Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2949580352', 'doi': 'https://doi.org/10.1101/368746', 'title': 'Myoglianin triggers the pre-metamorphosis stage in hemimetabolan insects', 'display_name': 'Myoglianin triggers the pre-metamorphosis stage in hemimetabolan insects', 'publication_year': 2018, 'publication_date': '2018-07-13', 'ids': {'openalex': 'https://openalex.org/W2949580352', 'doi': 'https://doi.org/10.1101/368746', 'mag': '2949580352'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/368746', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/07/13/368746.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'type': 'preprint', 'type_crossref': 'posted-content', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/07/13/368746.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064063623', 'display_name': 'Orathai Kamsoi', 'orcid': 'https://orcid.org/0000-0002-4245-6554'}, 'institutions': [{'id': 'https://openalex.org/I4210135169', 'display_name': 'Institut de Biologia Evolutiva', 'ror': 'https://ror.org/044mj7r89', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I170486558', 'https://openalex.org/I4210135169']}, {'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Orathai Kamsoi', 'raw_affiliation_strings': ['Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)'], 'affiliations': [{'raw_affiliation_string': 'Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)', 'institution_ids': ['https://openalex.org/I4210135169', 'https://openalex.org/I170486558']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024397445', 'display_name': 'Xavier Bellés', 'orcid': 'https://orcid.org/0000-0002-1566-303X'}, 'institutions': [{'id': 'https://openalex.org/I4210135169', 'display_name': 'Institut de Biologia Evolutiva', 'ror': 'https://ror.org/044mj7r89', 'country_code': 'ES', 'type': 'facility', 'lineage': ['https://openalex.org/I134820265', 'https://openalex.org/I170486558', 'https://openalex.org/I4210135169']}, {'id': 'https://openalex.org/I170486558', 'display_name': 'Pompeu Fabra University', 'ror': 'https://ror.org/04n0g0b29', 'country_code': 'ES', 'type': 'education', 'lineage': ['https://openalex.org/I170486558']}], 'countries': ['ES'], 'is_corresponding': False, 'raw_author_name': 'Xavier Belles', 'raw_affiliation_strings': ['Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)'], 'affiliations': [{'raw_affiliation_string': 'Institute of Evolutionary Biology (CSIC-Universitat Pompeu Fabra)', 'institution_ids': ['https://openalex.org/I4210135169', 'https://openalex.org/I170486558']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 0, 'citation_normalized_percentile': {'value': 0.0, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 0, 'max': 62}, 'biblio': {'volume': None, 'issue': None, 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12001', 'display_name': 'Fossil Insects in Amber', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12001', 'display_name': 'Fossil Insects in Amber', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/1105', 'display_name': 'Ecology, Evolution, Behavior and Systematics'}, 'field': {'id': 'https://openalex.org/fields/11', 'display_name': 'Agricultural and Biological Sciences'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10423', 'display_name': 'Neurobiology and Insect Physiology Research', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10702', 'display_name': 'Insect and Arachnid Ecology and Behavior', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/1311', 'display_name': 'Genetics'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/prothoracic-gland', 'display_name': 'Prothoracic gland', 'score': 0.95316535}, {'id': 'https://openalex.org/keywords/corpus-allatum', 'display_name': 'Corpus allatum', 'score': 0.8838669}, {'id': 'https://openalex.org/keywords/ecdysone-receptor', 'display_name': 'Ecdysone receptor', 'score': 0.6633532}], 'concepts': [{'id': 'https://openalex.org/C47002013', 'wikidata': 'https://www.wikidata.org/wiki/Q7251808', 'display_name': 'Prothoracic gland', 'level': 4, 'score': 0.95316535}, {'id': 'https://openalex.org/C2777180181', 'wikidata': 'https://www.wikidata.org/wiki/Q139085', 'display_name': 'Ecdysone', 'level': 3, 'score': 0.89560205}, {'id': 'https://openalex.org/C104314149', 'wikidata': 'https://www.wikidata.org/wiki/Q2081643', 'display_name': 'Corpus allatum', 'level': 4, 'score': 0.8838669}, {'id': 'https://openalex.org/C71220013', 'wikidata': 'https://www.wikidata.org/wiki/Q419220', 'display_name': 'Juvenile hormone', 'level': 3, 'score': 0.8821378}, {'id': 'https://openalex.org/C136397037', 'wikidata': 'https://www.wikidata.org/wiki/Q33753', 'display_name': 'Metamorphosis', 'level': 3, 'score': 0.8655143}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.7816929}, {'id': 'https://openalex.org/C2777346155', 'wikidata': 'https://www.wikidata.org/wiki/Q18123008', 'display_name': 'Cockroach', 'level': 2, 'score': 0.77019584}, {'id': 'https://openalex.org/C109130350', 'wikidata': 'https://www.wikidata.org/wiki/Q22325789', 'display_name': 'Ecdysone receptor', 'level': 5, 'score': 0.6633532}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.65796566}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.5848365}, {'id': 'https://openalex.org/C32476901', 'wikidata': 'https://www.wikidata.org/wiki/Q2179631', 'display_name': 'Instar', 'level': 3, 'score': 0.5486428}, {'id': 'https://openalex.org/C2777612826', 'wikidata': 'https://www.wikidata.org/wiki/Q1390', 'display_name': 'Insect', 'level': 2, 'score': 0.50480616}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.47715253}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.36000508}, {'id': 'https://openalex.org/C71315377', 'wikidata': 'https://www.wikidata.org/wiki/Q11364', 'display_name': 'Hormone', 'level': 2, 'score': 0.35983813}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.2808365}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.12978795}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12581679}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.09497532}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.084784895}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C63932345', 'wikidata': 'https://www.wikidata.org/wiki/Q422500', 'display_name': 'Nuclear receptor', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/368746', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/07/13/368746.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.201801511r', 'pdf_url': 'https://faseb.onlinelibrary.wiley.com/doi/pdfdirect/10.1096/fj.201801511R', 'source': None, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/368746', 'pdf_url': 'https://www.biorxiv.org/content/biorxiv/early/2018/07/13/368746.full.pdf', 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'score': 0.44, 'id': 'https://metadata.un.org/sdg/15', 'display_name': 'Life on land'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1539107524', 'https://openalex.org/W1969852276', 'https://openalex.org/W1970734250', 'https://openalex.org/W1986231903', 'https://openalex.org/W1991199800', 'https://openalex.org/W2003935374', 'https://openalex.org/W2005404568', 'https://openalex.org/W2008702561', 'https://openalex.org/W2016232806', 'https://openalex.org/W2018294978', 'https://openalex.org/W2032621098', 'https://openalex.org/W2035450796', 'https://openalex.org/W2035982884', 'https://openalex.org/W2040461990', 'https://openalex.org/W2053434076', 'https://openalex.org/W2053610930', 'https://openalex.org/W2058911622', 'https://openalex.org/W2059359550', 'https://openalex.org/W2081993030', 'https://openalex.org/W2083561654', 'https://openalex.org/W2090387776', 'https://openalex.org/W2091318688', 'https://openalex.org/W2092088565', 'https://openalex.org/W2094859123', 'https://openalex.org/W2095975089', 'https://openalex.org/W2097160865', 'https://openalex.org/W2097345042', 'https://openalex.org/W2101621428', 'https://openalex.org/W2103123452', 'https://openalex.org/W2146291151', 'https://openalex.org/W2149976220', 'https://openalex.org/W2171424147', 'https://openalex.org/W2171503771', 'https://openalex.org/W2206874273', 'https://openalex.org/W2250544263', 'https://openalex.org/W2346602210', 'https://openalex.org/W2395115705', 'https://openalex.org/W2496692163', 'https://openalex.org/W2497985779', 'https://openalex.org/W2548046333', 'https://openalex.org/W2807584310', 'https://openalex.org/W4299799362', 'https://openalex.org/W613851713'], 'related_works': ['https://openalex.org/W4388075926', 'https://openalex.org/W2817071602', 'https://openalex.org/W2413482825', 'https://openalex.org/W2389925967', 'https://openalex.org/W2371497524', 'https://openalex.org/W2094384614', 'https://openalex.org/W2088319796', 'https://openalex.org/W2049680616', 'https://openalex.org/W2028465958', 'https://openalex.org/W1973629818'], 'abstract_inverted_index': {'ABSTRACT': [0], 'Insect': [1], 'metamorphosis': [2], 'is': [3, 21, 46], 'triggered': [4], 'by': [5, 99], 'a': [6, 23, 39, 85, 111], 'decrease': [7], 'in': [8, 12, 41, 49, 108, 116, 138, 144, 167, 173], 'juvenile': [9, 15], 'hormone': [10], '(JH)': [11], 'the': [13, 29, 42, 50, 54, 66, 72, 80, 90, 100, 109, 119, 131, 134, 163], 'final': [14], 'instar.': [16], 'What': [17], 'induces': [18], 'this': [19], 'decline': [20], 'therefore': [22], 'very': [24], 'relevant': [25], 'question.': [26], 'Working': [27], 'with': [28], 'cockroach': [30], 'Blattella': [31], 'germanica': [32, 169], ',': [33, 84, 128, 170], 'we': [34], 'found': [35], 'that': [36, 160], 'Myoglianin': [37], '(Myo),': [38], 'ligand': [40], 'TGF-β': [43], 'signaling': [44], 'pathway,': [45], 'highly': [47], 'expressed': [48], 'corpora': [51], 'allata': [52], '(CA,': [53], 'JH': [55, 86, 93], 'producing': [56], 'glands)': [57], 'and': [58, 105, 171], 'prothoracic': [59], 'glands': [60], '(PG,': [61], 'which': [62, 150], 'produce': [63], 'ecdysone)': [64], 'during': [65, 77], 'penultimate': [67], 'nymphal': [68, 165], 'instar': [69, 166], '(N5).': [70], 'In': [71, 89], 'CA,': [73], 'high': [74], 'Myo': [75, 161], 'levels': [76, 94], 'N5': [78, 117, 145], 'repress': [79], 'expression': [81, 115, 120, 142], 'of': [82, 113, 121, 133], 'jhamt': [83], 'biosynthesis': [87, 123], 'gene.': [88], 'PG,': [91, 110], 'decreasing': [92], 'trigger': [95], 'gland': [96], 'degeneration,': [97], 'mediated': [98], 'factors': [101], 'Kr-h1,': [102], 'FTZ-F1,': [103], 'E93': [104], 'IAP1.': [106], 'Also': [107], 'peak': [112, 143], 'myo': [114, 141], 'stimulates': [118], 'ecdysone': [122, 136, 155], 'genes,': [124], 'such': [125], 'as': [126], 'nvd': [127], 'thus': [129], 'enhancing': [130], 'production': [132], 'metamorphic': [135], 'pulse': [137], 'N6.': [139], 'The': [140, 157], 'also': [146], 'represses': [147], 'cell': [148], 'proliferation,': [149], 'can': [151], 'contribute': [152], 'to': [153], 'enhance': [154], 'production.': [156], 'data': [158], 'indicate': [159], 'triggers': [162], 'pre-metamorphic': [164], 'B.': [168], 'possibly': [172], 'other': [174], 'hemimetabolan': [175], 'insects.': [176]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2949580352', 'counts_by_year': [], 'updated_date': '2024-12-11T01:29:13.939500', 'created_date': '2019-06-27'}