Non‐canonical <scp>cM</scp> et regulation by vimentin mediates Plk1 inhibitor–induced apoptosis

Name: Work Video:
Duration: 3 min 30 s
Ratnakar Singh; Shaohua Peng; Pavitra Viswanath; Vaishnavi Sambandam; Li Shen; Xiayu Rao; Bingliang Fang; Jing Wang; Faye M. Johnson
{'id': 'https://openalex.org/W2943232183', 'doi': 'https://doi.org/10.15252/emmm.201809960', 'title': 'Non‐canonical <scp>cM</scp> et regulation by vimentin mediates Plk1 inhibitor–induced apoptosis', 'display_name': 'Non‐canonical <scp>cM</scp> et regulation by vimentin mediates Plk1 inhibitor–induced apoptosis', 'publication_year': 2019, 'publication_date': '2019-04-30', 'ids': {'openalex': 'https://openalex.org/W2943232183', 'doi': 'https://doi.org/10.15252/emmm.201809960', 'mag': '2943232183', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31040125', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6505578'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.15252/emmm.201809960', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163075119', 'display_name': 'EMBO Molecular Medicine', 'issn_l': '1757-4676', 'issn': ['1757-4676', '1757-4684'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.15252/emmm.201809960', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5027620667', 'display_name': 'Ratnakar Singh', 'orcid': 'https://orcid.org/0000-0002-3226-3847'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Ratnakar Singh', 'raw_affiliation_strings': ['Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5110884902', 'display_name': 'Shaohua Peng', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Shaohua Peng', 'raw_affiliation_strings': ['Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025467437', 'display_name': 'Pavitra Viswanath', 'orcid': 'https://orcid.org/0000-0002-5647-3283'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Pavitra Viswanath', 'raw_affiliation_strings': ['Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074107640', 'display_name': 'Vaishnavi Sambandam', 'orcid': 'https://orcid.org/0000-0003-0013-8838'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vaishnavi Sambandam', 'raw_affiliation_strings': ['Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100683846', 'display_name': 'Li Shen', 'orcid': 'https://orcid.org/0000-0001-8427-9448'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Li Shen', 'raw_affiliation_strings': ['Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077700916', 'display_name': 'Xiayu Rao', 'orcid': 'https://orcid.org/0000-0001-5245-7449'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Xiayu Rao', 'raw_affiliation_strings': ['Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034128046', 'display_name': 'Bingliang Fang', 'orcid': 'https://orcid.org/0000-0001-9225-3010'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bingliang Fang', 'raw_affiliation_strings': ['Department of Thoracic and Cardiovascular Surgery The University of Texas MD Anderson Cancer Center Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic and Cardiovascular Surgery The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100378537', 'display_name': 'Jing Wang', 'orcid': 'https://orcid.org/0000-0002-5398-0802'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jing Wang', 'raw_affiliation_strings': ['Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA', 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'Department of Bioinformatics and Computational Biology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5024203346', 'display_name': 'Faye M. Johnson', 'orcid': 'https://orcid.org/0000-0002-2862-4160'}, 'institutions': [{'id': 'https://openalex.org/I1343551460', 'display_name': 'The University of Texas MD Anderson Cancer Center', 'ror': 'https://ror.org/04twxam07', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1343551460']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Faye M Johnson', 'raw_affiliation_strings': ['Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Thoracic/Head &amp; Neck Medical Oncology The University of Texas MD Anderson Cancer Center Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}, {'raw_affiliation_string': 'The University of Texas MD Anderson Cancer Center Graduate School of Biomedical Sciences Houston TX USA', 'institution_ids': ['https://openalex.org/I1343551460']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'apc_paid': {'value': 5000, 'currency': 'USD', 'value_usd': 5000, 'provenance': 'doaj'}, 'fwci': 1.757, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 20, 'citation_normalized_percentile': {'value': 0.99996, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 91, 'max': 92}, 'biblio': {'volume': '11', 'issue': '5', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10583', 'display_name': 'Cancer-related Molecular Pathways', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2730', 'display_name': 'Oncology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10492', 'display_name': 'Microtubule and mitosis dynamics', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1307', 'display_name': 'Cell Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/plk1', 'display_name': 'PLK1', 'score': 0.54328924}, {'id': 'https://openalex.org/keywords/non-canonical', 'display_name': 'Non canonical', 'score': 0.4831428}, {'id': 'https://openalex.org/keywords/flip', 'display_name': 'Flip', 'score': 0.47615597}], 'concepts': [{'id': 'https://openalex.org/C190283241', 'wikidata': 'https://www.wikidata.org/wiki/Q14599311', 'display_name': 'Apoptosis', 'level': 2, 'score': 0.700501}, {'id': 'https://openalex.org/C147447768', 'wikidata': 'https://www.wikidata.org/wiki/Q411624', 'display_name': 'Vimentin', 'level': 3, 'score': 0.6562851}, {'id': 'https://openalex.org/C146276462', 'wikidata': 'https://www.wikidata.org/wiki/Q21131841', 'display_name': 'PLK1', 'level': 4, 'score': 0.54328924}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5276469}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4927595}, {'id': 'https://openalex.org/C3018844941', 'wikidata': 'https://www.wikidata.org/wiki/Q6718887', 'display_name': 'Non canonical', 'level': 2, 'score': 0.4831428}, {'id': 'https://openalex.org/C2776591724', 'wikidata': 'https://www.wikidata.org/wiki/Q5459651', 'display_name': 'Flip', 'level': 3, 'score': 0.47615597}, {'id': 'https://openalex.org/C153911025', 'wikidata': 'https://www.wikidata.org/wiki/Q7202', 'display_name': 'Molecular biology', 'level': 1, 'score': 0.34304166}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.32937485}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.29566586}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21659404}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.1557087}, {'id': 'https://openalex.org/C29537977', 'wikidata': 'https://www.wikidata.org/wiki/Q188941', 'display_name': 'Cell cycle', 'level': 3, 'score': 0.14057213}, {'id': 'https://openalex.org/C204232928', 'wikidata': 'https://www.wikidata.org/wiki/Q899285', 'display_name': 'Immunohistochemistry', 'level': 2, 'score': 0.13395452}], 'mesh': [{'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000037', 'qualifier_name': 'antagonists & inhibitors', 'is_major_topic': True}, {'descriptor_ui': 'D019859', 'descriptor_name': 'Proto-Oncogene Proteins c-met', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D002289', 'descriptor_name': 'Carcinoma, Non-Small-Cell Lung', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D018797', 'descriptor_name': 'Cell Cycle Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D019008', 'descriptor_name': 'Drug Resistance, Neoplasm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D004847', 'descriptor_name': 'Epithelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058750', 'descriptor_name': 'Epithelial-Mesenchymal Transition', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019012', 'descriptor_name': 'Integrin beta1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D000097869', 'descriptor_name': 'Polo-Like Kinase 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D047428', 'descriptor_name': 'Protein Kinase Inhibitors', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017346', 'descriptor_name': 'Protein Serine-Threonine Kinases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D011518', 'descriptor_name': 'Proto-Oncogene Proteins', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019859', 'descriptor_name': 'Proto-Oncogene Proteins c-met', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011621', 'descriptor_name': 'Pteridines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D011621', 'descriptor_name': 'Pteridines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D016212', 'descriptor_name': 'Transforming Growth Factor beta', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014746', 'descriptor_name': 'Vimentin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 3, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.15252/emmm.201809960', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163075119', 'display_name': 'EMBO Molecular Medicine', 'issn_l': '1757-4676', 'issn': ['1757-4676', '1757-4684'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6505578', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31040125', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.15252/emmm.201809960', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S163075119', 'display_name': 'EMBO Molecular Medicine', 'issn_l': '1757-4676', 'issn': ['1757-4676', '1757-4684'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319965', 'host_organization_name': 'Springer Nature', 'host_organization_lineage': ['https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.87, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320306078', 'funder_display_name': 'U.S. Department of Defense', 'award_id': 'W81XWH‐17‐1‐0206'}, {'funder': 'https://openalex.org/F4320332161', 'funder_display_name': 'National Institutes of Health', 'award_id': 'U54CA224065'}, {'funder': 'https://openalex.org/F4320337351', 'funder_display_name': 'National Cancer Institute', 'award_id': 'P30CA016672'}], 'datasets': [], 'versions': [], 'referenced_works_count': 75, 'referenced_works': ['https://openalex.org/W1518200290', 'https://openalex.org/W1545792489', 'https://openalex.org/W1557877432', 'https://openalex.org/W1842992197', 'https://openalex.org/W1979427468', 'https://openalex.org/W1981145667', 'https://openalex.org/W1982547932', 'https://openalex.org/W1989786382', 'https://openalex.org/W1993017320', 'https://openalex.org/W1996863944', 'https://openalex.org/W2004981153', 'https://openalex.org/W2009931781', 'https://openalex.org/W2010522003', 'https://openalex.org/W2011707243', 'https://openalex.org/W2013824927', 'https://openalex.org/W2016580535', 'https://openalex.org/W2020606105', 'https://openalex.org/W2022538460', 'https://openalex.org/W2023678160', 'https://openalex.org/W2025880272', 'https://openalex.org/W2044179984', 'https://openalex.org/W2045299639', 'https://openalex.org/W2050416577', 'https://openalex.org/W2056528509', 'https://openalex.org/W2059072630', 'https://openalex.org/W2080377650', 'https://openalex.org/W2084478721', 'https://openalex.org/W2091965465', 'https://openalex.org/W2096439168', 'https://openalex.org/W2098920385', 'https://openalex.org/W2098962955', 'https://openalex.org/W2101379344', 'https://openalex.org/W2107763333', 'https://openalex.org/W2115890515', 'https://openalex.org/W2116265446', 'https://openalex.org/W2121262970', 'https://openalex.org/W2133061560', 'https://openalex.org/W2147974847', 'https://openalex.org/W2149931147', 'https://openalex.org/W2154402764', 'https://openalex.org/W2167831982', 'https://openalex.org/W2169105660', 'https://openalex.org/W2169624569', 'https://openalex.org/W2175767930', 'https://openalex.org/W2175970000', 'https://openalex.org/W2181186240', 'https://openalex.org/W2184535556', 'https://openalex.org/W2195247392', 'https://openalex.org/W2235393999', 'https://openalex.org/W2311257231', 'https://openalex.org/W2322127930', 'https://openalex.org/W2347151465', 'https://openalex.org/W2410267396', 'https://openalex.org/W2464405525', 'https://openalex.org/W2465518274', 'https://openalex.org/W2469307120', 'https://openalex.org/W2521303659', 'https://openalex.org/W2552674955', 'https://openalex.org/W2561714197', 'https://openalex.org/W2580400431', 'https://openalex.org/W2588627862', 'https://openalex.org/W2592643813', 'https://openalex.org/W2604267877', 'https://openalex.org/W2604488177', 'https://openalex.org/W2744579837', 'https://openalex.org/W2751924695', 'https://openalex.org/W2759119425', 'https://openalex.org/W2760276067', 'https://openalex.org/W2765831845', 'https://openalex.org/W2781525129', 'https://openalex.org/W2791057369', 'https://openalex.org/W2803806527', 'https://openalex.org/W2805550471', 'https://openalex.org/W2886954940', 'https://openalex.org/W2969837032'], 'related_works': ['https://openalex.org/W845363512', 'https://openalex.org/W4200394569', 'https://openalex.org/W3147393391', 'https://openalex.org/W2510077499', 'https://openalex.org/W2413186752', 'https://openalex.org/W2362612647', 'https://openalex.org/W2158114950', 'https://openalex.org/W2027574289', 'https://openalex.org/W1999778284', 'https://openalex.org/W184483572'], 'abstract_inverted_index': {'Research': [0], 'Article30': [1], 'April': [2], '2019Open': [3], 'Access': [4], 'Source': [5, 2911, 2919, 3434, 3442], 'DataTransparent': [6], 'process': [7, 810], 'Non-canonical': [8], 'cMet': [9, 873, 889, 897, 903, 927, 953, 985, 1000, 1057, 1075, 1091, 1113, 1138, 1155, 1727, 1750, 1767, 1781, 2014, 2147, 2367, 2384, 2931, 3100, 3188, 3214, 3638, 3676, 3711, 3729, 3736, 3756, 3780, 3791, 3805, 3875, 3896, 4010, 4031], 'regulation': [10, 1270, 1725, 3465], 'by': [11, 44, 73, 118, 147, 175, 203, 231, 275, 327, 357, 386, 431, 460, 488, 516, 544, 588, 640, 1142, 1307, 1745, 1899, 2499, 2613, 2654, 2739, 2747, 2753, 2861, 2871, 3430, 3517, 3862, 3969, 4288], 'vimentin': [12, 981, 1031, 1144, 1762], 'mediates': [13], 'Plk1': [14, 886, 899, 908, 916, 930, 943, 955, 971, 1003, 1028, 1038, 1052, 1081, 1094, 1107, 1115, 1281, 1302, 1343, 1394, 1481, 1483, 1556, 1609, 1611, 1618, 1635, 1690, 1720, 1730, 1742, 1759, 1789, 1799, 1839, 1896, 1949, 2001, 2008, 2023, 2049, 2056, 2193, 2214, 2323, 2391, 2526, 2590, 2628, 2718, 2757, 2778, 2943, 2955, 2971, 3006, 3157, 3185, 3229, 3476, 3645, 3672, 3691, 3768, 3789, 3810, 4012, 4029, 4322, 4343], 'inhibitor–induced': [15, 900, 909, 2719, 3811], 'apoptosis': [16, 1021, 1744, 2528, 2651, 2737, 3796, 3954, 4014, 4036, 4369], 'Ratnakar': [17, 19, 330, 332, 645, 750], 'Singh': [18, 20, 331, 333, 751], 'orcid.org/0000-0002-3226-3847': [21, 334], 'Department': [22, 51, 80, 125, 154, 182, 210, 254, 289, 335, 364, 393, 438, 467, 495, 523, 567, 602], 'of': [23, 31, 52, 60, 81, 89, 100, 108, 126, 134, 155, 162, 183, 190, 211, 218, 240, 248, 255, 262, 290, 298, 309, 317, 336, 344, 365, 373, 394, 402, 413, 421, 439, 447, 468, 475, 496, 503, 524, 531, 553, 561, 568, 575, 603, 611, 622, 630, 667, 675, 686, 694, 701, 708, 718, 725, 760, 773, 781, 796, 806, 862, 880, 952, 960, 996, 999, 1002, 1035, 1049, 1067, 1099, 1112, 1153, 1168, 1212, 1271, 1280, 1390, 1393, 1415, 1450, 1595, 1632, 1663, 1674, 1697, 1726, 1860, 1888, 1962, 1979, 2042, 2092, 2133, 2160, 2277, 2287, 2329, 2380, 2454, 2462, 2470, 2521, 2565, 2603, 2609, 2755, 2813, 2884, 2896, 2930, 2961, 3027, 3037, 3156, 3213, 3236, 3415, 3484, 3637, 3651, 3671, 3675, 3689, 3717, 3732, 3746, 3755, 3788, 3822, 3885, 3902, 3912, 3935, 4009, 4024, 4064, 4074, 4220, 4232, 4277, 4303, 4342], 'Thoracic/Head': [24, 53, 82, 127, 291, 337, 366, 395, 440, 604, 668], '&': [25, 54, 83, 128, 292, 338, 367, 396, 441, 605, 669, 830, 1363, 2731], 'Neck': [26, 55, 84, 129, 293, 339, 368, 397, 442, 606, 670], 'Medical': [27, 56, 85, 130, 294, 340, 369, 398, 443, 607, 671], 'Oncology,': [28, 57, 86, 131, 295, 341, 370, 399, 444, 608, 672], 'The': [29, 58, 87, 98, 132, 160, 188, 216, 238, 260, 296, 307, 342, 371, 400, 411, 445, 473, 501, 529, 551, 573, 609, 620, 673, 706, 723, 779, 950, 1110, 1630, 2131, 2164, 2273, 2348, 2378, 2607, 2717, 3316, 3513, 3786, 4294], 'University': [30, 59, 88, 99, 133, 161, 189, 217, 239, 261, 297, 308, 343, 372, 401, 412, 446, 474, 502, 530, 552, 574, 610, 621, 674, 685, 707, 724, 759, 772, 780], 'Texas': [32, 61, 90, 101, 135, 163, 191, 219, 241, 263, 299, 310, 345, 374, 403, 414, 448, 476, 504, 532, 554, 576, 612, 623, 676, 687, 709, 726, 782], 'MD': [33, 62, 91, 102, 136, 164, 192, 220, 242, 264, 300, 311, 346, 375, 404, 415, 449, 477, 505, 533, 555, 577, 613, 624, 677, 688, 710, 727, 783, 1827, 2084, 2239, 2421], 'Anderson': [34, 63, 92, 103, 137, 165, 193, 221, 243, 265, 301, 312, 347, 376, 405, 416, 450, 478, 506, 534, 556, 578, 614, 625, 678, 689, 711, 728, 784, 1828, 2085, 2240, 2422], 'Cancer': [35, 64, 93, 104, 138, 166, 194, 222, 244, 266, 302, 313, 348, 377, 406, 417, 451, 479, 507, 535, 557, 579, 615, 626, 679, 690, 712, 729, 785, 1844, 2067, 2226], 'Center,': [36, 65, 94, 139, 167, 195, 223, 267, 303, 349, 378, 407, 452, 480, 508, 536, 580, 616, 680, 713, 730], 'Houston,': [37, 66, 95, 111, 140, 168, 196, 224, 251, 268, 304, 320, 350, 379, 408, 424, 453, 481, 509, 537, 564, 581, 617, 633, 681, 697, 714, 731], 'TX,': [38, 67, 96, 112, 141, 169, 197, 225, 252, 269, 305, 321, 351, 380, 409, 425, 454, 482, 510, 538, 565, 582, 618, 634, 682, 698, 715, 732], 'USA': [39, 68, 97, 113, 142, 170, 198, 226, 253, 270, 306, 322, 352, 381, 410, 426, 455, 483, 511, 539, 566, 583, 619, 635, 683, 699, 716, 733], 'Search': [40, 69, 114, 143, 171, 199, 227, 271, 323, 353, 382, 427, 456, 484, 512, 540, 584, 636], 'for': [41, 70, 115, 144, 172, 200, 228, 272, 324, 354, 383, 428, 457, 485, 513, 541, 585, 637, 837, 841, 1209, 1221, 1299, 1455, 1805, 2021, 2054, 2112, 2121, 2263, 2321, 2452, 2508, 2535, 2551, 2794, 2831, 2842, 2903, 2916, 2921, 2951, 2975, 3001, 3010, 3261, 3326, 3356, 3389, 3403, 3439, 3444, 3561, 3809, 3826, 4028, 4033, 4066, 4114, 4125, 4145, 4155, 4186, 4201, 4240, 4291, 4358], 'more': [42, 71, 116, 145, 173, 201, 229, 273, 325, 355, 384, 429, 458, 486, 514, 542, 586, 638, 919, 940, 1456, 1553, 1948, 2311, 2708, 2742, 3953], 'papers': [43, 72, 117, 146, 174, 202, 230, 274, 326, 356, 385, 430, 459, 487, 515, 543, 587, 639], 'this': [45, 74, 119, 148, 176, 204, 232, 276, 328, 358, 387, 432, 461, 489, 517, 545, 589, 641, 790, 1603, 1643, 1652, 1679, 2036, 2495, 2917, 3083, 3440, 3456, 3652, 3918], 'author': [46, 75, 120, 149, 177, 205, 233, 277, 329, 359, 388, 433, 462, 490, 518, 546, 590, 642, 818], 'Shaohua': [47, 49, 360, 362, 647], 'Peng': [48, 50, 361, 363], 'Pavitra': [76, 78, 389, 391, 649, 763], 'Viswanath': [77, 79, 390, 392], 'Center': [105, 245, 314, 418, 558, 627, 691, 786], 'Graduate': [106, 246, 315, 419, 559, 628, 692], 'School': [107, 247, 316, 420, 560, 629, 693], 'Biomedical': [109, 249, 318, 422, 562, 631, 695], 'Sciences,': [110, 250, 319, 423, 563, 632, 696], 'Vaishnavi': [121, 123, 434, 436, 651], 'Sambandam': [122, 124, 435, 437], 'Li': [150, 152, 463, 465, 653], 'Shen': [151, 153, 464, 466], 'Bioinformatics': [156, 184, 256, 469, 497, 569, 702], 'and': [157, 185, 213, 257, 470, 498, 526, 570, 661, 703, 720, 799, 817, 882, 925, 954, 1004, 1029, 1032, 1039, 1058, 1085, 1103, 1114, 1196, 1217, 1263, 1274, 1290, 1336, 1493, 1499, 1534, 1537, 1545, 1565, 1571, 1621, 1642, 1666, 1717, 1734, 1748, 1755, 1782, 1815, 1837, 1876, 1883, 1931, 1970, 1977, 1991, 2030, 2061, 2099, 2128, 2162, 2170, 2211, 2219, 2232, 2275, 2284, 2298, 2335, 2366, 2399, 2428, 2436, 2467, 2485, 2545, 2573, 2578, 2639, 2663, 2697, 2699, 2703, 2809, 2820, 2838, 2845, 2852, 2866, 2937, 2945, 2985, 2992, 3016, 3057, 3063, 3082, 3090, 3124, 3170, 3206, 3220, 3231, 3244, 3246, 3253, 3265, 3286, 3305, 3342, 3359, 3381, 3399, 3462, 3468, 3489, 3527, 3530, 3544, 3546, 3550, 3565, 3586, 3606, 3624, 3644, 3790, 3824, 3829, 3865, 3944, 3962, 3973, 3979, 4011, 4030, 4035, 4040, 4092, 4148, 4249, 4258, 4301, 4334, 4349, 4363, 4374], 'Computational': [158, 186, 258, 471, 499, 571, 704], 'Biology,': [159, 187, 259, 472, 500, 572, 705], 'Xiayu': [178, 180, 491, 493, 655], 'Rao': [179, 181, 492, 494], 'Bingliang': [206, 208, 519, 521, 657], 'Fang': [207, 209, 520, 522], 'Thoracic': [212, 525, 719], 'Cardiovascular': [214, 527, 721], 'Surgery,': [215, 528, 722], 'Jing': [234, 236, 547, 549, 659], 'Wang': [235, 237, 548, 550, 2726], 'Faye': [278, 283, 591, 596, 662], 'M': [279, 284, 592, 597, 663], 'Johnson': [280, 285, 593, 598, 664], 'Corresponding': [281, 594], 'Author': [282, 595, 643], '[email': [286, 599, 743], 'protected]': [287, 600, 744], 'orcid.org/0000-0002-2862-4160': [288, 601], 'Information': [644], 'Singh1,': [646], 'Peng1,': [648], 'Viswanath1,2,': [650], 'Sambandam1,': [652], 'Shen3,': [654], 'Rao3,': [656], 'Fang4,': [658], 'Wang2,3': [660], '*,1,2': [665], '1Department': [666], '2The': [684], '3Department': [700], '4Department': [717], '*Corresponding': [734], 'author.': [735], 'Tel:': [736], '+1': [737, 740], '713-792-6363;': [738], 'Fax:': [739], '713-792-1220;': [741], 'E-mail:': [742], 'EMBO': [745], 'Mol': [746], 'Med': [747], '(2019)11:e9960https://doi.org/10.15252/emmm.201809960': [748], 'Dr.': [749], 'is': [752, 765, 1077, 1096, 1140, 1198, 1214, 1252, 1258, 2174, 2932, 3215, 3515, 3769, 3807], 'currently': [753, 766], 'a': [754, 767, 804, 992, 1063, 1097, 1149, 1218, 1253, 1265, 1405, 1411, 1458, 1645, 1707, 2115, 2292, 2300, 2522, 2610, 2617, 2799, 3025, 3067, 3080, 3096, 3518, 3764, 3820, 4061, 4365], 'postdoctoral': [755], 'fellow': [756], 'at': [757, 770, 778, 787, 1616, 2264, 2552, 4088], 'the': [758, 771, 788, 807, 835, 860, 1161, 1172, 1204, 1269, 1388, 1586, 1655, 1712, 1826, 1843, 1874, 1911, 1963, 1980, 2055, 2066, 2083, 2095, 2134, 2137, 2140, 2143, 2225, 2238, 2259, 2271, 2278, 2282, 2288, 2353, 2358, 2396, 2420, 2455, 2500, 2559, 2563, 2685, 2691, 2756, 2764, 2862, 2872, 2885, 2949, 2959, 2981, 2998, 3003, 3034, 3054, 3058, 3072, 3135, 3140, 3150, 3154, 3160, 3299, 3309, 3327, 3365, 3404, 3416, 3521, 3525, 3599, 3607, 3649, 3678, 3685, 3690, 3708, 3715, 3802, 3913, 3949, 3996, 4025, 4078, 4084, 4101, 4105, 4111, 4171, 4175, 4221, 4285, 4299, 4340], 'Illinois.': [761], 'Ms.': [762], 'Visvanath': [764], 'graduate': [768], 'student': [769], 'Utah.': [774], 'Both': [775], 'were': [776, 939, 947, 1552, 1559, 1613, 1858, 1890, 1915, 1941, 2063, 2080, 2504, 2707, 2788, 2825, 2835, 2840, 2849, 3127, 3163, 3174, 3255, 3274, 3281, 3322, 3384, 3396, 3401, 3509, 3555, 3574, 3581, 4141, 4162], 'employed': [777], 'time': [789], 'research': [791, 990, 3919], 'was': [792, 852, 874, 969, 1486, 1606, 1870, 1975, 1994, 2417, 2497, 2682, 2741, 2761, 2803, 2859, 2869, 3042, 3147, 3694, 3931, 4048, 4098, 4168, 4325], 'performed': [793, 1659, 3510], 'PDFDownload': [794], 'PDF': [795], 'article': [797], 'text': [798], 'main': [800], 'figures.': [801], 'Peer': [802], 'ReviewDownload': [803], 'summary': [805], 'editorial': [808, 812], 'decision': [809, 813], 'including': [811, 1235, 3295, 3595], 'letters,': [814], 'reviewer': [815], 'comments': [816], 'responses': [819, 1341, 1403], 'to': [820, 823, 854, 915, 942, 958, 1020, 1023, 1106, 1118, 1166, 1243, 1276, 1342, 1448, 1474, 1478, 1480, 1488, 1555, 1600, 1608, 1634, 1705, 1710, 1788, 1894, 1919, 1924, 1929, 1935, 1945, 2000, 2007, 2034, 2048, 2192, 2213, 2389, 2404, 2483, 2492, 2558, 2616, 2710, 2777, 2797, 2954, 3005, 3076, 3085, 3267, 3324, 3361, 3454, 3567, 3647, 3952, 4150, 4158], 'feedback.': [821], 'ToolsAdd': [822], 'favoritesDownload': [824], 'CitationsTrack': [825], 'CitationsPermissions': [826], 'ShareFacebookTwitterLinked': [827], 'InMendeleyWechatReddit': [828], 'Figures': [829], 'Info': [831], 'Abstract': [832], 'To': [833, 1650, 1793, 2529, 2947, 2996, 3800, 3834, 4338], 'address': [834, 1651], 'need': [836], 'improved': [838], 'systemic': [839], 'therapy': [840], 'non–small-cell': [842, 1189, 2103, 2151, 2196, 2343, 2783, 3222, 3470, 3503, 4016], 'lung': [843, 1012, 1050, 1070, 1190, 1500, 2104, 2152, 2197, 2344, 2784, 3223, 3471, 3504, 4017], 'cancer': [844, 1071, 1159, 1191, 1261, 1348, 2105, 2153, 2198, 2345, 2785, 3224, 3472, 3505, 4018], '(NSCLC),': [845], 'we': [846, 870, 1658, 1693, 1802, 1958, 2538, 2597, 2957, 3008, 3031, 3182, 3634, 3813, 3837, 4345], 'previously': [847, 1530], 'demonstrated': [848, 1400], 'that': [849, 872, 962, 1187, 1257, 1399, 1547, 1682, 1764, 1796, 1960, 2013, 2044, 2254, 2479, 2488, 2502, 2583, 2745, 2848, 3033, 3669, 3701, 3804, 3894], 'mesenchymal': [850, 883, 893, 937, 1011, 1135, 1548, 1708, 1735, 1773, 1981, 2523, 2611, 2645, 2686, 2704, 2773, 2800, 2938, 3017, 3151, 3221, 3248, 3287, 3343, 3469, 3548, 3587, 3679, 3783, 3964, 4039, 4328], 'NSCLC': [851, 866, 935, 1087, 1125, 1136, 1213, 1542, 1549, 1582, 1623, 1639, 1675, 1699, 1752, 1776, 1807, 2410, 2438, 2511, 2541, 2939, 3239, 3249, 3288, 3346, 3552, 3588, 3656, 3774, 3784, 3798, 3816, 3845, 3878, 4042, 4053, 4251, 4329, 4353], 'sensitive': [853, 941, 1554, 2006, 2709], 'polo-like': [855, 1014], 'kinase': [856, 1015, 1249, 1256, 3888], '(Plk1)': [857, 1017, 1251], 'inhibitors,': [858, 4344], 'but': [859, 978, 1404, 1517, 3106, 3153, 3196, 3682, 3723, 3749, 3777], 'mechanisms': [861, 1631], 'resistance': [863, 914, 1054, 1105, 1633, 2297, 3004], 'in': [864, 877, 892, 1045, 1062, 1083, 1122, 1126, 1171, 1201, 1260, 1268, 1287, 1347, 1396, 1417, 1496, 1502, 1519, 1563, 1566, 1585, 1592, 1619, 1637, 1648, 1654, 1669, 1714, 1732, 1741, 1751, 1753, 1756, 1772, 1791, 1873, 1910, 1996, 2004, 2102, 2108, 2142, 2150, 2176, 2195, 2201, 2203, 2270, 2308, 2314, 2409, 2433, 2562, 2620, 2632, 2649, 2658, 2661, 2665, 2684, 2712, 2763, 2935, 2980, 3099, 3103, 3108, 3119, 3143, 3149, 3193, 3198, 3218, 3276, 3298, 3308, 3466, 3502, 3511, 3576, 3598, 3655, 3677, 3684, 3696, 3719, 3766, 3772, 3782, 3797, 3844, 3876, 3886, 3917, 3933, 3959, 3989, 4015, 4020, 4038, 4052, 4104, 4152, 4174, 4256, 4271, 4305, 4327, 4352, 4368], 'epithelial': [865, 881, 920, 948, 1059, 1560, 1638, 1698, 1733, 1783, 1964, 2670, 2692, 2936, 3015, 3161, 3219, 3285, 3467, 3541, 3585, 3686, 3961, 4041, 4250], 'remain': [867, 1640], 'unknown.': [868], 'Here,': [869], 'show': [871, 3481], 'differentially': [875, 1078, 2933, 3011, 3043, 3216, 3282, 3582], 'regulated': [876, 1079, 1141, 2934, 3044, 3217, 3283, 3583], 'isogenic': [878, 1695, 2531, 2634, 2765, 2822, 2983, 3238], 'pairs': [879, 1696, 2534, 2766, 2984, 3235], 'cell': [884, 1069, 1073, 1088, 1237, 1300, 1543, 1550, 1561, 1583, 1624, 1676, 1700, 1777, 1808, 1877, 1997, 2106, 2154, 2199, 2316, 2346, 2411, 2439, 2512, 2532, 2600, 2635, 2687, 2705, 2786, 2823, 2940, 2989, 3018, 3074, 3226, 3240, 3250, 3289, 3318, 3347, 3473, 3506, 3553, 3589, 3657, 3680, 3698, 3721, 3775, 3817, 3914, 3937, 3965, 3991, 4043, 4054, 4071, 4107, 4139, 4177, 4252, 4307, 4330, 4354], 'lines.': [885, 1074, 1089, 1677, 2412, 3507, 3785, 4044], 'inhibition': [887, 906, 944, 956, 972, 1018, 1034, 1041, 1082, 1095, 1116, 1344, 1731, 1760, 2629, 2754, 2779, 2944, 2972, 3158, 3230, 3477, 3670, 3704, 3712, 3725, 3743, 3792, 3806, 3867, 4323], 'inhibits': [888, 3673, 3779, 3874], 'phosphorylation': [890, 986, 1076, 1139, 1145, 1728, 1763, 1768, 3102, 3146, 3190, 3464, 3674, 3716, 3745, 3754, 3781], 'only': [891, 1215, 1580, 1771, 2509, 3071, 3192, 3737, 3778, 3895], 'cells.': [894], 'Constitutively': [895], 'active': [896, 1284], 'abrogates': [898], 'apoptosis.': [901, 910, 1109], 'Likewise,': [902, 2678, 3180, 3948], 'silencing': [904, 4376], 'or': [905, 1345, 1947, 2900, 2964, 3040, 3392, 3735, 3757, 3793, 3923, 3928, 4002, 4060, 4236, 4284, 4313], 'enhances': [907, 3795, 4013], 'Cells': [911, 2834, 3395], 'with': [912, 1056, 1130, 1223, 1387, 1410, 1491, 1689, 1703, 1779, 1892, 1917, 1922, 1927, 1933, 1943, 1954, 2018, 2046, 2114, 2157, 2190, 2251, 2256, 2295, 2303, 2327, 2371, 2383, 2449, 2474, 2514, 2547, 2589, 2630, 2668, 2690, 2790, 2805, 2827, 2854, 2898, 2973, 3022, 3113, 3134, 3201, 3257, 3293, 3331, 3335, 3350, 3364, 3369, 3373, 3386, 3500, 3557, 3593, 3662, 3819, 3890, 3995, 3999, 4057, 4077, 4110, 4122, 4129, 4133, 4180, 4197, 4205, 4209, 4234, 4279, 4311, 4318, 4371], 'acquired': [913, 1104], 'inhibitors': [917, 1303, 1395, 1557, 1612, 1636, 1790, 1897, 1950, 2002, 2024, 2050, 2057, 2194, 2215, 2324, 3388, 3636], 'are': [918, 1240, 1282, 1304, 1338, 1385, 1786, 1908, 2110, 2188, 2268, 2310, 2325, 2879, 2906, 2913, 3410, 3428, 3436, 3524, 4215, 4243, 4254], 'than': [921, 946, 1457, 1558, 2003, 2744, 3904, 3955], 'their': [922, 2669], 'parental': [923, 2671, 2693, 3073], 'cells': [924, 1262, 1349, 2542, 2646, 2656, 2672, 2694, 3105, 3110, 3162, 3195, 3200, 3383, 3799, 3879, 4075, 4120, 4195, 4273], 'maintain': [926], 'activation': [928, 998, 1092, 1718], 'after': [929, 1080, 1719, 1729, 2627, 2970, 3020, 3111, 3291, 3498, 3591, 3993, 4274], 'inhibition.': [931, 1610, 1721], 'In': [932, 1010, 1134], 'four': [933, 1046, 1123, 1895, 2465], 'animal': [934], 'models,': [936], 'tumors': [938, 961, 1398, 1501], 'alone': [945, 4324], 'tumors.': [949], 'combination': [951, 1007, 1111, 3787, 3821, 3950, 3997, 4086, 4286, 4295], 'led': [957, 1117, 2557, 2615, 3084, 3951], 'regression': [959, 1121, 2169, 2360], 'did': [963, 973, 979, 1574, 2446, 2586, 3066, 3726, 3750, 3956], 'not': [964, 974, 1471, 1518, 1575, 2447, 2587, 3107, 3128, 3175, 3197, 3683, 3706, 3727, 3751], 'regrow': [965], 'when': [966, 3181], 'drug': [967, 1667, 2019, 2296, 2304, 2372, 2381, 2450, 2463, 2505, 3858], 'treatment': [968, 1181, 3021, 3112, 3292, 3499, 3592, 3958, 3994, 4001, 4278, 4296], 'stopped.': [970], 'affect': [975, 3728, 3753], 'HGF': [976], 'levels': [977, 2253, 3173], 'decrease': [980, 3098, 3142], 'phosphorylation,': [982], 'which': [983, 2556, 2802, 3767, 3840, 4161], 'regulates': [984, 1766], 'via': [987, 1146, 1769], 'β1-integrin.': [988], 'This': [989], 'defines': [991], 'heretofore': [993, 1150], 'unknown': [994, 1151], 'mechanism': [995, 1098, 1152, 2950], 'ligand-independent': [997, 1154], 'downstream': [1001], 'an': [1005, 1296, 1589, 1660, 1670, 2204, 2341], 'effective': [1006, 1200, 1615, 2400, 4326], 'therapy.': [1008], 'Synopsis': [1009], 'cancer,': [1013, 1164], '1': [1016, 1250], 'leads': [1019], 'owing': [1022], 'its': [1024], 'direct': [1025], 'effects': [1026, 3051, 3155, 3203], 'on': [1027, 1184, 2222, 3052, 3159, 3204], 'parallel': [1030], 'integrin-mediated': [1033], 'cMet.': [1036], 'Combining': [1037], 'cMET': [1040], 'shows': [1042], 'therapeutic': [1043], 'potentials': [1044], 'mouse': [1047], 'models': [1048, 1128], 'cancer.': [1051], 'inhibitor': [1053, 1484, 1691, 1800, 1840, 2392, 2591], 'correlates': [1055], 'protein': [1060, 1255, 1298, 1538, 1715, 1784, 1814, 1822, 1982, 2015, 2078, 2100, 2148, 2209, 2233, 2368, 2385, 2625, 3172, 3270, 3482, 3496, 3570], 'expression': [1061, 1539, 1716, 1785, 1817, 1961, 1978, 2016, 2041, 2074, 2101, 2149, 2210, 2234, 2252, 2328, 2369, 2386, 2564, 2626, 2960, 3036, 3483, 4351], 'large,': [1064], 'independent': [1065, 1124, 1671, 1859, 2205, 2602, 2889, 3420, 4225], 'dataset': [1066], 'non-small': [1068], '(NSCLC)': [1072, 1192, 3225, 4019], 'resistant/epithelial': [1084, 3109, 3199], 'sensitive/mesenchymal': [1086, 3104, 3194], 'Sustained': [1090], 'following': [1093, 2942, 3228, 3475], 'both': [1100, 3053, 3697, 3720, 4065], 'de': [1101], 'novo': [1102], 'inhibitor-induced': [1108], 'significant': [1119, 2618, 3097, 3130, 4366], 'tumor': [1120], 'vivo': [1127, 1754], 'treated': [1129, 1702, 2789, 2826, 3320, 3385, 3814, 4056, 4076, 4109, 4121, 4142], 'clinically': [1131], 'relevant': [1132, 3857], 'drugs.': [1133, 4080], 'cells,': [1137, 3152], 'Plk1-mediated': [1143], 'β1-integrin': [1147, 1770], 'through': [1148], 'activation.': [1156, 3730, 3741], 'Introduction': [1157], 'Lung': [1158], 'remains': [1160], 'most': [1162], 'lethal': [1163], 'contributing': [1165], '27%': [1167], 'cancer-related': [1169], 'deaths': [1170], 'United': [1173], 'States': [1174], '(Siegel': [1175, 1226], 'et': [1176, 1227, 1310, 1314, 1318, 1323, 1327, 1333, 1351, 1355, 1359, 1367, 1371, 1375, 1379, 1421, 1425, 1429, 1434, 1438, 1444, 1461, 1465, 1506, 1510, 1514, 1522, 1526, 1627, 1834, 1853, 1865, 2246, 2430, 2594, 2723, 2727, 2967, 3631, 3848, 3852, 3881, 3908], 'al,': [1177, 1228, 1311, 1315, 1319, 1324, 1328, 1334, 1352, 1356, 1360, 1368, 1372, 1376, 1380, 1422, 1426, 1430, 1435, 1439, 1445, 1462, 1466, 1507, 1511, 1515, 1523, 1527, 1628, 1835, 1854, 1866, 2247, 2595, 2724, 2728, 2968, 3632, 3849, 3853, 3882, 3909], '2018).': [1178, 1229], 'Although': [1179], 'personalized': [1180], 'approaches': [1182], 'based': [1183, 2221], 'genetic': [1185], 'mutations': [1186, 1495, 1573, 3922], 'underlie': [1188, 3707], 'have': [1193, 1470], 'been': [1194, 1472, 3842], 'developed': [1195], 'immunotherapy': [1197], 'very': [1199], 'some': [1202, 1503, 1871], 'patients,': [1203], '5-year': [1205], 'overall': [1206], 'survival': [1207], 'rate': [1208, 1408, 1414], 'all': [1210, 1806, 2022, 2633, 3773, 3990, 4306], 'stages': [1211], '18%': [1216], 'dismal': [1219], '5%': [1220], 'those': [1222, 2005, 2113, 3296, 3306, 3596], 'metastatic': [1224], 'disease': [1225, 1413, 1454], 'Therefore,': [1230], 'numerous': [1231], 'new': [1232], 'potential': [1233], 'targets,': [1234], 'several': [1236], 'cycle': [1238], 'kinases,': [1239], 'under': [1241, 1283, 2094, 2258, 2395], 'investigation': [1242], 'further': [1244], 'improve': [1245], 'patient': [1246], 'survival.': [1247], 'Polo-like': [1248], 'serine–threonine': [1254], 'overexpressed': [1259], 'plays': [1264], 'major': [1266, 1646], 'role': [1267, 1740], 'G2–M': [1272], 'transition': [1273, 1684, 2186, 2815], 'response': [1275, 1407], 'DNA': [1277, 2680, 2720, 2867, 3985], 'damage.': [1278], 'Inhibitors': [1279], 'clinical': [1285, 1391, 1402], 'development': [1286], 'oncology': [1288], '(NCT03414034': [1289], 'NCT03303339).': [1291], 'Despite': [1292], "Plk1's": [1293], 'reputation': [1294], 'as': [1295, 1987, 1989, 2652, 3079, 3354, 3860, 3967, 4143, 4184, 4199], 'essential': [1297], 'survival,': [1301], 'well': [1305, 1988], 'tolerated': [1306], 'patients': [1308, 1419, 1451, 1476, 3846], '(Nokihara': [1309, 1420], '2016;': [1312, 1316, 1423, 1427, 1463, 1524], 'Pujade-Lauraine': [1313, 1424], 'Schoffski': [1317, 1428], '2012,': [1320, 1431], '2010;': [1321, 1325, 1432, 1436, 1508], 'Sebastian': [1322, 1433, 1464], 'Stadler': [1326, 1437], '2014;': [1329, 1357, 1361, 1440, 2725], 'Van': [1330, 1441], 'den': [1331, 1442], 'Bossche': [1332, 1443], '2016)': [1335], 'there': [1337, 1869, 2503], 'diverse': [1339, 3164], 'biological': [1340], 'knockdown': [1346, 2946, 3232, 3794], '(Choi': [1350], '2015;': [1353, 1365, 1369], 'Craig': [1354], 'Driscoll': [1358], 'Gjertsen': [1362], 'Schoffski,': [1364], 'McCarroll': [1366], 'Medema': [1370], '2011;': [1373], 'Rudolph': [1374], '2009;': [1377, 1512], 'Spankuch-Schmitt': [1378], '2002).': [1381], 'These': [1382, 1856, 3047], 'laboratory': [1383], 'results': [1384, 1389, 3137, 3762], 'consistent': [1386, 4317], 'trials': [1392], 'solid': [1397], 'striking': [1401, 2743], 'low': [1406], '(4–14%),': [1409], 'stable': [1412, 1453], '26–42%': [1416], 'unselected': [1418], '2016).': [1446, 1629], 'Up': [1447], '11%': [1449], 'had': [1452, 1588, 3897], 'year': [1459], '(Pujade-Lauraine': [1460], '2010).': [1467], 'Predictive': [1468], 'biomarkers': [1469], 'used': [1473, 1694, 3635, 3856, 3916], 'select': [1475], 'likely': [1477], 'respond': [1479], 'inhibitors.': [1482, 2009], 'sensitivity': [1485, 1841, 1893, 1918, 1923, 1928, 1934, 1944, 2020, 2047, 2191, 2212, 2305, 2382, 2393, 2451, 2506, 2592, 2776, 2953], 'found': [1487, 2012], 'be': [1489, 3628], 'associated': [1490, 1891, 1906, 1916, 1942, 2189, 2486], 'KRAS': [1492], 'TP53': [1494], 'colon,': [1497], 'breast,': [1498], 'studies': [1504, 4037], '(Degenhardt': [1505], 'Luo': [1509], 'Sanhaji': [1513, 1525], '2013)': [1516], 'others': [1520], '(Ferrarotto': [1521, 1626, 1864, 2593], '2012).': [1528], 'We': [1529, 1722, 1737, 2010, 3065, 3855, 3981, 4266], 'compared': [1531, 2156, 2326, 2667, 2689, 3998, 4310, 4370], 'gene': [1532, 1536, 2406, 2414, 2443, 2584, 2604], 'mutation': [1533, 1591, 2585, 2605], 'basal': [1535], 'among': [1540], '63': [1541], 'lines': [1544, 1551, 1562, 1625, 1701, 1778, 1809, 1878, 1998, 2107, 2155, 2200, 2513, 2601, 2636, 2688, 2706, 2787, 2824, 2941, 2990, 3019, 3075, 3227, 3241, 3251, 3290, 3319, 3348, 3474, 3554, 3590, 3658, 3699, 3818, 3915, 3938, 3992, 4055, 4108, 4140, 4178, 4253, 4308, 4331, 4355], 'discovered': [1546], 'vitro': [1564, 1792, 2109, 2202, 2713, 3887, 4021], 'vivo;': [1567], 'however,': [1568], 'KRAS,': [1569], 'TP53,': [1570], 'MET': [1572, 1596, 2405, 2413, 2442, 2471, 2515, 3921, 3924, 4350], 'consistently': [1576], 'predict': [1577], 'sensitivity.': [1578, 3710], 'However,': [1579, 2494, 3117], 'one': [1581], 'line': [1584, 2166, 2533, 3681], 'analysis': [1587, 1662, 2496, 2812, 2895, 3069, 3094, 4231], 'activating': [1590, 1749], 'exon': [1593], '14': [1594, 2554, 2795], 'making': [1597], 'it': [1598], 'impossible': [1599], 'determine': [1601], 'whether': [1602], 'molecular': [1604], 'subgroup': [1605], 'resistant': [1607, 1787, 1999, 2315], 'equally': [1614], 'inhibiting': [1617], 'mesenchymal/sensitive': [1620, 2988], 'epithelial/resistant': [1622, 2540, 2782], 'unknown,': [1641], 'represents': [1644, 2167, 2340, 2352], 'gap': [1647], 'knowledge.': [1649], 'gap,': [1653], 'current': [1656], 'study,': [1657], 'integrated': [1661], 'functional': [1664], 'proteomics': [1665], 'screening': [1668], 'online': [1672, 2915, 3438], 'database': [1673, 1832, 1851, 2231, 2244], 'When': [1678], 'approach': [1680], 'confirmed': [1681, 1738, 2804, 3095], 'epithelial-to-mesenchymal': [1683, 2814], '(EMT)-related': [1685], 'proteins': [1686, 1889, 1914, 1940, 1965, 2043, 2187, 2307, 2331, 2847, 2963, 3013, 3039, 3280, 3329, 3580, 3603], 'correlated': [1687, 2017, 2370], 'significantly': [1688, 3752, 4297], 'sensitivity,': [1692, 2464], 'TGF-β': [1704, 2550, 2614, 2793, 2821, 3078], 'induce': [1706, 2798], 'phenotype': [1709, 2524, 2612, 2774], 'measure': [1711], 'changes': [1713, 2561, 3118], 'observed': [1723, 1959, 3032, 3932, 3983, 4364], 'differential': [1724, 3050, 3709], 'NSCLC.': [1736, 1774], "cMet's": [1739], 'inhibition–induced': [1743, 2527], 'inhibiting,': [1746], 'silencing,': [1747], 'vitro.': [1757], 'Further,': [1758], 'decreases': [1761], 'subsequently': [1765, 2850], 'Results': [1775, 3884], 'high': [1780], 'find': [1794], 'pathways': [1795], 'can': [1797, 3627], 'drive': [1798], 'resistance,': [1801], 'examined': [1803], 'data': [1804, 1857, 2053, 2075, 2223, 2235, 2279, 2338, 2507, 2912, 3048, 3435, 3864], 'from': [1810, 1825, 1842, 2065, 2082, 2224, 2237, 2419, 2481, 2490, 2887, 3418, 4119, 4194, 4223], 'two': [1811, 1946, 2266, 2322, 2460, 2510, 2986, 3247, 3547, 3960, 3963], 'sources:': [1812], '(i)': [1813], 'phosphoprotein': [1816], 'measured': [1818, 2653, 2738, 2746, 2752, 2860, 2870, 3492, 3830, 3968, 4049, 4099, 4169], 'using': [1819, 2893, 2978, 3070, 3186, 3424, 3493, 4050, 4100, 4164, 4170, 4229, 4356], 'reverse': [1820, 3268, 3494, 3568], 'phase': [1821, 2077, 3269, 3495, 3569], 'array': [1823, 3271, 3497, 3571], '(RPPA)': [1824], 'Cell': [1829, 2086, 2241, 2423, 4046], 'Line': [1830, 2087, 2242, 2424], 'Project': [1831, 2088, 2243, 2425], '(Li': [1833, 2245], '2017),': [1836], '(ii)': [1838], 'Therapeutics': [1845, 2068, 2227], 'Response': [1846, 2069, 2228], 'Portal': [1847, 2070, 2229], 'v2': [1848, 2071, 2230], '(CTRPv2;': [1849], 'https://portals.broadinstitute.org/ctrp/)': [1850], '(Seashore-Ludlow': [1852], '2015).': [1855], 'our': [1861, 1955, 3663, 4319], 'original': [1862], 'study': [1863], '2016),': [1867, 2596], 'although': [1868], 'overlap': [1872], 'drugs': [1875, 2267, 4113, 4124], 'tested': [1879, 3843, 4138, 4309], '(Appendix': [1880, 2714, 2767], 'Table': [1881, 3946], 'S1': [1882], 'Fig': [1884, 2580, 2641, 2676, 2701, 2715, 2768, 2994, 3942, 4336], 'S1).': [1885], 'Varying': [1886], 'numbers': [1887], '(selected': [1898], "Spearman's": [1900, 2090, 2475], 'rho': [1901, 2117, 2476], 'coefficient': [1902, 2118, 2477], 'value': [1903], '>': [1904, 2119, 2518], '0.3;': [1905], 'P-values': [1907, 2487], 'indicated': [1909, 2175, 2907, 3328, 3355, 3366, 3387, 3405, 3429, 4079, 4106, 4112, 4123, 4144, 4176, 4185, 4200, 4244, 4255], 'figures):': [1912], '33': [1913, 3038], 'BI2536,': [1920, 2058], '36': [1921], 'GSK461364,': [1925, 2059, 2217], '37': [1926], 'BRD-K70511574,': [1930, 2060, 2218], '26': [1932], 'GW-843682X': [1936, 2062, 2126, 2161], '(Fig': [1937, 1951, 2576, 2637, 2695, 3045, 3088, 3115, 3131, 3138, 3165, 3208, 3659, 3832, 3977, 4004, 4332, 4361, 4377], 'EV1A–D).': [1938], 'Thirty-three': [1939, 3279], '1A).': [1952], 'Consistent': [1953, 3661], 'previous': [1956], 'findings,': [1957, 3665], 'E-cadherin': [1966], '(P': [1967, 1972, 1984, 2025, 2673], '<': [1968, 1973, 1985, 2026, 2674, 2909, 3029, 3432, 4246], '0.001)': [1969, 1974], 'β-catenin': [1971], 'higher': [1976, 3984], 'Snail': [1983], '0.01),': [1986], 'ATM': [1990], 'thymidylate': [1992], 'synthase,': [1993], 'lower': [1995, 3528], 'also': [2011, 3713, 3982, 4267], '0.01;': [2027], 'Figs': [2028], '1B': [2029], 'EV1E).': [2031], 'Click': [2032, 3452], 'here': [2033, 3453], 'expand': [2035, 3455], 'figure.': [2037, 2918, 3441, 3457], 'Figure': [2038, 2183, 2770, 2922, 3210, 3445, 3458, 4006], 'EV1.': [2039], 'Basal': [2040, 2146], 'correlate': [2045, 2255, 2448, 2588], 'A–D.': [2051], 'Sensitivity': [2052], 'obtained': [2064, 2081, 2418], 'database.': [2072, 2089], 'Protein': [2073], '(reverse': [2076], 'array)': [2079], 'correlations': [2091, 2207], 'area': [2093, 2257, 2351], 'curve': [2096, 2260, 2397], '(AUC)': [2097, 2261, 2398], 'values': [2098, 2159, 2262, 2320, 2478, 3901], 'shown': [2111], 'Spearman': [2116], '0.3': [2120], 'BI2536': [2122], '(A),': [2123], 'GSK461364': [2124], '(B),': [2125], '(C),': [2127, 2865], 'BRD-K70511574': [2129], '(D).': [2130, 2875], 'color': [2132, 2274], 'bars': [2135, 3532], 'indicates': [2136, 2291], 'P-value': [2138], 'per': [2139], 'legend': [2141], 'graph.': [2144, 2272], 'E.': [2145, 3379, 4136], 'AUC': [2158, 2319], 'BRD-K70511574.': [2163], 'blue': [2165, 4257], 'linear': [2168, 2359], '95%': [2171, 2354], 'confidence': [2172, 2355], 'interval': [2173, 2356], 'dark': [2177], 'gray.': [2178], 'Download': [2179, 2181, 2374, 2376, 2925, 2927, 3448, 3450, 3617, 3619, 4262, 4264], 'figure': [2180, 2375, 2926, 3449, 3618, 4263], 'PowerPoint': [2182, 2377, 2928, 3451, 3620, 4265], '1.': [2184], 'Epithelial-to-mesenchymal': [2185], "datasetSpearman's": [2206], 'between': [2208, 3014, 3284, 3584], '(BI2536,': [2216], 'GW-843682X),': [2220], 'derived': [2236], '2017).': [2248, 3854], 'A.': [2249, 2780, 3233, 3478, 4022], 'Proteins': [2250], 'least': [2265, 2553], 'included': [2269], 'size': [2276, 4302], 'point': [2280, 2339], 'represent': [2281, 3533], 'direction': [2283], 'significance': [2285], '(P-value)': [2286], 'correlation.': [2289], 'Red': [2290], 'positive': [2293, 2301], 'correlation': [2294, 2302, 2379], 'green': [2299], '(i.e.,': [2306, 2459], 'red': [2309, 4259], 'highly': [2312], 'expressed': [2313, 3012], 'lines).': [2317], 'B.': [2318, 2818, 3278, 3539, 4045], 'selected': [2330], '(cMet,': [2332], 'E-cadherin,': [2333, 2363, 2571], 'β-catenin,': [2334, 2572], 'Snail);': [2336], 'each': [2337], 'individual': [2342], 'line.': [2347], 'gray': [2349], 'shaded': [2350], 'around': [2357], '(blue': [2361, 3303, 3344, 3604], 'line).': [2362], 'β': [2364], 'catenin,': [2365], 'resistance.': [2373], 'motivated': [2387], 'us': [2388], 'compare': [2390], '[area': [2394], 'dose': [2401], '50': [2402, 2828, 3258, 3558], '(ED50)]': [2403], 'copy': [2407, 2415, 2444, 2472, 2516], 'number': [2408, 2416, 2445, 2517, 4300], 'database,': [2426], 'CTRPv2,': [2427], 'Kubo': [2429], 'al': [2431], '(2009)': [2432], '41,': [2434], '185,': [2435], '29': [2437], 'lines,': [2440, 3722, 3776, 3966], 'respectively.': [2441, 4261], 'any': [2453], '24': [2456, 2976, 3262, 3393, 3562, 4115, 4126, 4146, 4275], 'possible': [2457], 'comparisons': [2458], 'measures': [2461], 'drugs,': [2466], 'three': [2468, 2888, 2982, 3419, 4224], 'sources': [2469], 'number)': [2473], 'ranged': [2480, 2489], '−0.428': [2482], '0.430': [2484], '0.078': [2491], '0.872.': [2493], 'limited': [2498], 'fact': [2501], '5.': [2519], 'Induction': [2520], 'increases': [2525, 2648, 2775], 'create': [2530], 'mechanistic': [2536], 'studies,': [2537], 'incubated': [2539, 3256, 3556], '(H1975,': [2543, 3242, 3542], 'HCC366,': [2544], 'HCC4006)': [2546], '5': [2548, 2791], 'ng/ml': [2549, 2792], 'days,': [2555], 'expected': [2560], 'vimentin,': [2566], 'Snail,': [2567], 'Slug,': [2568], 'ZEB1,': [2569], 'Twist,': [2570], 'claudin': [2574], '7': [2575], '2A': [2577], 'Appendix': [2579, 2640, 2700, 3945, 4335], 'S2).': [2581, 3947], 'Given': [2582], 'chose': [2598, 3838], 'these': [2599, 3666, 3761, 4272], 'status.': [2606], 'induction': [2608], 'increase': [2619, 4367], 'cleaved': [2621, 2843, 3971, 3974], 'poly(ADP-ribose)': [2622], 'polymerase': [2623], '(PARP)': [2624], 'volasertib': [2631, 2711, 2830, 2974, 3114, 3260, 3501, 3560, 3823], '2B': [2638, 2696], 'S3A).': [2642, 2769], 'Similarly,': [2643], 'TGF-β–treated': [2644, 3237], 'showed': [2647, 3668, 3893], 'volasertib-induced': [2650, 2679], 'BrdU-positive': [2655], '(threefold': [2657], 'H1975,': [2659], '4.1-fold': [2660, 2664], 'HCC4006,': [2662, 3243, 3543], 'HCC366)': [2666, 3245, 3545], '0.05;': [2675], '2C).': [2677], 'damage': [2681, 2721, 2868, 3986], 'increased': [2683], 'D,': [2698], 'S3A),': [2702], 'S3B).': [2716], '(Driscoll': [2722], '2018;': [2729], 'Yim': [2730], 'Erikson,': [2732], '2009)': [2733], 'may': [2734], 'explain': [2735], 'why': [2736], 'BrdU': [2740], 'PARP': [2748, 2844], 'cleavage.': [2749], 'Target': [2750], 'inhibition,': [2751, 2956, 3007], 'substrate': [2758, 3692], 'p-NPM': [2759], '(S4),': [2760], 'similar': [2762, 3068, 3086], '2.': [2771], 'TGF-β–induced': [2772], 'Three': [2781, 3234, 3540], 'days': [2796, 4157], 'phenotype,': [2801], 'Western': [2806, 3092, 3362], 'blot': [2807, 3093], '(left)': [2808, 4128, 4204], 'qPCR': [2810], '(right)': [2811], '(EMT)': [2816], 'markers.': [2817], 'Parental': [2819], 'nM': [2829, 3259, 3352, 3559, 3871, 3906, 4182], '72': [2832, 3827, 4067], 'h.': [2833, 3394, 4068, 4116, 4188], 'then': [2836, 3397], 'harvested,': [2837, 3398], 'lysates': [2839, 3400], 'immunoblotted': [2841, 3402], 'γH2AX': [2846], 'quantitated': [2851], 'normalized': [2853, 3334, 3372, 4132, 4208], 'β-actin.': [2855], 'C,': [2856], 'D.': [2857, 3338, 4117], 'Apoptosis': [2858, 4097, 4167], 'Apo-BrdU': [2863, 4102, 4172], 'assay': [2864, 2874, 4103, 4173], 'Comet': [2873], 'Data': [2876, 2878, 2920, 3407, 3409, 3443, 4212, 4214], 'information:': [2877, 3408, 4213], 'means': [2880, 3411, 4216], '±': [2881, 3412, 4217], 'standard': [2882, 3413, 3534, 4218], 'error': [2883, 3414, 3531, 4219], 'mean': [2886, 3035, 3417, 4222], 'experiments.': [2890, 3421, 4226], 'Significant': [2891, 3422, 4227], 'differences': [2892, 3423, 4228], 'two-way': [2894, 4230], 'variance': [2897, 4233], 'Bonferroni': [2899, 4235], 'Benjamini–Hochberg': [2901, 4237], 'correction': [2902, 4239], 'multiple': [2904, 4241], 'comparison': [2905, 4242], '(*P': [2908, 4245], '0.01).': [2910, 4247], 'available': [2914, 3437], '2': [2923], '[emmm201809960-sup-0003-SDataFig2.pdf]': [2924], 'Activation': [2929, 3212], 'elucidate': [2948], 'EMT-induced': [2952], 'analyzed': [2958], '301': [2962], 'phosphoproteins': [2965, 3041], '(Kalu': [2966], '2017)': [2969], 'h': [2977, 3358, 3391, 3828, 4127, 4147, 4203, 4276, 4360], 'RPPA': [2979, 3136, 3664], 'additional': [2987], '(Calu6': [2991, 3252, 3549], 'H1792;': [2993], '3A).': [2995], 'discover': [2997], 'pathway': [2999, 3060], 'responsible': [3000], 'driving': [3002], 'looked': [3009], 'volasertib.': [3023], 'At': [3024], 'cutoff': [3026], 'P': [3028], '0.05,': [3030], '3B).': [3046], 'revealed': [3049], 'cMet/FAK/Src': [3055, 3300, 3600], 'axis': [3056, 3302, 3312, 3602, 3610, 3654], 'PI3K/Akt': [3059, 3310, 3608], '(Figs': [3061], '3B': [3062], 'EV2A).': [3064], 'eliminate': [3077], 'confounder,': [3081], 'findings': [3087], 'EV2B': [3089], 'C).': [3091], '(Y1234/1235)': [3101, 3189], '3C).': [3116, 3132, 3166], 'Src': [3120, 3171, 3463, 3625, 3642, 3740, 3742], '(Y416),': [3121], 'FAK': [3122, 3144, 3640, 3718, 3724, 3747, 3758], '(Y925),': [3123], 'Akt': [3125], '(S473)': [3126], 'statistically': [3129], 'As': [3133], 'EV2A),': [3139], 'average': [3141], '(Y397)': [3145], 'greater': [3148], 'Total': [3167], 'cMet,': [3168, 3460, 3622, 3836], 'FAK,': [3169, 3461, 3623, 3734], 'affected,': [3176], 'supporting': [3177], 'posttranslational': [3178], 'changes.': [3179], 'knocked': [3183, 4346], 'down': [3184, 4347], 'siRNA,': [3187], 'decreased': [3191, 3744, 4298], 'variable': [3202], 'pSrc': [3205, 3490], 'pFAK': [3207, 3487], '3D).': [3209], '3.': [3211], 'H1792)': [3254, 3551], 'h,': [3263, 3563], 'lysed,': [3264, 3564], 'subjected': [3266, 3323, 3360, 3566], 'analysis.': [3272, 3572], 'Experiments': [3273, 3508, 3573], 'done': [3275, 3575], 'triplicate.': [3277, 3512, 3577], 'volasertib,': [3294, 3594, 4058, 4282], 'involved': [3297, 3307, 3597], 'signaling': [3301, 3311, 3601, 3609, 3626, 3653], 'text)': [3304, 3341, 3345, 3605], '(orange': [3313, 3611], 'text).': [3314, 3612], 'C.': [3315, 3578, 4096], 'same': [3317], 'identically': [3321], 'immunoblotting': [3325], '(upper)': [3330, 3368], 'densitometric': [3332, 3370, 4130, 4206], 'quantification': [3333, 3371, 4131, 4207], 'β-actin': [3336, 3374, 4134, 4210], '(lower).': [3337, 3375], 'Epithelial': [3339], '(red': [3340], 'transfected': [3349, 4179, 4196], '10': [3351, 4181], 'siRNA': [3353, 4183, 4198, 4357], '48': [3357, 4187, 4202, 4359], 'blotting': [3363], 'antibodies': [3367], 'NT,': [3376, 4189], 'non-targeting': [3377, 4190, 4372], 'control.': [3378, 4191], 'H1975': [3380], 'Calu6': [3382], '4': [3390], 'proteins.': [3406], 'two-sided': [3425], "Student's": [3426], 't-test': [3427], '*P': [3431], '0.05.': [3433], '3': [3446, 3976], '[emmm201809960-sup-0004-SDataFig3.pdf]': [3447], 'EV2.': [3459], 'Box': [3479], 'plots': [3480], 'p-cMet': [3485], '(Y1234/35),': [3486], '(Y397),': [3488], '(Y416)': [3491], 'median': [3514], 'marked': [3516], 'horizontal': [3519], 'line,': [3520], 'colored': [3522], 'boxes': [3523], 'upper': [3526], 'quartiles,': [3529], 'deviation.': [3535], 'FC,': [3536], 'fold': [3537], 'change.': [3538], 'Seventy': [3579], 'FDR,': [3613], 'false': [3614], 'discovery': [3615], 'rate.': [3616], 'Because': [3621], 'bi-directional': [3629], '(Sen': [3630], '2011),': [3633], '(tepotinib),': [3639], '(VS6063),': [3641], '(dasatinib),': [3643], '(volasertib)': [3646], 'distinguish': [3648], 'properties': [3650], '3E).': [3660], 'experiments': [3667], 'one.': [3687], 'Phosphorylation': [3688], 'NPM1': [3693], 'inhibited': [3695, 3714, 3771], 'confirming': [3700], 'efficient': [3702], 'target': [3703, 3866], 'does': [3705], 'Inhibition': [3731], 'Plk1,': [3733], 'minimally': [3738], 'affected': [3739], '(Y925)': [3748], '(Y397).': [3759], 'Together,': [3760], 'support': [3763], 'model': [3765], 'robustly': [3770], 'test': [3801], 'hypothesis': [3803], 'important': [3808], 'apoptosis,': [3812], 'eight': [3815, 3936], 'tepotinib': [3825, 3872], 'viability': [3831, 4034, 4047, 4072], '4A).': [3833], 'inhibit': [3835], 'tepotinib,': [3839, 4059, 4283], 'has': [3841], '(Friese-Hamim': [3847], '2017;': [3850], 'Reungwetwattana': [3851], 'concentrations': [3859], 'defined': [3861], 'pharmacokinetic': [3863], 'data.': [3868], 'Specifically,': [3869], '400': [3870], 'fully': [3873], 'intact': [3877], '(Bladt': [3880, 3907], '2013).': [3883, 3910], 'assays': [3889], '242': [3891], 'kinases': [3892], 'half-maximal': [3898], 'inhibitory': [3899], 'concentration': [3900], 'less': [3903], '600': [3905], 'None': [3911], 'harbor': [3920], 'amplification.': [3925], 'A': [3926], 'synergistic': [3927], 'additive': [3929], 'effect': [3930], 'seven': [3934], '(Fa': [3939], '=': [3940, 4090, 4094], '0.5;': [3941], '4B': [3943], 'single-agent': [3957, 4000, 4314], 'BrdU,': [3970], 'PARP,': [3972], 'caspase': [3975], '4C': [3978], 'D).': [3980], '(γ-H2AX': [3987], 'expression)': [3988], 'controls': [4003], '4D).': [4005], '4.': [4007], 'Co-targeting': [4008], 'Schematic': [4023], 'experimental': [4026], 'plan': [4027], 'inhibition/silencing': [4032], 'CellTiter-Glo': [4051], '1:2': [4062], 'ratio': [4063], 'Left:': [4069], 'representative': [4070], 'graph': [4073], 'Right:': [4081], 'heatmap': [4082], 'depicting': [4083], 'calculated': [4085], 'indices': [4087], 'Fa': [4089, 4093], '0.25': [4091], '0.5.': [4095], 'Immunoblots': [4118, 4193], '(right).': [4135, 4211], 'All': [4137], 'allowed': [4149], 'grow': [4151], 'drug-free': [4153, 4289], 'medium': [4154], '15–20': [4156], 'form': [4159], 'colonies,': [4160], 'counted': [4163], 'ImageJ.': [4165], 'F.': [4166], 'G.': [4192], '(BH)': [4238], 'Mesenchymal': [4248], 'text,': [4260], 'assessed': [4268], 'colony': [4269], 'formation': [4270], 'vehicle': [4280], 'control,': [4281], 'followed': [4287], 'incubation': [4290], '12–15': [4292], 'days.': [4293], 'colonies': [4304], 'control': [4312, 4373], 'treatment,': [4315], 'although,': [4316], 'prior': [4320], 'results,': [4321], '4E': [4333], 'S4).': [4337], 'demonstrate': [4339], 'specificity': [4341], 'PLK1': [4348], '4A)': [4362], 'single-gene': [4375], '4F).': [4378]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2943232183', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 6}, {'year': 2020, 'cited_by_count': 2}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-12-27T11:36:55.846204', 'created_date': '2019-05-09'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
