Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment

Name: Work Video:
Duration: 3 min 30 s
Elizabeth V. Nguyen; Brooke A. Pereira; Mitchell G. Lawrence; Xiuquan Ma; Richard J. Rebello; Howard Chan; Birunthi Niranjan; Yunjian Wu; Stuart J. Ellem; Xiaoqing Guan; Jianmin Wu; Joanna N. Skhinas; Thomas R. Cox; Gail P. Risbridger; Renea A. Taylor; Natalie Lister; Roger J. Daly
{'id': 'https://openalex.org/W2944168058', 'doi': 'https://doi.org/10.1074/mcp.ra119.001496', 'title': 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment', 'display_name': 'Proteomic Profiling of Human Prostate Cancer-associated Fibroblasts (CAF) Reveals LOXL2-dependent Regulation of the Tumor Microenvironment', 'publication_year': 2019, 'publication_date': '2019-05-07', 'ids': {'openalex': 'https://openalex.org/W2944168058', 'doi': 'https://doi.org/10.1074/mcp.ra119.001496', 'mag': '2944168058', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/33451524', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6601211'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.ra119.001496', 'pdf_url': 'https://www.mcponline.org/content/mcprot/18/7/1410.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.mcponline.org/content/mcprot/18/7/1410.full.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5023938819', 'display_name': 'Elizabeth V. Nguyen', 'orcid': 'https://orcid.org/0000-0002-6495-7827'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizabeth V. Nguyen', 'raw_affiliation_strings': ['Departments of §Biochemistry and Molecular Biology,', 'From the ‡Cancer Program, Biomedicine Discovery Institute,'], 'affiliations': [{'raw_affiliation_string': 'Departments of §Biochemistry and Molecular Biology,', 'institution_ids': []}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5085027792', 'display_name': 'Brooke A. Pereira', 'orcid': 'https://orcid.org/0000-0003-3513-1214'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Brooke A. Pereira', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and'], 'affiliations': [{'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005104377', 'display_name': 'Mitchell G. Lawrence', 'orcid': 'https://orcid.org/0000-0001-9520-3000'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}, {'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I4210103203', 'display_name': 'Victorian Comprehensive Cancer Centre', 'ror': 'https://ror.org/00st91468', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103203']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Mitchell G. Lawrence', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and', '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}, {'raw_affiliation_string': '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I4210103203']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052345144', 'display_name': 'Xiuquan Ma', 'orcid': 'https://orcid.org/0000-0001-7227-1289'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiuquan Ma', 'raw_affiliation_strings': ['Departments of §Biochemistry and Molecular Biology,', 'From the ‡Cancer Program, Biomedicine Discovery Institute,'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': 'Departments of §Biochemistry and Molecular Biology,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068112328', 'display_name': 'Richard J. Rebello', 'orcid': 'https://orcid.org/0000-0001-6271-6678'}, 'institutions': [{'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}, {'id': 'https://openalex.org/I4210103203', 'display_name': 'Victorian Comprehensive Cancer Centre', 'ror': 'https://ror.org/00st91468', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103203']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Richard J. Rebello', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and', '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia'], 'affiliations': [{'raw_affiliation_string': '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I4210103203']}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5113171253', 'display_name': 'Howard Chan', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Howard Chan', 'raw_affiliation_strings': ['Departments of §Biochemistry and Molecular Biology,', 'From the ‡Cancer Program, Biomedicine Discovery Institute,'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': 'Departments of §Biochemistry and Molecular Biology,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5020743196', 'display_name': 'Birunthi Niranjan', 'orcid': 'https://orcid.org/0000-0002-9555-8378'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Birunthi Niranjan', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036262416', 'display_name': 'Yunjian Wu', 'orcid': 'https://orcid.org/0000-0001-8941-2287'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yunjian Wu', 'raw_affiliation_strings': ['Departments of §Biochemistry and Molecular Biology,', 'From the ‡Cancer Program, Biomedicine Discovery Institute,'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': 'Departments of §Biochemistry and Molecular Biology,', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003116335', 'display_name': 'Stuart J. Ellem', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I185523456', 'display_name': 'University of Southern Queensland', 'ror': 'https://ror.org/04sjbnx57', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I185523456']}, {'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Stuart Ellem', 'raw_affiliation_strings': ['**School of Health and Wellbeing, University of Southern Queensland, Ipswich, Queensland, Australia', 'From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and'], 'affiliations': [{'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}, {'raw_affiliation_string': '**School of Health and Wellbeing, University of Southern Queensland, Ipswich, Queensland, Australia', 'institution_ids': ['https://openalex.org/I185523456']}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023938129', 'display_name': 'Xiaoqing Guan', 'orcid': 'https://orcid.org/0000-0001-8010-5715'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaoqing Guan', 'raw_affiliation_strings': ['‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China'], 'affiliations': [{'raw_affiliation_string': '‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5068746343', 'display_name': 'Jianmin Wu', 'orcid': 'https://orcid.org/0000-0002-8876-128X'}, 'institutions': [{'id': 'https://openalex.org/I20231570', 'display_name': 'Peking University', 'ror': 'https://ror.org/02v51f717', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I20231570']}, {'id': 'https://openalex.org/I4210093964', 'display_name': 'Peking University Cancer Hospital', 'ror': 'https://ror.org/00nyxxr91', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210093964']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jianmin Wu', 'raw_affiliation_strings': ['‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China'], 'affiliations': [{'raw_affiliation_string': '‡‡Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Center for Cancer Bioinformatics, Peking University Cancer Hospital & Institute, Beijing, China', 'institution_ids': ['https://openalex.org/I20231570', 'https://openalex.org/I4210093964']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003062884', 'display_name': 'Joanna N. Skhinas', 'orcid': 'https://orcid.org/0000-0001-8797-8228'}, 'institutions': [{'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210153363', 'display_name': 'The Kinghorn Cancer Centre', 'ror': 'https://ror.org/04fw0fr46', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153363']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Joanna N. Skhinas', 'raw_affiliation_strings': ['§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia'], 'affiliations': [{'raw_affiliation_string': '§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia', 'institution_ids': ['https://openalex.org/I136750679', 'https://openalex.org/I4210153363']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5033014692', 'display_name': 'Thomas R. Cox', 'orcid': 'https://orcid.org/0000-0001-9294-1745'}, 'institutions': [{'id': 'https://openalex.org/I4210123488', 'display_name': "St Vincent's Clinic", 'ror': 'https://ror.org/02rthxz10', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210123488']}, {'id': 'https://openalex.org/I31746571', 'display_name': 'UNSW Sydney', 'ror': 'https://ror.org/03r8z3t63', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I31746571']}, {'id': 'https://openalex.org/I136750679', 'display_name': 'Garvan Institute of Medical Research', 'ror': 'https://ror.org/01b3dvp57', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I136750679', 'https://openalex.org/I4210087284']}, {'id': 'https://openalex.org/I4210153363', 'display_name': 'The Kinghorn Cancer Centre', 'ror': 'https://ror.org/04fw0fr46', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153363']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Thomas R. Cox', 'raw_affiliation_strings': ['§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia', "¶¶St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia"], 'affiliations': [{'raw_affiliation_string': "¶¶St Vincent's Clinical School, Faculty of Medicine, UNSW Sydney, Sydney, Australia", 'institution_ids': ['https://openalex.org/I4210123488', 'https://openalex.org/I31746571']}, {'raw_affiliation_string': '§§The Garvan Institute of Medical Research and The Kinghorn Cancer Centre, Sydney, Australia', 'institution_ids': ['https://openalex.org/I136750679', 'https://openalex.org/I4210153363']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5089881929', 'display_name': 'Gail P. Risbridger', 'orcid': 'https://orcid.org/0000-0003-3089-4028'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}, {'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}, {'id': 'https://openalex.org/I4210103203', 'display_name': 'Victorian Comprehensive Cancer Centre', 'ror': 'https://ror.org/00st91468', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103203']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Gail P. Risbridger', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and', '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', '‖‖Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia'], 'affiliations': [{'raw_affiliation_string': '‖‖Sir Peter MacCallum Department of Oncology, The University of Melbourne, Parkville, Australia', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I2800555584']}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}, {'raw_affiliation_string': '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', 'institution_ids': ['https://openalex.org/I2800555584', 'https://openalex.org/I4210103203']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5078921079', 'display_name': 'Renea A. Taylor', 'orcid': 'https://orcid.org/0000-0003-2609-2380'}, 'institutions': [{'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}, {'id': 'https://openalex.org/I4210103203', 'display_name': 'Victorian Comprehensive Cancer Centre', 'ror': 'https://ror.org/00st91468', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210103203']}, {'id': 'https://openalex.org/I2800555584', 'display_name': 'Peter MacCallum Cancer Centre', 'ror': 'https://ror.org/02a8bt934', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800555584']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Renea A. Taylor', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', '‡‡‡Physiology, Monash University, Clayton, Australia'], 'affiliations': [{'raw_affiliation_string': '‡‡‡Physiology, Monash University, Clayton, Australia', 'institution_ids': ['https://openalex.org/I56590836']}, {'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '‖Cancer Research Division, Peter MacCallum Cancer Centre, Victorian Comprehensive Cancer Centre, Parkville, Australia', 'institution_ids': ['https://openalex.org/I4210103203', 'https://openalex.org/I2800555584']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016616007', 'display_name': 'Natalie Lister', 'orcid': 'https://orcid.org/0000-0001-9223-5875'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Natalie L. Lister', 'raw_affiliation_strings': ['From the ‡Cancer Program, Biomedicine Discovery Institute,', '¶Anatomy and Developmental Biology, and'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': '¶Anatomy and Developmental Biology, and', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5060521527', 'display_name': 'Roger J. Daly', 'orcid': 'https://orcid.org/0000-0002-5739-8027'}, 'institutions': [{'id': 'https://openalex.org/I2799424032', 'display_name': 'Discovery Institute', 'ror': 'https://ror.org/05t8s3y29', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2799424032']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Roger J. Daly', 'raw_affiliation_strings': ['Departments of §Biochemistry and Molecular Biology,', 'From the ‡Cancer Program, Biomedicine Discovery Institute,'], 'affiliations': [{'raw_affiliation_string': 'From the ‡Cancer Program, Biomedicine Discovery Institute,', 'institution_ids': ['https://openalex.org/I2799424032']}, {'raw_affiliation_string': 'Departments of §Biochemistry and Molecular Biology,', 'institution_ids': []}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 12, 'corresponding_author_ids': ['https://openalex.org/A5060521527'], 'corresponding_institution_ids': ['https://openalex.org/I2799424032'], 'apc_list': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'apc_paid': {'value': 2800, 'currency': 'USD', 'value_usd': 2800, 'provenance': 'doaj'}, 'fwci': 3.696, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 73, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '18', 'issue': '7', 'first_page': '1410', 'last_page': '1427'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12688', 'display_name': 'Microbial metabolism and enzyme function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12688', 'display_name': 'Microbial metabolism and enzyme function', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10678', 'display_name': 'Inflammatory mediators and NSAID effects', 'score': 0.9918, 'subfield': {'id': 'https://openalex.org/subfields/2736', 'display_name': 'Pharmacology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11884', 'display_name': 'Redox biology and oxidative stress', 'score': 0.9768, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/lysyl-oxidase', 'display_name': 'Lysyl Oxidase', 'score': 0.5159993}, {'id': 'https://openalex.org/keywords/cancer-associated-fibroblasts', 'display_name': 'Cancer-Associated Fibroblasts', 'score': 0.43528956}, {'id': 'https://openalex.org/keywords/proteome', 'display_name': 'Proteome', 'score': 0.41215464}], 'concepts': [{'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.6230024}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.55711454}, {'id': 'https://openalex.org/C2776107976', 'wikidata': 'https://www.wikidata.org/wiki/Q1786433', 'display_name': 'Tumor microenvironment', 'level': 3, 'score': 0.5462316}, {'id': 'https://openalex.org/C193143273', 'wikidata': 'https://www.wikidata.org/wiki/Q419389', 'display_name': 'Lysyl oxidase', 'level': 3, 'score': 0.5159993}, {'id': 'https://openalex.org/C151166631', 'wikidata': 'https://www.wikidata.org/wiki/Q904514', 'display_name': 'Focal adhesion', 'level': 3, 'score': 0.50051355}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.49105167}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.46640506}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.46603173}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.45012853}, {'id': 'https://openalex.org/C101544691', 'wikidata': 'https://www.wikidata.org/wiki/Q420511', 'display_name': 'Receptor tyrosine kinase', 'level': 3, 'score': 0.43832025}, {'id': 'https://openalex.org/C2909706936', 'wikidata': 'https://www.wikidata.org/wiki/Q42417562', 'display_name': 'Cancer-Associated Fibroblasts', 'level': 4, 'score': 0.43528956}, {'id': 'https://openalex.org/C104397665', 'wikidata': 'https://www.wikidata.org/wiki/Q860947', 'display_name': 'Proteome', 'level': 2, 'score': 0.41215464}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.33309042}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.32546866}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.21953711}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.2068041}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C3020616263', 'wikidata': 'https://www.wikidata.org/wiki/Q1216998', 'display_name': 'Tumor cells', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000594', 'descriptor_name': 'Amino Acid Oxidoreductases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000072645', 'descriptor_name': 'Cancer-Associated Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D019898', 'descriptor_name': 'Autocrine Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002465', 'descriptor_name': 'Cell Movement', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D005109', 'descriptor_name': 'Extracellular Matrix', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D019899', 'descriptor_name': 'Paracrine Communication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010750', 'descriptor_name': 'Phosphoproteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011467', 'descriptor_name': 'Prostate', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D020543', 'descriptor_name': 'Proteome', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D040901', 'descriptor_name': 'Proteomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015203', 'descriptor_name': 'Reproducibility of Results', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059016', 'descriptor_name': 'Tumor Microenvironment', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 7, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.ra119.001496', 'pdf_url': 'https://www.mcponline.org/content/mcprot/18/7/1410.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6601211', 'pdf_url': 'https://europepmc.org/articles/pmc6601211?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hdl.handle.net/11343/246195', 'pdf_url': 'http://minerva-access.unimelb.edu.au/bitstreams/d4266848-5ae4-5000-b28d-0530e73a1d2c/download', 'source': {'id': 'https://openalex.org/S4306402500', 'display_name': 'Minerva Access (University of Melbourne)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I165779595', 'host_organization_name': 'University of Melbourne', 'host_organization_lineage': ['https://openalex.org/I165779595'], 'host_organization_lineage_names': ['University of Melbourne'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://research.monash.edu/en/publications/27385060-d751-4a32-b224-62a6e1962d17', 'pdf_url': 'https://research.monash.edu/files/280430831/280371732_oa.pdf', 'source': {'id': 'https://openalex.org/S4306402625', 'display_name': 'Monash University Research Portal (Monash University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I56590836', 'host_organization_name': 'Monash University', 'host_organization_lineage': ['https://openalex.org/I56590836'], 'host_organization_lineage_names': ['Monash University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://researchmgt.monash.edu/ws/files/280430831/280371732_oa.pdf', 'pdf_url': 'https://researchmgt.monash.edu/ws/files/280430831/280371732_oa.pdf', 'source': {'id': 'https://openalex.org/S4306402625', 'display_name': 'Monash University Research Portal (Monash University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I56590836', 'host_organization_name': 'Monash University', 'host_organization_lineage': ['https://openalex.org/I56590836'], 'host_organization_lineage_names': ['Monash University'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6601211', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31061140', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1074/mcp.ra119.001496', 'pdf_url': 'https://www.mcponline.org/content/mcprot/18/7/1410.full.pdf', 'source': {'id': 'https://openalex.org/S104550190', 'display_name': 'Molecular & Cellular Proteomics', 'issn_l': '1535-9476', 'issn': ['1535-9476', '1535-9484'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Reduced inequalities', 'score': 0.68, 'id': 'https://metadata.un.org/sdg/10'}], 'grants': [{'funder': 'https://openalex.org/F4320310187', 'funder_display_name': 'Victorian Cancer Agency', 'award_id': '15023'}, {'funder': 'https://openalex.org/F4320320501', 'funder_display_name': 'Cancer Australia', 'award_id': 'ID NCG2616'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1102752'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1058540'}, {'funder': 'https://openalex.org/F4320334712', 'funder_display_name': 'Faculty of Medicine, Nursing and Health Sciences, Monash University', 'award_id': 'SGS16–0295'}], 'datasets': [], 'versions': [], 'referenced_works_count': 97, 'referenced_works': ['https://openalex.org/W1520162011', 'https://openalex.org/W1579383624', 'https://openalex.org/W1755463677', 'https://openalex.org/W175967323', 'https://openalex.org/W1894499695', 'https://openalex.org/W1959606306', 'https://openalex.org/W1964299476', 'https://openalex.org/W1971649337', 'https://openalex.org/W1975574047', 'https://openalex.org/W1976357851', 'https://openalex.org/W1980516263', 'https://openalex.org/W1982283713', 'https://openalex.org/W1982654262', 'https://openalex.org/W1990214118', 'https://openalex.org/W2000598211', 'https://openalex.org/W2001114745', 'https://openalex.org/W2001947856', 'https://openalex.org/W2008324315', 'https://openalex.org/W2011566841', 'https://openalex.org/W2013612743', 'https://openalex.org/W2014371105', 'https://openalex.org/W2016249226', 'https://openalex.org/W2018371450', 'https://openalex.org/W2027222148', 'https://openalex.org/W2030994367', 'https://openalex.org/W2037023229', 'https://openalex.org/W2041306701', 'https://openalex.org/W2043991982', 'https://openalex.org/W2055801606', 'https://openalex.org/W2056591712', 'https://openalex.org/W2057407996', 'https://openalex.org/W2058057410', 'https://openalex.org/W2062265555', 'https://openalex.org/W2062859898', 'https://openalex.org/W2072202269', 'https://openalex.org/W2073371472', 'https://openalex.org/W2078586977', 'https://openalex.org/W2080422007', 'https://openalex.org/W2082081720', 'https://openalex.org/W2084458818', 'https://openalex.org/W2090772441', 'https://openalex.org/W2096764577', 'https://openalex.org/W2097059887', 'https://openalex.org/W2099358710', 'https://openalex.org/W2100122781', 'https://openalex.org/W2101449318', 'https://openalex.org/W2104947426', 'https://openalex.org/W2105524728', 'https://openalex.org/W2105564769', 'https://openalex.org/W2112955251', 'https://openalex.org/W2113613985', 'https://openalex.org/W2114165700', 'https://openalex.org/W2114497102', 'https://openalex.org/W2116586864', 'https://openalex.org/W2122683221', 'https://openalex.org/W2123233784', 'https://openalex.org/W2127722806', 'https://openalex.org/W2127842409', 'https://openalex.org/W2127927969', 'https://openalex.org/W2127979123', 'https://openalex.org/W2131206883', 'https://openalex.org/W2131495509', 'https://openalex.org/W2132370499', 'https://openalex.org/W2133317416', 'https://openalex.org/W2141828060', 'https://openalex.org/W2145802927', 'https://openalex.org/W2145955140', 'https://openalex.org/W2147016321', 'https://openalex.org/W2152095891', 'https://openalex.org/W2153076514', 'https://openalex.org/W2157813647', 'https://openalex.org/W2166159531', 'https://openalex.org/W2217024048', 'https://openalex.org/W2346419906', 'https://openalex.org/W2408039933', 'https://openalex.org/W2413827320', 'https://openalex.org/W2415559729', 'https://openalex.org/W2415991235', 'https://openalex.org/W2476542314', 'https://openalex.org/W2508744997', 'https://openalex.org/W2514494800', 'https://openalex.org/W2544852806', 'https://openalex.org/W2583338722', 'https://openalex.org/W2588314637', 'https://openalex.org/W2590146273', 'https://openalex.org/W2594563391', 'https://openalex.org/W2624992840', 'https://openalex.org/W2739944480', 'https://openalex.org/W2745376284', 'https://openalex.org/W2762514399', 'https://openalex.org/W2776912235', 'https://openalex.org/W2782986679', 'https://openalex.org/W2798082234', 'https://openalex.org/W2906715838', 'https://openalex.org/W2950557897', 'https://openalex.org/W4236268856', 'https://openalex.org/W797317773'], 'related_works': ['https://openalex.org/W4281677589', 'https://openalex.org/W4234237736', 'https://openalex.org/W2423271224', 'https://openalex.org/W2123233784', 'https://openalex.org/W2076950581', 'https://openalex.org/W2061644739', 'https://openalex.org/W2061456248', 'https://openalex.org/W2008528819', 'https://openalex.org/W1988173412', 'https://openalex.org/W1810934078'], 'abstract_inverted_index': {'In': [0, 241, 524, 1578, 1810], 'prostate': [1, 12, 25, 213, 232, 242, 253, 266, 454, 473, 573, 609, 629, 666, 705, 758, 812, 877, 893, 978, 1014, 1064, 1190, 1221, 1267, 1320, 1356, 1402, 1468, 1513, 1548, 1583, 1661, 1694, 1791, 1892, 2107, 2119, 2147, 2173, 2307, 2505, 2544, 2587, 2637, 2657, 2678, 2717, 2770, 2796], 'cancer,': [2, 243], 'cancer-associated': [3, 244, 630, 780, 1324, 1386, 1464, 1524, 1737, 1888, 2501], 'fibroblasts': [4, 13, 245, 254, 781, 878, 1244, 1325, 1350, 1387, 1465, 1738, 1889, 2502], '(CAF)': [5, 246, 782], 'exhibit': [6, 247, 1559], 'contrasting': [7, 248], 'biological': [8, 249, 2835], 'properties': [9, 250, 1462, 1886, 1912, 2499], 'to': [10, 52, 251, 293, 497, 547, 779, 1185, 1457, 1881, 1907, 2124, 2168, 2339, 2432, 2494, 2924, 3046, 3077, 3093, 3169, 3192, 3221, 3372, 3389, 3459, 3474, 3493, 3573, 3625, 3634, 3708, 3727, 3941, 4147, 4217], 'non-malignant': [11, 252, 876], '(NPF)': [14, 255, 879], 'and': [15, 24, 40, 48, 93, 109, 128, 139, 155, 172, 181, 195, 235, 256, 265, 281, 289, 334, 350, 369, 380, 396, 413, 422, 436, 476, 489, 534, 595, 625, 637, 645, 668, 801, 811, 836, 842, 847, 875, 889, 908, 1066, 1076, 1220, 1259, 1264, 1323, 1329, 1385, 1547, 1570, 1613, 1696, 1733, 1794, 1797, 1823, 1835, 1910, 1935, 1967, 1975, 2055, 2063, 2073, 2111, 2129, 2142, 2149, 2195, 2197, 2234, 2238, 2259, 2323, 2328, 2344, 2356, 2390, 2412, 2420, 2425, 2441, 2445, 2524, 2614, 2680, 2795, 2810, 2867, 2922, 2935, 2966, 3019, 3050, 3067, 3106, 3121, 3172, 3190, 3254, 3363, 3404, 3416, 3525, 3571, 3632, 3657, 3662, 3676, 3698, 3715, 3725, 3847, 3866, 3882, 3885, 3894, 3919, 3960, 3967, 4007, 4024, 4044, 4089, 4118, 4135, 4145, 4185, 4200, 4215, 4255], 'promote': [16, 257, 1186], 'tumorigenesis.': [17, 258], 'Resolving': [18, 259], 'intercellular': [19, 228, 260, 469, 1543], 'signaling': [20, 261, 1659, 1766, 1786, 1934, 2103, 2163], 'pathways': [21, 262, 1615], 'between': [22, 263, 1545, 1610, 1821, 2106], 'CAF': [23, 47, 82, 98, 116, 175, 197, 264, 288, 323, 339, 357, 416, 438, 793, 825, 874, 901, 1181, 1546, 1768, 1822, 2110, 2148, 2258, 2411, 2523, 2613, 2809, 2839, 3881], 'tumor': [26, 214, 233, 267, 455, 474, 643, 796, 831, 1246, 1917, 1976, 2053, 2120, 2324], 'epithelium': [27, 268, 590], 'may': [28, 269, 1763], 'offer': [29, 270], 'novel': [30, 271, 2013], 'opportunities': [31, 272], 'for': [32, 87, 152, 273, 328, 393, 572, 652, 857, 1073, 1205, 1542, 1830, 2088, 2636, 2854, 2959, 3016, 3028, 3055, 3083, 3145, 3406, 3449, 3467, 3517, 3670, 3677, 3770, 3787, 3790, 3800, 3829, 3874, 3891, 3916, 3949, 4046, 4078, 4167], 'research': [33, 274, 2185], 'translation.': [34, 275], 'To': [35, 276, 2132, 2851, 4075], 'this': [36, 277, 1092, 2134, 2518, 2815], 'end,': [37, 278], 'the': [38, 88, 94, 107, 115, 135, 141, 208, 231, 279, 329, 335, 348, 356, 376, 382, 449, 472, 487, 502, 525, 564, 567, 588, 592, 597, 623, 786, 830, 1162, 1183, 1352, 1389, 1460, 1582, 1760, 1817, 1884, 1908, 1914, 2101, 2161, 2182, 2437, 2446, 2497, 2628, 2631, 2868, 2885, 2919, 2930, 2967, 2984, 3026, 3047, 3305, 3450, 3512, 3522, 3562, 3596, 3612, 3671, 3678, 3690, 3699, 3733, 3739, 3748, 3804, 3830, 3833, 3839, 3880, 4025, 4047, 4090, 4104, 4142, 4153, 4160, 4176], 'proteome': [39, 117, 280, 358, 3566], 'phosphoproteome': [41, 99, 282, 340], 'of': [42, 45, 103, 114, 170, 187, 210, 227, 283, 286, 344, 355, 411, 428, 451, 468, 491, 570, 628, 701, 757, 789, 829, 872, 892, 921, 977, 1010, 1063, 1188, 1213, 1248, 1266, 1283, 1319, 1355, 1383, 1391, 1401, 1463, 1518, 1581, 1651, 1657, 1692, 1735, 1741, 1755, 1799, 1816, 1827, 1887, 1913, 1930, 1973, 2008, 2145, 2306, 2352, 2436, 2448, 2500, 2542, 2586, 2634, 2713, 2769, 2865, 2941, 3036, 3141, 3151, 3162, 3186, 3290, 3319, 3332, 3350, 3367, 3564, 3595, 3601, 3630, 3644, 3651, 3659, 3711, 3732, 3773, 3832, 3843, 3870, 3879, 3944, 4087, 4109, 4196], 'four': [43, 284], 'pairs': [44, 285, 2526], 'patient-matched': [46, 287, 873, 2146], 'NPF': [49, 84, 290, 325, 1824, 2260, 2413, 2525, 2615, 2811, 2841, 3883], 'were': [50, 58, 85, 176, 291, 299, 326, 417, 2175, 2209, 2261, 2326, 2393, 2416, 2527, 2812, 2823, 2845, 2860, 2870, 2881, 2932, 2954, 2996, 3060, 3088, 3116, 3143, 3157, 3180, 3200, 3207, 3231, 3311, 3338, 3394, 3424, 3432, 3447, 3604, 3609, 3638, 3687, 3706, 3735, 3798, 4059, 4064, 4082, 4092, 4100, 4155, 4162, 4179, 4205], 'characterized': [51, 292], 'identify': [53, 294, 2012], 'discriminating': [54, 295], 'proteomic': [55, 296, 2141, 3777], 'signatures.': [56, 297], 'Samples': [57, 298, 3206], 'analyzed': [59, 300, 3208, 3433, 3610], 'by': [60, 178, 301, 419, 501, 1095, 1759, 1971, 2330, 3034, 3294, 3376, 4207], 'liquid': [61, 302, 3282], 'chromatography-tandem': [62, 303, 3283], 'mass': [63, 304, 2855, 3130, 3224, 3284, 3343, 3438, 3668, 3775], 'spectrometry': [64, 305, 2856, 3131, 3285], '(LC-MS/MS)': [65, 306, 3286], 'with': [66, 106, 124, 307, 347, 365, 642, 795, 1087, 1767, 2181, 2219, 2252, 2362, 2404, 2874, 2938, 2998, 3009, 3021, 3064, 3069, 3090, 3097, 3108, 3118, 3148, 3159, 3167, 3175, 3183, 3307, 3340, 3434, 3521, 3531, 3568, 3611, 3849, 3862, 4096, 4116], 'a': [67, 78, 119, 150, 200, 237, 308, 319, 360, 391, 441, 478, 699, 1654, 1939, 2169, 2331, 2617, 2711, 2826, 2863, 2925, 3070, 3098, 3119, 3176, 3195, 3295, 3314, 3328, 3351, 3417, 3437, 3647, 3742, 3867, 3942, 3954, 4067, 4085, 4148, 4182], 'hyper': [68, 309], 'reaction': [69, 310], 'monitoring': [70, 311], 'data-independent': [71, 312, 3569], 'acquisition': [72, 313, 3570], '(HRM-DIA)': [73, 314], 'workflow.': [74, 315], 'Proteins': [75, 316], 'that': [76, 162, 220, 317, 403, 461, 900, 1091, 1179, 2104, 2165, 2612], 'exhibited': [77, 100, 318, 341], 'significant': [79, 320], 'increase': [80, 321, 1698], 'in': [81, 174, 199, 322, 415, 440, 513, 540, 608, 622, 654, 665, 704, 764, 785, 905, 1013, 1069, 1097, 1193, 1270, 1395, 1397, 1466, 1522, 1529, 1562, 1618, 1660, 1699, 1789, 1890, 1964, 1968, 2061, 2077, 2156, 2160, 2211, 2346, 2398, 2503, 2517, 2530, 2607, 2656, 2677, 2716, 2776, 2814, 2825, 2884, 3002, 3025, 3123, 3194, 3202, 3426, 3506, 3723, 3741, 3747, 3845, 3935, 4011, 4066, 4103, 4175], 'versus': [83, 324, 928, 1290], 'enriched': [86, 327, 3144, 3934], 'functional': [89, 330, 1828, 3930, 3951, 4009], 'categories': [90, 331, 1829, 3931], '"cell': [91, 332], 'adhesion"': [92, 333], '"extracellular': [95, 336], 'matrix."': [96, 337], 'The': [97, 338, 661, 775, 807, 1962, 2118, 2673, 2791, 2962, 3058, 3197, 3335, 3345, 3422, 3429, 3444, 3486, 3606, 3667, 3684, 3704, 3718, 3795, 4040], 'enhanced': [101, 342, 1560], 'phosphorylation': [102, 343, 3658], 'proteins': [104, 345, 3933, 4006], 'associated': [105, 123, 346, 364], '"spliceosome"': [108, 349], '"actin': [110, 351], 'binding."': [111, 352], 'STRING': [112, 353, 3975, 4001], 'analysis': [113, 354, 1009, 1815, 3616, 3772], 'revealed': [118, 359, 899, 1825, 2152], 'prominent': [120, 361], 'interaction': [121, 362], 'hub': [122, 363], 'collagen': [125, 164, 366, 405], 'synthesis,': [126, 367], 'modification,': [127, 368], 'signaling.': [129, 370], 'It': [130, 371], 'contained': [131, 372], 'multiple': [132, 373, 827, 2078, 3801], 'collagens,': [133, 374], 'including': [134, 375, 833, 2158, 3974], 'fibrillar': [136, 153, 377, 394], 'types': [137, 378, 569, 2633], 'COL1A1/2': [138, 379], 'COL5A1;': [140, 381], 'receptor': [142, 147, 151, 383, 388, 392], 'tyrosine': [143, 384, 3663], 'kinase': [144, 385], 'discoidin': [145, 386], 'domain-containing': [146, 387], '2': [148, 158, 389, 399, 3139, 3243, 3273, 3315], '(DDR2),': [149, 390], 'collagens;': [154, 395], 'lysyl': [156, 397], 'oxidase-like': [157, 398], '(LOXL2),': [159, 400], 'an': [160, 224, 401, 465, 649, 1396, 1697, 2942, 3210, 3222, 3234, 3260, 3341, 3528, 3767, 3863, 4210], 'enzyme': [161, 402], 'promotes': [163, 404, 1616, 1690], 'crosslinking.': [165, 406], 'Increased': [166, 407], 'activity': [167, 408], 'and/or': [168, 409], 'expression': [169, 410, 639, 920, 1008, 1282, 1561, 1689, 1937, 2435], 'LOXL2': [171, 189, 222, 412, 430, 463, 4225], 'DDR2': [173, 414, 4231], 'confirmed': [177, 418], 'enzymatic': [179, 420], 'assays': [180, 421], 'Western': [182, 423, 4079], 'blotting': [183, 424], 'analyses.': [184, 425], 'Pharmacological': [185, 426], 'inhibition': [186, 427, 1740], 'CAF-derived': [188, 221, 429, 462], 'perturbed': [190, 431], 'extracellular': [191, 432, 843, 1831, 1977, 4041], 'matrix': [192, 433, 844, 2006], '(ECM)': [193, 434, 845], 'organization': [194, 435], 'decreased': [196, 437], 'migration': [198, 439], 'wound': [201, 442], 'healing': [202, 443], 'assay.': [203, 444], 'Further,': [204, 445], 'it': [205, 446], 'significantly': [206, 447], 'impaired': [207, 448], 'motility': [209, 450, 1734], 'co-cultured': [211, 452], 'RWPE-2': [212, 453, 2201], 'epithelial': [215, 456, 532, 1191, 1393, 1549, 1700, 1761, 2108, 2449, 2545], 'cells.': [216, 457], 'These': [217, 458], 'results': [218, 459], 'indicate': [219, 460], 'is': [223, 236, 464, 477, 783, 1093, 1787, 1903, 2114, 2122], 'important': [225, 466, 2153], 'mediator': [226, 467, 1656], 'communication': [229, 470, 1544], 'within': [230, 471], 'microenvironment': [234, 475, 504, 512, 565, 810, 832, 1456, 1880, 2121, 2493, 2629, 2794], 'potential': [238, 479, 1263], 'therapeutic': [239, 480, 2130], 'target.': [240, 481], 'Although': [482], 'initially': [483], 'considered': [484], 'cell-autonomous,': [485], 'both': [486], 'development': [488, 533], 'progression': [490, 656, 802, 1247, 1918], 'solid': [492], 'tumors': [493], 'are': [494, 2074, 2616], 'now': [495], 'known': [496], 'be': [498, 881, 2605], 'markedly': [499], 'influenced': [500], 'stromal': [503, 528, 923, 1214, 1285], '(1Martin': [505], 'M.': [506, 689, 691, 745, 753, 954, 995, 1005, 1119, 1127, 1149, 1346, 1433, 1487, 1495, 1598, 1780, 1857, 2283, 2470, 2563, 2701, 2703, 2757, 2765, 3753, 3810, 3820, 3979, 3981, 3995], 'Wei': [507], 'H.': [508, 721, 911, 966, 1117, 1131, 1273, 1344, 1681, 1957, 2295, 2575, 2733, 4033], 'Lu': [509], 'T.': [510, 731, 749, 1133, 2743, 2761, 3540, 3548, 3757, 3761, 3989], 'Targeting': [511], 'cancer': [514, 610, 759, 813, 858, 979, 1065, 1074, 1163, 1268, 1321, 1330, 1357, 1584, 1792, 2089, 2308, 2419, 2588, 2658, 2771, 2797], 'therapeutics.Oncotarget.': [515], '2016;': [516, 1746, 4051], '7:': [517, 1407], '52575-52583Crossref': [518], 'PubMed': [519, 554, 579, 616, 673, 770, 820, 864, 936, 987, 1021, 1082, 1169, 1226, 1298, 1336, 1364, 1409, 1473, 1534, 1592, 1627, 1667, 1712, 1805, 1897, 1945, 1990, 2019, 2068, 2095, 2316, 2510, 2596, 2643, 2664, 2685, 2782, 2804, 3588, 3782, 3857, 3926, 4019, 4054], 'Scopus': [520, 555, 580, 617, 674, 771, 821, 865, 937, 988, 1022, 1083, 1170, 1227, 1299, 1337, 1365, 1410, 1474, 1535, 1593, 1628, 1668, 1713, 1749, 1806, 1898, 1946, 1991, 2020, 2069, 2096, 2317, 2511, 2597, 2644, 2665, 2686, 2783, 2805, 3589, 3783, 3858, 4020, 4055], '(46)': [521], 'Google': [522, 557, 582, 619, 676, 712, 773, 823, 867, 939, 990, 1024, 1085, 1172, 1229, 1257, 1301, 1339, 1367, 1412, 1476, 1537, 1595, 1630, 1670, 1715, 1751, 1808, 1900, 1948, 1993, 2022, 2071, 2098, 2319, 2513, 2599, 2646, 2667, 2688, 2724, 2785, 2807, 3591, 3785, 3860, 3927, 4022, 4057], 'Scholar).': [523, 583, 620, 774, 824, 868, 1173, 1538, 1809, 1901, 2099, 2320, 2514, 2600, 3592, 3928], 'normal': [526, 778, 929, 1291, 1384, 1974], 'prostate,': [527], 'cells': [529, 924, 1192, 1215, 1269, 1286, 1322, 1394, 1550, 1762, 2202, 2341, 2546, 2822, 2869, 2921, 4063, 4091, 4144], 'tightly': [530], 'regulate': [531, 826], 'differentiation': [535, 1798], '(2Cunha': [536], 'G.R.': [537, 1242, 1647], 'Epithelio-mesenchymal': [538], 'interactions': [539, 1208, 3970, 4010], 'primordial': [541], 'gland': [542], 'structures': [543], 'which': [544, 647, 792, 1564], 'become': [545], 'responsive': [546], 'androgenic': [548], 'stimulation.Anat.': [549], 'Rec.': [550], '1972;': [551], '172:': [552], '179-195Crossref': [553], '(107)': [556], 'Scholar,': [558, 677, 713, 940, 991, 1025, 1230, 1302, 1340, 1368, 1413, 1477, 1596, 1631, 1671, 1716, 1949, 1994, 2023, 2647, 2668, 2689, 2725, 2786], '3Goldstein': [559], 'A.S.': [560, 1037, 2624], 'Witte': [561, 1684, 2625], 'O.N.': [562, 1685, 2626], 'Does': [563, 2627], 'influence': [566, 1382, 1916, 2630], 'cell': [568, 870, 1932, 2414, 2632, 2969, 3836], 'origin': [571, 2635], 'cancer?.Genes': [574, 2638], 'Dev.': [575, 2639], '2013;': [576, 861, 984, 1470, 1802, 1894, 2092, 2313, 2507, 2593, 2640], '27:': [577, 2641], '1539-1544Crossref': [578, 2642], '(30)': [581, 2645], 'However,': [584], 'during': [585, 3838], 'malignant': [586, 888], 'progression,': [587], 'transformed': [589], 'invades': [591], 'surrounding': [593], 'stroma': [594, 607, 697, 809, 854, 1012, 1068, 1793, 2054, 2085, 2655, 2709, 2793], 'activates': [596], 'tumor-stromal': [598], 'niche': [599], '(4Tuxhorn': [600], 'J.A.': [601, 681, 733, 2649, 2693, 2745], 'Ayala': [602, 1000, 2650], 'G.E.': [603, 2651], 'Rowley': [604, 694, 805, 1002, 2652, 2706, 2789], 'D.R.': [605, 695, 806, 1922, 2653, 2707, 2790], 'Reactive': [606, 696, 2654, 2708], 'progression.J.': [611, 2659], 'Urol.': [612, 2660], '2001;': [613, 2661], '166:': [614, 2662], '2472-2483Crossref': [615, 2663], '(396)': [618, 2666], 'Alterations': [621], 'morphology': [624], 'cellular': [626], 'composition': [627], 'stroma,': [631], 'as': [632, 634, 698, 855, 1653, 2086, 2267, 2547, 2710, 3292, 3527, 3646, 3664], 'well': [633], 'corresponding': [635], 'gene': [636, 919, 1007, 1281, 1812, 1936], 'protein': [638, 1744, 2853, 2980, 2987, 3078, 3716, 3792, 4077, 4190, 4197], 'profiles,': [640], 'correlate': [641], 'grade': [644], 'prognosis': [646], 'highlights': [648], 'active': [650, 1788], 'role': [651, 1517], 'tumor-stroma': [653], 'disease': [655, 3844], '(5Hagglof': [657], 'C.': [658, 1153, 1443, 1867, 2480, 2670, 3554, 3985, 4000], 'Bergh': [659, 2671], 'A.': [660, 685, 719, 741, 1031, 1109, 1137, 1489, 1491, 1679, 1718, 1724, 1730, 1951, 1996, 2672, 2697, 2731, 2753, 3993, 4029], 'stroma-a': [662, 2674], 'key': [663, 1516, 2675], 'regulator': [664, 2676], 'function': [667, 909, 2679, 3837], 'malignancy.Cancers.': [669, 2681], '2012;': [670, 817, 1981, 2682, 2801], '4:': [671, 2683, 3924], '531-548Crossref': [672, 2684], '(47)': [675, 2687], '6Ayala': [678, 2690], 'G.': [679, 1001, 1722, 1774, 2691, 3901], 'Tuxhorn': [680, 2692], 'Wheeler': [682, 690, 2694, 2702], 'T.M.': [683, 2695], 'Frolov': [684, 2696], 'Scardino': [686, 2698], 'P.T.': [687, 2699], 'Ohori': [688, 2700], 'Spitler': [692, 2704], 'J.': [693, 739, 751, 850, 852, 948, 1111, 1139, 1141, 1778, 2081, 2083, 2277, 2557, 2705, 2751, 2763, 3907, 3987], 'predictor': [700, 2712], 'biochemical-free': [702, 2714], 'recurrence': [703, 2715], 'cancer.Clin.': [706, 1015, 2718], 'Cancer': [707, 957, 1016, 1404, 1440, 1864, 2286, 2477, 2566, 2719], 'Res.': [708, 766, 1017, 1078, 1165, 1253, 1332, 1360, 1405, 1623, 1663, 2720, 2778, 4015], '2003;': [709, 2721, 3923], '9:': [710, 2722], '4792-4801PubMed': [711, 2723], '7Jia': [714, 2726], 'Z.': [715, 2727, 3826], 'Wang': [716, 965, 1116, 2294, 2574, 2728], 'Y.': [717, 2729, 3552, 3808, 3822, 3824], 'Sawyers': [718, 2730], 'Yao': [720, 2732], 'Rahmatpanah': [722, 2734], 'F.': [723, 743, 1306, 2735, 2755], 'Xia': [724, 2736], 'X.Q.': [725, 2737], 'Xu': [726, 2738], 'Q.': [727, 2739], 'Pio': [728, 2740], 'R.': [729, 946, 999, 1055, 1101, 2275, 2555, 2741, 3536], 'Turan': [730, 2742], 'Koziol': [732, 2744], 'Goodison': [734, 2746], 'S.': [735, 950, 1035, 1039, 1135, 1310, 1376, 1427, 1431, 1635, 1673, 1728, 1851, 1855, 1955, 2279, 2464, 2468, 2559, 2747, 3546, 3816, 3818, 3983], 'Carpenter': [736, 2748], 'P.': [737, 1049, 1129, 1147, 1316, 1348, 2749, 3991, 3997], 'Wang-Rodriguez': [738, 2750], 'Simoneau': [740, 2752], 'Meyskens': [742, 2754], 'Sutton': [744, 2756], 'Lernhardt': [746, 2758], 'W.': [747, 1115, 2035, 2039, 2759, 3909], 'Beach': [748, 2760], 'Monforte': [750, 2762], 'McClelland': [752, 2764], 'Mercola': [754, 2766], 'D.': [755, 1003, 1602, 1604, 2041, 2767, 3759, 3814], 'Diagnosis': [756, 2768], 'using': [760, 980, 2309, 2529, 2589, 2772, 2887, 2983, 3313, 3327, 3618, 3803, 3889, 4106, 4181], 'differentially': [761, 1818, 2773], 'expressed': [762, 1819, 2774], 'genes': [763, 1820, 2775], 'stroma.Cancer': [765, 2777], '2011;': [767, 2065, 2779], '71:': [768, 2780], '2476-2487Crossref': [769, 2781], '(64)': [772, 2784], 'transition': [776, 1328, 1528], 'from': [777, 887, 926, 1216, 1288, 2264, 2418, 2837, 2847, 3370, 3387, 3442, 3971], 'initiated': [784, 1249, 2543], 'early': [787, 2621], 'stages': [788], 'tumorigenesis': [790, 1187], 'after': [791, 1739], 'co-evolve': [794], 'cells,': [797, 2109], 'influencing': [798], 'their': [799, 906, 2112, 4008], 'pathogenesis': [800], '(8Barron': [803], 'D.A.': [804, 2045, 2788, 3905], 'reactive': [808, 1011, 2792], 'progression.Endocr.': [814, 2798], 'Relat.': [815, 2799], 'Cancer.': [816, 2800], '19:': [818, 2802], 'R187-R204Crossref': [819, 2803], '(213)': [822, 2806], 'facets': [828], 'growth': [834, 1075, 1390, 2223, 2383], 'factor': [835, 2224, 2384, 3466], 'cytokine': [837, 1612], 'production,': [838], 'immune': [839], 'modulation,': [840], 'angiogenesis': [841], 'deposition': [846], 'remodeling': [848], '(9Zhang': [849, 2080], 'Liu': [851, 1956, 2082], 'Tumor': [853, 2084], 'targets': [856, 2087], 'therapy.Pharmacol.': [859, 2090], 'Ther.': [860, 2091], '137:': [862, 2093], '200-215Crossref': [863, 2094], '(140)': [866, 2097], 'Primary': [869, 2820, 4061], 'cultures': [871], 'can': [880, 1260, 2604], 'derived': [882], 'following': [883, 2177, 2183, 3137], 'radical': [884, 2178], 'prostatectomy': [885, 2179], '(RP)': [886, 2180], 'benign': [890, 1217, 1619, 2322, 2421], 'regions': [891, 2325], 'tissue,': [894], 'respectively.': [895], 'Subsequent': [896], 'characterization': [897, 1970], 'has': [898], 'have': [902, 1551, 2138], 'distinct': [903, 1210], 'alterations': [904], 'phenotype': [907], '(10Zhao': [910, 1272], 'Ramos': [912, 1274], 'C.F.': [913, 1275], 'Brooks': [914, 1276], 'J.D.': [915, 1277], 'Peehl': [916, 1278], 'D.M.': [917, 1279], 'Distinctive': [918, 1280], 'prostatic': [922, 1180, 1218, 1251, 1284, 1621, 1736], 'cultured': [925, 1287, 2345, 2824, 4065], 'diseased': [927, 1289], 'tissues.J.': [930, 1292], 'Cell.': [931, 1293, 1703, 1979, 3578], 'Physiol.': [932, 1294], '2007;': [933, 1295, 1624, 1704], '210:': [934, 1296], '111-121Crossref': [935, 1297], '(37)': [938, 1300], '11Lawrence': [941], 'M.G.': [942, 964, 1103, 1447, 1499, 1871, 2271, 2293, 2484, 2551, 2573], 'Taylor': [943, 1150, 1418, 1500, 1783, 1842, 2272, 2455, 2552], 'R.A.': [944, 1151, 1419, 1501, 1784, 1843, 2273, 2456, 2553, 3913], 'Toivanen': [945, 2274, 2554], 'Pedersen': [947, 1138, 1428, 1777, 1852, 2276, 2465, 2556], 'Norden': [949, 1134, 1430, 1854, 2278, 2467, 2558], 'Pook': [951, 1436, 1860, 2280, 2473, 2560], 'D.W.': [952, 1437, 1451, 1503, 1861, 1875, 2281, 2474, 2488, 2561], 'Frydenberg': [953, 1148, 1432, 1494, 1779, 1856, 2282, 2469, 2562], 'Australian': [955, 1438, 1862, 2284, 2475, 2564], 'Prostate': [956, 1439, 1863, 2285, 2476, 2565], 'B.': [958, 962, 1107, 1421, 1441, 1493, 1637, 1845, 1865, 2031, 2287, 2291, 2458, 2478, 2567, 2571, 3763], 'Papargiris': [959, 1126, 1496, 2288, 2568], 'M.M.': [960, 1497, 2289, 2569], 'Niranjan': [961, 1106, 1420, 1492, 1844, 2290, 2457, 2570], 'Richards': [963, 1118, 2292, 2572], 'Collins': [967, 2296, 2576], 'A.T.': [968, 2297, 2577], 'Maitland': [969, 2298, 2578], 'N.J.': [970, 1123, 2299, 2579], 'Risbridger': [971, 1154, 1452, 1506, 1576, 1781, 1876, 2300, 2489, 2580], 'G.P.': [972, 1155, 1453, 1507, 1577, 1782, 1877, 2301, 2490, 2581], 'A': [973, 1203, 1454, 1878, 2302, 2491, 2582, 3498], 'preclinical': [974, 2303, 2583], 'xenograft': [975, 2304, 2584], 'model': [976, 1400, 2305, 2585, 3745], 'human': [981, 1250, 1392, 1467, 1512, 1620, 1790, 1891, 2009, 2184, 2310, 2504, 2590, 3691], 'tumors.Nat.': [982, 2311, 2591], 'Protoc.': [983, 2312, 2592], '8:': [985, 1747, 2314, 2594], '836-848Crossref': [986, 2315, 2595], '(83)': [989, 2318, 2598], '12Dakhova': [992], 'O.': [993, 1720, 1776, 3556, 3558, 3765], 'Ozen': [994], 'Creighton': [996], 'C.J.': [997], 'Li': [998, 2040], 'Ittmann': [1004], 'Global': [1006], '2009;': [1018, 1406, 1942, 4016], '15:': [1019], '3979-3989Crossref': [1020], '(116)': [1023], '13Sung': [1026], 'S.Y.': [1027], 'Hsieh': [1028], 'C.L.': [1029], 'Law': [1030], 'Zhau': [1032], 'H.E.': [1033], 'Pathak': [1034], 'Multani': [1036], 'Lim': [1038], 'Coleman': [1040], 'I.M.': [1041], 'Wu': [1042, 1680], 'L.C.': [1043], 'Figg': [1044], 'W.D.': [1045], 'Dahut': [1046], 'W.L.': [1047], 'Nelson': [1048], 'Lee': [1050], 'J.K.': [1051], 'Amin': [1052], 'M.B.': [1053], 'Lyles': [1054], 'Johnstone': [1056], 'P.A.': [1057], 'Marshall': [1058], 'F.F.': [1059], 'Chung': [1060], 'L.W.': [1061], 'Coevolution': [1062], 'bone': [1067], 'three-dimensional': [1070, 3575], 'coculture:': [1071], 'implications': [1072], 'metastasis.Cancer': [1077], '2008;': [1079], '68:': [1080], '9996-10003Crossref': [1081], '(125)': [1084], 'Scholar),': [1086, 1258, 2072], 'recent': [1088], 'work': [1089], 'indicating': [1090], 'encoded': [1094], 'differences': [1096, 2154], 'DNA': [1098], 'methylation': [1099], '(14Pidsley': [1100], 'Lawrence': [1102, 1446, 1498, 1870, 2483], 'Zotenko': [1104, 1424, 1848, 2461], 'E.': [1105, 1304, 1312, 1425, 1726, 1849, 2462], 'Statham': [1108], 'Song': [1110, 2038], 'Chabanon': [1112], 'R.M.': [1113], 'Qu': [1114], 'Nair': [1120], 'S.S.': [1121], 'Armstrong': [1122], 'Nim': [1124], 'H.T.': [1125], 'Balanathan': [1128], 'French': [1130], 'Peters': [1132], 'Ryan': [1136], 'Kench': [1140], 'Daly': [1142], 'R.J.': [1143], 'Horvath': [1144], 'L.G.': [1145], 'Stricker': [1146], 'Stirzaker': [1152, 1442, 1866, 2479], 'Clark': [1156, 1444, 1868, 2481], 'S.J.': [1157, 1445, 1449, 1505, 1573, 1869, 1873, 2482, 2486], 'Enduring': [1158], 'epigenetic': [1159], 'landmarks': [1160], 'define': [1161], 'microenvironment.Genome': [1164], '2018;': [1166], '28:': [1167, 1943], '625-638Crossref': [1168], '(62)': [1171], 'Moreover,': [1174], 'tissue': [1175, 2266, 2335, 2422, 2532], 'recombination': [1176, 2533], 'experiments': [1177, 2534], 'identified': [1178, 2327, 3946], 'retain': [1182], 'ability': [1184], '"initiated"': [1189], 'vivo': [1194, 1969, 2531], '(15Barclay': [1195], 'W.W.': [1196], 'Woodruff': [1197], 'R.D.': [1198, 2037], 'Hall': [1199], 'M.C.': [1200], 'Cramer': [1201], 'S.D.': [1202], 'system': [1204, 3216], 'studying': [1206], 'epithelial-stromal': [1207], 'reveals': [1209], 'inductive': [1211], 'abilities': [1212], 'hyperplasia': [1219], 'cancer.Endocrinology.': [1222], '2005;': [1223, 1664], '146:': [1224], '13-18Crossref': [1225], '(96)': [1228, 1366], '16Olumi': [1231], 'A.F.': [1232], 'Grossfeld': [1233], 'G.D.': [1234], 'Hayward': [1235, 1607, 1644, 1727], 'S.W.': [1236, 1608, 1645], 'Carroll': [1237], 'P.R.': [1238], 'Tlsty': [1239], 'T.D.': [1240], 'Cunha': [1241, 1646], 'Carcinoma-associated': [1243], 'direct': [1245], 'epithelium.Cancer': [1252, 1622], '1999;': [1254], '59:': [1255], '5002-5011PubMed': [1256], 'enhance': [1261, 1351], 'tumorigenic': [1262, 1461, 1885, 2498], 'invasiveness': [1265], 'vitro': [1271, 1398, 1579], '17Giannoni': [1303], 'Bianchini': [1305], 'Masieri': [1307], 'L.': [1308, 1314, 1485, 1675, 1772, 3560], 'Serni': [1309], 'Torre': [1311], 'Calorini': [1313], 'Chiarugi': [1315], 'Reciprocal': [1317], 'activation': [1318], 'stimulates': [1326], 'epithelial-mesenchymal': [1327], 'stemness.Cancer': [1331], '2010;': [1333, 1361], '70:': [1334, 1362], '6945-6956Crossref': [1335], '(414)': [1338], '18Liao': [1341], 'C.-P.': [1342], 'Adisetiyo': [1343], 'Liang': [1345], 'Roy-Burman': [1347], 'Cancer-associated': [1349], 'gland-forming': [1353], 'capability': [1354], 'stem': [1358], 'cells.Cancer': [1359], '7294-7303Crossref': [1363], '19Paland': [1369], 'N.': [1370, 1378, 3812], 'Kamer': [1371], 'I.': [1372, 1374], 'Kogan-Sakin': [1373], 'Madar': [1375], 'Goldfinger': [1377], 'Rotter': [1379], 'V.': [1380, 3550], 'Differential': [1381], 'on': [1388, 2862, 3209, 3259, 3304, 3481, 3511, 3713, 4005, 4084, 4209], 'cocultivation': [1399], 'cancer.Mol.': [1403], '1212-1223Crossref': [1408], '(54)': [1411], '20Clark': [1414], 'A.K.': [1415, 1839, 2452], 'Taubenberger': [1416, 1840, 2453], 'A.V.': [1417, 1841, 2454], 'Chea': [1422, 1846, 2459], 'Z.Y.': [1423, 1847, 2460], 'Sieh': [1426, 1850, 2463], 'J.S.': [1429, 1641, 1853, 2466], 'Grummet': [1434, 1858, 2471], 'J.P.': [1435, 1859, 2472], 'Ellem': [1448, 1504, 1872, 2485], 'Hutmacher': [1450, 1502, 1874, 2487], 'bioengineered': [1455, 1879, 2492], 'quantitatively': [1458, 1882, 2495], 'measure': [1459, 1883, 2496], 'cancer.Biomaterials.': [1469, 1893, 2506], '34:': [1471, 1895, 2508], '4777-4785Crossref': [1472, 1896, 2509], '(49)': [1475, 1899, 2512], '21Pereira': [1478], 'B.A.': [1479], 'Lister': [1480], 'N.L.': [1481], 'Hashimoto': [1482], 'K.': [1483, 1606], 'Teng': [1484], 'Flandes-Iparraguirre': [1486], 'Eder': [1488], 'Sanchez-Herrero': [1490], 'De-Juan-Pardo': [1508, 1574], 'E.M.': [1509, 1575], 'Tissue': [1510], 'engineered': [1511], 'microtissues': [1514], 'reveal': [1515], 'mast': [1519], 'cell-derived': [1520], 'tryptase': [1521], 'potentiating': [1523], 'fibroblast': [1525, 2347, 2382, 2438, 2821, 4062], '(CAF)-induced': [1526], 'morphometric': [1527], 'vitro.Biomaterials.': [1530], '2019;': [1531], '197:': [1532], '72-85Crossref': [1533], '(25)': [1536], 'Several': [1539], 'candidate': [1540, 1655, 2127], 'mechanisms': [1541], 'been': [1552], 'identified.': [1553], 'For': [1554, 3134, 3280, 3593], 'example,': [1555], 'several': [1556, 3972], 'paracrine': [1557, 1687], 'mediators': [1558], 'CAF,': [1563, 2157, 2536], 'include': [1565], 'SFRP1,': [1566], 'CXCL12,': [1567], 'TGFβ1,': [1568], 'HSP90,': [1569], 'FGF10': [1571, 1688], '(22Ellem': [1572], 'modeling': [1580], 'microenvironment.Advanced': [1585], 'Drug': [1586], 'Delivery': [1587], 'Reviews.': [1588], '2014;': [1589, 2016, 3779], '79:': [1590], '214-221Crossref': [1591], '(41)': [1594], '23Ao': [1597], 'Franco': [1599, 1642, 1719], 'O.E.': [1600, 1643], 'Park': [1601], 'Raman': [1603], 'Williams': [1605], 'Cross-talk': [1609], 'paracrine-acting': [1611], 'chemokine': [1614], 'malignancy': [1617], '67:': [1625], '4244-4253Crossref': [1626], '(220)': [1629, 2021], '24Joesting': [1632], 'M.S.': [1633], 'Perrin': [1634], 'Elenbaas': [1636], 'Fawell': [1638], 'S.E.': [1639, 1770], 'Rubin': [1640], 'Marker': [1648], 'P.C.': [1649], 'Identification': [1650], 'SFRP1': [1652], 'stromal-to-epithelial': [1658], 'cancer.Cancer': [1662], '65:': [1665], '10423-10430Crossref': [1666], '(131)': [1669], '25Memarzadeh': [1672], 'Xin': [1674], 'Mulholland': [1676], 'D.J.': [1677], 'Mansukhani': [1678], 'Teitell': [1682], 'M.A.': [1683], 'Enhanced': [1686], 'formation': [1691], 'multifocal': [1693], 'adenocarcinoma': [1695], 'androgen': [1701], 'receptor.Cancer': [1702], '12:': [1705], '572-585Abstract': [1706], 'Full': [1707, 1709, 1985, 1987, 3583, 3585], 'Text': [1708, 1710, 1986, 1988, 3584, 3586], 'PDF': [1711, 1989, 3587], '(150)': [1714], '26Henke': [1717], 'Stewart': [1721], 'Riddick': [1723], 'Katz': [1725], 'Thomson': [1729], 'Reduced': [1731], 'contractility': [1732], 'heat': [1742, 2366], 'shock': [1743], '90.Cancers.': [1745], '77Crossref': [1748], '(14)': [1750], 'Scholar)': [1752, 2808, 3786, 3861, 4023, 4058], 'whereas': [1753], 'production': [1754], 'Hedgehog': [1756, 1785], '(Hh)': [1757], 'ligands': [1758], 'initiate': [1764], 'reciprocal': [1765, 2102], '(27Wilkinson': [1769], 'Furic': [1771], 'Buchanan': [1773], 'Larsson': [1775], 'regulates': [1795], 'proliferation': [1796], 'adjacent': [1800], 'epithelium.Prostate.': [1801], '73:': [1803], '1810-1823Crossref': [1804], '(36)': [1807], 'addition,': [1811], 'set': [1813, 3458, 3473, 3492, 3624], 'enrichment': [1814, 1826, 3952, 3956], 'matrix,': [1832], 'basal': [1833], 'lamina': [1834], 'basement': [1836], 'membrane': [1837], '(20Clark': [1838, 2451], 'This': [1902, 2151], 'notable,': [1904], 'because': [1905], 'changes': [1906, 2159, 2254, 2406], 'architecture': [1909], 'biophysical': [1911], 'ECM': [1915, 2113, 2162], '(28Provenzano': [1919], 'P.P.': [1920], 'Inman': [1921], 'Eliceiri': [1923], 'K.W.': [1924], 'Keely': [1925], 'P.J.': [1926, 2047], 'Matrix': [1927], 'density-induced': [1928], 'mechanoregulation': [1929], 'breast': [1931], 'phenotype,': [1933], 'through': [1938, 3381], 'FAK-ERK': [1940], 'linkage.Oncogene.': [1941], '4326-4343Crossref': [1944], '(474)': [1947], '29Naba': [1950], 'Clauser': [1952, 1997, 4030], 'K.R.': [1953, 1998, 4031], 'Hoersch': [1954], 'Carr': [1958, 2001, 4036], 'S.A.': [1959, 2002, 4037], 'Hynes': [1960, 2003, 4038], 'R.O.': [1961, 2004, 4039], 'matrisome:': [1963], 'silico': [1965], 'definition': [1966], 'proteomics': [1972], 'matrices.Mol.': [1978], 'Proteomics.': [1980, 3579], '11': [1982], '(M111': [1983], '014647)Abstract': [1984], '(641)': [1992], '30Naba': [1995], 'Lamar': [1999], 'J.M.': [2000], 'Extracellular': [2005], 'signatures': [2007], 'mammary': [2010], 'carcinoma': [2011, 2060], 'metastasis': [2014], 'promoters.Elife.': [2015], '3:': [2017], 'e01308Crossref': [2018], '31Beatty': [2024], 'G.L.': [2025], 'Chiorean': [2026], 'E.G.': [2027], 'Fishman': [2028], 'M.P.': [2029], 'Saboury': [2030], 'Teitelbaum': [2032], 'U.R.': [2033], 'Sun': [2034], 'Huhn': [2036], 'Sharp': [2042], 'L.L.': [2043], 'Torigian': [2044], "O'Dwyer": [2046], 'Vonderheide': [2048], 'R.H.': [2049], 'CD40': [2050], 'agonists': [2051], 'alter': [2052], 'show': [2056, 2433], 'efficacy': [2057], 'against': [2058, 3689], 'pancreatic': [2059], 'mice': [2062], 'humans.Science.': [2064], '331:': [2066], '1612-1616Crossref': [2067], '(1179)': [2070], 'prognostic': [2075], 'biomarkers': [2076, 2128], 'cancers': [2079], 'Yet,': [2100], 'occurs': [2105], 'still': [2115], 'poorly': [2116], 'understood.': [2117], 'likely': [2123], 'contain': [2125], 'additional': [2126], 'targets.': [2131], 'address': [2133], 'knowledge': [2135], 'gap,': [2136], 'we': [2137], 'undertaken': [2139], 'unbiased': [2140], 'phosphoproteomic': [2143], 'profiling': [2144, 3567], 'NPF.': [2150], 'present': [2155], 'network': [2164], 'collectively': [2166], 'contribute': [2167], 'protumorigenic': [2170], 'microenvironment.': [2171], 'Human': [2172], 'specimens': [2174], 'obtained': [2176, 2846], 'ethics': [2186], 'committee': [2187], 'approvals:': [2188], 'Cabrini': [2189], 'Institute': [2190], '(03-14-04-08),': [2191], 'Epworth': [2192], 'HealthCare': [2193], '(34306': [2194], '53611)': [2196], 'Monash': [2198, 2359], 'University': [2199], '(2004/145).': [2200], '(American': [2203], 'Type': [2204], 'Culture': [2205], 'Collection,': [2206], 'Dublin,': [2207], 'IRL)': [2208], 'maintained': [2210, 2394], 'keratinocyte': [2212], 'serum': [2213, 2371], 'free': [2214], 'medium': [2215], '(KSF-M;': [2216], 'Gibco)': [2217], 'supplemented': [2218, 2361], '5': [2220, 3010, 3247], 'ng/ml': [2221, 2380], 'epidermal': [2222], '(EGF;': [2225], 'Gibco),': [2226, 2233], '50': [2227, 2915, 3184, 3269], 'mg/ml': [2228, 2240], 'bovine': [2229, 2370], 'pituitary': [2230], 'extract': [2231], '(BPE;': [2232], '100': [2235, 2239, 3237, 3249, 3275], 'U/ml': [2236], 'penicillin': [2237], 'streptomycin': [2241], '(P/S;': [2242], 'Sigma-Aldrich,': [2243], 'St.': [2244], 'Louis,': [2245], 'MS)': [2246], 'at': [2247, 2395, 2429, 2956, 2973, 3013, 3052, 3080, 3324, 3355, 3396, 3495, 3502, 4164, 4170], '37': [2248, 2396, 3014, 3053, 3081], '°C,': [2249], '5%': [2250, 2365, 2399, 2401], 'CO2,': [2251, 2400], 'media': [2253, 2348, 2405], 'every': [2255, 2407], '2–3': [2256, 2408], 'days.': [2257, 2409], 'directly': [2262, 2883, 4102], 'isolated': [2263], 'patient': [2265, 2602], 'previously': [2268, 2548], 'described': [2269, 2549], '(11Lawrence': [2270, 2550], 'Briefly,': [2321], 'excised': [2329], 'trained': [2332], 'pathologist.': [2333], 'Whole': [2334], 'was': [2336, 2964, 2971, 2981, 3032, 3044, 3258, 3302, 3412, 3457, 3472, 3484, 3491, 3509, 3623, 3673, 3681, 3721, 3872, 3887, 3939], 'enzymatically': [2337], 'digested': [2338, 3068], 'release': [2340], 'into': [2342], 'suspension': [2343], '(RPMI': [2349], '1640': [2350], '(School': [2351], 'Biomedical': [2353], 'Sciences,': [2354], 'Media': [2355], 'Prep': [2357], 'Services,': [2358], 'University))': [2360], 'phenol': [2363], 'red,': [2364], 'inactivated': [2367], 'HyClone': [2368], 'fetal': [2369], '(HI-FBS;': [2372], 'GE': [2373], 'Healthcare),': [2374], '1': [2375, 2905, 2926, 3017, 3029, 3056, 3146, 3288, 4131, 4136, 4149], 'nm': [2376], 'testosterone': [2377], '(Sigma-Aldrich),': [2378], '10': [2379, 2948, 4125, 4128, 4168, 4199], 'basic': [2381], '(bFGF;': [2385], 'Merck': [2386], 'Millipore,': [2387], 'Burlington,': [2388], 'MA)': [2389, 3105], 'P/S.': [2391], 'Cells': [2392, 2880, 4099], '°C': [2397, 2975, 3015, 3054, 3082], 'O2': [2402], 'atmosphere,': [2403], 'Matched': [2410], 'lines': [2415], 'established': [2417], 'pieces': [2423], 'respectively': [2424], 'verified': [2426, 3966], 'via': [2427, 3233], 'IHC': [2428], 'passage': [2430, 2622], '4': [2431, 4171], 'homogenous': [2434], 'markers': [2439], 'vimentin': [2440], 'α-smooth': [2442], 'muscle': [2443], 'actin': [2444], 'absence': [2447], 'cytokeratins': [2450], 'Before': [2515], 'use': [2516], 'study,': [2519], 'most': [2520], '(5/6)': [2521], 'matched': [2522], 'validated': [2528], 'whereby': [2535], 'but': [2537], 'not': [2538], 'NPF,': [2539], 'promoted': [2540], 'tumorigenicity': [2541], 'All': [2601], 'information': [2603], 'found': [2606], 'supplemental': [2608], 'Table': [2609], 'S1.': [2610], 'Given': [2611], 'primary,': [2618], 'patient-derived': [2619], 'line,': [2620], '(3Goldstein': [2623], '4Tuxhorn': [2648], '5Hagglof': [2669], '8Barron': [2787], 'used': [2813, 3448], 'study': [2816], 'unless': [2817], 'otherwise': [2818], 'stated.': [2819], '15': [2827, 2960, 4068], 'cm': [2828, 4069], 'Petri': [2829, 4070], 'dish': [2830, 2886, 4071, 4105], 'until': [2831, 2976, 4072], '80%': [2832, 3320, 4073], 'confluent.': [2833, 4074], 'Three': [2834], 'replicates': [2836], 'each': [2838, 3281, 3518, 3602, 3791, 3936], 'or': [2840, 3793, 4212], 'line': [2842], '(Patients': [2843], '1–4)': [2844], 'three': [2848], 'separate': [2849], 'passages.': [2850], 'harvest': [2852, 4076], '(MS)': [2857, 3132], 'analysis,': [2858, 3287], 'dishes': [2859, 4081], 'placed': [2861, 4083], 'bed': [2864, 4086], 'ice': [2866, 2875, 4088], 'first': [2871, 3840, 4093], 'washed': [2872, 4094], 'twice': [2873, 4095], 'cold': [2876], 'phosphate-buffered': [2877], 'saline': [2878], '(PBS).': [2879], 'lysed': [2882, 2920, 4101, 4143], '500': [2888], 'μl': [2889, 3161, 3185, 4108], 'lysis': [2890], 'buffer': [2891, 4113], '(8': [2892], 'm': [2893, 3000, 3164], 'Urea,': [2894], '20': [2895, 3682], 'mm': [2896, 2899, 2902, 2906, 2949, 3004, 3011, 3023, 3038, 4122, 4132, 4137], 'HEPES,': [2897], '2.5': [2898, 2901, 3149], 'sodium-pyrophosphate,': [2900], 'β-glycerol': [2903], 'phosphate,': [2904], 'sodium': [2907, 4133, 4138], 'orthovanadate,': [2908], 'Roche': [2909], 'protease': [2910, 4117], 'inhibitors': [2911, 4120], '(1': [2912, 4121], 'tablet': [2913], 'per': [2914, 4203], 'ml)).': [2916], 'After': [2917, 2951, 4140, 4158], 'scraping': [2918, 4141], 'transferring': [2923, 4146], 'ml': [2927, 4150], 'Eppendorf': [2928, 4151], 'tube,': [2929, 4152], 'samples': [2931, 2953, 3059, 3740, 4154, 4161], 'vortexed,': [2933], 'sonicated': [2934], 'precipitated': [2936], 'overnight': [2937], '4×': [2939], 'volume': [2940], 'ice-cold': [2943, 4097], 'acetone': [2944], 'solution': [2945], '(80%': [2946], 'acetone,': [2947], 'NaCl).': [2950], 'this,': [2952, 4159], 'centrifuged': [2955, 4163], '3500': [2957], 'RPM': [2958, 4166], 'mins.': [2961], 'supernatant': [2963, 4178], 'discarded,': [2965], 'remaining': [2968], 'pellet': [2970], 'stored': [2972], '−80': [2974], 'trypsin': [2977, 3073], 'digestion.': [2978], 'Total': [2979], 'measured': [2982, 3293], 'Bicinchoninic': [2985], 'acid': [2986, 3111, 3127], 'assay': [2988, 4112, 4191], '(Bio-Rad,': [2989], 'Hercules,': [2990], 'CA).': [2991], 'Protein': [2992, 4173], 'extracts': [2993], '(100': [2994, 3240], 'μg)': [2995], 'denatured': [2997], '6': [2999], 'urea': [3001], '25': [3003], 'ammonium': [3005, 3065], 'bicarbonate': [3006, 3066], 'before': [3007, 3129], 'reduction': [3008], 'TCEP': [3012], 'h': [3018, 3147, 3316], 'alkylation': [3020], '32': [3022], 'iodoacetamide': [3024], 'dark': [3027], 'h.': [3030, 3057, 3085], 'Alkylation': [3031], 'stopped': [3033], 'addition': [3035], '27': [3037], 'DTT.': [3039], 'PNGase': [3040], 'F': [3041], '(5000': [3042], 'U)': [3043], 'added': [3045], 'sample': [3048, 3603, 3937], 'mixture': [3049], 'incubated': [3051], 'then': [3061], 'diluted': [3062], '1:10': [3063], '1:50': [3071], 'modified': [3072], '(Promega,': [3074], 'Madison,': [3075], 'WI)': [3076], 'weight': [3079], '18': [3084], 'Tryptic': [3086], 'digests': [3087], 'acidified': [3089, 3166], '10%': [3091, 4213], 'TFA': [3092, 3168], 'pH': [3094, 3170], '2–3,': [3095, 3171], 'desalted': [3096, 3173], 'C18': [3099, 3177], 'column': [3100, 3239, 3265], '(Thermo': [3101, 3217, 3299], 'Fisher': [3102, 3218, 3228, 3252, 3278, 3300], 'Scientific,': [3103], 'Waltham,': [3104], 'eluted': [3107, 3158, 3181, 3312], '0.1%': [3109, 3187], 'trifluoroacetic': [3110], '(TFA)/40%': [3112], 'acetonitrile': [3113], '(ACN).': [3114], 'Peptides': [3115, 3230, 3310], 'dried': [3117, 3198], 'SpeedVac': [3120], 're-suspended': [3122], '2%': [3124, 3203], 'ACN/0.1%': [3125, 3321], 'formic': [3126], '(FA)': [3128], 'analysis.': [3133], 'phosphopeptide': [3135], 'enrichment,': [3136], 'desalting,': [3138], 'mg': [3140, 3150], 'peptides': [3142, 3199, 3291, 3337, 3516, 3734], 'TiO2': [3152], '(GL': [3153], 'Science,': [3154], 'Japan).': [3155], 'Phosphopeptides': [3156, 3179], '150': [3160], '0.3': [3163], 'NH4OH,': [3165], 'immediately': [3174], 'column.': [3178], 'manually': [3182], 'FA/80%': [3188], 'ACN': [3189], 'evaporated': [3191], 'dryness': [3193], 'SpeedVac.': [3196], 'reconstituted': [3201], 'ACN/0.5%': [3204], 'FA.': [3205], 'UltiMate': [3211], '3000': [3212], 'RSLC': [3213, 3263], 'nano': [3214], 'LC': [3215], 'Scientific)': [3219, 3253, 3301], 'coupled': [3220], 'LTQ-Orbitrap': [3223], 'spectrometer': [3225, 3439], '(LTQ-Orbitrap,': [3226], 'Thermo': [3227, 3251, 3277], 'Scientific).': [3229, 3279], 'loaded': [3232, 3303], 'Acclaim': [3235, 3261], 'PepMap': [3236, 3262], 'trap': [3238], 'μm': [3241, 3267], '×': [3242, 3268], 'cm,': [3244, 3270], 'nanoViper,': [3245, 3271], 'C18,': [3246, 3272], 'μm,': [3248, 3274], 'Å,': [3250, 3276], 'subsequent': [3255], 'peptide': [3256, 3496, 3499, 3628, 3714], 'separation': [3257], 'analytical': [3264], '(75': [3266], 'μg': [3289, 4202], 'nanodrop': [3296], '1000': [3297], 'spectrophotometer': [3298], 'pre-column': [3306], 'microliter': [3308], 'pickup.': [3309], 'linear': [3317, 3743], 'gradient': [3318, 3331], 'FA': [3322], 'flowing': [3323], '250': [3325], 'nL/min': [3326], 'mobile': [3329], 'phase': [3330], '2.5–42.5%': [3333], 'ACN.': [3334], 'eluting': [3336], 'interrogated': [3339], 'Orbitrap': [3342], 'spectrometer.': [3344], 'HRM': [3346, 3701], 'DIA': [3347, 3384, 3430], 'method': [3348, 3806], 'consisted': [3349], 'survey': [3352], 'scan': [3353], '(MS1)': [3354], '35,000': [3356, 3397], 'resolution': [3357, 3398], '(automatic': [3358, 3399], 'gain': [3359, 3400], 'control': [3360, 3401], 'target': [3361, 3402], '5e6': [3362], 'maximum': [3364], 'injection': [3365, 3407], 'time': [3366, 3454], '120': [3368], 'ms)': [3369], '400': [3371], '1,220': [3373], 'm/z': [3374, 3419], 'followed': [3375], 'tandem': [3377], 'MS/MS': [3378, 3392], 'scans': [3379, 3393], '(MS2)': [3380], '19': [3382], 'overlapping': [3383], 'windows': [3385], 'increasing': [3386], '30': [3388, 3418, 4201], '222': [3390], 'Da.': [3391], 'acquired': [3395], '3e6': [3403], 'auto': [3405], 'time).': [3408], 'Stepped': [3409], 'collision': [3410], 'energy': [3411], '22.5%,': [3413], '25%,': [3414], '27.5%,': [3415], 'isolation': [3420], 'window.': [3421], 'spectra': [3423, 3608], 'recorded': [3425], 'profile': [3427], 'type.': [3428], 'data': [3431], 'Spectronaut': [3435, 3451, 3532, 3724], '8,': [3436], 'vendor-independent': [3440], 'software': [3441, 3534, 3617, 3898], 'Biognosys.': [3443], 'default': [3445, 3523, 3619], 'settings': [3446], 'search.': [3452], 'Retention': [3453, 3462], 'prediction': [3455, 3831], 'type': [3456], 'dynamic': [3460], 'indexed': [3461], 'Time': [3463], '(iRT;': [3464], 'correction': [3465, 3480], 'window': [3468], '1).': [3469], 'Decoy': [3470], 'generation': [3471, 3594], 'scrambled': [3475], '(no': [3476], 'decoy': [3477], 'limit).': [3478], 'Interference': [3479], 'MS2': [3482], 'level': [3483], 'enabled.': [3485], 'false': [3487], 'discovery': [3488, 3896], 'rate': [3489], '(FDR)': [3490], '1%': [3494, 3712], 'level.': [3497, 3717], 'identification': [3500], 'required': [3501, 3873, 3953], 'least': [3503], '3': [3504, 3514, 3635], 'transitions': [3505], 'quantification.': [3507], 'Quantification': [3508], 'based': [3510], 'top': [3513], 'proteotypic': [3515], 'protein,': [3519], 'normalized': [3520, 3726], 'settings,': [3524], 'exported': [3526], 'excel': [3529], 'file': [3530], '8': [3533, 4211], '(32Bruderer': [3535], 'Bernhardt': [3537], 'O.M.': [3538], 'Gandhi': [3539], 'Miladinovic': [3541], 'S.M.': [3542], 'Cheng': [3543], 'L.Y.': [3544], 'Messner': [3545], 'Ehrenberger': [3547], 'Zanotelli': [3549], 'Butscheid': [3551], 'Escher': [3553], 'Vitek': [3555, 3764], 'Rinner': [3557], 'Reiter': [3559], 'Extending': [3561], 'limits': [3563], 'quantitative': [3565, 3774], 'application': [3572], 'acetaminophen-treated': [3574], 'liver': [3576], 'microtissues.Mol.': [3577], '2015;': [3580], '14:': [3581], '1400-1410Abstract': [3582], '(275)': [3590], 'spectral': [3597, 3719], 'libraries,': [3598], 'DDA': [3599, 3607, 3685], 'measurements': [3600], 'performed.': [3605], 'MaxQuant': [3613], 'Version': [3614], '1.5.2.8': [3615], 'settings.': [3620], 'Enzyme': [3621], 'specificity': [3622], 'Trypsin/P,': [3626], 'minimal': [3627], 'length': [3629], '6,': [3631], 'up': [3633], 'missed': [3636], 'cleavages': [3637], 'allowed.': [3639], 'Search': [3640], 'criteria': [3641], 'included': [3642], 'carbamidomethylation': [3643], 'cysteine': [3645], 'fixed': [3648], 'modification;': [3649], 'oxidation': [3650], 'methionine;': [3652], 'acetyl': [3653], '(protein': [3654], 'N': [3655], 'terminus);': [3656], 'serine,': [3660], 'threonine,': [3661], 'variable': [3665], 'modifications.': [3666], 'tolerance': [3669], 'precursor': [3672], '4.5': [3674], 'ppm': [3675], 'fragment': [3679], 'ions': [3680], 'ppm.': [3683], 'files': [3686], 'searched': [3688], 'UniProt': [3692], 'fasta': [3693], 'database': [3694, 3890, 3915], '(v2015–08,': [3695], '20,210': [3696], 'entries)': [3697], 'Biognosys': [3700], 'calibration': [3702], 'peptides.': [3703, 3729], 'identifications': [3705], 'filtered': [3707], 'satisfy': [3709], 'FDR': [3710, 3864, 3958], 'library': [3720], 'generated': [3722], 'iRT': [3728], 'Log2': [3730], 'intensities': [3731], 'summarized': [3736], 'across': [3737], 'all': [3738, 3945], 'mixed': [3744], 'implemented': [3746], 'R': [3749, 3768], 'package': [3750, 3769], 'MSstats': [3751], '(33Choi': [3752], 'Chang': [3754], 'C.Y.': [3755], 'Clough': [3756], 'Broudy': [3758], 'Killeen': [3760], 'MacLean': [3762], 'MSstats:': [3766], 'statistical': [3771], 'spectrometry-based': [3776], 'experiments.Bioinformatics.': [3778], '30:': [3780], '2524-2526Crossref': [3781], '(518)': [3784], 'pairwise': [3788], 'comparison': [3789], 'phosphopeptide.': [3794], 'p': [3796, 3962], 'values': [3797], 'adjusted': [3799, 3961], 'testing': [3802], 'Benjamini-Horchberg': [3805], '(34Klipper-Aurbach': [3807], 'Wasserman': [3809], 'Braunspiegel-Weintrob': [3811], 'Borstein': [3813], 'Peleg': [3815], 'Assa': [3817], 'Karp': [3819], 'Benjamini': [3821], 'Hochberg': [3823], 'Laron': [3825], 'Mathematical': [3827], 'formulae': [3828], 'residual': [3834], 'beta': [3835], 'two': [3841], 'years': [3842], 'children': [3846], 'adolescents': [3848], 'insulin-dependent': [3850], 'diabetes': [3851], 'mellitus.Med.': [3852], 'Hypotheses.': [3853], '1995;': [3854], '45:': [3855], '486-490Crossref': [3856], '(205)': [3859], '<0.05': [3865], 'fold': [3868, 3955], 'change': [3869], '>1.5': [3871], 'differential': [3875], 'expression.': [3876], 'Functional': [3877], 'annotation': [3878], 'proteomes': [3884], 'phosphoproteomes': [3886], 'conducted': [3888], 'annotation,': [3892, 3917], 'visualization,': [3893, 3918], 'integrated': [3895, 3920], '(DAVID)': [3897], '(35Dennis': [3899], 'Jr,': [3900], 'Sherman': [3902], 'B.T.': [3903], 'Hosack': [3904], 'Yang': [3906], 'Gao': [3908], 'Lane': [3910], 'H.C.': [3911], 'Lempicki': [3912], 'DAVID:': [3914], 'discovery.Genome': [3921], 'Biol.': [3922, 4050], 'P3Crossref': [3925], 'Overrepresented': [3929], 'among': [3932], 'population': [3938], 'relative': [3940], 'background': [3943], 'proteins.': [3947], 'Criteria': [3948], 'reported': [3950], '>1.5,': [3957], '<0.05,': [3959], 'value': [3963], '<0.05.': [3964], 'Experimentally': [3965], 'published': [3968], 'protein-protein': [3969], 'resources': [3973], '(36Jensen': [3976], 'L.J.': [3977], 'Kuhn': [3978], 'Stark': [3980], 'Chaffron': [3982], 'Creevey': [3984], 'Muller': [3986], 'Doerks': [3988], 'Julien': [3990], 'Roth': [3992], 'Simonovic': [3994], 'Bork': [3996], 'von': [3998], 'Mering': [3999], '8–a': [4002], 'global': [4003], 'view': [4004], '630': [4012], 'organisms.Nucleic': [4013], 'Acids': [4014], '37:': [4017], 'D412-D416Crossref': [4018], '(1904)': [4021], 'Matrisome': [4026], 'Project': [4027], '(37Naba': [4028], 'Ding': [4032], 'Whittaker': [4034], 'C.A.': [4035], 'matrix:': [4042], 'Tools': [4043], 'insights': [4045], '"omics"': [4048], 'era.Matrix': [4049], '49:': [4052], '10-24Crossref': [4053], '(507)': [4056], 'assessed.': [4060], 'blotting,': [4080], 'PBS.': [4098], '200': [4107], 'radioimmune': [4110], 'precipitation': [4111], '(RIPA;': [4114], 'Millipore)': [4115], 'phosphatase': [4119], 'phenylmethylsulfonyl': [4123], 'fluoride,': [4124], 'μg/ml': [4126, 4129], 'aprotinin,': [4127], 'leupeptin,': [4130], 'fluoride': [4134], 'orthovanadate).': [4139], 'briefly': [4156], 'vortexed.': [4157], '10,000': [4165], 'min': [4169], '°C.': [4172], 'concentrations': [4174], 'resulting': [4177], 'determined': [4180], 'reducing': [4183], 'agent': [4184], 'detergent': [4186], 'compatible': [4187], '(RC': [4188], 'DC)': [4189], 'kit': [4192], '(Bio-Rad).': [4193], 'Equal': [4194], 'amounts': [4195], '(between': [4198], 'lane)': [4204], 'separated': [4206], 'SDS-PAGE': [4208], 'gel': [4214], 'transferred': [4216], 'PVDF': [4218], 'membranes': [4219], '(Millipore,': [4220], 'Minneapolis,': [4221, 4235], 'MN).': [4222], 'Antibodies': [4223], 'detecting': [4224], '(#55470;': [4226], 'Abcam,': [4227], 'Cambridge,': [4228], 'UK;': [4229], '1:2000),': [4230], '(#AF2538;': [4232], 'R&D': [4233], 'Systems,': [4234], 'MN;': [4236], '1:4000),': [4237], 'FAK': [4238], '(#610088;': [4239], 'BD': [4240], 'Biosciences,': [4241], 'Franklin': [4242], 'Lakes,': [4243], 'NJ;': [4244], '1:1000),': [4245], 'phospho-FAK': [4246], '925': [4247], '(#3284;': [4248], 'Cell': [4249], 'Signaling': [4250], 'Technology,': [4251], 'Danvers,': [4252], 'MA;': [4253], '1:1000)': [4254], 'α-tubul': [4256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2944168058', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 19}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-20T15:19:24.146300', 'created_date': '2019-05-16'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
