Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2941414041', 'doi': 'https://doi.org/10.1097/01.ju.0000555908.70308.28', 'title': 'MP34-15 TREATMENT OUTCOME OF DOSE REDUCTION OF ENZALUTAMIDE AGAINST CRPC', 'display_name': 'MP34-15 TREATMENT OUTCOME OF DOSE REDUCTION OF ENZALUTAMIDE AGAINST CRPC', 'publication_year': 2019, 'publication_date': '2019-04-01', 'ids': {'openalex': 'https://openalex.org/W2941414041', 'doi': 'https://doi.org/10.1097/01.ju.0000555908.70308.28', 'mag': '2941414041'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555908.70308.28', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555908.70308.28', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555908.70308.28', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5005838599', 'display_name': 'Naokazu Ibuki', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Naokazu Ibuki*', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5065751906', 'display_name': 'Teruo Inamoto', 'orcid': 'https://orcid.org/0000-0002-1351-1315'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Teruo Inamoto', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5031579083', 'display_name': 'Atsushi Ichihashi', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Atsushi Ichihashi', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082726168', 'display_name': 'Hirofumi Uehara', 'orcid': 'https://orcid.org/0000-0002-3177-0804'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hirofumi Uehara', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071593174', 'display_name': 'Kazumasa Komura', 'orcid': 'https://orcid.org/0000-0003-4157-1929'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Kazumasa Komura', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036689077', 'display_name': 'Hajime Hirano', 'orcid': 'https://orcid.org/0000-0002-2097-2662'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hajime Hirano', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023997019', 'display_name': 'Hayahito Nomi', 'orcid': None}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Hayahito Nomi', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5030580122', 'display_name': 'Haruhito Azuma', 'orcid': 'https://orcid.org/0000-0001-5497-1679'}, 'institutions': [], 'countries': ['JP'], 'is_corresponding': False, 'raw_author_name': 'Haruhito Azuma', 'raw_affiliation_strings': ['Osaka, Japan'], 'affiliations': [{'raw_affiliation_string': 'Osaka, Japan', 'institution_ids': []}]}], 'countries_distinct_count': 1, 'institutions_distinct_count': 0, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 0.0, 'has_fulltext': False, 'cited_by_count': 1, 'citation_normalized_percentile': {'value': 0.540304, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 62, 'max': 70}, 'biblio': {'volume': '201', 'issue': 'Supplement 4', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10458', 'display_name': 'Diagnosis and Treatment of Bladder Cancer', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10458', 'display_name': 'Diagnosis and Treatment of Bladder Cancer', 'score': 0.9902, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T14078', 'display_name': 'Epidemiology of Multiple Primary Cancers', 'score': 0.9849, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11069', 'display_name': 'Testicular Germ Cell Tumors and Treatment', 'score': 0.9738, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/enzalutamide', 'display_name': 'Enzalutamide', 'score': 0.9659648}, {'id': 'https://openalex.org/keywords/treatment', 'display_name': 'Treatment', 'score': 0.558352}], 'concepts': [{'id': 'https://openalex.org/C2776551883', 'wikidata': 'https://www.wikidata.org/wiki/Q1996756', 'display_name': 'Enzalutamide', 'level': 5, 'score': 0.9659648}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.74677414}, {'id': 'https://openalex.org/C197934379', 'wikidata': 'https://www.wikidata.org/wiki/Q2047938', 'display_name': 'Adverse effect', 'level': 2, 'score': 0.5840729}, {'id': 'https://openalex.org/C2777288759', 'wikidata': 'https://www.wikidata.org/wiki/Q4164182', 'display_name': 'Dosing', 'level': 2, 'score': 0.5630523}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3063404}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.22143534}, {'id': 'https://openalex.org/C2780192828', 'wikidata': 'https://www.wikidata.org/wiki/Q181257', 'display_name': 'Prostate cancer', 'level': 3, 'score': 0.17852134}, {'id': 'https://openalex.org/C61367390', 'wikidata': 'https://www.wikidata.org/wiki/Q416601', 'display_name': 'Androgen receptor', 'level': 4, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555908.70308.28', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555908.70308.28', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/01.ju.0000555908.70308.28', 'pdf_url': 'https://www.auajournals.org/doi/pdf/10.1097/01.JU.0000555908.70308.28', 'source': {'id': 'https://openalex.org/S30525748', 'display_name': 'The Journal of Urology', 'issn_l': '0022-5347', 'issn': ['0022-5347', '1527-3792'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310315671', 'host_organization_name': 'Lippincott Williams & Wilkins', 'host_organization_lineage': ['https://openalex.org/P4310315671', 'https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Lippincott Williams & Wilkins', 'Wolters Kluwer'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.83}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'You': [0], 'have': [1], 'accessJournal': [2], 'of': [3, 142, 144, 207, 293, 300, 312, 319, 327, 337, 349, 431, 487, 503, 529], 'UrologyProstate': [4], 'Cancer:': [5], 'Advanced': [6], '(including': [7], 'Drug': [8], 'Therapy)': [9], 'IV': [10], '(MP34)1': [11], 'Apr': [12], '2019MP34-15': [13], 'TREATMENT': [14], 'OUTCOME': [15], 'OF': [16, 19], 'DOSE': [17], 'REDUCTION': [18], 'ENZALUTAMIDE': [20], 'AGAINST': [21], 'CRPC': [22, 94, 320], 'Naokazu': [23, 40, 563], 'Ibuki*,': [24], 'Teruo': [25, 44, 570], 'Inamoto,': [26], 'Atsushi': [27, 48, 577], 'Ichihashi,': [28], 'Hirofumi': [29, 52, 584], 'Uehara,': [30], 'Kazumasa': [31, 56, 591], 'Komura,': [32], 'Hajime': [33, 60, 598], 'Hirano,': [34], 'Hayahito': [35, 64, 605], 'Nomi,': [36], 'and': [37, 68, 95, 117, 139, 149, 166, 181, 189, 209, 258, 261, 315, 331, 372, 396, 434, 447, 490, 505, 515, 540, 559], 'Haruhito': [38, 69, 612], 'Azuma': [39, 71, 613], 'Ibuki*Naokazu': [41], 'Ibuki*': [42, 564], ',': [43, 47, 51, 55, 59, 63, 67], 'InamotoTeruo': [45], 'Inamoto': [46, 571], 'IchihashiAtsushi': [49], 'Ichihashi': [50, 578], 'UeharaHirofumi': [53], 'Uehara': [54, 585], 'KomuraKazumasa': [57], 'Komura': [58, 592], 'HiranoHajime': [61], 'Hirano': [62, 599], 'NomiHayahito': [65], 'Nomi': [66, 606], 'AzumaHaruhito': [70], 'View': [72], 'All': [73, 194, 620], 'Author': [74], 'Informationhttps://doi.org/10.1097/01.JU.0000555908.70308.28AboutPDF': [75], 'ToolsAdd': [76], 'to': [77, 135, 156, 267, 270, 280, 283, 437, 455, 483], 'favoritesDownload': [78], 'CitationsTrack': [79], 'CitationsPermissionsReprints': [80], 'ShareFacebookLinked': [81], 'InTwitterEmail': [82], 'Abstract': [83], 'INTRODUCTION': [84], 'AND': [85], 'OBJECTIVES:': [86], 'Enzalutamide': [87, 105, 118, 145, 159, 218, 504], 'has': [88, 106], 'a': [89, 122, 174], 'good': [90], 'therapeutic': [91, 140, 492], 'effect': [92, 183, 493], 'on': [93], 'is': [96, 115, 119], 'widely': [97], 'administered': [98, 120, 162, 172, 275, 499, 508], 'as': [99], 'an': [100, 526], 'important': [101], 'treatment': [102, 182, 190], 'option.': [103, 527], 'But,': [104], 'various': [107], 'adverse': [108], 'reactions,': [109], 'especially': [110], 'in': [111, 121, 125, 146, 163, 167, 173, 215, 222, 252, 272, 324, 334, 346, 357, 360, 364, 367, 373, 377, 380, 391, 416, 442, 452, 464, 494, 500, 509], 'cases': [112, 169, 260, 263, 362, 375, 414, 422, 430], 'where': [113], 'fatigue': [114], 'observed,': [116], 'reduced': [123, 150, 277, 296, 338, 350, 381, 418, 510, 520], 'amount': [124, 502], 'the': [126, 245, 253, 273, 291, 298, 325, 328, 335, 347, 368, 385, 392, 417, 443, 470, 479, 484, 491, 497, 506], 'actual': [127], 'clinical': [128], 'setting.': [129], 'In': [130, 290], 'this': [131, 568, 575, 582, 589, 596, 603, 610, 617], 'study,': [132], 'we': [133], 'aim': [134], 'examine': [136], 'side': [137, 179, 358, 407, 432, 456, 488], 'effects': [138, 141, 180, 359, 408, 489], 'administration': [143, 250, 256, 294, 330, 522], 'normal': [147], 'dose': [148, 255, 339, 351, 370, 382, 394, 419, 445, 521], 'dose.': [151, 511], 'METHODS:': [152], 'From': [153], 'February': [154], '2014': [155], 'May': [157], '2017,': [158], 'was': [160, 171, 196, 219, 225, 242, 251, 305, 321, 344, 440, 449, 460, 476], 'normally': [161], '113': [164, 365], 'cases,': [165, 287, 406, 410, 428], '42': [168, 378], 'it': [170], 'dose-reduced': [175], 'manner.': [176], 'Patient': [177], 'background,': [178], 'were': [184, 192, 285, 354, 401, 423], 'compared.': [185], 'The': [186, 202, 307, 341], 'patient': [187], 'background': [188], 'outcome': [191], 'evaluated.': [193], 'data': [195], 'analyzed': [197], 'using': [198], 'SPSS': [199], 'ver24.': [200], 'RESULTS:': [201], 'median': [203, 308], 'age,': [204], 'dosing': [205], 'period': [206], 'Enzalutamide,': [208], 'biopsy': [210], 'Gleason': [211], 'score': [212], 'are': [213], 'examples': [214, 221], 'which': [216, 223], 'all': [217], 'administered,': [220], 'dosage': [224], 'reduced,': [226], '74.1': [227], 'years': [228, 231], 'old,': [229, 232], '73.4': [230], '7': [233], 'months,': [234, 236], '8': [235, 262, 427], '8.3,': [237], '8.5,': [238], 'And': [239], 'no': [240, 355, 450, 461], 'difference': [241, 451, 463, 475], 'found': [243], 'between': [244, 469, 478, 496], 'two': [246, 471, 480], 'groups.': [247, 472], 'PS': [248, 265, 304], 'before': [249], 'total': [254, 329, 393, 501], 'group': [257, 274, 371, 395, 446, 498, 507], '105': [259], 'with': [264, 276, 295, 302, 399, 517], '0': [266, 279], '1,': [268, 281], '2': [269, 282, 409, 411, 429], '3,': [271], 'dose,': [278, 297], '3': [284], '36': [286], '6': [288], 'cases.': [289], 'case': [292, 326, 336, 348], 'percentage': [299], 'patients': [301, 366, 389, 398, 516], 'poor': [303, 518], 'high.': [306], 'PSA': [309, 316, 342, 439, 465], 'at': [310, 317], 'diagnosis': [311, 318], 'prostate': [313], 'cancer': [314], '94.0,': [322], '8.03': [323], '81.4,': [332], '5.62': [333], 'administration.': [340, 352], 'value': [343], 'low': [345], 'There': [353], 'differences': [356], '31': [361], '(27.4%)': [363], 'whole': [369, 444], '10': [374, 421], '(23.8%)': [376], 'subjects': [379], 'group.': [383], 'During': [384], 'study': [386], 'period,': [387], '69': [388], 'continued': [390, 415], '44': [397, 402], 'withdrawal': [400], '(PSA': [403, 425], 'elevation': [404], '40': [405], 'deaths),': [412], '32': [413], 'group,': [420], 'withdrawn': [424], 'increased': [426], 'effects),': [433], 'interruption': [435], 'due': [436, 454, 482], 'elevated': [438], 'abundant': [441], 'there': [448, 459], 'discontinuation': [453], 'effects.': [457], 'And,': [458], 'significant': [462], 'progression': [466], 'free': [467], 'survival': [468], 'CONCLUSIONS:': [473], 'No': [474], 'observed': [477], 'groups': [481], 'occurrence': [485], 'rate': [486], 'comparison': [495], 'For': [512], 'elderly': [513], 'people': [514], 'PS,': [519], 'could': [523], 'be': [524], 'considered': [525], 'Source': [528], 'Funding:': [530], 'none': [531], 'Osaka,': [532], 'Japan©': [533], '2019': [534, 553], 'by': [535, 554, 567, 574, 581, 588, 595, 602, 609, 616], 'American': [536, 555], 'Urological': [537, 556], 'Association': [538, 557], 'Education': [539, 558], 'Research,': [541, 560], 'Inc.FiguresReferencesRelatedDetails': [542], 'Volume': [543], '201Issue': [544], 'Supplement': [545], '4April': [546], '2019Page:': [547], 'e501-e501': [548], 'Advertisement': [549, 621], 'Copyright': [550], '&': [551], 'Permissions©': [552], 'Inc.MetricsAuthor': [561], 'Information': [562], 'More': [565, 572, 579, 586, 593, 600, 607, 614], 'articles': [566, 573, 580, 587, 594, 601, 608, 615], 'author': [569, 576, 583, 590, 597, 604, 611, 618], 'Expand': [619], 'PDF': [622], 'downloadLoading': [623], '...': [624]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2941414041', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}], 'updated_date': '2024-09-11T18:57:12.286935', 'created_date': '2019-05-03'}