Emerging Function and Clinical Values of Exosomal MicroRNAs in Cancer

Name: Work Video:
Duration: 3 min 30 s
Man Wang; Fei Yu; Han Ding; Yu Wang; Peifeng Li; Kun Wang
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'of': [4, 20, 53, 80, 108, 123, 133, 145, 162, 175, 185, 191, 207, 240, 267, 295, 310, 320, 332, 349, 362, 372, 381, 392, 452, 516, 523, 542, 581, 588, 623, 699, 761, 767, 773, 779, 788, 793, 837, 902, 923, 938, 970, 1033, 1061, 1092, 1112, 1123, 1128, 1148, 1207, 1239, 1266, 1302, 1351, 1421, 1434, 1474, 1482, 1551, 1565, 1600, 1627, 1648, 1661, 1677, 1685, 1701, 1708, 1728, 1778, 1785, 1808, 1823, 1833, 1837, 1869, 1883, 1899, 1970, 1991, 2016, 2057, 2064, 2076, 2081, 2152, 2171, 2234, 2265, 2272, 2279, 2287, 2321, 2341, 2365, 2396, 2414, 2446, 2571, 2617, 2678, 2682, 2699, 2862, 2899, 2976, 2984, 3004, 3029, 3035, 3066, 3094, 3120, 3131, 3142, 3148, 3229, 3249, 3269, 3272, 3280, 3284, 3290, 3349, 3400, 3417, 3427, 3430, 3436, 3460, 3464, 3501, 3509, 3533, 3540, 3545, 3550, 3561, 3571, 3584, 3623, 3666, 3729, 3740, 3883, 3939, 3973, 4000, 4021, 4029, 4049, 4076, 4168], 'membrane-bound': [5, 192], 'extracellular': [6, 193, 379, 636, 932, 1741, 2195, 2675, 2751, 3457], 'vesicles': [7, 194, 380, 454, 634, 673, 727, 1692, 1940], 'with': [8, 62, 195, 249, 545, 625, 728, 1072, 1730, 2001, 2236, 2246, 2508, 2789, 2870, 2939, 3235, 3247, 4172], 'diameters': [9, 196], 'ranging': [10, 197], 'from': [11, 198, 433, 1169, 1455, 1617, 1879, 2684, 2710, 2718, 3198, 3466], '30': [12, 199], 'to': [13, 89, 94, 101, 126, 200, 276, 281, 288, 313, 377, 920, 1102, 1229, 1414, 1682, 1748, 1773, 1866, 1937, 2078, 2179, 2185, 2310, 2361, 2443, 2505, 2644, 2651, 2895, 2924, 2936, 3059, 3100, 3160, 3233, 3323, 3374, 3378, 3523, 3581, 4116], '100': [14, 201], 'nm.': [15, 202], 'enclose': [17, 204], 'variety': [19, 206, 391, 1147, 2286], 'molecules,': [21, 208, 394], 'such': [22, 209, 395, 758, 1241, 1910, 2450], 'as': [23, 42, 91, 178, 210, 229, 278, 365, 396, 759, 1205, 1242, 1534, 1568, 1737, 1911, 2451, 2649, 3706], 'lipids,': [24, 211, 399, 1720], 'proteins,': [25, 212, 1718, 1909], 'and': [26, 51, 78, 103, 117, 130, 183, 213, 238, 265, 290, 304, 317, 370, 388, 400, 416, 442, 595, 617, 661, 696, 771, 818, 853, 877, 895, 934, 951, 999, 1035, 1041, 1070, 1155, 1202, 1237, 1246, 1264, 1272, 1307, 1328, 1357, 1379, 1391, 1409, 1419, 1438, 1476, 1556, 1580, 1583, 1598, 1659, 1719, 1776, 1806, 1811, 1817, 1829, 1858, 1916, 1929, 2036, 2042, 2071, 2103, 2111, 2147, 2169, 2190, 2248, 2298, 2377, 2433, 2455, 2464, 2487, 2581, 2619, 2640, 2779, 2817, 2823, 2868, 2958, 2963, 3056, 3062, 3253, 3292, 3376, 3443, 3491, 3514, 3537, 3548, 3587, 3618, 3662, 3671, 3738, 3813, 3856, 3880, 3898, 4025, 4089, 4092, 4118, 4197], 'non-coding': [27, 214, 1063], 'RNAs.': [28, 215], 'In': [29, 150, 216, 337, 1540, 3026], 'the': [30, 49, 73, 120, 127, 155, 159, 171, 181, 217, 236, 260, 307, 314, 342, 346, 358, 368, 521, 526, 589, 596, 626, 765, 777, 791, 834, 854, 921, 931, 936, 1056, 1090, 1096, 1109, 1235, 1417, 1459, 1545, 1549, 1562, 1618, 1631, 1675, 1678, 1683, 1698, 1706, 1731, 1740, 1774, 1804, 1821, 1835, 1851, 1859, 1867, 1870, 1880, 1884, 1897, 1900, 1968, 1984, 1989, 1998, 2017, 2065, 2074, 2079, 2082, 2108, 2153, 2187, 2194, 2232, 2237, 2273, 2277, 2363, 2369, 2444, 2700, 2750, 2896, 2932, 2982, 3033, 3043, 3064, 3092, 3113, 3117, 3124, 3128, 3139, 3143, 3149, 3192, 3221, 3270, 3288, 3397, 3418, 3424, 3434, 3499, 3506, 3531, 3551, 3569, 3582, 3621, 3664, 3682, 3736, 3877, 3894, 3959, 3971, 3998, 4019, 4027, 4074], 'past': [31, 218], 'decades,': [32, 219], 'microRNAs': [33, 220, 1071, 1204, 1352, 1477, 2459, 2683, 2859, 3006, 3465], '(miRNAs)': [34, 221, 1054], 'have': [35, 222, 754, 1226, 1745, 2305, 3520], 'attracted': [36, 223, 2306], 'great': [37, 224, 390, 2285], 'attention': [38, 225, 2308], 'in': [39, 48, 72, 115, 136, 165, 226, 235, 259, 302, 323, 352, 408, 419, 455, 561, 584, 653, 676, 701, 732, 790, 820, 839, 880, 905, 945, 1002, 1039, 1075, 1121, 1145, 1211, 1234, 1269, 1304, 1324, 1353, 1388, 1416, 1554, 1571, 1586, 1602, 1705, 1751, 1767, 1841, 1891, 1926, 1988, 2038, 2281, 2314, 2325, 2417, 2482, 2535, 2578, 2626, 2647, 2707, 2755, 2785, 2860, 2981, 3127, 3196, 3277, 3409, 3423, 3483, 3498, 3677, 3715, 3818, 3830, 3862, 3963, 3978, 4053, 4175, 4193], 'cancer': [40, 166, 227, 353, 414, 420, 906, 949, 1003, 1076, 1270, 1326, 1355, 1377, 1389, 1557, 1569, 2282, 2509, 2712, 2720, 2759, 2786, 2866, 3008, 3528, 3534, 3546, 3562, 3597, 3615, 3641, 3766, 3833, 3885, 3905, 3943, 3964, 3981, 4031, 4056, 4079, 4121, 4194], 'research,': [41, 228], 'they': [43, 139, 230, 326, 618, 753, 1818], 'play': [44, 231, 1230, 1922], 'an': [45, 112, 232, 299, 1231, 1824, 2679, 2979, 3154, 3461, 3900], 'important': [46, 233, 1232, 3155], 'role': [47, 161, 234, 348, 451, 836, 1032, 1074, 1233, 1265, 1350, 1550, 1599, 1925, 2278], 'occurrence': [50, 237, 1418], 'development': [52, 239, 1420, 3583], 'cancer.': [54, 124, 149, 186, 241, 311, 336, 373, 1539], 'Increasing': [55, 242], 'evidence': [56, 243, 832, 3590], 'indicates': [57, 244], 'that': [58, 245, 1529, 2106, 2176, 2267, 2441, 2655, 2819, 2888, 3158, 3339, 3564, 3592], 'tumor': [59, 66, 74, 96, 246, 253, 261, 283, 443, 537, 840, 847, 851, 893, 946, 1022, 1243, 1917, 2109, 2114, 3552, 3585, 3672, 3708, 3762, 4173], 'cells': [60, 67, 70, 247, 254, 257, 485, 519, 538, 848, 852, 1457, 1582, 2714, 2883, 3197, 3625, 3679, 3886, 4081], 'communicate': [61, 248], 'not': [63, 250, 1933], 'only': [64, 251, 1934], 'other': [65, 252, 2719], 'but': [68, 255, 1941], 'also': [69, 169, 256, 356, 1560, 1942, 3421], 'present': [71, 258, 675, 3482], 'microenvironment': [75, 262, 947, 2110, 3553], 'via': [76, 263, 1100, 2753, 3710, 3764], 'secretion': [77, 264, 1660, 2155, 2170], 'transfer': [79, 266, 1433, 1473, 3003, 3377], 'exosomal': [81, 85, 109, 134, 163, 268, 272, 296, 321, 350, 1407, 1410, 1530, 1552, 1566, 2773, 2959, 2985, 3002, 3036, 3060, 3118, 3340, 3425, 3438, 3510, 3594, 3769, 3937, 3955, 3968, 4051, 4070], 'miRNAs.': [82, 269, 3037, 3428], 'More': [83, 270, 2499], 'importantly,': [84, 271, 2500], 'miRNAs': [86, 110, 135, 164, 177, 273, 297, 322, 351, 364, 1088, 1142, 1225, 1371, 1387, 1404, 1411, 1531, 1553, 1567, 2304, 2317, 2359, 2432, 2573, 2657, 2774, 2900, 2909, 2926, 3061, 3067, 3095, 3121, 3401, 3484, 3502, 3511, 3519, 3595, 3956, 4071], 'found': [88, 275, 1228, 1585, 1747, 2504, 2643, 2923, 2935, 3232], 'serve': [90, 277, 1533], 'signaling': [92, 279, 3606, 3713, 3961], 'molecules': [93, 280, 2288], 'regulate': [95, 282, 1089, 3007, 3596], 'growth,': [97, 284, 1244, 3535], 'angiogenesis,': [98, 285, 929], 'metastasis,': [99, 286, 417, 3538, 4198], 'sensitivity': [100, 287], 'chemotherapy,': [102, 289], 'immune': [104, 291, 440, 774, 821, 939, 3542], 'evasion.': [105, 292], 'Deregulated': [106, 293], 'expression': [107, 294, 1091, 2364, 2534, 2625, 2783, 3031, 3812, 3972, 4020], 'is': [111, 298, 1478, 1771, 1801, 1905, 2020, 2177, 2503, 2574, 2746, 3218, 3321, 3557, 3565, 3577, 3814, 4199], 'early': [113, 300, 1686], 'event': [114, 301, 2577], 'carcinogenesis': [116, 303, 1555], 'may': [118, 140, 305, 327, 1372, 1532, 2059, 2230, 3485, 3495], 'reflect': [119, 306], 'malignant': [121, 308, 2582], 'characteristics': [122, 309, 1020], 'Owing': [125, 312], 'wide': [128, 315], 'existence': [129, 316], 'high': [131, 318], 'stability': [132, 319], 'body': [137, 324, 656, 1588, 1787, 2040], 'fluids,': [138, 325, 657], 'represent': [141, 328], 'novel': [143, 330, 1480, 2263], 'class': [144, 331, 1060], 'non-invasive': [146, 333, 1536], 'biomarkers': [147, 179, 334, 366, 418, 1375, 1537, 1570], 'for': [148, 180, 335, 367, 413, 749, 1376, 1512, 1538, 1759, 1764, 1803, 2022, 2034, 2907, 4112], 'this': [151, 338, 1541, 1711], 'review,': [152, 339, 1542], 'we': [153, 340, 1543], 'highlight': [154, 341], 'recent': [156, 343], 'advances': [157, 344], 'on': [158, 345, 1548, 1896, 1997, 3138, 3527, 3903], 'functional': [160, 347, 3816], 'pathogenesis.': [167, 354], 'We': [168, 355, 1559], 'discuss': [170, 357, 1561], 'potential': [172, 359, 1563, 2905], 'clinical': [173, 360, 1439, 1572], 'utility': [174, 361], 'exosome-shuttled': [176, 363], 'diagnosis': [182, 369, 1378, 1390], 'treatment': [184, 371], '30-': [376], '100-nm': [378], 'endosomal': [382, 1619, 1632, 1702, 1755, 1825, 3324], 'origin,': [383], 'comprising': [384], 'lipid': [386], 'bilayer': [387], 'bioactive': [393, 2302], 'nucleic': [397, 1716], 'acids,': [398, 1717], 'proteins.1Abak': [401], 'A.': [402, 404, 449, 507, 807, 1383, 1465, 1952, 1956, 2085, 2136, 2549, 2665, 2726, 3084, 3447, 3924, 3930], 'Abhari': [403], 'Rahimzadeh': [405], 'S.': [406, 551, 994, 1293, 2087, 2130, 2564, 2595, 2611, 2738, 2797, 2946, 2956, 3299, 3691, 3749, 3987, 4147], 'cancer:': [409], 'small': [410, 2415, 3193, 3319], 'vesicular': [411], 'transporters': [412], 'progression': [415, 950, 1238, 3563, 3897, 4174], 'therapeutics.PeerJ.': [421], '2018;': [422, 3647, 3720, 3773, 3822], '6:': [423, 4125], 'e4763Crossref': [424], 'PubMed': [425, 463, 497, 533, 605, 644, 684, 711, 740, 801, 826, 886, 913, 959, 978, 1010, 1048, 1083, 1137, 1187, 1219, 1279, 1316, 1336, 1365, 1399, 1445, 1492, 1523, 1610, 1641, 1669, 1795, 1977, 2008, 2050, 2120, 2162, 2217, 2254, 2354, 2387, 2402, 2426, 2472, 2494, 2543, 2589, 2633, 2692, 2766, 2832, 2877, 2970, 3021, 3107, 3209, 3262, 3331, 3390, 3474, 3650, 3723, 3776, 3870, 3949, 4061, 4127, 4181], 'Scopus': [426, 464, 606, 645, 685, 712, 741, 802, 827, 914, 960, 979, 1011, 1049, 1084, 1138, 1188, 1220, 1280, 1317, 1337, 1366, 1400, 1446, 1493, 1524, 1611, 1642, 1670, 1796, 1978, 2009, 2051, 2121, 2163, 2218, 2255, 2355, 2388, 2403, 2427, 2473, 2495, 2544, 2590, 2634, 2693, 2767, 2833, 2878, 2971, 3022, 3108, 3210, 3263, 3332, 3391, 3475, 3651, 3724, 3777, 3871, 3950, 4012, 4128, 4182], '(6)': [427], 'Google': [428, 466, 498, 534, 569, 608, 647, 687, 714, 743, 804, 829, 887, 916, 962, 981, 1013, 1051, 1086, 1140, 1190, 1222, 1282, 1319, 1339, 1368, 1402, 1448, 1495, 1526, 1613, 1644, 1672, 1798, 1980, 2011, 2053, 2123, 2165, 2220, 2257, 2357, 2390, 2405, 2429, 2475, 2497, 2546, 2592, 2636, 2695, 2769, 2835, 2880, 2973, 3024, 3110, 3212, 3265, 3334, 3393, 3477, 3653, 3726, 3779, 3825, 3873, 3952, 4014, 4062, 4130, 4184], 'Scholar': [429, 535, 609, 648, 744, 830, 888, 917, 1014, 1052, 1087, 1141, 1223, 1369, 1403, 1449, 1527, 1614, 1645, 1673, 1799, 1981, 2012, 2054, 2166, 2221, 2258, 2358, 2430, 2498, 2637, 2696, 2770, 2881, 2974, 3025, 3111, 3213, 3266, 3335, 3394, 3478, 3654, 3727, 3780, 3826, 3874, 3953, 4015, 4063, 4131, 4185], 'released': [432, 1736], 'all': [434, 655, 1587], 'cell': [435, 1152, 1679, 2452, 2461, 2483, 2485, 2686, 2760, 2864, 3009, 3346, 3468, 3572, 3598, 3602, 3660, 3767, 3785, 3895, 3906, 3911, 4068, 4136, 4142, 4195], 'types,': [436], 'including': [437, 658, 1151, 1715, 2294, 3440, 3530], 'epithelial': [438, 484], 'cells,': [439, 441, 2653, 3617, 3834], 'cells.2Pap': [444], 'E.': [445, 447, 1950, 1964, 2197], 'Pállinger': [446], 'Falus': [448], 'The': [450, 900, 1031, 1349, 1646, 1754, 1873, 2167, 2394, 2916, 3038, 3134, 3145, 3214, 3226, 4186], 'membrane': [453, 1680, 1839, 1871, 1877, 1902, 2188], 'tumorigenesis.Crit.': [456], 'Rev.': [457, 1393, 1634, 2419], 'Oncol.': [458], 'Hematol.': [459], '2011;': [460, 602, 823, 910, 975, 1276, 2874], '79:': [461], '213-223Crossref': [462], '(0)': [465, 3725], 'Scholar,': [467, 499, 570, 688, 715, 805, 963, 982, 1191, 1283, 1320, 1340, 1496, 2124, 2391, 2406, 2476, 2547, 2593, 2836], '3van': [468], 'Niel': [469], 'G.': [470, 472, 511, 631, 669, 784, 811, 869, 992, 1119, 1498, 1954, 1995, 2134, 2199, 2852, 3693], 'Raposo': [471, 510, 630, 668, 810, 2133], 'Candalh': [473], 'C.': [474, 509, 513, 667, 671, 813, 897, 941, 967, 1115, 1117, 1285, 1500, 1657, 1962, 2091, 2099, 2854, 2952, 3070, 3072, 3239, 3355, 3359, 3695, 4033], 'Boussac': [475], 'M.': [476, 482, 719, 786, 809, 984, 1068, 1253, 1381, 1385, 1467, 1594, 1655, 2029, 2097, 2126, 2558, 2599, 2803, 2844, 2950, 3086, 3168, 3241, 3365, 3368, 3985, 4151], 'Hershberg': [477], 'R.': [478, 725, 943, 986, 1297, 2562, 2856, 3363], 'Cerf-Bensussan': [479], 'N.': [480, 501, 2987, 3080, 3179, 3753], 'Heyman': [481], 'Intestinal': [483], 'secrete': [486, 539], 'exosome-like': [487], 'vesicles.Gastroenterology.': [488], '2001;': [489], '121:': [490], '337-349Abstract': [491], 'Full': [492, 494, 1182, 1184, 1520, 2212, 2214, 2349, 2351, 2382, 2384, 3016, 3018, 3204, 3206, 3385, 3387], 'Text': [493, 495, 1183, 1185, 1521, 2213, 2215, 2350, 2352, 2383, 2385, 3017, 3019, 3205, 3207, 3386, 3388], 'PDF': [496, 1186, 1522, 2216, 2353, 2386, 3020, 3208, 3389], '4Blanchard': [500], 'Lankar': [502, 664], 'D.': [503, 572, 665, 3076, 3166, 3177, 3703, 3989, 4149], 'Faure': [504], 'F.': [505, 1960, 2089, 2605, 2995, 3074, 3088, 3357], 'Regnault': [506], 'Dumont': [508], 'Hivroz': [512], 'TCR': [514], 'activation': [515, 772], 'human': [517, 585, 677, 702, 733, 2583, 4077], 'T': [518], 'induces': [520, 1943], 'production': [522, 3665], 'exosomes': [524, 543, 700, 789, 838, 890, 904, 998, 1016, 1034, 1451, 1601, 1649, 1738, 2172, 2280, 2648, 2708, 2754, 2911, 3097, 3375, 3734], 'bearing': [525], 'TCR/CD3/zeta': [527], 'complex.J.': [528], 'Immunol.': [529, 600, 680, 909], '2002;': [530], '168:': [531], '3235-3241Crossref': [532], 'Notably,': [536, 1224], 'excessive': [540, 3278], 'amounts': [541], 'compared': [544, 2650, 2788], 'normal': [546, 1579], 'proliferating': [547], 'cells.5Kharaziha': [548], 'P.': [549, 861, 990, 3175], 'Ceder': [550], 'Li': [552, 2945, 2947, 2949, 3308, 3754, 3796, 3984, 3994], 'Q.': [553, 3699, 3801, 3848], 'Panaretakis': [554], 'T.': [555, 690, 1157, 1780, 2553, 2742, 2794, 2997, 3632, 4145, 4155, 4161], 'Tumor': [556, 3575], 'cell-derived': [557, 4107], 'exosomes:': [558], 'message': [560], 'bottle.Biochim.': [563], 'Biophys.': [564, 1078], 'Acta.': [565, 1079], '2012;': [566, 1333, 1442, 1974, 2005, 2117, 2346, 2689, 3471], '1826:': [567], '103-111PubMed': [568], '6Dabitao': [571], 'Margolick': [573], 'J.B.': [574], 'Lopez': [575], 'J.': [576, 863, 1028, 1066, 1131, 1291, 1427, 1621, 1653, 2201, 2331, 2410, 2489, 2560, 2663, 2792, 2838, 2873, 2944, 2954, 3078, 3445, 3636, 3701, 3745, 3755, 3795, 3922, 4157], 'Bream': [577], 'J.H.': [578, 1782, 1993, 2527, 3846, 4102], 'Multiplex': [579], 'measurement': [580], 'proinflammatory': [582], 'cytokines': [583, 3668], 'serum:': [586], 'comparison': [587], 'Meso': [590], 'Scale': [591], 'Discovery': [592], 'electrochemiluminescence': [593], 'assay': [594], 'Cytometric': [597], 'Bead': [598], 'Array.J.': [599], 'Methods.': [601], '372:': [603], '71-77Crossref': [604], '(93)': [607], 'form': [611, 2340], 'within': [612, 1108], 'intracellular': [613, 768], 'multivesicular': [614, 1786, 2039], 'bodies': [615, 3245], '(MVBs),': [616], 'secreted': [620, 2748], 'upon': [621, 3643], 'fusion': [622, 1727, 2233], 'MVBs': [624, 1729, 2077, 2235, 3273], 'plasma': [627, 1732, 2861, 4166], 'membrane.7Février': [628], 'B.': [629, 1030, 1295, 2667, 3183, 3449], 'Exosomes:': [632], 'endosomal-derived': [633], 'shipping': [635], 'messages.Curr.': [637], 'Opin.': [638, 1663, 2466], 'Cell': [639, 1487, 1636, 1664, 1972, 2003, 2157, 2207, 2344, 2421, 2827, 3257, 3326, 3853], 'Biol.': [640, 1275, 1488, 1637, 1665, 1973, 2004, 2045, 2158, 2208, 2345, 2422, 2828, 3011, 3258, 3327], '2004;': [641, 708, 2379, 2399], '16:': [642], '415-421Crossref': [643], '(804)': [646], 'can': [650, 843, 891, 1017, 1452, 1721, 1819, 2112, 2289, 3957], 'be': [651, 844, 1373, 1453, 1722, 1749, 2290, 2506, 2645, 2937, 3496, 3611, 3836], 'detected': [652], 'almost': [654], 'blood,': [659], 'urine,': [660], 'saliva.8Caby': [662], 'M.P.': [663, 1165], 'Vincendeau-Scherrer': [666], 'Bonnerot': [670], 'Exosomal-like': [672], 'blood': [678], 'plasma.Int.': [679], '2005;': [681, 2469], '17:': [682, 1135, 2048], '879-887Crossref': [683], '(925)': [686], '9Pisitkun': [689], 'Shen': [691], 'R.F.': [692], 'Knepper': [693], 'M.A.': [694], 'Identification': [695], 'proteomic': [697], 'profiling': [698, 2616], 'urine.Proc.': [703], 'Natl.': [704], 'Acad.': [705], 'Sci.': [706, 1133, 1332, 1606], 'USA.': [707], '101:': [709], '13368-13373Crossref': [710], '(1561)': [713], '10Ogawa': [716], 'Y.': [717, 721, 1287, 1958, 2732, 2736, 2993, 3634, 3751, 3757, 3797, 3916, 3918, 3983], 'Kanai-Azuma': [718], 'Akimoto': [720], 'Kawakami': [722], 'H.': [723, 1322, 1425, 1461, 2329, 2989, 4041, 4045, 4100, 4163], 'Yanoshita': [724], 'Exosome-like': [726], 'dipeptidyl': [729], 'peptidase': [730], 'IV': [731], 'saliva.Biol.': [734], 'Pharm.': [735], 'Bull.': [736], '2008;': [737, 1007, 2540, 2630, 2829], '31:': [738], '1059-1062Crossref': [739], '(180)': [742], 'critical': [747, 1406, 4110], 'vehicles': [748], 'intercellular': [750, 2342], 'communication.': [751], 'Thus,': [752, 1827, 2882], 'multiple': [755, 2685, 3467], 'physiological': [756], 'roles,': [757], 'maintenance': [760], 'cellular': [762, 794, 1149, 2083, 2238, 3398], 'homeostasis': [763], 'through': [764, 776, 1630, 3098], 'release': [766], 'harmful': [769], 'components': [770, 3228, 3248], 'responses': [775], 'delivery': [778], 'antigens': [780], 'or': [781, 849, 1104, 3402, 3605], 'activating': [782], 'ligands.11Desdín-Micó': [783], 'Mittelbrunn': [785, 3085], 'Role': [787], 'protection': [792], 'homeostasis.Cell': [795], 'Adhes.': [796], 'Migr.': [797], '2017;': [798, 1179, 1216, 3867, 3946, 4178], '11:': [799, 3260, 3329], '127-134Crossref': [800], '(16)': [803], '12Bobrie': [806], 'Colombo': [808], 'Théry': [812, 1656, 2098], 'Exosome': [814, 2957], 'secretion:': [815], 'molecular': [816, 1436, 2274], 'mechanisms': [817, 1437, 2105, 2275, 2887, 3508], 'roles': [819, 901, 2033], 'responses.Traffic.': [822], '12:': [824, 2160], '1659-1668Crossref': [825], '(718)': [828], 'Emerging': [831, 3589], 'demonstrates': [833, 3591], 'crucial': [835, 1924, 3559], 'development.': [841], 'trafficked': [845], 'between': [846, 850, 1485, 3613], 'surrounding': [855], 'microenvironment.13Bullock': [856], 'M.D.': [857], 'Silva': [858], 'A.M.': [859, 2810], 'Kanlikilicer-Unaldi': [860], 'Filant': [862], 'Rashed': [864], 'M.H.': [865], 'Sood': [866], 'A.K.': [867], 'Lopez-Berestein': [868], 'Calin': [870, 2612], 'G.A.': [871, 2613], 'Exosomal': [872, 1166, 1203, 1507, 2259, 3518, 3608, 3655, 3781, 3808, 3827, 3849, 3891, 4016, 4132], 'Non-Coding': [873], 'RNAs:': [874], 'Diagnostic,': [875], 'Prognostic': [876], 'Therapeutic': [878, 1309], 'Applications': [879], 'Cancer.Noncoding': [881], 'RNA.': [882], '2015;': [883, 1045, 1313, 1607, 2967], '1:': [884], '53-68Crossref': [885], 'Cancer-associated': [889], 'promote': [892, 1820, 2113, 2820], 'survival': [894], 'growth.14Yang': [896], 'Robbins': [898], 'P.D.': [899], 'tumor-derived': [903], 'pathogenesis.Clin.': [907], 'Dev.': [908, 2468], '2011:': [911], '842849Crossref': [912], '(233)': [915], 'They': [918], 'contribute': [919, 2442], 'establishment': [922], 'tumor-promoting': [925], 'niche': [926], 'by': [927, 1577, 1697, 1789, 3122, 3220, 3318, 3345, 3568, 3600, 3626, 3680, 3787, 3859, 3887, 3908, 4005, 4082, 4138], 'inducing': [928, 1834, 4113], 'remodeling': [930, 3549], 'matrix,': [933], 'impairing': [935], 'function': [937, 2313, 2360], 'cells.15Kahlert': [940], 'Kalluri': [942], 'influence': [948], 'metastasis.J.': [952, 3010], 'Mol.': [953, 1132, 1274, 1330, 1360, 1394, 1604, 1635, 2420], 'Med.': [954, 1361, 3821], '(Berl.).': [955], '2013;': [956, 3013, 3104], '91:': [957], '431-437Crossref': [958], '(569)': [961], '16Taylor': [964], 'D.D.': [965, 1504], 'Gercel-Taylor': [966], 'Exosomes/microvesicles:': [968], 'mediators': [969], 'cancer-associated': [971], 'immunosuppressive': [972], 'microenvironments.Semin.': [973], 'Immunopathol.': [974], '33:': [976], '441-454Crossref': [977], '(300)': [980], '17Iero': [983], 'Valenti': [985], 'Huber': [987], 'V.': [988, 2393, 2840, 4037], 'Filipazzi': [989], 'Parmiani': [991], 'Fais': [993], 'Rivoltini': [995], 'L.': [996, 1024, 1299, 2801, 2846, 2848, 2948, 3932, 3995], 'Tumour-released': [997], 'their': [1000, 2311, 2434, 3403, 3487], 'implications': [1001], 'immunity.Cell': [1004], 'Death': [1005], 'Differ.': [1006], '15:': [1008, 2470], '80-88Crossref': [1009], '(395)': [1012], 'Additionally,': [1015, 3411], 'transmit': [1018], 'drug-resistance': [1019], 'among': [1021], 'cells.18Zhao': [1023], 'Liu': [1025, 2608, 3692, 3798], 'W.': [1026, 4153], 'Xiao': [1027, 3635], 'Cao': [1029], '"exosomal': [1036], 'shuttle': [1037], 'microRNA"': [1038], 'tumorigenesis': [1040], 'drug': [1042, 3881], 'resistance.Cancer': [1043], 'Lett.': [1044], '356:': [1046], '339-346Crossref': [1047], '(130)': [1050], 'MicroRNAs': [1053, 1323, 2481], 'most': [1057], 'extensively': [1058], 'studied': [1059], 'short': [1062, 2319], 'RNAs': [1064, 2416, 3320, 3370], '(ncRNAs).19Liz': [1065], 'Esteller': [1067], 'lncRNAs': [1069], 'development.Biochim.': [1077], '2016;': [1080, 1134, 4009, 4124], '1859:': [1081], '169-176Crossref': [1082], '(405)': [1085], 'target': [1093, 1113, 2435, 3351, 3404], 'genes': [1094, 2367, 2436], 'at': [1095, 2368], 'post-transcriptional': [1097, 2370], 'level,': [1098], 'primarily': [1099], 'binding': [1101, 3099], 'fully': [1103], 'partially': [1105], 'complementary': [1106], 'sites': [1107], '3′': [1110, 3129, 3140, 3146], 'UTR': [1111], 'mRNAs.20Catalanotto': [1114], 'Cogoni': [1116], 'Zardo': [1118], 'MicroRNA': [1120, 1167, 2533, 3850], 'Control': [1122], 'Gene': [1124], 'Expression:': [1125], 'An': [1126], 'Overview': [1127], 'Nuclear': [1129], 'Functions.Int.': [1130], '1712Crossref': [1136], '(616)': [1139], 'involved': [1144, 1750, 3497], 'processes,': [1150, 2449], 'proliferation,': [1153, 2453, 2484, 3878], 'differentiation,': [1154, 2454], 'death.21Hayashi': [1156], 'Lombaert': [1158], 'I.M.': [1159], 'Hauser': [1160], 'B.R.': [1161], 'Patel': [1162], 'V.N.': [1163, 2408], 'Hoffman': [1164], 'Transport': [1168], 'Salivary': [1170], 'Mesenchyme': [1171], 'Regulates': [1172], 'Epithelial': [1173], 'Progenitor': [1174], 'Expansion': [1175], 'during': [1176], 'Organogenesis.Dev.': [1177], 'Cell.': [1178, 1359, 1441, 2046, 3718], '40:': [1180], '95-103Abstract': [1181], '(34)': [1189], '22Cho': [1192], 'Y.E.': [1193], 'Kim': [1194, 2518, 2522, 2524, 2528, 3302, 4101], 'S.H.': [1195], 'Lee': [1196, 1468, 2526], 'B.H.': [1197], 'Baek': [1198], 'M.C.': [1199, 2095, 2412], 'Circulating': [1200], 'Plasma': [1201], 'Indicators': [1206], 'Drug-Induced': [1208], 'Organ': [1209], 'Injury': [1210], 'Rodent': [1212], 'Models.Biomol.': [1213], 'Ther.': [1214], '(Seoul).': [1215], '25:': [1217], '367-373Crossref': [1218], '(33)': [1221], 'been': [1227, 1746, 3521], 'onset': [1236, 1271], 'cancer,': [1240], 'invasion,': [1245], 'metastasis.23Palmero': [1247], 'E.I.': [1248], 'de': [1249, 1254, 3184], 'Campos': [1250, 1252], 'S.G.': [1251], 'Souza': [1255], 'N.C.': [1256], 'Guerreiro': [1257], 'I.D.': [1258], 'Carvalho': [1259], 'A.L.': [1260], 'Marques': [1261], 'M.M.': [1262], 'Mechanisms': [1263, 1626], 'microRNA': [1267, 2618, 2624, 2744, 3372], 'deregulation': [1268, 3570], 'progression.Genet.': [1273], '34:': [1277], '363-370Crossref': [1278], '(88)': [1281], '24Li': [1284], 'Gao': [1286], 'Zhang': [1288, 1343, 1426, 1430, 1947, 2330, 2334, 3746, 3931, 3990], 'K.': [1289, 1429, 1463, 2140, 2333, 2722, 2724, 2728, 2730, 2734, 2740, 2991, 3303, 3311, 3799, 3993, 4039, 4043, 4159], 'Chen': [1290, 1298, 3633], 'Han': [1292, 2409], 'Feng': [1294], 'Wang': [1296, 1345, 3696, 3988], 'Multiple': [1300, 1690], 'Roles': [1301], 'MicroRNA-100': [1303], 'Human': [1305, 4001, 4064, 4103], 'Cancer': [1306, 2538, 4003], 'its': [1308, 3162], 'Potential.Cell.': [1310], 'Physiol.': [1311, 3719, 3865], 'Biochem.': [1312, 3866], '37:': [1314, 2875], '2143-2159Crossref': [1315], '(45)': [1318], '25Liu': [1321], 'breast': [1325, 2584, 3832, 3840, 3884, 3980, 4030, 4055], 'initiation': [1327, 1356], 'progression.Cell.': [1329], 'Life': [1331, 1605], '69:': [1334], '3587-3599Crossref': [1335], '(59)': [1338], '26Li': [1341], 'S.D.': [1342], 'J.R.': [1344], 'Y.Q.': [1346], 'Wan': [1347], 'X.P.': [1348], 'ovarian': [1354, 4078, 4120], 'progression.J.': [1358], '2010;': [1362, 1396, 1792, 2159, 2763], '14:': [1363, 1975, 2006, 2541], '2240-2249Crossref': [1364], '(43)': [1367], 'Therefore,': [1370], 'promising': [1374], 'prognosis.27Ferracin': [1380], 'Veronese': [1382], 'Negrini': [1384], 'Micromarkers:': [1386], 'prognosis.Expert': [1392], 'Diagn.': [1395], '10:': [1397, 1518, 2424, 2830], '297-308Crossref': [1398], '(210)': [1401], 'constituents,': [1408, 1714], 'confirmed': [1413], 'participate': [1415], 'cancer.28Chen': [1422], 'X.': [1423, 2327, 3309, 3747, 3920, 3926], 'Liang': [1424, 2328], 'Zen': [1428, 2332, 3992], 'C.Y.': [1431, 2335, 3991], 'Horizontal': [1432], 'microRNAs:': [1435, 2337], 'applications.Protein': [1440], '3:': [1443], '28-37Crossref': [1444], '(199)': [1447], 'miRNA-containing': [1450], 'shed': [1454], 'parental': [1456], 'into': [1458, 1724, 1739, 2193, 2292, 2661, 2749, 2892, 2901, 2910, 2928, 2942, 3068, 3096, 3164, 3274, 3489, 3503, 3733, 3838], 'circulation,29Valadi': [1460], 'Ekström': [1462], 'Bossios': [1464], 'Sjöstrand': [1466], 'J.J.': [1469, 2515, 3307], 'Lötvall': [1470], 'J.O.': [1471], 'Exosome-mediated': [1472, 3637], 'mRNAs': [1475, 3405], 'mechanism': [1481, 1784, 3041], 'genetic': [1483], 'exchange': [1484], 'cells.Nat.': [1486], '2007;': [1489], '9:': [1490], '654-659Crossref': [1491], '(8422)': [1494], '30Rabinowits': [1497], 'Gerçel-Taylor': [1499], 'Day': [1501], 'J.M.': [1502, 2850, 3181], 'Taylor': [1503], 'Kloecker': [1505], 'G.H.': [1506], 'microRNA:': [1508, 2960], 'diagnostic': [1510, 2825], 'marker': [1511], 'lung': [1513, 2865], 'cancer.Clin.': [1514], 'Lung': [1515], 'Cancer.': [1516, 2490], '2009;': [1517, 2209, 2251, 2423, 3259, 3328], '42-46Abstract': [1519], '(1020)': [1525], 'demonstrating': [1528, 2654], 'ideal': [1535], 'summarize': [1544], 'current': [1546], 'knowledge': [1547, 2271], 'progression.': [1558, 2283], 'applications': [1564], 'practice.': [1573], 'generated': [1576], 'both': [1578, 2579], 'pathological': [1581], 'fluids.31Brinton': [1589], 'L.T.': [1590], 'Sloane': [1591], 'H.S.': [1592], 'Kester': [1593], 'Kelly': [1595], 'K.A.': [1596], 'Formation': [1597], 'cancer.Cell.': [1603], '72:': [1608, 2118], '659-671Crossref': [1609], '(154)': [1612], 'originate': [1616], 'compartment.32Gruenberg': [1620], 'van': [1622, 2795, 3171], 'der': [1623], 'Goot': [1624], 'F.G.': [1625], 'pathogen': [1628], 'entry': [1629], 'compartments.Nat.': [1633], '2006;': [1638, 2047, 2491], '7:': [1639], '495-504Crossref': [1640], '(269)': [1643], 'biogenesis': [1647, 1788, 1969], 'involves': [1650, 3042], 'two': [1651], 'steps.33Kowal': [1652], 'Tkach': [1654], 'Biogenesis': [1658, 2413], 'exosomes.Curr.': [1662], '2014;': [1666, 2586, 3201, 3382, 4058], '29:': [1667], '116-125Crossref': [1668], '(1073)': [1671], 'First,': [1674], 'internalization': [1676, 1822], 'leads': [1681], 'formation': [1684, 1707, 1836, 1990, 2041, 2168, 3286], 'endosomes': [1687], '(Figure': [1688, 2914, 3554], '1).': [1689], 'intraluminal': [1691], '(ILVs)': [1693], 'then': [1695, 1847], 'formed': [1696], 'inward': [1699, 2043], 'invagination': [1700, 1775], 'membranes,': [1703], 'resulting': [1704, 1987], 'MVBs.': [1709, 3410], 'During': [1710], 'process,': [1712], 'cytosolic': [1713], 'sorted': [1723], 'ILVs.': [1725], 'Upon': [1726], 'membrane,': [1733], 'ILVs': [1734, 1892, 2192], 'milieu.': [1742], 'Some': [1743], 'factors': [1744, 4111], 'exosome': [1752, 1930, 1999, 2154], 'biogenesis.': [1753, 1931], 'sorting': [1756, 1770, 2886, 2908, 2927, 3040, 3093, 3156, 3216, 3342, 3373, 3507, 3732, 3938], 'complexes': [1757, 2229, 3252, 3494], 'required': [1758, 2021], 'transport': [1760, 2815], '(ESCRTs)': [1761], 'essential': [1763], 'MVB': [1765, 2027, 2061, 3285], 'biogenesis,': [1766, 2375], 'which': [1768, 1842], 'cargo': [1769, 1927, 2260], 'coupled': [1772], 'detachment': [1777], 'ILVs.34Wollert': [1779], 'Hurley': [1781], 'Molecular': [1783], 'ESCRT': [1790, 2018], 'complexes.Nature.': [1791], '464:': [1793], '864-869Crossref': [1794], '(504)': [1797], 'ESCRT-0': [1800], 'responsible': [1802], 'assembly': [1805], 'gathering': [1807], 'cargoes.': [1809], 'ESCRT-I': [1810, 1828], '-II': [1812, 1830], 'harbor': [1813], 'various': [1814, 2447], 'membrane-binding': [1815], 'sites,': [1816], 'membrane.': [1826], 'capable': [1832], 'bud,': [1840], 'cargoes': [1843, 1888, 1936], 'confined.': [1845], 'ESCRT-II': [1846], 'recruits': [1848, 1983], 'ESCRT-III': [1849, 1874, 1985], 'subunits,': [1850], 'vacuolar': [1852], 'protein': [1853, 1855, 1863, 1913, 2226, 3493, 3913, 3976], 'sorting-associated': [1854], '20': [1856], '(Vps20)': [1857], 'eukaryotic': [1860], 'sucrose': [1861], 'non-fermenting': [1862], '7': [1864], '(Snf7),': [1865], 'neck': [1868], 'bud.': [1872, 1885], 'complex': [1875, 3224], 'directs': [1876], 'scission': [1878], 'cytoplasmic': [1881], 'side': [1882], 'Following': [1886], 'scission,': [1887], 'entrapped': [1890], 'while': [1893, 3282], 'ESCR-III': [1894], 'persists': [1895], 'outside': [1898], 'remaining': [1901], 'until': [1903], 'it': [1904, 3619], 'recycled.': [1906], 'Moreover,': [1907, 2431, 3267, 3954], 'accessory': [1908], 'ALG-2-interacting': [1912], 'X': [1914, 3975], '(ALIX)': [1915], 'susceptibility': [1918], 'gene': [1919, 2315, 3295], '101': [1920], '(TSG101),': [1921], 'packaging': [1928, 2941], 'ALIX': [1932, 1982], 'encloses': [1935], 'enter': [1938], 'internalized': [1939], 'vesicle': [1944], 'formation.35Baietti': [1945], 'M.F.': [1946], 'Z.': [1948, 2568, 3630, 3697, 3928], 'Mortier': [1949], 'Melchior': [1951], 'Degeest': [1953], 'Geeraerts': [1955], 'Ivarsson': [1957], 'Depoortere': [1959], 'Coomans': [1961], 'Vermeiren': [1963], 'et': [1965, 2145, 2569, 2614, 2857, 3187, 3316, 3935, 4164], 'al.Syndecan-syntenin-ALIX': [1966], 'regulates': [1967], 'exosomes.Nat.': [1971], '677-685Crossref': [1976], '(1022)': [1979], 'complex,': [1986], 'ILVs.36Hurley': [1992], 'Odorizzi': [1994], 'Get': [1996], 'bus': [2000], 'ALIX.Nat.': [2002], '654-655Crossref': [2007], '(145)': [2010], 'TSG101,': [2013], 'component': [2015, 3416], 'machinery,': [2019], 'epidermal': [2023], 'growth': [2024, 2822, 3576, 3737, 3763, 3791], 'factor': [2025, 2224, 3580, 3674, 3687, 3792], '(EGF)-stimulated': [2026], 'formation.37Razi': [2028], 'Futter': [2030], 'C.E.': [2031], 'Distinct': [2032], 'Tsg101': [2035], 'Hrs': [2037], 'vesiculation.Mol.': [2044], '3469-3483Crossref': [2049], '(191)': [2052], 'Accordingly,': [2055], 'depletion': [2056], 'TSG101': [2058], 'suppress': [2060, 2362, 3761], 'formation.': [2062], 'Members': [2063], 'Rab': [2066], 'GTPase': [2067], 'family': [2068, 2703, 2745, 3052], '(e.g.,': [2069, 2775], 'Rab27a': [2070, 2100], 'Rab27b)': [2072], 'mediate': [2073], 'trafficking': [2075], 'site': [2080], 'membrane.38Bobrie': [2084], 'Krumeich': [2086, 2129], 'Reyal': [2088], 'Recchi': [2090], 'Moita': [2092, 2137], 'L.F.': [2093], 'Seabra': [2094], 'Ostrowski': [2096], 'supports': [2101], 'exosome-dependent': [2102], '-independent': [2104], 'modify': [2107], 'progression.Cancer': [2115], 'Res.': [2116, 2539, 2629], '4920-4930Crossref': [2119], '(399)': [2122], '39Ostrowski': [2125], 'Carmo': [2127], 'N.B.': [2128], 'Fanget': [2131], 'I.': [2132, 2555, 4035], 'Savina': [2135], 'C.F.': [2138], 'Schauer': [2139], 'Hume': [2141], 'A.N.': [2142], 'Freitas': [2143], 'R.P.': [2144], 'al.Rab27a': [2146], 'Rab27b': [2148], 'control': [2149, 2460], 'different': [2150, 2782], 'steps': [2151], 'pathway.Nat.': [2156], '19-30Crossref': [2161], '(1516)': [2164], 'requires': [2173], 'contractile': [2174], 'machinery': [2175], 'able': [2178], 'draw': [2180], 'opposing': [2181], 'membranes': [2182], 'together': [2183], 'prior': [2184], 'shearing': [2186], 'connection': [2189], 'releasing': [2191], 'milieu.40Cocucci': [2196], 'Racchetti': [2198], 'Meldolesi': [2200], 'Shedding': [2202], 'microvesicles:': [2203], 'artefacts': [2204], 'no': [2205], 'more.Trends': [2206], '19:': [2210], '43-51Abstract': [2211], '(1360)': [2219], 'Soluble': [2222], 'N-ethylmaleimide-sensitive': [2223], 'attachment': [2225], 'receptor': [2227, 3684, 4023], '(SNARE)': [2228], 'facilitate': [2231], 'membrane.41Südhof': [2239], 'T.C.': [2240], 'Rothman': [2241], 'J.E.': [2242], 'Membrane': [2243], 'fusion:': [2244], 'grappling': [2245], 'SNARE': [2247], 'SM': [2249], 'proteins.Science.': [2250], '323:': [2252], '474-477Crossref': [2253], '(1404)': [2256], 'represents': [2261], 'focus': [2264], 'investigation': [2266], 'would': [2268], 'enrich': [2269], 'our': [2270], 'underlying': [2276], 'A': [2284], 'incorporated': [2291], 'exosomes,': [2293, 2893, 3490], 'miRNAs,': [2295, 3439], 'DNAs,': [2296], 'RNAs,': [2297], 'proteins.': [2299, 3574], 'Among': [2300], 'these': [2301, 2656], 'compositions,': [2303], 'substantial': [2307], 'owing': [2309], 'regulatory': [2312, 2439], 'expression.': [2316], 'ncRNAs': [2320], 'approximately': [2322], '19–24': [2323], 'nt': [2324], 'length.42Chen': [2326], 'Secreted': [2336], 'new': [2339], 'communication.Trends': [2343], '22:': [2347], '125-132Abstract': [2348], '(573)': [2356], 'protein-coding': [2366], 'level.43Bartel': [2371], 'D.P.': [2372], 'MicroRNAs:': [2373], 'genomics,': [2374], 'mechanism,': [2376], 'function.Cell.': [2378], '116:': [2380], '281-297Abstract': [2381], '(28659)': [2389], '44Ambros': [2392], 'functions': [2395], 'animal': [2397], 'microRNAs.Nature.': [2398], '431:': [2400], '350-355Crossref': [2401], '(8837)': [2404], '45Kim': [2407], 'Siomi': [2411], 'animals.Nat.': [2418], '126-139Crossref': [2425], '(2504)': [2428], 'constitute': [2437], 'complicated': [2438], 'networks': [2440], 'fine-tuning': [2445], 'biological': [2448], 'death.46Miska': [2456], 'E.A.': [2457], 'How': [2458], 'division,': [2462], 'differentiation': [2463], 'death.Curr.': [2465], 'Genet.': [2467], '563-568Crossref': [2471], '(701)': [2474], '47Hwang': [2477], 'H.W.': [2478], 'Mendell': [2479], 'J.T.': [2480], 'death,': [2486], 'tumorigenesis.Br.': [2488], '94:': [2492], '776-780Crossref': [2493], '(941)': [2496], 'miRNA': [2501, 2702, 2890, 2940, 3132, 3150, 3250, 3255, 3341, 3350, 3407], 'dysregulation': [2502], 'associated': [2507, 2938, 4171], 'progression.48Lee': [2510], 'J.W.': [2511], 'Choi': [2512, 2514, 4097], 'C.H.': [2513], 'Park': [2516], 'Y.A.': [2517], 'S.J.': [2519], 'Hwang': [2520], 'S.Y.': [2521], 'W.Y.': [2523], 'T.J.': [2525], 'B.G.': [2529], 'Bae': [2530], 'D.S.': [2531], 'Altered': [2532], 'cervical': [2536], 'carcinomas.Clin.': [2537], '2535-2542Crossref': [2542], '(279)': [2545], '49Tahiri': [2548], 'Leivonen': [2550], 'S.K.': [2551], 'Lüders': [2552], 'Steinfeld': [2554], 'Ragle': [2556], 'Aure': [2557], 'Geisler': [2559], 'Mäkelä': [2561], 'Nord': [2563], 'Riis': [2565], 'M.L.': [2566, 3353, 3934], 'Yakhini': [2567], 'al.Deregulation': [2570], 'cancer-related': [2572], 'common': [2576], 'benign': [2580], 'tumors.Carcinogenesis.': [2585], '35:': [2587], '76-85Crossref': [2588], '(97)': [2591], '50Ambs': [2594], 'Prueitt': [2596], 'R.L.': [2597], 'Yi': [2598], 'Hudson': [2600], 'R.S.': [2601], 'Howe': [2602], 'T.M.': [2603], 'Petrocca': [2604], 'Wallace': [2606], 'T.A.': [2607], 'C.G.': [2609], 'Volinia': [2610], 'al.Genomic': [2615], 'messenger': [2620], 'RNA': [2621, 2816, 3194], 'reveals': [2622], 'deregulated': [2623], 'prostate': [2627], 'cancer.Cancer': [2628], '68:': [2631], '6162-6170Crossref': [2632], '(594)': [2635], 'miR-142-3p,': [2638, 3441], 'miR-150,': [2639, 3442], 'miR-451': [2641], 'were': [2642, 2658, 2704, 3231], 'enriched': [2646, 3829], 'parent': [2652], 'preferentially': [2659], 'packaged': [2660], 'exosomes.51Guduric-Fuchs': [2662], "O'Connor": [2664, 3446], 'Camp': [2666, 3448], "O'Neill": [2668, 3450], 'C.L.': [2669, 3451], 'Medina': [2670, 3452], 'R.J.': [2671, 3453], 'Simpson': [2672, 3454], 'D.A.': [2673, 3455], 'Selective': [2674, 3456], 'vesicle-mediated': [2676, 3458], 'export': [2677, 3459], 'overlapping': [2680, 3462], 'set': [2681, 3463], 'types.BMC': [2687, 3469], 'Genomics.': [2688, 3470], '13:': [2690, 2968, 3472], '357Crossref': [2691, 3473], '(363)': [2694, 3476], 'Likewise,': [2697], 'members': [2698], 'let-7': [2701], 'more': [2705], 'abundant': [2706], 'derived': [2709, 2717, 3768], 'gastric': [2711, 2758, 4176], '(GC)': [2713], 'than': [2715], 'those': [2716], 'cells.52Ohshima': [2721], 'Inoue': [2723], 'Fujiwara': [2725], 'Hatakeyama': [2727], 'Kanto': [2729], 'Watanabe': [2731], 'Muramatsu': [2733], 'Fukuda': [2735], 'Ogura': [2737], 'Yamaguchi': [2739], 'Mochizuki': [2741], 'Let-7': [2743], 'selectively': [2747], 'environment': [2752], 'metastatic': [2757, 3831], 'line.PLoS': [2761], 'ONE.': [2762], '5:': [2764, 4059], 'e13247Crossref': [2765], '(484)': [2768], 'Remarkably,': [2771], 'some': [2772, 3437], 'miR-21,': [2776], 'let-7f,': [2777], 'miR-20b,': [2778], 'miR-30e-3p)': [2780], 'exhibited': [2781], 'levels': [2784, 3034, 3399, 4048, 4167], 'patients': [2787, 2867], 'healthy': [2790], 'controls.53Skog': [2791], 'Würdinger': [2793], 'Rijn': [2796], 'Meijer': [2798], 'D.H.': [2799, 3313], 'Gainche': [2800], 'Sena-Esteves': [2802], 'Curry': [2804], 'Jr.,': [2805], 'W.T.': [2806], 'Carter': [2807], 'B.S.': [2808], 'Krichevsky': [2809], 'Breakefield': [2811], 'X.O.': [2812], 'Glioblastoma': [2813], 'microvesicles': [2814], 'proteins': [2818, 3053, 3604, 4085], 'tumour': [2821], 'provide': [2824], 'biomarkers.Nat.': [2826], '1470-1476Crossref': [2831], '(3541)': [2834], '54Silva': [2837], 'García': [2839, 2849], 'Zaballos': [2841], 'Á.': [2842], 'Provencio': [2843], 'Lombardía': [2845], 'Almonacid': [2847], 'Domínguez': [2851], 'Peña': [2853], 'Diaz': [2855], 'al.Vesicle-related': [2858], 'nonsmall': [2863], 'correlation': [2869], 'survival.Eur.': [2871], 'Respir.': [2872], '617-623Crossref': [2876], '(219)': [2879], 'adopt': [2884], 'specific': [2885, 3101, 3492], 'direct': [2889], 'loading': [2891, 3065, 3500], 'leading': [2894], 'selective': [2897], 'encapsulation': [2898], 'cell-secreted': [2902], 'exosomes.': [2903, 2929, 3504], 'Four': [2904], 'pathways': [2906], 'proposed': [2913], '2).': [2915], 'neural': [2917], 'sphingomyelinase': [2918, 2999], '2': [2919, 3000, 3413], '(nSMase2)-dependent': [2920, 3001], 'pathway': [2921, 3136, 3217, 3714, 3962], 'was': [2922, 2931, 3337, 3343, 3420], 'guide': [2925], 'nSMase2': [2930, 2977, 3030], 'first': [2933], 'molecule': [2934], 'exosomes.55Zhang': [2943], 'Guo': [2951, 3806], 'Yao': [2953], 'Mi': [2955], 'trafficking,': [2961], 'sorting,': [2962], 'function.Genomics': [2964], 'Proteomics': [2965], 'Bioinformatics.': [2966], '17-24Crossref': [2969], '(1050)': [2972], 'Overexpression': [2975], 'caused': [2978, 3287], 'increase': [2980], 'abundance': [2983, 3435], 'miRNAs.56Kosaka': [2986], 'Iguchi': [2988], 'Hagiwara': [2990], 'Yoshioka': [2992], 'Takeshita': [2994], 'Ochiya': [2996], 'Neutral': [2998], 'angiogenic': [3005], 'Chem.': [3012], '288:': [3014], '10849-10859Abstract': [3015], '(497)': [3023], 'contrast,': [3027], 'inhibition': [3028], 'decreased': [3032], 'second': [3039], 'sumoylated': [3044, 3114], 'heterogeneous': [3045], 'nuclear': [3046], 'ribonucleoprotein': [3047], '(hnRNP)-dependent': [3048], 'pathway.': [3049], 'Three': [3050], 'hnRNP': [3051], '(hnRNPA2B1,': [3054], 'hnRNPA1,': [3055], 'hnRNPC)': [3057], 'bound': [3058], 'induced': [3063], 'exosomes.57Villarroya-Beltri': [3069], 'Gutiérrez-Vázquez': [3071], 'Sánchez-Cabo': [3073], 'Pérez-Hernández': [3075], 'Vázquez': [3077], 'Martin-Cofreces': [3079], 'Martinez-Herrera': [3081], 'D.J.': [3082, 3237], 'Pascual-Montano': [3083], 'Sánchez-Madrid': [3087], 'Sumoylated': [3089], 'hnRNPA2B1': [3090, 3115], 'controls': [3091], 'motifs.Nat.': [3102], 'Commun.': [3103, 3945], '4:': [3105], '2980Crossref': [3106], '(1124)': [3109], 'Specially,': [3112], 'controlled': [3116, 3344], 'assortment': [3119, 3426], 'recognizing': [3123], 'GGAG': [3125], 'motif': [3126], 'part': [3130], 'sequences.': [3133], 'third': [3135], 'depends': [3137], 'end': [3141, 3147], 'miRNA.': [3144], 'sequence': [3151], 'might': [3152], 'contain': [3153], 'signal': [3157], 'contributed': [3159], 'guiding': [3161], 'incorporation': [3163], 'exosomes.58Koppers-Lalic': [3165], 'Hackenberg': [3167], 'Bijnsdorp': [3169], 'I.V.': [3170], 'Eijndhoven': [3172], 'M.A.J.': [3173], 'Sadek': [3174], 'Sie': [3176], 'Zini': [3178], 'Middeldorp': [3180], 'Ylstra': [3182], 'Menezes': [3185], 'R.X.': [3186], 'al.Nontemplated': [3188], 'nucleotide': [3189], 'additions': [3190], 'distinguish': [3191], 'composition': [3195], 'exosomes.Cell': [3199], 'Rep.': [3200, 3381, 4123], '8:': [3202, 3383, 3947, 4179], '1649-1658Abstract': [3203], '(371)': [3211], 'last': [3215], 'mediated': [3219], 'miRNA-induced': [3222], 'silencing': [3223], '(miRISC).': [3225], 'primary': [3227], 'miRISC': [3230, 3291], 'co-localize': [3234], 'MVBs.59Gibbings': [3236], 'Ciaudo': [3238], 'Erhardt': [3240], 'Voinnet': [3242], 'O.': [3243], 'Multivesicular': [3244], 'associate': [3246], 'effector': [3251], 'modulate': [3254, 3371], 'activity.Nat.': [3256], '1143-1149Crossref': [3261], '(787)': [3264], 'blockade': [3268], 'turnover': [3271], 'lysosomes': [3275], 'resulted': [3276], 'accumulation': [3279], 'miRISCs,': [3281], 'suppression': [3283], 'loss': [3289], 'relieved': [3293], 'miRNA-mediated': [3294], 'silencing.60Lee': [3296], 'Y.S.': [3297], 'Pressman': [3298], 'Andress': [3300], 'A.P.': [3301], 'White': [3304], 'J.L.': [3305], 'Cassidy': [3306], 'Lubell': [3310], 'Lim': [3312], 'Cho': [3314], 'I.S.': [3315], 'al.Silencing': [3317], 'linked': [3322], 'trafficking.Nat.': [3325], '1150-1156Crossref': [3330], '(270)': [3333], 'It': [3336], 'reported': [3338], 'activation-dependent': [3347], 'changes': [3348], 'abundance.61Squadrito': [3352], 'Baer': [3354], 'Burdet': [3356], 'Maderna': [3358], 'Gilfillan': [3360], 'G.D.': [3361], 'Lyle': [3362], 'Ibberson': [3364], 'De': [3366], 'Palma': [3367], 'Endogenous': [3369], 'acceptor': [3379], 'cells.Cell': [3380], '1432-1446Abstract': [3384], '(417)': [3392], 'Artificially': [3395], 'elevating': [3396], 'benefited': [3406], 'enrichment': [3408], 'Argonaute': [3412], '(Ago2),': [3414], 'RISC,': [3419], 'implicated': [3422], 'Knockout': [3429], 'Ago2': [3431], 'could': [3432, 3610, 3657, 3835, 4072], 'reduce': [3433], 'miR-451.51Guduric-Fuchs': [3444], 'Collectively,': [3479], 'certain': [3480], 'sequences': [3481], 'favor': [3486], 'uptake': [3488], 'Nevertheless,': [3505], 'remain': [3512], 'unclear': [3513], 'deserve': [3515], 'further': [3516], 'investigation.': [3517], 'shown': [3522], 'exert': [3524], 'multifaceted': [3525], 'effects': [3526], 'progression,': [3529], 'regulation': [3532], 'angiogenesis': [3536, 3586], 'domination': [3539], 'host': [3541], 'responses,': [3543], 'manipulation': [3544], 'chemoresistance,': [3547], '3).': [3555], 'Proliferation': [3556, 3999], 'aspect': [3560], 'commonly': [3566], 'manifested': [3567], 'cycle-related': [3573], 'contributing': [3579], 'metastasis.': [3588], 'cancer-secreted': [3593], 'proliferation': [3599, 3622, 3642, 3661, 3786, 3907], 'targeting': [3601, 3711, 3789, 3910, 4139], 'cycle-associated': [3603, 3912], 'pathways.': [3607], 'miR-200b': [3609, 3638], 'transmitted': [3612], 'colorectal': [3614, 3640, 3716], '(CRC)': [3616], 'promoted': [3620, 3876, 4134], 'recipient': [3624, 3979], 'lowering': [3627], 'p27': [3628], 'expression.62Zhang': [3629], 'Xing': [3631], 'promotes': [3639, 3941], 'TGF-β1': [3644], 'exposure.Biomed.': [3645], 'Pharmacother.': [3646], '106:': [3648], '1135-1143Crossref': [3649], '(2)': [3652], 'miR-6869-5p': [3656], 'depress': [3658], 'CRC': [3659, 3678], 'inhibit': [3663], 'inflammatory': [3667], '(interleukin-6': [3669], '[IL-6]': [3670], 'necrosis': [3673], 'alpha': [3675], '[TNF-α])': [3676], 'blocking': [3681], 'Toll-like': [3683], '4': [3685], '(TLR4)/nuclear': [3686], 'κB': [3688], '(NF-κB)-signaling': [3689], 'pathway.63Yan': [3690], 'Jin': [3694], 'Duan': [3698], 'Xu': [3700, 3702], 'MicroRNA-6869-5p': [3704], 'acts': [3705], 'suppressor': [3709], 'TLR4/NF-κB': [3712], 'cancer.J.': [3717], '233:': [3721], '6660-6668Crossref': [3722], 'Inhibition': [3728], 'oncogenic': [3730], 'miR-21': [3731], 'suppressed': [3735], 'migration': [3739], 'hepatocellular': [3741, 3819], 'carcinoma': [3742], '(HCC)': [3743], 'cells.64Liang': [3744], 'He': [3748], 'Miao': [3750], 'Wu': [3752], 'Gan': [3756], 'Sphk2': [3758], 'RNAi': [3759], 'nanoparticles': [3760], 'downregulating': [3765, 3888, 4093], 'microRNA.J.': [3770], 'Control.': [3771], 'Release.': [3772], '286:': [3774], '348-357Crossref': [3775], '(1)': [3778], 'miR-9-3p': [3782, 3809], 'restrained': [3783], 'HCC': [3784], 'directly': [3788, 3909], 'fibroblast': [3790], '5': [3793], '(HBGF-5).65Tang': [3794], 'Zhu': [3800], 'Yang': [3802], 'W.H.': [3803], 'Xiong': [3804], 'L.K.': [3805], 'D.L.': [3807], 'suppresses': [3810], 'HBGF-5': [3811], 'biomarker': [3817], 'carcinoma.Minerva': [3820], '109:': [3823], '15-23PubMed': [3824], 'miR-1246,': [3828], 'transferred': [3837], 'non-malignant': [3839], 'cells.66Li': [3841], 'X.J.': [3842], 'Ren': [3843, 3917], 'Z.J.': [3844], 'Tang': [3845], 'Yu': [3847], 'MiR-1246': [3851], 'Promotes': [3852], 'Proliferation,': [3854], 'Invasion': [3855], 'Drug': [3857], 'Resistance': [3858], 'Targeting': [3860], 'CCNG2': [3861], 'Breast': [3863, 4002], 'Cancer.Cell.': [3864], '44:': [3868], '1741-1748Crossref': [3869], '(167)': [3872], 'miR-1246': [3875], 'migration,': [3879], 'resistance': [3882], 'cyclin-G2': [3889], '(CCNG2).': [3890], 'miR-193a': [3892, 3940], 'impeded': [3893], 'cycle': [3896], 'exerted': [3899], 'inhibitory': [3901], 'effect': [3902], 'colon': [3904, 3942], '1': [3914], '(Caprin1).67Teng': [3915], 'Hu': [3919], 'Mu': [3921], 'Samykutty': [3923], 'Zhuang': [3925], 'Deng': [3927], 'Kumar': [3929], 'Merchant': [3933], 'al.MVP-mediated': [3936], 'progression.Nat.': [3944], '14448Crossref': [3948], '(260)': [3951], 'orchestrate': [3958], 'apoptotic': [3960, 4084], 'cells.': [3965], 'For': [3966], 'instance,': [3967], 'miR-128': [3969], 'reduced': [3970], 'Bcl-2-associated': [3974], '(Bax)': [3977], 'cells.68Wei': [3982], 'Cui': [3986], 'Shikonin': [3996], 'Inhibits': [3997], 'Cells': [4004], 'Reducing': [4006], 'Tumor-Derived': [4007], 'Exosomes.Molecules.': [4008], '21:': [4010], '777Crossref': [4011], '(21)': [4013], 'miR-373': [4017], 'repressed': [4018], 'estrogen': [4022], '(ER)': [4024], 'inhibited': [4026], 'apoptosis': [4028, 4075, 4137], 'cells.69Eichelser': [4032], 'Stückrath': [4034], 'Müller': [4036], 'Milde-Langosch': [4038], 'Wikman': [4040], 'Pantel': [4042], 'Schwarzenbach': [4044], 'Increased': [4046], 'serum': [4047], 'circulating': [4050], 'microRNA-373': [4052], 'receptor-negative': [4054], 'patients.Oncotarget.': [4057], '9650-9663Crossref': [4060], 'adipose': [4065, 4104], 'mesenchymal': [4066, 4105], 'stem': [4067, 4106], '(hAMSC)-derived': [4069], 'induce': [4073], '(OC)': [4080], 'upregulating': [4083], '(Bax,': [4086], 'caspase': [4087, 4090], '3,': [4088], '9)': [4091], 'anti-apoptotic': [4094, 4140], 'Bcl-2.70Reza': [4095], 'A.M.M.T.': [4096], 'Y.J.': [4098], 'Yasuda': [4099], 'exosomal-miRNAs': [4108], 'anti-proliferation': [4114], 'signalling': [4115], 'A2780': [4117], 'SKOV-3': [4119], 'cells.Sci.': [4122], '38498Crossref': [4126], '(31)': [4129], 'miR-101': [4133, 4169], 'GC': [4135], 'myeloid': [4141], 'leukemia-1': [4143], '(Mcl-1).71Imamura': [4144], 'Komatsu': [4146], 'Ichikawa': [4148], 'Miyamae': [4150], 'Okajima': [4152], 'Ohashi': [4154], 'Kiuchi': [4156], 'Nishibeppu': [4158], 'Kosuga': [4160], 'Konishi': [4162], 'al.Low': [4165], 'cancer.Oncotarget.': [4177], '106538-106550Crossref': [4180], '(9)': [4183], 'epithelial-mesenchymal': [4187], 'transition': [4188], '(EMT),': [4189], 'vital': [4191], 'process': [4192], 'invasion': [4196], 'characterized': [4200]}, 'cited_by_api_url': 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