Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2949924125', 'doi': 'https://doi.org/10.1371/journal.pone.0198307', 'title': 'Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats', 'display_name': 'Renoprotective effects of dexmedetomidine against ischemia-reperfusion injury in streptozotocin-induced diabetic rats', 'publication_year': 2018, 'publication_date': '2018-08-16', 'ids': {'openalex': 'https://openalex.org/W2949924125', 'doi': 'https://doi.org/10.1371/journal.pone.0198307', 'mag': '2949924125', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30114208', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6095484'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0198307', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198307&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198307&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100454638', 'display_name': 'Seung Hyun Kim', 'orcid': 'https://orcid.org/0000-0003-2127-6324'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Seung Hyun Kim', 'raw_affiliation_strings': ['Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I193775966', 'https://openalex.org/I2799970807']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006824750', 'display_name': 'Ji Hae Jun', 'orcid': 'https://orcid.org/0000-0002-8080-0715'}, 'institutions': [{'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Ji Hae Jun', 'raw_affiliation_strings': ['Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031905445', 'display_name': 'Ju Eun Oh', 'orcid': 'https://orcid.org/0000-0001-5774-6346'}, 'institutions': [{'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Ju Eun Oh', 'raw_affiliation_strings': ['Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5008345574', 'display_name': 'Eun-Jung Shin', 'orcid': 'https://orcid.org/0009-0006-2472-3264'}, 'institutions': [{'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Eun-Jung Shin', 'raw_affiliation_strings': ['Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5081928233', 'display_name': 'Young Jun Oh', 'orcid': 'https://orcid.org/0000-0002-6258-5695'}, 'institutions': [{'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}, {'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Young Jun Oh', 'raw_affiliation_strings': ['Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}, {'raw_affiliation_string': 'Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5080094516', 'display_name': 'Yong Seon Choi', 'orcid': 'https://orcid.org/0000-0002-5348-864X'}, 'institutions': [{'id': 'https://openalex.org/I193775966', 'display_name': 'Yonsei University', 'ror': 'https://ror.org/01wjejq96', 'country_code': 'KR', 'type': 'education', 'lineage': ['https://openalex.org/I193775966']}, {'id': 'https://openalex.org/I2799970807', 'display_name': 'Severance Hospital', 'ror': 'https://ror.org/044kjp413', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799970807', 'https://openalex.org/I4210160791']}], 'countries': ['KR'], 'is_corresponding': True, 'raw_author_name': 'Yong Seon Choi', 'raw_affiliation_strings': ['Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea'], 'affiliations': [{'raw_affiliation_string': 'Anesthesia and Pain Research Institute, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I193775966', 'https://openalex.org/I2799970807']}, {'raw_affiliation_string': 'Department of Anesthesiology and Pain Medicine, Severance Hospital, Yonsei University College of Medicine, Seoul, Korea', 'institution_ids': ['https://openalex.org/I2799970807', 'https://openalex.org/I193775966']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5100454638', 'https://openalex.org/A5006824750', 'https://openalex.org/A5031905445', 'https://openalex.org/A5008345574', 'https://openalex.org/A5081928233', 'https://openalex.org/A5080094516'], 'corresponding_institution_ids': ['https://openalex.org/I193775966', 'https://openalex.org/I2799970807', 'https://openalex.org/I2799970807', 'https://openalex.org/I193775966', 'https://openalex.org/I2799970807', 'https://openalex.org/I193775966', 'https://openalex.org/I2799970807', 'https://openalex.org/I193775966', 'https://openalex.org/I2799970807', 'https://openalex.org/I193775966', 'https://openalex.org/I193775966', 'https://openalex.org/I2799970807'], 'apc_list': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'apc_paid': {'value': 1805, 'currency': 'USD', 'value_usd': 1805, 'provenance': 'doaj'}, 'fwci': 2.132, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 19, 'citation_normalized_percentile': {'value': 0.787498, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '13', 'issue': '8', 'first_page': 'e0198307', 'last_page': 'e0198307'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11057', 'display_name': 'Pathophysiology of Myocardial Reperfusion Injury', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11057', 'display_name': 'Pathophysiology of Myocardial Reperfusion Injury', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2734', 'display_name': 'Pathology and Forensic Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10684', 'display_name': 'Management and Outcomes of Acute Kidney Injury', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2727', 'display_name': 'Nephrology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10155', 'display_name': 'Role of Nitric Oxide in Health and Disease', 'score': 0.9976, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/dexmedetomidine', 'display_name': 'Dexmedetomidine', 'score': 0.60392135}, {'id': 'https://openalex.org/keywords/ischemia-reperfusion-injury', 'display_name': 'Ischemia-Reperfusion Injury', 'score': 0.567949}, {'id': 'https://openalex.org/keywords/renal-ischemia', 'display_name': 'Renal ischemia', 'score': 0.5427085}, {'id': 'https://openalex.org/keywords/remote-ischemic-conditioning', 'display_name': 'Remote Ischemic Conditioning', 'score': 0.503599}], 'concepts': [{'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.83974576}, {'id': 'https://openalex.org/C541997718', 'wikidata': 'https://www.wikidata.org/wiki/Q188151', 'display_name': 'Ischemia', 'level': 2, 'score': 0.69296956}, {'id': 'https://openalex.org/C2780114680', 'wikidata': 'https://www.wikidata.org/wiki/Q1413991', 'display_name': 'Reperfusion injury', 'level': 3, 'score': 0.62640184}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.6165503}, {'id': 'https://openalex.org/C2781302539', 'wikidata': 'https://www.wikidata.org/wiki/Q412133', 'display_name': 'Dexmedetomidine', 'level': 3, 'score': 0.60392135}, {'id': 'https://openalex.org/C2779280383', 'wikidata': 'https://www.wikidata.org/wiki/Q257331', 'display_name': 'Streptozotocin', 'level': 3, 'score': 0.57770264}, {'id': 'https://openalex.org/C2780721119', 'wikidata': 'https://www.wikidata.org/wiki/Q7312492', 'display_name': 'Renal ischemia', 'level': 4, 'score': 0.5427085}, {'id': 'https://openalex.org/C2776151105', 'wikidata': 'https://www.wikidata.org/wiki/Q898814', 'display_name': 'Oxidative stress', 'level': 2, 'score': 0.50925696}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.49259335}, {'id': 'https://openalex.org/C2777209026', 'wikidata': 'https://www.wikidata.org/wiki/Q412405', 'display_name': 'Inflammasome', 'level': 3, 'score': 0.48029444}, {'id': 'https://openalex.org/C2778938600', 'wikidata': 'https://www.wikidata.org/wiki/Q389934', 'display_name': 'Agonist', 'level': 3, 'score': 0.4403494}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.39823616}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.39330286}, {'id': 'https://openalex.org/C42219234', 'wikidata': 'https://www.wikidata.org/wiki/Q131130', 'display_name': 'Anesthesia', 'level': 1, 'score': 0.38227546}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.2822785}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.16697699}, {'id': 'https://openalex.org/C2776814716', 'wikidata': 'https://www.wikidata.org/wiki/Q574801', 'display_name': 'Sedation', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D020927', 'descriptor_name': 'Dexmedetomidine', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000098', 'qualifier_name': 'blood supply', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019610', 'descriptor_name': 'Cytoprotection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020927', 'descriptor_name': 'Dexmedetomidine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D003921', 'descriptor_name': 'Diabetes Mellitus, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003928', 'descriptor_name': 'Diabetic Nephropathies', 'qualifier_ui': 'Q000517', 'qualifier_name': 'prevention & control', 'is_major_topic': False}, {'descriptor_ui': 'D006439', 'descriptor_name': 'Hemodynamics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006439', 'descriptor_name': 'Hemodynamics', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D007668', 'descriptor_name': 'Kidney', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018384', 'descriptor_name': 'Oxidative Stress', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051381', 'descriptor_name': 'Rats', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': 'Q000503', 'qualifier_name': 'physiopathology', 'is_major_topic': False}, {'descriptor_ui': 'D015427', 'descriptor_name': 'Reperfusion Injury', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013311', 'descriptor_name': 'Streptozocin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0198307', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198307&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6095484', 'pdf_url': 'https://europepmc.org/articles/pmc6095484?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6095484', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/325894', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30114208', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pone.0198307', 'pdf_url': 'https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0198307&type=printable', 'source': {'id': 'https://openalex.org/S202381698', 'display_name': 'PLoS ONE', 'issn_l': '1932-6203', 'issn': ['1932-6203'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320322120', 'funder_display_name': 'National Research Foundation of Korea', 'award_id': 'NRF2014R1A1A3053428'}], 'datasets': [], 'versions': [], 'referenced_works_count': 33, 'referenced_works': ['https://openalex.org/W1486305617', 'https://openalex.org/W1933832368', 'https://openalex.org/W1975394768', 'https://openalex.org/W1990886132', 'https://openalex.org/W1997778988', 'https://openalex.org/W1999977772', 'https://openalex.org/W2018607502', 'https://openalex.org/W2026113125', 'https://openalex.org/W2035039019', 'https://openalex.org/W2051258088', 'https://openalex.org/W2061541252', 'https://openalex.org/W2063735457', 'https://openalex.org/W2090548255', 'https://openalex.org/W2119085035', 'https://openalex.org/W2123024844', 'https://openalex.org/W2124842151', 'https://openalex.org/W2143009766', 'https://openalex.org/W2155186492', 'https://openalex.org/W2159117338', 'https://openalex.org/W2168160025', 'https://openalex.org/W2169856031', 'https://openalex.org/W2210151709', 'https://openalex.org/W2258464106', 'https://openalex.org/W2300776102', 'https://openalex.org/W2317629072', 'https://openalex.org/W2399675037', 'https://openalex.org/W2542088718', 'https://openalex.org/W2547643921', 'https://openalex.org/W2585288703', 'https://openalex.org/W2619672730', 'https://openalex.org/W2732932829', 'https://openalex.org/W2739003874', 'https://openalex.org/W2753785995'], 'related_works': ['https://openalex.org/W4283651791', 'https://openalex.org/W4226366349', 'https://openalex.org/W3157038629', 'https://openalex.org/W3097570152', 'https://openalex.org/W29610814', 'https://openalex.org/W2951941796', 'https://openalex.org/W2905624574', 'https://openalex.org/W2372612005', 'https://openalex.org/W2166714786', 'https://openalex.org/W2065321766'], 'abstract_inverted_index': {'Background': [0], 'Diabetic': [1], 'patients': [2], 'are': [3, 199], 'susceptible': [4], 'to': [5, 11, 30, 49], 'renal': [6, 31, 96, 124, 154, 196, 219], 'ischemia-reperfusion': [7, 32, 45, 85, 197, 220], 'injury,': [8, 149], 'which': [9], 'leads': [10], 'perioperative': [12], 'complications.': [13], 'Activation': [14], 'of': [15, 26, 58, 94, 193, 213, 218], 'NOD-like': [16], 'receptor': [17], 'protein': [18], '3': [19], '(NLRP3)': [20], 'inflammasome': [21], 'participates': [22], 'in': [23, 61, 89, 138, 174, 195, 201, 215], 'the': [24, 51, 190, 211], 'development': [25], 'diabetes,': [27], 'and': [28, 55, 81, 128, 143, 153, 179, 182, 204], 'contributes': [29], 'injury.': [33, 46, 221], 'Dexmedetomidine': [34], '(DEX),': [35], 'a': [36, 208], 'highly': [37], 'selective': [38], 'α2-adrenoreceptor': [39], 'agonist,': [40], 'shows': [41, 188], 'renoprotective': [42], 'effects': [43, 192], 'against': [44], 'We': [47], 'aimed': [48], 'elucidate': [50], 'effects,': [52], 'underlying': [53], 'mechanisms,': [54], 'optimal': [56], 'timing': [57], 'DEX': [59, 107, 132, 161, 167, 194, 214], 'treatment': [60, 133, 165, 217], 'diabetic': [62, 90, 202], 'rats.': [63], 'Methods': [64], 'Male': [65], 'Sprague-Dawley': [66], 'rats': [67, 91], '(n': [68], '=': [69], '12': [70], 'per': [71], 'group)': [72], 'were': [73, 157], 'randomly': [74], 'divided': [75], 'into': [76], 'normal-sham,': [77], 'diabetes-sham,': [78], 'diabetes-ischemia-reperfusion-control,': [79], 'diabetes-ischemia-reperfusion-DEX-pre-treatment,': [80], 'diabetes-ischemia-reperfusion-DEX-post-treatment': [82], 'groups.': [83], 'Renal': [84], 'injury': [86, 198], 'was': [87, 110, 126, 168], 'induced': [88], 'by': [92, 102, 160], 'occlusion': [93], 'both': [95], 'arteries': [97], 'for': [98, 104, 210], '45': [99], 'min,': [100], 'followed': [101], 'reperfusion': [103, 120], '24': [105], 'h.': [106], '(10': [108], 'μg/kg)': [109], 'administered': [111], 'intraperitoneally': [112], '1': [113], 'h': [114], 'before': [115], 'ischemia': [116, 135], '(pre-treatment)': [117], 'or': [118], 'upon': [119], '(post-treatment).': [121], 'After': [122], 'reperfusion,': [123], 'tissue': [125], 'biochemically': [127], 'histopathologically': [129], 'evaluated.': [130], 'Results': [131], 'attenuated': [134], 'reperfusion-induced': [136], 'increase': [137], 'NLRP3,': [139], 'caspase-1,': [140], 'IL-1β,': [141], 'phospho-AKT,': [142], 'phospho-ERK': [144], 'signaling.': [145], 'Moreover,': [146], 'oxidative': [147, 183], 'stress': [148], 'inflammatory': [150], 'reactions,': [151], 'apoptosis,': [152], 'tubular': [155], 'damage': [156], 'favorably': [158], 'modulated': [159], 'treatment.': [162], 'Furthermore,': [163], 'post-reperfusion': [164], 'with': [166], 'significantly': [169], 'more': [170], 'effective': [171], 'than': [172], 'pre-treatment': [173], 'modulating': [175], 'NLRP3': [176], 'inflammasome,': [177], 'AKT': [178], 'ERK': [180], 'signaling,': [181], 'stress.': [184], 'Conclusions': [185], 'This': [186], 'study': [187], 'that': [189], 'protective': [191], 'preserved': [200], 'conditions': [203], 'may': [205], 'potentially': [206], 'provide': [207], 'basis': [209], 'use': [212], 'clinical': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2949924125', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-09-11T23:29:02.222926', 'created_date': '2019-06-27'}