Title: A novel isotonic-balanced electrolyte solution with 1% glucose for intraoperative fluid therapy in children: results of a prospective multicentre observational post-authorization safety study (PASS)
Abstract: Pediatric AnesthesiaVolume 20, Issue 11 p. 977-981 A novel isotonic-balanced electrolyte solution with 1% glucose for intraoperative fluid therapy in children: results of a prospective multicentre observational post-authorization safety study (PASS) ROBERT SÜMPELMANN MD, PhD, ROBERT SÜMPELMANN MD, PhD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this authorTHOMAS MADER MD, THOMAS MADER MD St. Elisabeth-Krankenhaus, Abteilung für Anästhesie und Intensivmedizin, HalleSearch for more papers by this authorCHRISTOPH EICH MD, PhD, CHRISTOPH EICH MD, PhD Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin, Universitätsmedizin Göttingen, Göttingen, GermanySearch for more papers by this authorLARS WITT MD, LARS WITT MD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this authorWILHELM A. OSTHAUS MD, PhD, WILHELM A. OSTHAUS MD, PhD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this author ROBERT SÜMPELMANN MD, PhD, ROBERT SÜMPELMANN MD, PhD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this authorTHOMAS MADER MD, THOMAS MADER MD St. Elisabeth-Krankenhaus, Abteilung für Anästhesie und Intensivmedizin, HalleSearch for more papers by this authorCHRISTOPH EICH MD, PhD, CHRISTOPH EICH MD, PhD Zentrum Anaesthesiologie, Rettungs- und Intensivmedizin, Universitätsmedizin Göttingen, Göttingen, GermanySearch for more papers by this authorLARS WITT MD, LARS WITT MD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this authorWILHELM A. OSTHAUS MD, PhD, WILHELM A. OSTHAUS MD, PhD Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, HannoverSearch for more papers by this author First published: 22 October 2010 https://doi.org/10.1111/j.1460-9592.2010.03428.xCitations: 43 Robert Sümpelmann, MD, PhD, Medizinische Hochschule Hannover, Klinik für Anästhesiologie und Intensivmedizin-OE 8050, Carl-Neuberg-Str. 1, D-30625 Hannover, Germany (email: [email protected]). Section Editor: Andrew Davidson Read the full textAboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Summary Background: The recommendations for intraoperative fluid therapy in children have been adapted from hypotonic to isotonic electrolyte solutions with lower glucose concentrations (1–2.5% instead of 5%) to avoid hyponatremia and hyperglycemia. Objective: The objective of this prospective multicentre observational post-authorization safety study was to evaluate the intraoperative use of a novel isotonic-balanced electrolyte solution with 1% glucose (BS-G1) with a particular focus on changes in acid–base status, electrolyte and glucose concentrations. Methods: Following local ethics committee approval, pediatric patients aged up to 4 years with an ASA risk score of I–III undergoing intraoperative administration of BS-G1 were enrolled. Patient demographics, the performed procedure, adverse drug reactions, hemodynamic data, and the results of blood gas analysis before and after infusion were documented with a focus on changes in acid–base status, electrolyte and glucose concentrations. Results: In 107 patients (ASA I–III; age 16.2 ± 15.4, range day of birth to 47.7 months; body weight 8.8 ± 4.8, range 1.6–18.8 kg), the mean volume infused was 20 ± 12.6 (range 3.6–83.3) ml·kg−1 BS-G1. During the infusion, hemoglobin, hematocrit, anion gap, strong ion difference, and calcium decreased and chloride and glucose increased significantly within the physiologic range. All other measured parameters including sodium, bicarbonate, base excess, and lactate remained stable. Neither hypoglycemia (glucose <2.5 mmol·l−1) nor hyperglycemia (glucose >10 mmol·l−1) was documented after BS-G1 infusion. No adverse drug reactions were reported. Conclusion: The studied isotonic-balanced electrolyte solution with 1% glucose helps to avoid perioperative acid–base imbalance, hyponatremia, hyperglycemia, and ketoacidosis in infants and toddlers and may therefore enhance patient safety. Citing Literature Volume20, Issue11November 2010Pages 977-981 RelatedInformation
Publication Year: 2010
Publication Date: 2010-10-22
Language: en
Type: article
Indexed In: ['crossref', 'pubmed']
Access and Citation
Cited By Count: 54
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot