Exosomes: composition, biogenesis, and mechanisms in cancer metastasis and drug resistance

Name: Work Video:
Duration: 3 min 30 s
Ladan Mashouri; Hassan Yousefi; Amir Reza Aref; Ali Mohammad Ahadi; Fatemeh Molaei; Suresh K. Alahari
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'https://openalex.org/W2896759930', 'https://openalex.org/W2529223554', 'https://openalex.org/W2111545764', 'https://openalex.org/W2073918425', 'https://openalex.org/W2067275497', 'https://openalex.org/W1970650594'], 'abstract_inverted_index': {'Tumor-derived': [0], 'exosomes': [1, 52, 78], '(TDEs)': [2], 'participate': [3], 'in': [4, 29, 54, 82], 'formation': [5], 'and': [6, 20, 47, 58, 91, 95, 103, 122], 'progression': [7, 117], 'of': [8, 65, 128], 'different': [9], 'cancer': [10, 116, 129], 'processes,': [11], 'including': [12], 'tumor': [13, 50, 55], 'microenvironment': [14, 56], '(TME)': [15], 'remodeling,': [16, 57], 'angiogenesis,': [17], 'invasion,': [18], 'metastasis': [19, 46, 102, 124], 'drug-resistance.': [21], 'Exosomes': [22], 'initiate': [23], 'or': [24], 'suppress': [25], 'various': [26], 'signaling': [27, 96], 'pathways': [28, 97], 'the': [30, 92], 'recipient': [31], 'cells': [32], 'via': [33], 'transmitting': [34], 'heterogeneous': [35], 'cargoes.': [36], 'In': [37], 'this': [38], 'review': [39], 'we': [40, 74], 'discuss': [41, 75], 'exosome': [42, 44, 63, 87], 'biogenesis,': [43, 88], 'mediated': [45, 105], 'chemoresistance.': [48], 'Furthermore,': [49], 'derived': [51], 'role': [53], 'angiogenesis': [59], 'is': [60, 70], 'reviewed.': [61], 'Also,': [62], 'induction': [64], 'epithelial': [66], 'mesenchymal': [67], 'transition': [68], '(EMT)': [69], 'highlighted.': [71], 'More': [72], 'importantly,': [73], 'extensively': [76], 'how': [77], 'regulate': [79], 'drug': [80], 'resistance': [81], 'several': [83], 'cancers.': [84], 'Thus,': [85], 'understanding': [86], 'their': [89], 'contents': [90], 'molecular': [93], 'mechanisms': [94], 'that': [98], 'are': [99], 'responsible': [100], 'for': [101, 115], 'drug-resistance': [104], 'by': [106], 'TDEs': [107], 'may': [108], 'help': [109], 'to': [110, 119], 'devise': [111], 'novel': [112], 'therapeutic': [113], 'approaches': [114], 'particularly': [118], 'overcome': [120], 'therapy-resistance': [121], 'preventing': [123], 'as': [125], 'major': [126], 'factors': [127], 'mortality.': [130]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2944131287', 'counts_by_year': [{'year': 2024, 'cited_by_count': 256}, {'year': 2023, 'cited_by_count': 274}, {'year': 2022, 'cited_by_count': 254}, {'year': 2021, 'cited_by_count': 191}, {'year': 2020, 'cited_by_count': 106}, {'year': 2019, 'cited_by_count': 22}], 'updated_date': '2025-01-07T19:13:49.208305', 'created_date': '2019-05-16'}
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