Vibeke': [732], 'Strand': [733], 'Bayer,': [738], 'CORRONA,': [744], 'Crescendo,': [745], 'EMD': [746], 'Serono,': [747], 'GSK,': [749], 'Horizon,': [750], 'Inmedix,': [751], 'Kezar,': [753], 'Regeneron,': [758], 'Sandoz,': [760], 'Servier,': [762], 'UCB.': [763]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2949948327', 'counts_by_year': [{'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-17T04:37:24.568710', 'created_date': '2019-06-27'}