Publication Information

{'id': 'https://openalex.org/W2947893479', 'doi': 'https://doi.org/10.1056/nejmoa1903835', 'title': 'Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer', 'display_name': 'Enzalutamide with Standard First-Line Therapy in Metastatic Prostate Cancer', 'publication_year': 2019, 'publication_date': '2019-06-02', 'ids': {'openalex': 'https://openalex.org/W2947893479', 'doi': 'https://doi.org/10.1056/nejmoa1903835', 'mag': '2947893479', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31157964'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1903835', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903835?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903835?articleTools=true', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5064732405', 'display_name': 'Ian D. Davis', 'orcid': 'https://orcid.org/0000-0002-9066-8244'}, 'institutions': [{'id': 'https://openalex.org/I2801239119', 'display_name': 'Australian Regenerative Medicine Institute', 'ror': 'https://ror.org/02qa5kg76', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2801037857', 'https://openalex.org/I2801239119', 'https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I4210098920', 'display_name': 'Eastern Health', 'ror': 'https://ror.org/00vyyx863', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210098920']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Ian D. Davis', 'raw_affiliation_strings': ['Eastern Health', 'Monash University'], 'affiliations': [{'raw_affiliation_string': 'Monash University', 'institution_ids': ['https://openalex.org/I2801239119', 'https://openalex.org/I56590836']}, {'raw_affiliation_string': 'Eastern Health', 'institution_ids': ['https://openalex.org/I4210098920']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024778370', 'display_name': 'Andrew Martin', 'orcid': 'https://orcid.org/0000-0001-5804-2295'}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Andrew J. Martin', 'raw_affiliation_strings': ['Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061757629', 'display_name': 'Martin R. Stockler', 'orcid': 'https://orcid.org/0000-0003-3793-8724'}, 'institutions': [{'id': 'https://openalex.org/I4210093547', 'display_name': 'Chris O’Brien Lifehouse', 'ror': 'https://ror.org/00qeks103', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210093547']}, {'id': 'https://openalex.org/I2800249840', 'display_name': 'Concord Repatriation General Hospital', 'ror': 'https://ror.org/04b0n4406', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800249840']}, {'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Martin R. Stockler', 'raw_affiliation_strings': ["Chris O'Brien Lifehouse", 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'Sydney, Concord Cancer Centre, Concord Repatriation General Hospital, Concord, NSW'], 'affiliations': [{'raw_affiliation_string': "Chris O'Brien Lifehouse", 'institution_ids': ['https://openalex.org/I4210093547']}, {'raw_affiliation_string': 'Sydney, Concord Cancer Centre, Concord Repatriation General Hospital, Concord, NSW', 'institution_ids': ['https://openalex.org/I2800249840']}, {'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076009998', 'display_name': 'Stephen Begbie', 'orcid': 'https://orcid.org/0000-0001-9277-6479'}, 'institutions': [{'id': 'https://openalex.org/I4210145864', 'display_name': 'Port Macquarie Base Hospital', 'ror': 'https://ror.org/04901sx27', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210145864']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Stephen Begbie', 'raw_affiliation_strings': ['Port Macquarie Base Hospital and Mid North Coast Cancer Institute Port Macquarie, Port Macquarie, NSW'], 'affiliations': [{'raw_affiliation_string': 'Port Macquarie Base Hospital and Mid North Coast Cancer Institute Port Macquarie, Port Macquarie, NSW', 'institution_ids': ['https://openalex.org/I4210145864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005231494', 'display_name': 'Kim N.', 'orcid': 'https://orcid.org/0000-0002-3782-7226'}, 'institutions': [{'id': 'https://openalex.org/I141945490', 'display_name': 'University of British Columbia', 'ror': 'https://ror.org/03rmrcq20', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I141945490']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Kim N. Chi', 'raw_affiliation_strings': ['BC Cancer and the University of British Columbia, Vancouver'], 'affiliations': [{'raw_affiliation_string': 'BC Cancer and the University of British Columbia, Vancouver', 'institution_ids': ['https://openalex.org/I141945490']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110735930', 'display_name': 'Simon Chowdhury', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I200166805', 'display_name': "Guy's and St Thomas' NHS Foundation Trust", 'ror': 'https://ror.org/00j161312', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I200166805']}, {'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}, {'id': 'https://openalex.org/I2801316944', 'display_name': 'Cancer Research UK', 'ror': 'https://ror.org/054225q67', 'country_code': 'GB', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2801316944']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon Chowdhury', 'raw_affiliation_strings': ["Guy's and St. Thomas' NHS Foundation Trust Biomedical Research Centre, Cancer Research UK and King's College London, and Sarah Cannon Research UK, London"], 'affiliations': [{'raw_affiliation_string': "Guy's and St. Thomas' NHS Foundation Trust Biomedical Research Centre, Cancer Research UK and King's College London, and Sarah Cannon Research UK, London", 'institution_ids': ['https://openalex.org/I200166805', 'https://openalex.org/I183935753', 'https://openalex.org/I2801316944']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068552855', 'display_name': 'Xanthi Coskinas', 'orcid': 'https://orcid.org/0000-0002-5898-508X'}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Xanthi Coskinas', 'raw_affiliation_strings': ['Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065579020', 'display_name': 'Mark Frydenberg', 'orcid': 'https://orcid.org/0000-0003-4445-3573'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I4210099869', 'display_name': 'Urology Associates', 'ror': 'https://ror.org/011krwa35', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099869']}, {'id': 'https://openalex.org/I2801239119', 'display_name': 'Australian Regenerative Medicine Institute', 'ror': 'https://ror.org/02qa5kg76', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2801037857', 'https://openalex.org/I2801239119', 'https://openalex.org/I56590836']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mark Frydenberg', 'raw_affiliation_strings': ['Australian Urology Associates', 'Monash University'], 'affiliations': [{'raw_affiliation_string': 'Monash University', 'institution_ids': ['https://openalex.org/I56590836', 'https://openalex.org/I2801239119']}, {'raw_affiliation_string': 'Australian Urology Associates', 'institution_ids': ['https://openalex.org/I4210099869']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053122280', 'display_name': 'Wendy Hague', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Wendy E. Hague', 'raw_affiliation_strings': ['Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5084855225', 'display_name': 'Lisa G. Horvath', 'orcid': 'https://orcid.org/0000-0001-6842-9223'}, 'institutions': [{'id': 'https://openalex.org/I2799732068', 'display_name': 'Royal Prince Alfred Hospital', 'ror': 'https://ror.org/05gpvde20', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799732068']}, {'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}, {'id': 'https://openalex.org/I4210093547', 'display_name': 'Chris O’Brien Lifehouse', 'ror': 'https://ror.org/00qeks103', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210093547']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Lisa G. Horvath', 'raw_affiliation_strings': ["Chris O'Brien Lifehouse", 'Royal Prince Alfred Hospital', 'University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Royal Prince Alfred Hospital', 'institution_ids': ['https://openalex.org/I2799732068']}, {'raw_affiliation_string': 'University of Sydney', 'institution_ids': ['https://openalex.org/I129604602']}, {'raw_affiliation_string': "Chris O'Brien Lifehouse", 'institution_ids': ['https://openalex.org/I4210093547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085333470', 'display_name': 'Anthony M. Joshua', 'orcid': 'https://orcid.org/0000-0001-5159-4580'}, 'institutions': [{'id': 'https://openalex.org/I4210087110', 'display_name': "St Vincent's Hospital", 'ror': 'https://ror.org/001kjn539', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087110', 'https://openalex.org/I4210098850']}, {'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210092045', 'display_name': "St. Vincent's Hospital", 'ror': 'https://ror.org/00msb1w96', 'country_code': 'KR', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092045']}, {'id': 'https://openalex.org/I4210091615', 'display_name': "Saint Vincent's Catholic Medical Center", 'ror': 'https://ror.org/00cwrhn79', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210091615']}], 'countries': ['AU', 'KR', 'US'], 'is_corresponding': False, 'raw_author_name': 'Anthony M. Joshua', 'raw_affiliation_strings': ["Kinghorn Cancer Centre, St. Vincent's Hospital, and Garvan Institute of Medical Research"], 'affiliations': [{'raw_affiliation_string': "Kinghorn Cancer Centre, St. Vincent's Hospital, and Garvan Institute of Medical Research", 'institution_ids': ['https://openalex.org/I4210087110', 'https://openalex.org/I136750679', 'https://openalex.org/I4210092045', 'https://openalex.org/I4210091615']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103028589', 'display_name': 'Nicola Jane Lawrence', 'orcid': 'https://orcid.org/0000-0003-1545-1923'}, 'institutions': [{'id': 'https://openalex.org/I2801418622', 'display_name': 'Auckland City Hospital', 'ror': 'https://ror.org/05e8jge82', 'country_code': 'NZ', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801418622', 'https://openalex.org/I4210114327']}], 'countries': ['NZ'], 'is_corresponding': False, 'raw_author_name': 'Nicola J. Lawrence', 'raw_affiliation_strings': ['Auckland City Hospital, Auckland'], 'affiliations': [{'raw_affiliation_string': 'Auckland City Hospital, Auckland', 'institution_ids': ['https://openalex.org/I2801418622']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064106888', 'display_name': 'Gavin Marx', 'orcid': 'https://orcid.org/0000-0002-1016-6544'}, 'institutions': [{'id': 'https://openalex.org/I129604602', 'display_name': 'University of Sydney', 'ror': 'https://ror.org/0384j8v12', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I129604602']}, {'id': 'https://openalex.org/I2799377600', 'display_name': 'Sydney Adventist Hospital', 'ror': 'https://ror.org/00q10wd18', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799377600', 'https://openalex.org/I4210129032']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Gavin Marx', 'raw_affiliation_strings': ['Sydney Adventist Hospital, Wahroonga, NSW', 'University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'University of Sydney', 'institution_ids': ['https://openalex.org/I129604602']}, {'raw_affiliation_string': 'Sydney Adventist Hospital, Wahroonga, NSW', 'institution_ids': ['https://openalex.org/I2799377600']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103187939', 'display_name': 'John McCaffrey', 'orcid': 'https://orcid.org/0000-0002-0179-9067'}, 'institutions': [{'id': 'https://openalex.org/I4210103332', 'display_name': 'Cancer Trials Ireland', 'ror': 'https://ror.org/01dpkyq75', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103332']}, {'id': 'https://openalex.org/I2803071314', 'display_name': 'Mater Misericordiae University Hospital', 'ror': 'https://ror.org/040hqpc16', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2803071314']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'John McCaffrey', 'raw_affiliation_strings': ['Cancer Trials Ireland', 'Mater Misericordiae University Hospital'], 'affiliations': [{'raw_affiliation_string': 'Cancer Trials Ireland', 'institution_ids': ['https://openalex.org/I4210103332']}, {'raw_affiliation_string': 'Mater Misericordiae University Hospital', 'institution_ids': ['https://openalex.org/I2803071314']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006249276', 'display_name': 'Ray McDermott', 'orcid': 'https://orcid.org/0000-0002-8952-4315'}, 'institutions': [{'id': 'https://openalex.org/I100930933', 'display_name': 'University College Dublin', 'ror': 'https://ror.org/05m7pjf47', 'country_code': 'IE', 'type': 'education', 'lineage': ['https://openalex.org/I100930933']}, {'id': 'https://openalex.org/I4210103332', 'display_name': 'Cancer Trials Ireland', 'ror': 'https://ror.org/01dpkyq75', 'country_code': 'IE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210103332']}, {'id': 'https://openalex.org/I4210115218', 'display_name': "St. Vincent's University Hospital", 'ror': 'https://ror.org/029tkqm80', 'country_code': 'IE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210115218']}], 'countries': ['IE'], 'is_corresponding': False, 'raw_author_name': 'Ray McDermott', 'raw_affiliation_strings': ['Cancer Trials Ireland', "St. Vincent's University Hospital and University College Dublin"], 'affiliations': [{'raw_affiliation_string': "St. Vincent's University Hospital and University College Dublin", 'institution_ids': ['https://openalex.org/I100930933', 'https://openalex.org/I4210115218']}, {'raw_affiliation_string': 'Cancer Trials Ireland', 'institution_ids': ['https://openalex.org/I4210103332']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000296685', 'display_name': 'Margaret McJannett', 'orcid': 'https://orcid.org/0009-0000-1640-8068'}, 'institutions': [{'id': 'https://openalex.org/I4210158109', 'display_name': 'Australian and New Zealand Urogenital and Prostate Cancer Trials Group', 'ror': 'https://ror.org/05jtex909', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210158109']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Margaret McJannett', 'raw_affiliation_strings': ['ANZUP Cancer Trials Group, Camperdown, NSW'], 'affiliations': [{'raw_affiliation_string': 'ANZUP Cancer Trials Group, Camperdown, NSW', 'institution_ids': ['https://openalex.org/I4210158109']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061626918', 'display_name': 'Scott North', 'orcid': 'https://orcid.org/0000-0003-4427-5439'}, 'institutions': [{'id': 'https://openalex.org/I2801345345', 'display_name': 'Cancer Institute (WIA)', 'ror': 'https://ror.org/01tc10z29', 'country_code': 'IN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801345345']}, {'id': 'https://openalex.org/I154425047', 'display_name': 'University of Alberta', 'ror': 'https://ror.org/0160cpw27', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I154425047']}], 'countries': ['CA', 'IN'], 'is_corresponding': False, 'raw_author_name': 'Scott A. North', 'raw_affiliation_strings': ['Cross Cancer Institute and the University of Alberta, Edmonton'], 'affiliations': [{'raw_affiliation_string': 'Cross Cancer Institute and the University of Alberta, Edmonton', 'institution_ids': ['https://openalex.org/I2801345345', 'https://openalex.org/I154425047']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111509089', 'display_name': 'Francis Parnis', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5681781', 'display_name': 'University of Adelaide', 'ror': 'https://ror.org/00892tw58', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I5681781']}, {'id': 'https://openalex.org/I4210140852', 'display_name': 'Centre for Cancer Biology', 'ror': 'https://ror.org/03yg7hz06', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I107656453', 'https://openalex.org/I170239107', 'https://openalex.org/I4210140852']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Francis Parnis', 'raw_affiliation_strings': ['Adelaide Cancer Centre and the University of Adelaide'], 'affiliations': [{'raw_affiliation_string': 'Adelaide Cancer Centre and the University of Adelaide', 'institution_ids': ['https://openalex.org/I5681781', 'https://openalex.org/I4210140852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064939755', 'display_name': 'Wendy R. Parulekar', 'orcid': 'https://orcid.org/0000-0002-6007-7494'}, 'institutions': [{'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Wendy Parulekar', 'raw_affiliation_strings': ["Canadian Cancer Trials Group, Queen's University"], 'affiliations': [{'raw_affiliation_string': "Canadian Cancer Trials Group, Queen's University", 'institution_ids': ['https://openalex.org/I204722609']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090641762', 'display_name': 'David Pook', 'orcid': 'https://orcid.org/0000-0002-1744-3022'}, 'institutions': [{'id': 'https://openalex.org/I2801239119', 'display_name': 'Australian Regenerative Medicine Institute', 'ror': 'https://ror.org/02qa5kg76', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I2801037857', 'https://openalex.org/I2801239119', 'https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I4210121067', 'display_name': 'Monash Health', 'ror': 'https://ror.org/02t1bej08', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210121067']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'David W. Pook', 'raw_affiliation_strings': ['Monash Health', 'Monash University'], 'affiliations': [{'raw_affiliation_string': 'Monash University', 'institution_ids': ['https://openalex.org/I2801239119', 'https://openalex.org/I56590836']}, {'raw_affiliation_string': 'Monash Health', 'institution_ids': ['https://openalex.org/I4210121067']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017887586', 'display_name': 'M. Neil Reaume', 'orcid': 'https://orcid.org/0000-0002-9214-222X'}, 'institutions': [{'id': 'https://openalex.org/I4388482656', 'display_name': 'Ottawa Hospital Research Institute', 'ror': 'https://ror.org/05jtef216', 'country_code': None, 'type': 'healthcare', 'lineage': ['https://openalex.org/I153718931', 'https://openalex.org/I2800722420', 'https://openalex.org/I4388482656']}, {'id': 'https://openalex.org/I2800722420', 'display_name': 'Ottawa Hospital', 'ror': 'https://ror.org/03c62dg59', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800722420']}, {'id': 'https://openalex.org/I153718931', 'display_name': 'University of Ottawa', 'ror': 'https://ror.org/03c4mmv16', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I153718931']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'M. Neil Reaume', 'raw_affiliation_strings': ['University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Kingston, ON'], 'affiliations': [{'raw_affiliation_string': 'University of Ottawa and the Ottawa Hospital Research Institute, Ottawa, Kingston, ON', 'institution_ids': ['https://openalex.org/I4388482656', 'https://openalex.org/I2800722420', 'https://openalex.org/I153718931']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064026461', 'display_name': 'Shahneen Sandhu', 'orcid': 'https://orcid.org/0000-0002-8660-4475'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Shahneen K. Sandhu', 'raw_affiliation_strings': ['Peter MacCallum Cancer Centre and the University of Melbourne'], 'affiliations': [{'raw_affiliation_string': 'Peter MacCallum Cancer Centre and the University of Melbourne', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091618780', 'display_name': 'Alvin Tan', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Alvin Tan', 'raw_affiliation_strings': ['Waikato District Health Board, Hamilton'], 'affiliations': [{'raw_affiliation_string': 'Waikato District Health Board, Hamilton', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110503703', 'display_name': 'Thean Hsiang Tan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1320133117', 'display_name': 'Royal Adelaide Hospital', 'ror': 'https://ror.org/00carf720', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1320133117', 'https://openalex.org/I4392738059']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'T. Hsiang Tan', 'raw_affiliation_strings': ['Royal Adelaide Hospital'], 'affiliations': [{'raw_affiliation_string': 'Royal Adelaide Hospital', 'institution_ids': ['https://openalex.org/I1320133117']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5010277875', 'display_name': 'Alastair Thomson', 'orcid': 'https://orcid.org/0000-0001-6666-1088'}, 'institutions': [{'id': 'https://openalex.org/I2799759729', 'display_name': 'Royal Cornwall Hospital', 'ror': 'https://ror.org/00cfdk448', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799477489', 'https://openalex.org/I2799759729']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Alastair Thomson', 'raw_affiliation_strings': ['Royal Cornwall Hospital, Truro'], 'affiliations': [{'raw_affiliation_string': 'Royal Cornwall Hospital, Truro', 'institution_ids': ['https://openalex.org/I2799759729']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5109254781', 'display_name': 'Emily Tu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Emily Tu', 'raw_affiliation_strings': ['Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021202830', 'display_name': 'Francisco E. Vera‐Badillo', 'orcid': 'https://orcid.org/0000-0003-1068-3258'}, 'institutions': [{'id': 'https://openalex.org/I4210156381', 'display_name': 'Kingston Health Sciences Centre', 'ror': 'https://ror.org/05bwaty49', 'country_code': 'CA', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210156381']}, {'id': 'https://openalex.org/I204722609', 'display_name': "Queen's University", 'ror': 'https://ror.org/02y72wh86', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I204722609']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Francisco Vera-Badillo', 'raw_affiliation_strings': ["Canadian Cancer Trials Group, Queen's University", 'Kingston Health Sciences Center'], 'affiliations': [{'raw_affiliation_string': 'Kingston Health Sciences Center', 'institution_ids': ['https://openalex.org/I4210156381']}, {'raw_affiliation_string': "Canadian Cancer Trials Group, Queen's University", 'institution_ids': ['https://openalex.org/I204722609']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082622296', 'display_name': 'Scott Williams', 'orcid': 'https://orcid.org/0000-0002-1357-0884'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Scott G. Williams', 'raw_affiliation_strings': ['Peter MacCallum Cancer Centre and the University of Melbourne'], 'affiliations': [{'raw_affiliation_string': 'Peter MacCallum Cancer Centre and the University of Melbourne', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I165779595']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003030864', 'display_name': 'Sonia Yip', 'orcid': 'https://orcid.org/0009-0001-2574-487X'}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Sonia Yip', 'raw_affiliation_strings': ['Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079624958', 'display_name': 'Alison Y. Zhang', 'orcid': 'https://orcid.org/0000-0002-1902-6863'}, 'institutions': [{'id': 'https://openalex.org/I42131985', 'display_name': 'National Health and Medical Research Council', 'ror': 'https://ror.org/011kf5r70', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I2801453606', 'https://openalex.org/I3149551504', 'https://openalex.org/I42131985']}, {'id': 'https://openalex.org/I99043593', 'display_name': 'Macquarie University', 'ror': 'https://ror.org/01sf06y89', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I99043593']}, {'id': 'https://openalex.org/I4210093547', 'display_name': 'Chris O’Brien Lifehouse', 'ror': 'https://ror.org/00qeks103', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210093547']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alison Y. Zhang', 'raw_affiliation_strings': ["Chris O'Brien Lifehouse", 'Macquarie University', 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney'], 'affiliations': [{'raw_affiliation_string': 'Melbourne, VIC, the National Health and Medical Research Council Clinical Trials Centre, University of Sydney', 'institution_ids': ['https://openalex.org/I42131985']}, {'raw_affiliation_string': 'Macquarie University', 'institution_ids': ['https://openalex.org/I99043593']}, {'raw_affiliation_string': "Chris O'Brien Lifehouse", 'institution_ids': ['https://openalex.org/I4210093547']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021031069', 'display_name': 'Robert Zielinski', 'orcid': 'https://orcid.org/0000-0002-4807-8523'}, 'institutions': [{'id': 'https://openalex.org/I63525965', 'display_name': 'Western Sydney University', 'ror': 'https://ror.org/03t52dk35', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I63525965']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Robert R. Zielinski', 'raw_affiliation_strings': ['Adelaide, SA, and Orange Health Service, Central West Cancer Care Centre, Orange, NSW', 'Western Sydney University'], 'affiliations': [{'raw_affiliation_string': 'Western Sydney University', 'institution_ids': ['https://openalex.org/I63525965']}, {'raw_affiliation_string': 'Adelaide, SA, and Orange Health Service, Central West Cancer Care Centre, Orange, NSW', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002909668', 'display_name': 'Christopher J. Sweeney', 'orcid': 'https://orcid.org/0000-0002-0398-6018'}, 'institutions': [{'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Christopher J. Sweeney', 'raw_affiliation_strings': ['Dana–Farber Cancer Institute and Harvard Medical School'], 'affiliations': [{'raw_affiliation_string': 'Dana–Farber Cancer Institute and Harvard Medical School', 'institution_ids': ['https://openalex.org/I4210117453', 'https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 8, 'institutions_distinct_count': 43, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 146.718, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 1213, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '381', 'issue': '2', 'first_page': '121', 'last_page': '131'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10543', 'display_name': 'Prostate Cancer Treatment and Research', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10124', 'display_name': 'Prostate Cancer Diagnosis and Treatment', 'score': 0.9863, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11395', 'display_name': 'Radiopharmaceutical Chemistry and Applications', 'score': 0.9854, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.9645345}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.6457015}, {'id': 'https://openalex.org/keywords/progression-free-survival', 'display_name': 'Progression-free survival', 'score': 0.46667612}, {'id': 'https://openalex.org/keywords/discontinuation', 'display_name': 'Discontinuation', 'score': 0.45466393}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.9645345}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.8096595}, {'id': 'https://openalex.org/C207103383', 'wikidata': 'https://www.wikidata.org/wiki/Q3930246', 'display_name': 'Hazard ratio', 'level': 3, 'score': 0.80374694}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.74669766}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.6457015}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.64109457}, {'id': 'https://openalex.org/C143998085', 'wikidata': 'https://www.wikidata.org/wiki/Q162555', 'display_name': 'Oncology', 'level': 1, 'score': 0.5489033}, {'id': 'https://openalex.org/C2781190966', 'wikidata': 'https://www.wikidata.org/wiki/Q420436', 'display_name': 'Docetaxel', 'level': 3, 'score': 0.49364173}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.49019414}, {'id': 'https://openalex.org/C2780739268', 'wikidata': 'https://www.wikidata.org/wiki/Q2112244', 'display_name': 'Progression-free survival', 'level': 3, 'score': 0.46667612}, {'id': 'https://openalex.org/C2778715236', 'wikidata': 'https://www.wikidata.org/wiki/Q55622662', 'display_name': 'Discontinuation', 'level': 2, 'score': 0.45466393}, {'id': 'https://openalex.org/C2777899217', 'wikidata': 'https://www.wikidata.org/wiki/Q4759439', 'display_name': 'Androgen deprivation therapy', 'level': 4, 'score': 0.43039915}, {'id': 'https://openalex.org/C2779322244', 'wikidata': 'https://www.wikidata.org/wiki/Q574820', 'display_name': 'Antiandrogen', 'level': 4, 'score': 0.41725942}, {'id': 'https://openalex.org/C44249647', 'wikidata': 'https://www.wikidata.org/wiki/Q208498', 'display_name': 'Confidence interval', 'level': 2, 'score': 0.41713026}, {'id': 'https://openalex.org/C168563851', 'wikidata': 'https://www.wikidata.org/wiki/Q1436668', 'display_name': 'Randomized controlled trial', 'level': 2, 'score': 0.3585046}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.33009148}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.17795593}, {'id': 'https://openalex.org/C3019894029', 'wikidata': 'https://www.wikidata.org/wiki/Q332823', 'display_name': 'Overall survival', 'level': 2, 'score': 0.17370886}], 'mesh': [{'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': True}, {'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000031', 'qualifier_name': 'analogs & derivatives', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000230', 'descriptor_name': 'Adenocarcinoma', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059002', 'descriptor_name': 'Androgen Receptor Antagonists', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000971', 'descriptor_name': 'Antineoplastic Combined Chemotherapy Protocols', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D001859', 'descriptor_name': 'Bone Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D004067', 'descriptor_name': 'Digestive System Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004067', 'descriptor_name': 'Digestive System Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': False}, {'descriptor_ui': 'D004067', 'descriptor_name': 'Digestive System Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D005221', 'descriptor_name': 'Fatigue', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005221', 'descriptor_name': 'Fatigue', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}, {'descriptor_ui': 'D005500', 'descriptor_name': 'Follow-Up Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D053208', 'descriptor_name': 'Kaplan-Meier Estimate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': False}, {'descriptor_ui': 'D010669', 'descriptor_name': 'Phenylthiohydantoin', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000077982', 'descriptor_name': 'Progression-Free Survival', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000401', 'qualifier_name': 'mortality', 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012640', 'descriptor_name': 'Seizures', 'qualifier_ui': 'Q000139', 'qualifier_name': 'chemically induced', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1903835', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903835?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31157964', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1056/nejmoa1903835', 'pdf_url': 'https://www.nejm.org/doi/pdf/10.1056/NEJMoa1903835?articleTools=true', 'source': {'id': 'https://openalex.org/S62468778', 'display_name': 'New England Journal of Medicine', 'issn_l': '0028-4793', 'issn': ['0028-4793', '1533-4406'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320239', 'host_organization_name': 'Massachusetts Medical Society', 'host_organization_lineage': ['https://openalex.org/P4310320239'], 'host_organization_lineage_names': ['Massachusetts Medical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.83, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320307769', 'funder_display_name': 'Astellas Pharma US', 'award_id': None}, {'funder': 'https://openalex.org/F4320320118', 'funder_display_name': 'Canadian Cancer Society', 'award_id': '704970'}, {'funder': 'https://openalex.org/F4320320501', 'funder_display_name': 'Cancer Australia', 'award_id': 'Support for Cancer Clinical Trials Program'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': 'Program Grants 1037786 and 1150467'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': 'Practitioner Fellowship APP1102604'}], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1997468904', 'https://openalex.org/W2019607817', 'https://openalex.org/W2030780868', 'https://openalex.org/W2100471642', 'https://openalex.org/W2120292596', 'https://openalex.org/W2142466432', 'https://openalex.org/W2148643283', 'https://openalex.org/W2150865892', 'https://openalex.org/W2166918329', 'https://openalex.org/W2167331614', 'https://openalex.org/W2178183066', 'https://openalex.org/W2210989209', 'https://openalex.org/W2214621962', 'https://openalex.org/W2464502417', 'https://openalex.org/W2620746860', 'https://openalex.org/W2620798309', 'https://openalex.org/W2787804990', 'https://openalex.org/W2788160989', 'https://openalex.org/W2788841415', 'https://openalex.org/W2898446483', 'https://openalex.org/W3014472365', 'https://openalex.org/W3022934276', 'https://openalex.org/W3023359653', 'https://openalex.org/W3023820492', 'https://openalex.org/W3024601170'], 'related_works': ['https://openalex.org/W4400163990', 'https://openalex.org/W4250573295', 'https://openalex.org/W4243340328', 'https://openalex.org/W3169367773', 'https://openalex.org/W2665384252', 'https://openalex.org/W2616956194', 'https://openalex.org/W2567523803', 'https://openalex.org/W2515537233', 'https://openalex.org/W2134988422', 'https://openalex.org/W2094236169'], 'abstract_inverted_index': {'Enzalutamide,': [0], 'an': [1], 'androgen-receptor': [2], 'inhibitor,': [3], 'has': [4], 'been': [5], 'associated': [6, 247], 'with': [7, 13, 27, 37, 164, 248, 260, 285], 'improved': [8], 'overall': [9, 72, 137, 253], 'survival': [10, 34, 79, 138, 172, 186, 254], 'in': [11, 35, 110, 117, 148, 158, 169, 183, 205, 210, 224, 230, 233, 239, 242, 258], 'men': [12, 36, 97, 259], 'castration-resistant': [14], 'prostate': [15, 40, 263], 'cancer.': [16], 'It': [17], 'is': [18], 'not': [19], 'known': [20], 'whether': [21], 'adding': [22], 'enzalutamide': [23, 58, 112, 150, 165, 207, 226, 235, 269], 'to': [24, 51, 129, 199], 'testosterone': [25, 53, 266], 'suppression,': [26], 'or': [28, 59], 'without': [29], 'early': [30, 286], 'docetaxel,': [31], 'will': [32], 'improve': [33], 'metastatic,': [38, 261], 'hormone-sensitive': [39, 262], 'cancer.In': [41], 'this': [42], 'open-label,': [43], 'randomized,': [44], 'phase': [45], '3': [46, 140], 'trial,': [47], 'we': [48], 'assigned': [49], 'patients': [50, 232, 241], 'receive': [52], 'suppression': [54], 'plus': [55], 'either': [56], 'open-label': [57], 'a': [60, 272], 'standard': [61, 256], 'nonsteroidal': [62], 'antiandrogen': [63], 'therapy': [64], '(standard-care': [65], 'group).': [66], 'The': [67, 268], 'primary': [68], 'end': [69, 75], 'point': [70], 'was': [71, 103, 202, 221, 246], 'survival.': [73], 'Secondary': [74], 'points': [76], 'included': [77], 'progression-free': [78, 89, 171, 185, 251], 'as': [80], 'determined': [81], 'by': [82, 289], 'the': [83, 100, 111, 118, 149, 159, 206, 211, 225, 234, 243], 'prostate-specific': [84], 'antigen': [85], '(PSA)': [86], 'level,': [87], 'clinical': [88, 184], 'survival,': [90], 'and': [91, 114, 152, 174, 182, 188, 216, 238, 252, 277, 292, 295, 306], 'adverse': [92, 200], 'events.A': [93], 'total': [94], 'of': [95, 136, 275], '1125': [96], 'underwent': [98], 'randomization;': [99], 'median': [101], 'follow-up': [102], '34': [104], 'months.': [105], 'There': [106], 'were': [107, 142, 166], '102': [108], 'deaths': [109, 116], 'group': [113, 120, 151, 208, 213, 236, 270], '143': [115], 'standard-care': [119, 160, 212, 244], '(hazard': [121], 'ratio,': [122, 179, 193], '0.67;': [123], '95%': [124], 'confidence': [125], 'interval': [126], '[CI],': [127], '0.52': [128], '0.86;': [130], 'P': [131], '=': [132], '0.002).': [133], 'Kaplan-Meier': [134], 'estimates': [135], 'at': [139], 'years': [141], '80%': [143], '(based': [144, 154], 'on': [145, 155], '94': [146], 'events)': [147, 157], '72%': [153], '130': [156], 'group.': [161], 'Better': [162], 'results': [163], 'also': [167], 'seen': [168], 'PSA': [170], '(174': [173], '333': [175], 'events,': [176, 190, 218], 'respectively;': [177, 191], 'hazard': [178, 192], '0.39;': [180], 'P<0.001)': [181], '(167': [187], '320': [189], '0.40;': [194], 'P<0.001).': [195], 'Treatment': [196], 'discontinuation': [197], 'due': [198], 'events': [201, 215], 'more': [203, 222], 'frequent': [204], 'than': [209, 255], '(33': [214], '14': [217], 'respectively).': [219], 'Fatigue': [220], 'common': [223], 'group;': [227], 'seizures': [228, 276], 'occurred': [229], '7': [231], '(1%)': [237], 'no': [240], 'group.Enzalutamide': [245], 'significantly': [249], 'longer': [250], 'care': [257], 'cancer': [264], 'receiving': [265], 'suppression.': [267], 'had': [271], 'higher': [273], 'incidence': [274], 'other': [278], 'toxic': [279], 'effects,': [280], 'especially': [281], 'among': [282], 'those': [283], 'treated': [284], 'docetaxel.': [287], '(Funded': [288], 'Astellas': [290], 'Scientific': [291], 'Medical': [293], 'Affairs': [294], 'others;': [296], 'ENZAMET': [297], '(ANZUP': [298], '1304)': [299], 'ANZCTR': [300], 'number,': [301, 304, 311], 'ACTRN12614000110684;': [302], 'ClinicalTrials.gov': [303], 'NCT02446405;': [305], 'EU': [307], 'Clinical': [308], 'Trials': [309], 'Register': [310], '2014-003190-42.).': [312]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2947893479', 'counts_by_year': [{'year': 2024, 'cited_by_count': 204}, {'year': 2023, 'cited_by_count': 222}, {'year': 2022, 'cited_by_count': 272}, {'year': 2021, 'cited_by_count': 256}, {'year': 2020, 'cited_by_count': 193}, {'year': 2019, 'cited_by_count': 51}, {'year': 2018, 'cited_by_count': 1}, {'year': 2017, 'cited_by_count': 1}], 'updated_date': '2024-12-15T08:29:50.391135', 'created_date': '2019-06-07'}