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189], 'interstitial': [7], 'cells': [8], 'of': [9, 14, 81, 93, 100, 106, 123, 129, 137, 160, 176], 'Cajal': [10], 'are': [11], 'mesenchymal': [12], 'gastrointestinal': [16], 'tract': [17], 'and': [18, 26, 37, 48, 79, 83, 90, 118, 144, 163, 184], 'have': [19], 'been': [20], 'found': [21, 57], 'to': [22, 58, 73, 141, 166, 182], 'harbor': [23], 'c-KIT': [24], 'mutations': [25, 40], 'KIT': [27, 101], '(CD117)': [28], 'expression': [29], 'since': [30], '1998.': [31], 'Later,': [32], 'PDGFRA': [33], 'mutations,': [34], 'SDH': [35], 'alterations,': [36], 'other': [38], 'drive': [39], 'were': [41, 56], 'identified': [42], 'in': [43, 61, 88, 102, 131, 155], 'GISTs.': [44, 69, 94, 132, 152, 192], 'In': [45, 171], 'addition,': [46], 'more': [47, 49, 110], 'protein': [50], 'markers': [51, 78], 'such': [52], 'as': [53], 'DOG1,': [54], 'PKCθ': [55], 'be': [59, 188], 'expressed': [60], 'GISTs': [62, 82, 107, 138, 156, 165, 180, 186], 'which': [63, 124], 'might': [64], 'help': [65], 'clinicians': [66, 85, 140], 'diagnose': [67], 'CD117-negative': [68], 'Therefore,': [70], 'we': [71], 'plan': [72], 'comprehensively': [74], 'review': [75], 'molecular': [77, 119, 135], 'genetics': [80], 'provide': [84], 'useful': [86], 'information': [87], 'diagnostic': [89], 'therapeutic': [91], 'strategies': [92], 'Twenty': [95], 'years': [96], 'after': [97], 'discovery': [99], 'GISTs,': [103], 'diagnosis': [105, 130, 136], 'became': [108], 'much': [109], 'accurate': [111], 'by': [112], 'using': [113], 'immunohistochemical': [114], '(IHC)': [115], 'panel': [116], '(CD117/DOG1)': [117], 'analysis': [120], '(KIT/PDGFRA),': [121], 'both': [122], 'constitute': [125], 'gold': [127], 'standard': [128], 'The': [133], 'accurately': [134], 'guides': [139], 'precision': [142], 'medicine': [143], 'provides': [145], 'optimal': [146], 'treatment': [147, 154, 178], 'for': [148, 179, 191], 'patients': [150, 162], 'with': [151], 'Successful': [153], 'prolongs': [157], 'survival': [159], 'GIST': [161], 'causes': 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