Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2944462489', 'doi': 'https://doi.org/10.1002/jlb.3mr1217-497r', 'title': 'The role of type 2 innate lymphoid cells in eosinophilic asthma', 'display_name': 'The role of type 2 innate lymphoid cells in eosinophilic asthma', 'publication_year': 2019, 'publication_date': '2019-05-07', 'ids': {'openalex': 'https://openalex.org/W2944462489', 'doi': 'https://doi.org/10.1002/jlb.3mr1217-497r', 'mag': '2944462489', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31063647'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jlb.3mr1217-497r', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S199011235', 'display_name': 'Journal of Leukocyte Biology', 'issn_l': '0741-5400', 'issn': ['0741-5400', '1938-3673'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5031238472', 'display_name': 'Brittany Salter', 'orcid': 'https://orcid.org/0000-0002-4253-2924'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Brittany M Salter', 'raw_affiliation_strings': ['CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5007136366', 'display_name': 'Michael Aw', 'orcid': 'https://orcid.org/0000-0002-1702-0863'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': False, 'raw_author_name': 'Michael Aw', 'raw_affiliation_strings': ['CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5016053143', 'display_name': 'Roma Sehmi', 'orcid': 'https://orcid.org/0000-0003-0968-6304'}, 'institutions': [{'id': 'https://openalex.org/I98251732', 'display_name': 'McMaster University', 'ror': 'https://ror.org/02fa3aq29', 'country_code': 'CA', 'type': 'education', 'lineage': ['https://openalex.org/I98251732']}], 'countries': ['CA'], 'is_corresponding': True, 'raw_author_name': 'Roma Sehmi', 'raw_affiliation_strings': ['CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada'], 'affiliations': [{'raw_affiliation_string': 'CardioRespiratory Research Group, McMaster University , Hamilton, Ontario, Canada', 'institution_ids': ['https://openalex.org/I98251732']}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5016053143'], 'corresponding_institution_ids': ['https://openalex.org/I98251732'], 'apc_list': {'value': 3350, 'currency': 'USD', 'value_usd': 3350, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.294, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 21, 'citation_normalized_percentile': {'value': 0.413571, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 92, 'max': 93}, 'biblio': {'volume': '106', 'issue': '4', 'first_page': '889', 'last_page': '901'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12528', 'display_name': 'Innate Lymphoid Cells in Immunity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12528', 'display_name': 'Innate Lymphoid Cells in Immunity', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12538', 'display_name': 'Diagnosis and Management of Eosinophilic Esophagitis', 'score': 0.9949, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9813, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/innate-lymphoid-cell', 'display_name': 'Innate lymphoid cell', 'score': 0.8995731}, {'id': 'https://openalex.org/keywords/innate-lymphoid-cells', 'display_name': 'Innate Lymphoid Cells', 'score': 0.565245}, {'id': 'https://openalex.org/keywords/type-2-immunity', 'display_name': 'Type 2 Immunity', 'score': 0.535939}, {'id': 'https://openalex.org/keywords/pulmonary-eosinophilia', 'display_name': 'Pulmonary Eosinophilia', 'score': 0.42647415}], 'concepts': [{'id': 'https://openalex.org/C47742525', 'wikidata': 'https://www.wikidata.org/wiki/Q13418826', 'display_name': 'Innate lymphoid cell', 'level': 4, 'score': 0.8995731}, {'id': 'https://openalex.org/C2779758542', 'wikidata': 'https://www.wikidata.org/wiki/Q2106364', 'display_name': 'Eosinophilic', 'level': 2, 'score': 0.80481744}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.7518315}, {'id': 'https://openalex.org/C2777129736', 'wikidata': 'https://www.wikidata.org/wiki/Q505142', 'display_name': 'Eosinophilia', 'level': 2, 'score': 0.6676767}, {'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.52421486}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5105375}, {'id': 'https://openalex.org/C181901479', 'wikidata': 'https://www.wikidata.org/wiki/Q14877650', 'display_name': 'Interleukin 5', 'level': 4, 'score': 0.50539684}, {'id': 'https://openalex.org/C207480886', 'wikidata': 'https://www.wikidata.org/wiki/Q42982', 'display_name': 'Allergy', 'level': 2, 'score': 0.44870463}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.4413666}, {'id': 'https://openalex.org/C136449434', 'wikidata': 'https://www.wikidata.org/wiki/Q428253', 'display_name': 'Innate immune system', 'level': 3, 'score': 0.43943417}, {'id': 'https://openalex.org/C2909466502', 'wikidata': 'https://www.wikidata.org/wiki/Q505142', 'display_name': 'Pulmonary Eosinophilia', 'level': 4, 'score': 0.42647415}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.41771147}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.30569655}, {'id': 'https://openalex.org/C2777037409', 'wikidata': 'https://www.wikidata.org/wiki/Q107238', 'display_name': 'Eosinophil', 'level': 3, 'score': 0.2834702}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.22242057}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.16111481}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.14888984}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D007113', 'descriptor_name': 'Immunity, Innate', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': 'Q000150', 'qualifier_name': 'complications', 'is_major_topic': True}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006410', 'descriptor_name': 'Hematopoiesis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008214', 'descriptor_name': 'Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011657', 'descriptor_name': 'Pulmonary Eosinophilia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/jlb.3mr1217-497r', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S199011235', 'display_name': 'Journal of Leukocyte Biology', 'issn_l': '0741-5400', 'issn': ['0741-5400', '1938-3673'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310311648', 'host_organization_name': 'Oxford University Press', 'host_organization_lineage': ['https://openalex.org/P4310311647', 'https://openalex.org/P4310311648'], 'host_organization_lineage_names': ['University of Oxford', 'Oxford University Press'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31063647', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'score': 0.84, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 114, 'referenced_works': ['https://openalex.org/W1167372180', 'https://openalex.org/W1575966267', 'https://openalex.org/W1907278795', 'https://openalex.org/W1929917332', 'https://openalex.org/W1969324457', 'https://openalex.org/W1972109738', 'https://openalex.org/W1975975357', 'https://openalex.org/W1978311073', 'https://openalex.org/W1989019305', 'https://openalex.org/W1994875855', 'https://openalex.org/W1995070836', 'https://openalex.org/W1998846885', 'https://openalex.org/W1999709152', 'https://openalex.org/W2004538946', 'https://openalex.org/W2006120252', 'https://openalex.org/W2008996473', 'https://openalex.org/W2011998167', 'https://openalex.org/W2013105339', 'https://openalex.org/W2014437975', 'https://openalex.org/W2015234837', 'https://openalex.org/W2023152671', 'https://openalex.org/W2025926163', 'https://openalex.org/W2027462139', 'https://openalex.org/W2029529774', 'https://openalex.org/W2033289727', 'https://openalex.org/W2038846887', 'https://openalex.org/W2040166126', 'https://openalex.org/W2050209022', 'https://openalex.org/W2051465794', 'https://openalex.org/W2055172715', 'https://openalex.org/W2062783549', 'https://openalex.org/W2062918919', 'https://openalex.org/W2078498449', 'https://openalex.org/W2078558151', 'https://openalex.org/W2080177623', 'https://openalex.org/W2083665488', 'https://openalex.org/W2083850524', 'https://openalex.org/W2085246851', 'https://openalex.org/W2086914849', 'https://openalex.org/W2087691206', 'https://openalex.org/W2089685608', 'https://openalex.org/W2093537882', 'https://openalex.org/W2096545973', 'https://openalex.org/W2100379729', 'https://openalex.org/W2102829493', 'https://openalex.org/W2106790228', 'https://openalex.org/W2121327269', 'https://openalex.org/W2126612550', 'https://openalex.org/W2127303736', 'https://openalex.org/W2127499918', 'https://openalex.org/W2129022159', 'https://openalex.org/W2130365803', 'https://openalex.org/W2130509509', 'https://openalex.org/W2137337213', 'https://openalex.org/W2138797177', 'https://openalex.org/W2140083164', 'https://openalex.org/W2140206763', 'https://openalex.org/W2145818079', 'https://openalex.org/W2150464681', 'https://openalex.org/W2152222824', 'https://openalex.org/W2154263136', 'https://openalex.org/W2157527047', 'https://openalex.org/W2158045379', 'https://openalex.org/W2158206794', 'https://openalex.org/W2165638693', 'https://openalex.org/W2170948066', 'https://openalex.org/W2182536415', 'https://openalex.org/W2191813810', 'https://openalex.org/W2211024346', 'https://openalex.org/W2216745061', 'https://openalex.org/W2230635575', 'https://openalex.org/W2257684394', 'https://openalex.org/W2317368558', 'https://openalex.org/W2325574333', 'https://openalex.org/W2330262984', 'https://openalex.org/W2343795401', 'https://openalex.org/W2344776862', 'https://openalex.org/W2420291148', 'https://openalex.org/W2468936205', 'https://openalex.org/W2471110308', 'https://openalex.org/W2474544116', 'https://openalex.org/W2516341826', 'https://openalex.org/W2530089097', 'https://openalex.org/W2554650621', 'https://openalex.org/W2562858382', 'https://openalex.org/W2580636831', 'https://openalex.org/W2586238008', 'https://openalex.org/W2597696030', 'https://openalex.org/W2606710770', 'https://openalex.org/W2607108166', 'https://openalex.org/W2618818828', 'https://openalex.org/W2737540268', 'https://openalex.org/W2739396982', 'https://openalex.org/W2750992365', 'https://openalex.org/W2751504652', 'https://openalex.org/W2751852104', 'https://openalex.org/W2752584372', 'https://openalex.org/W2754140340', 'https://openalex.org/W2755681539', 'https://openalex.org/W2756252542', 'https://openalex.org/W2774218093', 'https://openalex.org/W2777204306', 'https://openalex.org/W2779574560', 'https://openalex.org/W2783334998', 'https://openalex.org/W2784029682', 'https://openalex.org/W2786548885', 'https://openalex.org/W2788432546', 'https://openalex.org/W2788714509', 'https://openalex.org/W2789828774', 'https://openalex.org/W2802377817', 'https://openalex.org/W2911700485', 'https://openalex.org/W387031605', 'https://openalex.org/W4319308391', 'https://openalex.org/W880475159'], 'related_works': ['https://openalex.org/W781118132', 'https://openalex.org/W4206366838', 'https://openalex.org/W3181867215', 'https://openalex.org/W2944462489', 'https://openalex.org/W2902079152', 'https://openalex.org/W2440184407', 'https://openalex.org/W2073330059', 'https://openalex.org/W2069778146', 'https://openalex.org/W1967774498', 'https://openalex.org/W1965182053'], 'abstract_inverted_index': {'Abstract': [0], 'Eosinophilic': [1], 'asthma': [2, 82, 149], 'has': [3], 'conventionally': [4], 'been': [5], 'proposed': [6], 'to': [7, 72, 92, 104], 'be': [8], 'a': [9, 19, 49], 'T': [10, 46, 64, 98], 'helper': [11], '2': [12, 24, 75], 'driven': [13], 'disease': [14], 'but': [15], 'emerging': [16], 'evidence': [17], 'supports': [18], 'central': [20], 'role': [21], 'of': [22, 116, 123, 155], 'type': [23, 74], 'innate': [25], 'lymphoid': [26], 'cells': [27, 33, 65, 99], '(ILC2s).': [28], 'These': [29], 'are': [30, 111], 'non-T,': [31], 'non-B': [32], 'that': [34, 60, 84], 'lack': [35], 'antigen': [36], 'specificity': [37], 'and': [38, 42, 62, 102, 145], 'produce': [39], 'more': [40], 'IL-5': [41], 'IL-13': [43], 'than': [44], 'CD4+': [45, 63, 97], 'lymphocytes,': [47], 'on': [48], 'cell': [50, 52], 'per': [51], 'basis,': [53], 'in': [54, 67, 80, 127, 148, 169], 'vitro.': [55], 'Although': [56, 139], 'it': [57], 'is': [58], 'clear': [59], 'ILC2s': [61, 85, 110, 144, 156], 'work': [66], 'concert': [68], 'with': [69, 119, 132], 'each': [70], 'other': [71], 'drive': [73], 'immune': [76], 'responses,': [77, 95], 'kinetic': [78], 'studies': [79], 'allergic': [81], 'suggest': [83], 'may': [86, 160], 'act': [87, 100], 'locally': [88, 101], 'within': [89, 113, 157], 'the': [90, 114, 120, 140, 153, 158], 'airways': [91, 115, 159, 170], '“initiate”': [93], 'eosinophilic': [94, 106, 167], 'whereas': [96], 'systemically': [103], '“perpetuate”': [105], 'inflammatory': [107], 'responses.': [108], 'Importantly,': [109], 'increased': [112], 'severe': [117, 130], 'asthmatics,': [118], 'greatest': [121], 'number': [122], 'IL-5+IL-13+ILC2s': [124], 'being': [125], 'detected': [126], 'sputum': [128], 'from': [129], 'asthmatics': [131], 'uncontrolled': [133], 'eosinophilia': [134], 'despite': [135], 'high-dose': [136], 'steroid': [137, 146], 'therapy.': [138], 'precise': [141], 'relationship': [142], 'between': [143], 'sensitivity': [147], 'remains': [150], 'unclear,': [151], 'controlling': [152], 'activation': [154], 'provide': [161], 'an': [162], 'effective': [163], 'therapeutic': [164], 'target': [165], 'for': [166], 'inflammation': [168], 'diseases.': [171]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2944462489', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 4}], 'updated_date': '2024-09-13T14:25:38.717756', 'created_date': '2019-05-16'}