Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2947068622', 'doi': 'https://doi.org/10.1371/journal.pntd.0007432', 'title': 'Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti', 'display_name': 'Molecular evidence of sequential evolution of DDT- and pyrethroid-resistant sodium channel in Aedes aegypti', 'publication_year': 2019, 'publication_date': '2019-06-03', 'ids': {'openalex': 'https://openalex.org/W2947068622', 'doi': 'https://doi.org/10.1371/journal.pntd.0007432', 'mag': '2947068622', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31158225', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6564045'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0007432', 'pdf_url': 'https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007432&type=printable', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007432&type=printable', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5101889704', 'display_name': 'Mengli Chen', 'orcid': 'https://orcid.org/0000-0001-8262-8827'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}, {'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN', 'US'], 'is_corresponding': True, 'raw_author_name': 'Mengli Chen', 'raw_affiliation_strings': ['Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'institution_ids': ['https://openalex.org/I87216513']}, {'raw_affiliation_string': 'Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042155000', 'display_name': 'Yuzhe Du', 'orcid': 'https://orcid.org/0000-0001-6896-922X'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yuzhe Du', 'raw_affiliation_strings': ['Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'institution_ids': ['https://openalex.org/I87216513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5044032111', 'display_name': 'Shaoying Wu', 'orcid': 'https://orcid.org/0000-0003-4695-5390'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Shaoying Wu', 'raw_affiliation_strings': ['Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'institution_ids': ['https://openalex.org/I87216513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5104706426', 'display_name': 'Yoshiko Nomura', 'orcid': 'https://orcid.org/0000-0001-6021-0542'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Yoshiko Nomura', 'raw_affiliation_strings': ['Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'institution_ids': ['https://openalex.org/I87216513']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100858585', 'display_name': 'Guonian Zhu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I76130692', 'display_name': 'Zhejiang University', 'ror': 'https://ror.org/00a2xv884', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I76130692']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Guonian Zhu', 'raw_affiliation_strings': ['Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China'], 'affiliations': [{'raw_affiliation_string': 'Institute of Pesticide and Environmental Toxicology, Zhejiang University, Hangzhou, China', 'institution_ids': ['https://openalex.org/I76130692']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088059071', 'display_name': 'Boris S. Zhorov', 'orcid': 'https://orcid.org/0000-0002-3630-7114'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}, {'id': 'https://openalex.org/I163234304', 'display_name': 'Institute of Evolutionary Physiology and Biochemistry', 'ror': 'https://ror.org/02vf4sk45', 'country_code': 'RU', 'type': 'facility', 'lineage': ['https://openalex.org/I1313323035', 'https://openalex.org/I163234304', 'https://openalex.org/I4210115279']}], 'countries': ['CA', 'RU'], 'is_corresponding': True, 'raw_author_name': 'Boris S. Zhorov', 'raw_affiliation_strings': ['Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada', 'Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia'], 'affiliations': [{'raw_affiliation_string': 'Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732']}, {'raw_affiliation_string': 'Sechenov Institute of Evolutionary Physiology & Biochemistry, Russian Academy of Sciences, St. Petersburg, Russia', 'institution_ids': ['https://openalex.org/I163234304']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5029077264', 'display_name': 'Ke Dong', 'orcid': 'https://orcid.org/0000-0002-9773-6350'}, 'institutions': [{'id': 'https://openalex.org/I87216513', 'display_name': 'Michigan State University', 'ror': 'https://ror.org/05hs6h993', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I87216513']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Ke Dong', 'raw_affiliation_strings': ['Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America'], 'affiliations': [{'raw_affiliation_string': 'Department of Entomology, Genetics and Neuroscience Programs, Michigan State University, East Lansing, United States of America', 'institution_ids': ['https://openalex.org/I87216513']}]}], 'institution_assertions': [], 'countries_distinct_count': 4, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5101889704', 'https://openalex.org/A5042155000', 'https://openalex.org/A5044032111', 'https://openalex.org/A5104706426', 'https://openalex.org/A5100858585', 'https://openalex.org/A5088059071', 'https://openalex.org/A5029077264'], 'corresponding_institution_ids': ['https://openalex.org/I87216513', 'https://openalex.org/I76130692', 'https://openalex.org/I87216513', 'https://openalex.org/I87216513', 'https://openalex.org/I87216513', 'https://openalex.org/I76130692', 'https://openalex.org/I98251732', 'https://openalex.org/I163234304', 'https://openalex.org/I87216513'], 'apc_list': {'value': 2495, 'currency': 'USD', 'value_usd': 2495, 'provenance': 'doaj'}, 'apc_paid': {'value': 2495, 'currency': 'USD', 'value_usd': 2495, 'provenance': 'doaj'}, 'fwci': 9.856, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 61, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '13', 'issue': '6', 'first_page': 'e0007432', 'last_page': 'e0007432'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10091', 'display_name': 'Malaria Research and Control', 'score': 0.9962, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11075', 'display_name': 'Insect Resistance and Genetics', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/knockdown-resistance', 'display_name': 'Knockdown resistance', 'score': 0.88641596}], 'concepts': [{'id': 'https://openalex.org/C2776035571', 'wikidata': 'https://www.wikidata.org/wiki/Q745766', 'display_name': 'Pyrethroid', 'level': 3, 'score': 0.93112123}, {'id': 'https://openalex.org/C2780211283', 'wikidata': 'https://www.wikidata.org/wiki/Q6422844', 'display_name': 'Knockdown resistance', 'level': 5, 'score': 0.88641596}, {'id': 'https://openalex.org/C2777553912', 'wikidata': 'https://www.wikidata.org/wiki/Q422257', 'display_name': 'Deltamethrin', 'level': 3, 'score': 0.8837631}, {'id': 'https://openalex.org/C2777775583', 'wikidata': 'https://www.wikidata.org/wiki/Q1148004', 'display_name': 'Aedes aegypti', 'level': 3, 'score': 0.8523697}, {'id': 'https://openalex.org/C50952357', 'wikidata': 'https://www.wikidata.org/wiki/Q424960', 'display_name': 'Sodium channel', 'level': 3, 'score': 0.8173052}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.65967906}, {'id': 'https://openalex.org/C2779752676', 'wikidata': 'https://www.wikidata.org/wiki/Q411635', 'display_name': 'Permethrin', 'level': 3, 'score': 0.6274723}, {'id': 'https://openalex.org/C143065580', 'wikidata': 'https://www.wikidata.org/wiki/Q3285695', 'display_name': 'Mutant', 'level': 3, 'score': 0.49704674}, {'id': 'https://openalex.org/C33070731', 'wikidata': 'https://www.wikidata.org/wiki/Q7218', 'display_name': 'Toxicology', 'level': 1, 'score': 0.46344283}, {'id': 'https://openalex.org/C537181965', 'wikidata': 'https://www.wikidata.org/wiki/Q658', 'display_name': 'Sodium', 'level': 2, 'score': 0.3646061}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.3572355}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.3403004}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.27019355}, {'id': 'https://openalex.org/C161176658', 'wikidata': 'https://www.wikidata.org/wiki/Q131656', 'display_name': 'Pesticide', 'level': 2, 'score': 0.25272197}, {'id': 'https://openalex.org/C59822182', 'wikidata': 'https://www.wikidata.org/wiki/Q441', 'display_name': 'Botany', 'level': 1, 'score': 0.12356663}, {'id': 'https://openalex.org/C173758957', 'wikidata': 'https://www.wikidata.org/wiki/Q129270', 'display_name': 'Larva', 'level': 2, 'score': 0.09714177}, {'id': 'https://openalex.org/C2778635518', 'wikidata': 'https://www.wikidata.org/wiki/Q61641151', 'display_name': 'Cyfluthrin', 'level': 4, 'score': 0.06695455}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06395692}, {'id': 'https://openalex.org/C18903297', 'wikidata': 'https://www.wikidata.org/wiki/Q7150', 'display_name': 'Ecology', 'level': 1, 'score': 0.060609132}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D003634', 'descriptor_name': 'DDT', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D019143', 'descriptor_name': 'Evolution, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007305', 'descriptor_name': 'Insecticide Resistance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007306', 'descriptor_name': 'Insecticides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011722', 'descriptor_name': 'Pyrethrins', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000330', 'descriptor_name': 'Aedes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019943', 'descriptor_name': 'Amino Acid Substitution', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002478', 'descriptor_name': 'Cells, Cultured', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003634', 'descriptor_name': 'DDT', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015870', 'descriptor_name': 'Gene Expression', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007306', 'descriptor_name': 'Insecticides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000072138', 'descriptor_name': 'Mosquito Vectors', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000072138', 'descriptor_name': 'Mosquito Vectors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000072138', 'descriptor_name': 'Mosquito Vectors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050505', 'descriptor_name': 'Mutant Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020125', 'descriptor_name': 'Mutation, Missense', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011722', 'descriptor_name': 'Pyrethrins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D015222', 'descriptor_name': 'Sodium Channels', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014981', 'descriptor_name': 'Xenopus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0007432', 'pdf_url': 'https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007432&type=printable', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/f3696c7e4480469493d80346883c7f1b', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6564045', 'pdf_url': 'https://europepmc.org/articles/pmc6564045?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6564045', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31158225', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1371/journal.pntd.0007432', 'pdf_url': 'https://journals.plos.org/plosntds/article/file?id=10.1371/journal.pntd.0007432&type=printable', 'source': {'id': 'https://openalex.org/S46544255', 'display_name': 'PLoS neglected tropical diseases', 'issn_l': '1935-2727', 'issn': ['1935-2727', '1935-2735'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315706', 'host_organization_name': 'Public Library of Science', 'host_organization_lineage': ['https://openalex.org/P4310315706'], 'host_organization_lineage_names': ['Public Library of Science'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320321079', 'funder_display_name': 'Russian Foundation for Basic Research', 'award_id': '17-04-00549'}, {'funder': 'https://openalex.org/F4320335443', 'funder_display_name': 'Postdoctoral Research Foundation of China', 'award_id': '2017M621946'}, {'funder': 'https://openalex.org/F4320337354', 'funder_display_name': 'National Institute of General Medical Sciences', 'award_id': 'R01GM115475'}], 'datasets': [], 'versions': [], 'referenced_works_count': 69, 'referenced_works': ['https://openalex.org/W1502029758', 'https://openalex.org/W1839046251', 'https://openalex.org/W1979403170', 'https://openalex.org/W1982038156', 'https://openalex.org/W1988272966', 'https://openalex.org/W1993012916', 'https://openalex.org/W2007930273', 'https://openalex.org/W2010969866', 'https://openalex.org/W2015664193', 'https://openalex.org/W2016810759', 'https://openalex.org/W2019834558', 'https://openalex.org/W2023162642', 'https://openalex.org/W2023270829', 'https://openalex.org/W2027003482', 'https://openalex.org/W2027284191', 'https://openalex.org/W2038267430', 'https://openalex.org/W2040732710', 'https://openalex.org/W2040766687', 'https://openalex.org/W2058087381', 'https://openalex.org/W2059205340', 'https://openalex.org/W2064289452', 'https://openalex.org/W2074903656', 'https://openalex.org/W2076059917', 'https://openalex.org/W2100813531', 'https://openalex.org/W2101288752', 'https://openalex.org/W2101769407', 'https://openalex.org/W2104162362', 'https://openalex.org/W2106523433', 'https://openalex.org/W2110976836', 'https://openalex.org/W2111344124', 'https://openalex.org/W2118432293', 'https://openalex.org/W2119441209', 'https://openalex.org/W2119819266', 'https://openalex.org/W2125067724', 'https://openalex.org/W2128489222', 'https://openalex.org/W2130565605', 'https://openalex.org/W2135572133', 'https://openalex.org/W2161273195', 'https://openalex.org/W2163151214', 'https://openalex.org/W2163820632', 'https://openalex.org/W2168653390', 'https://openalex.org/W2175074924', 'https://openalex.org/W2183672795', 'https://openalex.org/W2188444587', 'https://openalex.org/W2195165660', 'https://openalex.org/W2280220883', 'https://openalex.org/W2285279013', 'https://openalex.org/W2333253878', 'https://openalex.org/W2465934898', 'https://openalex.org/W2473014184', 'https://openalex.org/W2542372422', 'https://openalex.org/W2587120326', 'https://openalex.org/W2588940923', 'https://openalex.org/W2603006155', 'https://openalex.org/W2606667865', 'https://openalex.org/W2736600747', 'https://openalex.org/W2768752679', 'https://openalex.org/W2792953553', 'https://openalex.org/W2805071219', 'https://openalex.org/W2877681630', 'https://openalex.org/W2904547943', 'https://openalex.org/W2917389701', 'https://openalex.org/W2994718838', 'https://openalex.org/W3016624862', 'https://openalex.org/W3023109461', 'https://openalex.org/W3023230768', 'https://openalex.org/W4231548197', 'https://openalex.org/W4240712239', 'https://openalex.org/W4250208619'], 'related_works': ['https://openalex.org/W991097398', 'https://openalex.org/W4298233413', 'https://openalex.org/W3200419880', 'https://openalex.org/W2795429214', 'https://openalex.org/W2467235805', 'https://openalex.org/W2081439157', 'https://openalex.org/W2063610174', 'https://openalex.org/W1978434195', 'https://openalex.org/W1948928617', 'https://openalex.org/W1483934638'], 'abstract_inverted_index': {'Background': [0], 'Multiple': [1], 'mutations': [2, 299, 321], 'in': [3, 20, 41, 114, 143, 160, 260, 275, 300, 310], 'the': [4, 42, 173, 189, 197, 215, 255, 281, 292], 'voltage-gated': [5], 'sodium': [6, 32, 65, 125, 149, 246], 'channel': [7, 33, 66, 150, 166, 282], 'have': [8], 'been': [9], 'associated': [10], 'with': [11, 110, 277], 'knockdown': [12], 'resistance': [13, 34, 67, 97, 123, 283], '(kdr)': [14], 'to': [15, 35, 59, 69, 78, 170, 192, 204, 211, 221, 226, 240, 284, 312], 'DDT': [16], 'and': [17, 89, 136, 142, 163, 168, 223, 232, 286, 323, 328], 'pyrethroid': [18, 96, 122, 256, 332], 'insecticides': [19], 'a': [21, 38, 92, 105, 148, 315], 'major': [22], 'human': [23], 'disease': [24], 'vector': [25], 'Aedes': [26, 152], 'aegypti.': [27, 153, 302], 'One': [28], 'mutation,': [29, 61], 'V1016G,': [30, 134], 'confers': [31, 64], 'pyrethroids,': [36], 'but': [37, 76, 208, 235, 274], 'different': [39], 'substitution': [40], 'same': [43], 'position': [44], 'V1016I': [45, 55, 118, 182, 322], 'alone': [46, 141, 185], 'had': [47], 'no': [48], 'effect.': [49], 'In': [50, 213], 'pyrethroid-resistant': [51], 'Ae.': [52, 301], 'aegypti': [53], 'populations,': [54], 'is': [56], 'often': [57], 'linked': [58], 'another': [60], 'F1534C,': [62, 207], 'which': [63], 'only': [68], 'Type': [70, 79], 'I': [71], 'pyrethroids': [72, 81, 171], 'including': [73, 82], 'permethrin': [74], '(PMT),': [75], 'not': [77, 187, 236, 266], 'II': [80], 'deltamethrin': [83], '(DMT).': [84], 'Mosquitoes': [85], 'carrying': [86, 100, 127], 'both': [87], 'V1016G': [88], 'F1534C': [90, 101, 111, 128, 137, 233, 278, 307], 'exhibited': [91], 'greater': [93, 327], 'level': [94], 'of': [95, 124, 245, 254, 269, 297, 320, 331], 'than': [98, 206, 228], 'those': [99], 'alone.': [102], 'More': [103], 'recently,': [104], 'new': [106], 'mutation': [107, 306], 'T1520I': [108, 120, 135, 184, 250, 324], 'co-existing': [109], 'was': [112, 201, 219], 'detected': [113], 'India.': [115], 'However,': [116, 196], 'whether': [117], 'or': [119, 183, 194, 272], 'enhances': [121], 'channels': [126, 156, 247], 'remains': [129], 'unknown.': [130], 'Methodology/Principal': [131], 'findings': [132], 'V1016I,': [133], 'substitutions': [138], 'were': [139, 157, 238], 'introduced': [140], 'various': [144], 'combinations': [145], 'into': [146], 'AaNav1-1,': [147], 'from': [151], 'The': [154, 178, 262], 'mutant': [155, 199, 217], 'then': [158], 'expressed': [159], 'Xenopus': [161], 'oocytes': [162], 'examined': [164], 'for': [165, 317], 'properties': [167], 'sensitivity': [169, 191], 'using': [172], 'two-electrode': [174], 'voltage': [175], 'clamping': [176], 'technique.': [177], 'results': [179], 'showed': [180], 'that': [181, 249, 305, 325], 'did': [186], 'alter': [188], 'AaNav1-1': [190], 'PMT': [193, 205, 227, 271, 285], 'DMT.': [195, 212], 'double': [198, 216], 'T1520I+F1534C': [200], 'more': [202, 224], 'resistant': [203, 220, 225, 239], 'remained': [209], 'sensitive': [210], 'contrast,': [214], 'V1016I+F1534C': [218], 'DMT': [222], 'F1534C.': [229], 'Furthermore,': [230], 'V1016I/G': [231], 'channels,': [234], 'T1520I,': [237], 'dichlorodiphenyltrichloroethane': [241], '(DDT).': [242], 'Cryo-EM': [243], 'structures': [244], 'suggest': [248], 'allosterically': [251], 'deforms': [252], 'geometry': [253], 'receptor': [257], 'site': [258], 'PyR1': [259], 'AaNav1-1.': [261], 'small': [263], 'deformation': [264], 'does': [265], 'affect': [267], 'binding': [268], 'DDT,': [270], 'DMT,': [273], 'combination': [276], 'it': [279], 'increases': [280], 'DDT.': [287], 'Conclusions/Significance': [288], 'Our': [289], 'data': [290], 'corroborated': [291], 'previously': [293], 'proposed': [294, 304], 'sequential': [295], 'selection': [296, 319], 'kdr': [298], 'We': [303], 'first': [308], 'emerged': [309], 'response': [311], 'DDT/pyrethroids': [313], 'providing': [314], 'platform': [316], 'subsequent': [318], 'confer': [326], 'broader': [329], 'spectrum': [330], 'resistance.': [333]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2947068622', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 7}], 'updated_date': '2024-12-11T04:12:51.904377', 'created_date': '2019-06-07'}