Publication Information

{'id': 'https://openalex.org/W2943843605', 'doi': 'https://doi.org/10.1016/j.phymed.2019.152949', 'title': 'Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway', 'display_name': 'Qishen granule attenuates cardiac fibrosis by regulating TGF-β /Smad3 and GSK-3β pathway', 'publication_year': 2019, 'publication_date': '2019-05-08', 'ids': {'openalex': 'https://openalex.org/W2943843605', 'doi': 'https://doi.org/10.1016/j.phymed.2019.152949', 'mag': '2943843605', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31102891'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2019.152949', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1016/j.phymed.2019.152949', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5048033974', 'display_name': 'Zifan Zeng', 'orcid': 'https://orcid.org/0000-0002-1720-905X'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}, {'id': 'https://openalex.org/I200296433', 'display_name': 'Chinese Academy of Medical Sciences & Peking Union Medical College', 'ror': 'https://ror.org/02drdmm93', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I200296433']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zifan Zeng', 'raw_affiliation_strings': ['Institute Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China', 'School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}, {'raw_affiliation_string': 'Institute Materia Medica, Chinese Academy of Medical Sciences & Peking Union Medical College, Beijing 100050, China', 'institution_ids': ['https://openalex.org/I200296433']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5112485819', 'display_name': 'Qiyan Wang', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qiyan Wang', 'raw_affiliation_strings': ['School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015512627', 'display_name': 'Xiaomin Yang', 'orcid': 'https://orcid.org/0000-0001-9126-9280'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xiaomin Yang', 'raw_affiliation_strings': ['School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046936123', 'display_name': 'Yinglu Ren', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yinglu Ren', 'raw_affiliation_strings': ['School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5083996793', 'display_name': 'Shihong Jiao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Shihong Jiao', 'raw_affiliation_strings': ['School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101639549', 'display_name': 'Qingqing Zhu', 'orcid': 'https://orcid.org/0000-0001-7201-9462'}, 'institutions': [{'id': 'https://openalex.org/I4210096354', 'display_name': 'The Seventh Affiliated Hospital of Sun Yat-sen University', 'ror': 'https://ror.org/00rfd5b88', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210096354']}, {'id': 'https://openalex.org/I157773358', 'display_name': 'Sun Yat-sen University', 'ror': 'https://ror.org/0064kty71', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I157773358']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Qingqing Zhu', 'raw_affiliation_strings': ['The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China'], 'affiliations': [{'raw_affiliation_string': 'The Seventh Affiliated Hospital, Sun Yat-sen University, Shenzhen 518107, China', 'institution_ids': ['https://openalex.org/I4210096354', 'https://openalex.org/I157773358']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056378571', 'display_name': 'Dongqing Guo', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Dongqing Guo', 'raw_affiliation_strings': ['School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101572149', 'display_name': 'Kai Xia', 'orcid': 'https://orcid.org/0000-0001-6569-9455'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Kai Xia', 'raw_affiliation_strings': ['School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100780735', 'display_name': 'Yong Wang', 'orcid': 'https://orcid.org/0000-0002-5669-0819'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yong Wang', 'raw_affiliation_strings': ['School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Life Sciences, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100373884', 'display_name': 'Chun Li', 'orcid': 'https://orcid.org/0000-0001-8643-9679'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Chun Li', 'raw_affiliation_strings': ['Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'Modern Research Center for Traditional Chinese Medicine, Beijing University of Chinese Medicine, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100391660', 'display_name': 'Wei Wang', 'orcid': 'https://orcid.org/0000-0001-5401-3331'}, 'institutions': [{'id': 'https://openalex.org/I17747738', 'display_name': 'Beijing University of Chinese Medicine', 'ror': 'https://ror.org/05damtm70', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I17747738']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Wei Wang', 'raw_affiliation_strings': ['School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China'], 'affiliations': [{'raw_affiliation_string': 'School of Traditional Chinese Medicine, Beijing University of Chinese Medicine, No. 11, Bei San Huan Dong Lu, Chaoyang District, Beijing 100029, China', 'institution_ids': ['https://openalex.org/I17747738']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5100373884', 'https://openalex.org/A5100391660'], 'corresponding_institution_ids': ['https://openalex.org/I17747738', 'https://openalex.org/I17747738'], 'apc_list': {'value': 3390, 'currency': 'USD', 'value_usd': 3390, 'provenance': 'doaj'}, 'apc_paid': {'value': 3390, 'currency': 'USD', 'value_usd': 3390, 'provenance': 'doaj'}, 'fwci': 7.634, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 78, 'citation_normalized_percentile': {'value': 0.99996, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '62', 'issue': None, 'first_page': '152949', 'last_page': '152949'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11962', 'display_name': 'Cardiac Fibrosis and Remodeling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11962', 'display_name': 'Cardiac Fibrosis and Remodeling', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/2705', 'display_name': 'Cardiology and Cardiovascular Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11501', 'display_name': 'TGF-β signaling in diseases', 'score': 0.9954, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12505', 'display_name': 'Peptidase Inhibition and Analysis', 'score': 0.9897, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/myocardial-fibrosis', 'display_name': 'Myocardial fibrosis', 'score': 0.614692}, {'id': 'https://openalex.org/keywords/timp1', 'display_name': 'TIMP1', 'score': 0.5915071}, {'id': 'https://openalex.org/keywords/cardiac-fibrosis', 'display_name': 'Cardiac Fibrosis', 'score': 0.5691227}, {'id': 'https://openalex.org/keywords/gsk3b', 'display_name': 'GSK3B', 'score': 0.41281864}], 'concepts': [{'id': 'https://openalex.org/C3018763269', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Myocardial fibrosis', 'level': 3, 'score': 0.614692}, {'id': 'https://openalex.org/C2780692422', 'wikidata': 'https://www.wikidata.org/wiki/Q18031995', 'display_name': 'TIMP1', 'level': 4, 'score': 0.5915071}, {'id': 'https://openalex.org/C2777420927', 'wikidata': 'https://www.wikidata.org/wiki/Q5038318', 'display_name': 'Cardiac fibrosis', 'level': 3, 'score': 0.5691227}, {'id': 'https://openalex.org/C2780559512', 'wikidata': 'https://www.wikidata.org/wiki/Q605709', 'display_name': 'Fibrosis', 'level': 2, 'score': 0.5680522}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.51928115}, {'id': 'https://openalex.org/C2776415932', 'wikidata': 'https://www.wikidata.org/wiki/Q48743', 'display_name': 'Western blot', 'level': 3, 'score': 0.5084285}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.48772034}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.47664008}, {'id': 'https://openalex.org/C111566952', 'wikidata': 'https://www.wikidata.org/wiki/Q1303462', 'display_name': 'Cardiac function curve', 'level': 3, 'score': 0.46832424}, {'id': 'https://openalex.org/C118131993', 'wikidata': 'https://www.wikidata.org/wiki/Q423671', 'display_name': 'Transforming growth factor', 'level': 2, 'score': 0.46310183}, {'id': 'https://openalex.org/C78085059', 'wikidata': 'https://www.wikidata.org/wiki/Q641303', 'display_name': 'Ejection fraction', 'level': 3, 'score': 0.45382178}, {'id': 'https://openalex.org/C189165786', 'wikidata': 'https://www.wikidata.org/wiki/Q193825', 'display_name': 'Extracellular matrix', 'level': 2, 'score': 0.44268614}, {'id': 'https://openalex.org/C104629339', 'wikidata': 'https://www.wikidata.org/wiki/Q18258585', 'display_name': 'GSK3B', 'level': 4, 'score': 0.41281864}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.38810676}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.35045505}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.33145207}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.31364024}, {'id': 'https://openalex.org/C182996813', 'wikidata': 'https://www.wikidata.org/wiki/Q910847', 'display_name': 'GSK-3', 'level': 3, 'score': 0.27462792}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2543109}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.15798739}, {'id': 'https://openalex.org/C150194340', 'wikidata': 'https://www.wikidata.org/wiki/Q26972', 'display_name': 'Gene expression', 'level': 3, 'score': 0.1281223}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.09174973}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000071679', 'descriptor_name': 'Glycogen Synthase Kinase 3 beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D024042', 'descriptor_name': 'Collagen Type I', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D024042', 'descriptor_name': 'Collagen Type I', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004365', 'descriptor_name': 'Drugs, Chinese Herbal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005355', 'descriptor_name': 'Fibrosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000071679', 'descriptor_name': 'Glycogen Synthase Kinase 3 beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D006321', 'descriptor_name': 'Heart', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': 'Q000209', 'qualifier_name': 'etiology', 'is_major_topic': False}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D006333', 'descriptor_name': 'Heart Failure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009206', 'descriptor_name': 'Myocardium', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019869', 'descriptor_name': 'Phosphatidylinositol 3-Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017207', 'descriptor_name': 'Rats, Sprague-Dawley', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D051900', 'descriptor_name': 'Smad3 Protein', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2019.152949', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31102891', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.phymed.2019.152949', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S180051340', 'display_name': 'Phytomedicine', 'issn_l': '0944-7113', 'issn': ['0944-7113', '1618-095X'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.78, 'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81470191'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81530100'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81673802'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81503379'}, {'funder': 'https://openalex.org/F4320326297', 'funder_display_name': 'Fok Ying Tung Education Foundation', 'award_id': '151044'}, {'funder': 'https://openalex.org/F4320334978', 'funder_display_name': 'Beijing Nova Program', 'award_id': 'Z171100001117028'}], 'datasets': [], 'versions': [], 'referenced_works_count': 45, 'referenced_works': ['https://openalex.org/W1540900252', 'https://openalex.org/W1676600749', 'https://openalex.org/W1971054665', 'https://openalex.org/W1973804859', 'https://openalex.org/W1982815250', 'https://openalex.org/W1985732903', 'https://openalex.org/W1996427377', 'https://openalex.org/W2007412101', 'https://openalex.org/W2009358874', 'https://openalex.org/W2025826819', 'https://openalex.org/W2035653659', 'https://openalex.org/W2037749195', 'https://openalex.org/W2043278104', 'https://openalex.org/W2045663276', 'https://openalex.org/W2050862994', 'https://openalex.org/W2064913654', 'https://openalex.org/W2079131177', 'https://openalex.org/W2081339485', 'https://openalex.org/W2082690341', 'https://openalex.org/W2106493153', 'https://openalex.org/W2107359871', 'https://openalex.org/W2108244474', 'https://openalex.org/W2118328682', 'https://openalex.org/W2121179755', 'https://openalex.org/W2128239138', 'https://openalex.org/W2147553923', 'https://openalex.org/W2154824835', 'https://openalex.org/W2158987422', 'https://openalex.org/W2164530918', 'https://openalex.org/W2167263842', 'https://openalex.org/W2167721417', 'https://openalex.org/W2299099463', 'https://openalex.org/W2326077138', 'https://openalex.org/W2339046060', 'https://openalex.org/W2348591993', 'https://openalex.org/W2398350456', 'https://openalex.org/W2471207043', 'https://openalex.org/W2547898348', 'https://openalex.org/W2556132128', 'https://openalex.org/W2605537211', 'https://openalex.org/W2750808153', 'https://openalex.org/W2761466495', 'https://openalex.org/W4237556664', 'https://openalex.org/W4376453938', 'https://openalex.org/W47839471'], 'related_works': ['https://openalex.org/W4386945927', 'https://openalex.org/W4362469413', 'https://openalex.org/W4200248193', 'https://openalex.org/W3170395972', 'https://openalex.org/W3158446721', 'https://openalex.org/W2995381739', 'https://openalex.org/W2604561621', 'https://openalex.org/W2378827008', 'https://openalex.org/W2343473696', 'https://openalex.org/W2074067577'], 'abstract_inverted_index': {'Cardiac': [0], 'fibrosis': [1, 143, 303], 'is': [2, 24], 'a': [3, 25, 40, 221], 'common': [4], 'pathological': [5], 'progress': [6], 'of': [7, 15, 33, 72, 93, 141, 157, 168, 193, 227, 250, 261, 278, 316, 327, 343, 353, 364, 373, 398, 405], 'cardiovascular': [8], 'disease': [9], 'resulting': [10], 'from': [11, 45], 'the': [12, 70, 78, 136, 205, 217, 225, 234, 248, 258, 262, 267, 287, 293, 298, 314, 341, 371, 396, 399, 403], 'excessive': [13], 'accumulation': [14], 'extracellular': [16], 'matrix': [17], '(ECM).': [18], 'Transforming': [19], 'growth': [20], 'factor': [21], '(TGF)-β/SMADs': [22], 'pathway': [23, 28, 76, 378, 401], 'canonical': [26], 'signaling': [27, 176, 377], 'which': [29], 'directly': [30], 'induces': [31], 'expressions': [32, 277, 352], 'ECM': [34], 'related': [35], 'genes.': [36], 'Qishen': [37], 'Granule': [38], '(QSG),': [39], 'traditional': [41], 'Chinese': [42], 'formula': [43], 'developed': [44], 'Zhen-Wu': [46], 'Decoration': [47], 'for': [48, 126, 199], 'heart': [49, 137], 'failure': [50], '(HF),': [51], 'has': [52], 'been': [53], 'proven': [54], 'to': [55, 134], 'have': [56], 'definite': [57], 'therapeutic': [58], 'effects': [59, 71, 391], 'on': [60, 74, 97], 'cardiac': [61, 142, 191, 207, 259, 302, 328, 380, 383, 387], 'fibrosis.': [62, 388], 'However,': [63], 'its': [64], 'underlying': [65], 'mechanisms': [66], 'remain': [67], 'unclear.To': [68], 'investigate': [69], 'QSG': [73, 114, 230, 271, 288, 299, 337, 368], 'TGF-β': [75], 'and': [77, 83, 116, 129, 151, 160, 170, 174, 186, 211, 231, 236, 244, 253, 281, 319, 322, 346, 348, 357, 375, 402], 'downstream': [79], 'mediators': [80], 'including': [81, 109], 'Smad3': [82, 374], 'Glycogen': [84], 'synthase': [85], 'kinase': [86], '(GSK)-3β.HF': [87], 'model': [88, 112, 218, 263, 294], 'was': [89, 132, 144], 'induced': [90], 'by': [91, 146, 164, 180, 333, 362, 395], 'ligation': [92], 'left': [94], 'coronary': [95], 'artery': [96], 'male': [98], 'Sprague-Dawley': [99], '(SD)': [100], 'rats.': [101], 'Rat': [102], 'were': [103, 124, 162, 178, 197, 283, 330, 359], 'randomly': [104], 'divided': [105], 'into': [106], 'four': [107], 'groups': [108], 'sham': [110, 268], 'group,': [111, 113, 295], 'group': [115, 123, 219, 264, 269, 290], 'Fosinopril': [117, 232], 'control': [118], 'group.': [119], 'Rats': [120], 'in': [121, 172, 200, 216, 257, 286, 379], 'each': [122], 'treated': [125], '28': [127], 'days,': [128], '2D': [130], 'echocardiography': [131], 'adopted': [133, 198], 'evaluate': [135], 'function.': [138], 'The': [139, 389], 'degree': [140], 'assessed': [145, 163], 'Hematoxylin-Eosin': [147], '(HE),': [148], "Masson's": [149], 'trichrome': [150], 'Picrosirius': [152], 'red': [153], '(PSR)': [154], 'staining.': [155], 'Contents': [156], 'collagen': [158, 251, 274, 321, 344], 'Ⅰ': [159, 318, 345], 'Ⅲ': [161, 320, 347], 'immunohistochemical': [165], 'method.': [166], 'Expressions': [167], 'genes': [169], 'proteins': [171], 'TGF-β/SMADs': [173], 'PI3K-GSK-3': [175], 'pathways': [177], 'detected': [179], 'Real-time': [181], 'Fluorescence': [182], 'Quantitative': [183], 'PCR': [184], '(RT-qPCR)': [185], 'Western': [187], 'blot': [188], 'respectively.': [189], 'TGF-β1-treated': [190], 'fibroblasts': [192, 329], 'neonatal': [194], 'SD': [195], 'rats': [196], 'vitro': [201, 309], 'studies.28': [202], 'days': [203], 'after': [204], 'surgery,': [206], 'ejection': [208], 'fraction': [209], '(EF)': [210], 'fractional': [212], 'shortening': [213], '(FS)': [214], 'values': [215], 'showed': [220, 246, 312], 'remarkable': [222], 'decrease,': [223], 'indicating': [224], 'induction': [226], 'HF': [228], 'model.': [229], 'elevated': [233], 'EF': [235], 'FS': [237], 'values,': [238], 'demonstrating': [239], 'cardio-protective': [240], 'effects.': [241], 'Pathological': [242], 'staining': [243], 'immunohistochemistry': [245], 'that': [247, 297, 313], 'contents': [249], 'I': [252], 'III': [254], 'dramatically': [255], 'increased': [256, 332], 'tissue': [260], 'compared': [265, 291], 'with': [266, 292, 335, 367], 'while': [270], 'treatment': [272, 289], 'reduced': [273], 'contents.': [275], 'Furthermore,': [276], 'TGF-β1,': [279], 'p-Smad3': [280], 'p-GSK-3β': [282, 358], 'significantly': [284, 331, 360], 'decreased': [285], 'suggesting': [296], 'may': [300], 'attenuate': [301], 'through': [304, 385], 'regulating': [305], 'TGF-β/Smad3': [306, 400], 'pathway.': [307], 'In': [308], 'study': [310], 'further': [311], 'productions': [315], 'type': [317], 'α-smooth': [323], 'muscle': [324], 'actin': [325], '(α-SMA)': [326], 'incubation': [334], 'TGF-β1.': [336, 365], 'could': [338, 369], 'markedly': [339], 'reduce': [340], 'secretion': [342], 'α-SMA': [349], 'expression.': [350], 'Protein': [351], 'p-Smad3,': [354], 'PI3K,': [355], 'p-Akt': [356], 'up-regulated': [361], 'stimulation': [363], 'Treatment': [366], 'suppress': [370], 'activity': [372], 'PI3K-GSK-3β': [376], 'fibroblasts.QSG': [381], 'improves': [382], 'function': [384], 'inhibiting': [386], 'anti-fibrotic': [390], 'are': [392], 'potentially': [393], 'mediated': [394], 'inhibition': [397], 'phosphorylation': [404], 'GSK-3β.': [406]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2943843605', 'counts_by_year': [{'year': 2024, 'cited_by_count': 18}, {'year': 2023, 'cited_by_count': 17}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 14}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-18T03:33:16.723713', 'created_date': '2019-05-16'}