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[1104], '293T': [1105], 'homozygous': [1108], 'positioning': [1113], '[G]).Given': [1125], 'relationship': [1127], 'structure,': [1134], 'assessed': [1136, 1155, 1255], 'all-cause': [1145], 'dilated': [1149, 1169], 'cardiomyopathy': [1150], 'electrocardiography': [1159], '[H]).1,3,4': [1161], 'With': [1162], 'collection': [1164], '1540': [1166], 'cases': [1167], 'cardiomyopathy,': [1170], '18%': [1174], 'risk': [1175, 2247], 'reduction': [1176, 1417], 'per': [1177], 'copy': [1178], '(P=1×10–4).': [1183], 'Also': [1184], 'significant': [1192, 1275], 'increase': [1193], 'systolic': [1196], 'shortening': [1200, 1295], '(P=3×10–5)': [1201], 'decrease': [1204], 'several': [1211], 'measures.Integrating': [1212], 'various': [1214], 'observations,': [1215], 'hypothesized': [1217], 'mouse': [1225, 1238], 'would': [1227], 'result': [1228], 'favorable': [1230], 'echocardiographic': [1231], 'changes.': [1232], 'generated': [1234], 'Mtss1': [1236], 'knockout': [1237, 1258, 1271], '[I]);': [1242], 'viable': [1246], 'fertile.': [1248], 'Focusing': [1249], 'specifically': [1250], 'on': [1251, 1482], 'heart,': [1253, 1343, 2543], 'wild-type': [1256], 'littermates': [1259], 'weeks': [1262], 'age': [1264], '[J]).': [1268], 'mice,': [1272], 'decreases': [1276], '(P=0.0034)': [1281], 'end-systolic': [1284], '(P=0.0016),': [1286], 'well': [1288], 'trends': [1290], 'toward': [1291], 'increased': [1292], '(P=0.027)—highly': [1296], 'concordant': [1297], 'findings.MTSS1': [1302], '(metastasis': [1303], 'suppressor': [1304], '1)': [1306], 'member': [1309], 'I-BAR': [1312], '(inverse': [1313], 'Bin-amphiphysin-Rvs)': [1314], 'family': [1316], 'interacts': [1318], 'actin': [1321], 'cytoskeleton': [1322], 'membrane': [1326], 'regulate': [1328], 'intercellular': [1332], 'junctions.': [1333], 'expressed': [1336], 'variety': [1339], 'organs': [1341], 'besides': [1342], 'disruption': [1345], 'can': [1348], 'diverse': [1351], 'effects.': [1352], 'kidney': [1354], 'epithelium,': [1355], 'colocalizes': [1357], 'F-actin': [1359], 'E-cadherin': [1361], 'adherens': [1363], 'junctions': [1364], 'induced': [1367], 'response': [1369], 'shear': [1371], 'stress': [1372], 'via': [1373], 'MEF2': [1374], '(myocyte': [1375], 'factor': [1377], '2),': [1378], 'suggesting': [1379], 'role': [1381, 1394], 'stress-responsive': [1383], 'tissue': [1384], 'remodeling.5': [1385], 'speculate': [1387], 'may': [1390], 'play': [1391], 'similar': [1393], 'myocytes': [1397], 'remodeling.': [1400], 'Given': [1401], 'our': [1402], 'evidence': [1403], 'reduce': [1408], 'cardioprotective,': [1412], 'suggest': [1414], 'therapeutic': [1416], 'could': [1425], 'represent': [1426], 'novel': [1428], 'approach': [1429], 'address': [1431], 'burden': [1433], 'failure.Sources': [1437], 'FundingThis': [1439], 'work': [1440], 'supported': [1442], 'US': [1445], 'National': [1446], 'Institutes': [1447], 'Health': [1449], '(Grants': [1450], 'HL105993,': [1451, 1453], 'HL088577,': [1452], 'HL092577,': [1454], 'HL128914),': [1456], 'Fondation': [1458], 'Leducq': [1459], '(Grant': [1460], '14CVD01),': [1461], 'Winkelman': [1464], 'Family': [1465], 'Innovation': [1466], 'Fund.DisclosuresDr': [1467], 'receives': [1469], 'grant': [1470], 'support': [1471, 1500], 'Bayer': [1473], 'AG': [1474], 'Institute': [1478], 'research': [1480, 2269], 'focused': [1481], 'development': [1484, 2305, 2337], 'therapeutics': [1486], 'disease.Footnotes*M.P.': [1489], 'Dr': [1492], 'contributed': [1494], 'equally.https://www.ahajournals.org/journal/circData': [1495], 'sharing:': [1496], 'findings': [1502], 'this': [1504], 'available': [1507], 'corresponding': [1510], 'authors': [1511], 'upon': [1512], 'reasonable': [1513], 'request.Thomas': [1514], 'ScM,': [1518], '11-113': [1526], 'South': [1527], 'Tower,': [1528], '3400': [1529], 'Civic': [1530], 'Blvd,': [1532], 'Philadelphia,': [1533], 'PA': [1534], '19104.': [1535], 'Email': [1536], 'thomas.[email': [1537], 'protected]upenn.eduReferences1.': [1538], 'Wild': [1539], 'PS,': [1540], 'JF,': [1542, 2111, 2167], 'Schillert': [1543], 'A,': [1544, 1546, 1631, 1679, 1681, 1725, 1904, 1908, 1934, 1940, 1962, 1970, 1996, 2000, 2115, 2140, 2144, 2179, 2215, 2417, 2504, 2506], 'Teumer': [1545], 'Chen': [1547, 1905, 2438], 'MH,': [1548], 'Leening': [1549], 'MJG,': [1550], 'Völker': [1551, 2069], 'U,': [1552, 1609, 2070], 'Großmann': [1553], 'V,': [1554, 1757, 1882, 2068, 2123], 'Brody': [1555], 'JA,': [1556, 1952, 2040], 'Irvin': [1557], 'MR,': [1558, 1589], 'Shah': [1559], 'SJ,': [1560, 1938], 'Pramana': [1561], 'S,': [1562, 1611, 1671, 1675, 1715, 1775, 1857, 1859, 1880, 1972, 1974, 1976, 1994, 2010, 2018, 2107, 2113, 2121, 2171, 2283, 2415, 2447, 2451, 2522, 2526], 'Lieb': [1563, 2184], 'W,': [1564, 1729, 1874, 2038, 2185, 2326, 2405, 2421, 2433, 2497], 'Schmidt': [1565, 1700, 2021], 'R,': [1566, 1645, 1707, 1721, 1763, 1845, 1896, 2377, 2423, 2449, 2508], 'Stanton': [1567], 'AV,': [1568, 1572, 1863], 'Malzahn': [1569], 'Sundström': [1573], 'Minelli': [1575], 'Ruggiero': [1577], 'Lyytikäinen': [1579, 1848], 'LP,': [1580, 1849], 'Tiller': [1581], 'JG,': [1584], 'Monnereau': [1585], 'Di': [1587], 'Tullio': [1588], 'Musani': [1590], 'SK,': [1591], 'Morrison': [1592, 2168], 'AC,': [1593, 2169], 'Pers': [1594, 1991], 'TH,': [1595, 1992], 'M,': [1597, 1621, 1637, 1649, 1669, 1747, 1751, 1839, 1861, 1865, 1926, 1942, 1944, 2056, 2072, 2105, 2324, 2427, 2429, 2431, 2443, 2495, 2524], 'Kleber': [1598], 'ME,': [1599, 1888], 'Aragam': [1600], 'Benjamin': [1602, 2192], 'EJ,': [1603, 2014], 'Bis': [1604, 1893, 2188], 'JC,': [1605, 1894, 2136, 2189, 2236], 'Bisping': [1606], 'Broeckel': [1608], 'Cheng': [1610], 'Deckers': [1612], 'JW,': [1613, 1869, 2119], 'Del': [1614, 1870], 'Greco': [1615, 1871], 'M': [1616, 2354], 'Edelmann': [1618], 'Fornage': [1620], 'Franke': [1622, 1829], 'L,': [1623, 1643, 1755, 1830, 1916, 2381, 2439], 'Friedrich': [1624], 'N,': [1625, 1709, 1826, 1841, 1936], 'Harris': [1626, 1921], 'TB,': [1627, 1922], 'Hofer': [1628], 'Hofman': [1630, 1933, 2214], 'Huang': [1632], 'Hughes': [1634], 'AD,': [1635], 'Kähönen': [1636, 1941], 'Kruppa': [1638], 'Lackner': [1640], 'KJ,': [1641], 'Lannfelt': [1642], 'Laskowski': [1644], 'Launer': [1646, 1957], 'LJ,': [1647, 1958], 'Leosdottir': [1648], 'Lin': [1650], 'Lindgren': [1652], 'CM,': [1653, 2059, 2232], 'Loley': [1654], 'MacRae': [1656], 'CA,': [1657], 'Mascalzoni': [1658], 'Mayet': [1660], 'Medenwald': [1662], 'Morris': [1664], 'AP,': [1665], 'Müller': [1666], 'Müller-Nurasyid': [1668, 1860], 'Nappo': [1670, 1971], 'Nilsson': [1672], 'PM,': [1673, 1982, 2066], 'Nuding': [1674], 'Nutile': [1676, 1979], 'T,': [1677, 1727, 1749, 1783, 1853, 1884, 1968, 1980, 2109, 2181, 2197, 2287, 2441, 2493, 2512], 'Peters': [1678, 1995], 'Pfeufer': [1680, 1999], 'Pietzner': [1682], 'Pramstaller': [1684, 2003], 'PP,': [1685, 2004, 2209], 'Raitakari': [1686, 2007], 'OT,': [1687, 2008], 'Rice': [1688, 2011, 2212], 'KM,': [1689, 2012, 2213], 'Rivadeneira': [1690, 2186], 'Rotter': [1692, 2015, 2224], 'JI,': [1693, 2016, 2225], 'Ruohonen': [1694], 'ST,': [1695, 2046], 'Sacco': [1696], 'RL,': [1697], 'Samdarshi': [1698], 'TE,': [1699], 'Sharp': [1702], 'ASP,': [1703], 'Shields': [1704], 'DC,': [1705], 'Sorice': [1706, 1844], 'Sotoodehnia': [1708, 1840], 'Stricker': [1710, 2100, 2204], 'BH,': [1711, 2080, 2101, 2205], 'Surendran': [1712], 'P,': [1713, 1821, 1892, 2117, 2453, 2459, 2499, 2520], 'Thom': [1714], 'Töglhofer': [1716], 'AM,': [1717], 'Uitterlinden': [1718, 2051, 2222], 'AG,': [1719, 2052, 2223], 'Wachter': [1720], 'Völzke': [1722], 'Ziegler': [1724], 'Münzel': [1726], 'März': [1728], 'TP,': [1731], 'Hirschhorn': [1732, 1931], 'JN,': [1733, 1932], 'Mitchell': [1734], 'GF,': [1735], 'NL,': [1737, 2165, 2173], 'Fox': [1738, 2218], 'ER,': [1739, 2219], 'Dueker': [1740], 'ND,': [1741], 'Jaddoe': [1742], 'VWV,': [1743], 'Melander': [1744], 'O,': [1745, 1847, 1851], 'Russ': [1746], 'Lehtimäki': [1748, 2108], 'Ciullo': [1750, 2104], 'Hicks': [1752, 2133], 'AA,': [1753, 2134], 'Lind': [1754], 'Gudnason': [1756, 2122], 'Pieske': [1758], 'Barron': [1760], 'AJ,': [1761], 'Zweiker': [1762], 'Schunkert': [1764], 'Ingelsson': [1766], 'Liu': [1768], 'K,': [1769, 1890, 1956, 2032, 2044, 2419, 2437], 'Arnett': [1770], 'DK,': [1771], 'Psaty': [1772, 2102, 2233], 'BM,': [1773, 1898, 2103, 2234], 'Blankenberg': [1774], 'Larson': [1776], 'MG,': [1777, 2002], 'SB,': [1779, 2125], 'Franco': [1780], 'OH,': [1781], 'Zeller': [1782], 'Vasan': [1784, 2239], 'RS,': [1785], 'Dörr': [1786, 1864], 'M.': [1787], 'Large-scale': [1788], 'analysis': [1790], 'identifies': [1791], 'function.J': [1799], 'Clin': [1800], 'Invest.': [1801], '2017;': [1802], '127:1798–1812.': [1803], 'doi:': [1804, 1815, 2161, 2279, 2311], '10.1172/JCI84840CrossrefMedlineGoogle': [1805], 'Scholar2.': [1806], '(GTEx)': [1810], 'project.Nat': [1811], 'Genet.': [1812, 2276], '2013;': [1813], '45:580–585.': [1814], '10.1038/ng.2653CrossrefMedlineGoogle': [1816], 'Scholar3.': [1817], 'Setten': [1823], 'Verweij': [1825], 'Vogler': [1827], 'Maurano': [1831], 'MT,': [1832], 'X,': [1834, 2285], 'Mateo': [1835], 'Leach': [1836], 'Eijgelsheim': [1838], 'Hayward': [1842], 'Meirelles': [1846], 'Polašek': [1850], 'Tanaka': [1852], 'Arking': [1854], 'DE,': [1855], 'Ulivi': [1856], 'Trompet': [1858], 'Kerr': [1866], 'KF,': [1867], 'Magnani': [1868], 'MF,': [1872, 2030], 'Zhang': [1873, 2376], 'Nolte': [1875], 'IM,': [1876], 'Silva': [1877], 'CT,': [1878], 'Padmanabhan': [1879], 'Tragante': [1881], 'Esko': [1883], 'Abecasis': [1885], 'GR,': [1886], 'Adriaens': [1887], 'Andersen': [1889], 'Barnett': [1891], 'Bodmer': [1895], 'Buckley': [1897], 'Campbell': [1899], 'Cannon': [1901], 'MV,': [1902], 'Chakravarti': [1903], 'LY,': [1906], 'Delitala': [1907], 'Devereux': [1909], 'RB,': [1910], 'Doevendans': [1911], 'PA,': [1912], 'Dominiczak': [1913], 'AF,': [1914, 2090], 'Ferrucci': [1915], 'Ford': [1917], 'Gieger': [1919], 'Haugen': [1923], 'Heinig': [1925], 'Hernandez': [1927], 'DG,': [1928], 'Hillege': [1929], 'HL,': [1930], 'Hubner': [1935], 'Hwang': [1937], 'Iorio': [1939], 'Kellis': [1943], 'Kolcic': [1945], 'Kooner': [1947, 1949], 'IK,': [1948], 'JS,': [1950, 2064, 2207], 'Kors': [1951], 'Lakatta': [1953], 'EG,': [1954], 'Lage': [1955], 'Levy': [1959, 2228], 'Lundby': [1961], 'Macfarlane': [1963], 'PW,': [1964], 'May': [1965], 'Meitinger': [1967], 'Metspalu': [1969], 'Naitza': [1973], 'Neph': [1975], 'Nord': [1977], 'AS,': [1978], 'Okin': [1981], 'Olsen': [1983], 'JV,': [1984], 'Oostra': [1985], 'BA,': [1986], 'Penninger': [1987], 'JM,': [1988], 'Pennacchio': [1989], 'LA,': [1990, 2094, 2177], 'Perz': [1993], 'Pinto': [1997], 'YM,': [1998], 'Pilia': [2001], 'Prins': [2005], 'BP,': [2006], 'Raychaudhuri': [2009], 'Rossin': [2013], 'Schafer': [2017], 'Schlessinger': [2019], 'CO,': [2022], 'Sehmi': [2023], 'Silljé': [2025], 'HHW,': [2026], 'Sinagra': [2027], 'Sinner': [2029], 'Slowikowski': [2031], 'Soliman': [2033], 'EZ,': [2034], 'Spector': [2035], 'TD,': [2036], 'Spiering': [2037], 'Stamatoyannopoulos': [2039], 'Stolk': [2041], 'RP,': [2042], 'Strauch': [2043], 'Tan': [2045, 2325, 2404, 2412], 'Tarasov': [2047], 'KV,': [2048], 'Trinh': [2049], 'den': [2054], 'Boogaard': [2055], 'Duijn': [2058, 2231], 'Gilst': [2061], 'WH,': [2062], 'Viikari': [2063], 'Visscher': [2065], 'Vitart': [2067], 'Waldenberger': [2071], 'Weichenberger': [2073], 'CX,': [2074], 'Westra': [2075], 'HJ,': [2076], 'Wijmenga': [2077], 'Wolffenbuttel': [2079], 'Yang': [2081, 2382], 'Bezzina': [2083], 'CR,': [2084], 'Munroe': [2085], 'PB,': [2086], 'Snieder': [2087], 'Wright': [2089], 'Rudan': [2091], 'Boyer': [2093], 'Asselbergs': [2095], 'FW,': [2096], 'Veldhuisen': [2098], 'DJ,': [2099], 'Sanna': [2106], 'Wilson': [2110], 'Bandinelli': [2112], 'Alonso': [2114], 'Gasparini': [2116], 'Jukema': [2118], 'Kääb': [2120], 'Heckbert': [2126, 2216], 'SR,': [2127, 2217], 'de': [2128, 2147, 2502], 'Boer': [2129], 'RA,': [2130], 'Newton-Cheh': [2131], 'Chambers': [2135, 2444], 'Jamshidi': [2137], 'Y,': [2138, 2379], 'Visel': [2139], 'Christoffels': [2141], 'VM,': [2142], 'Isaacs': [2143], 'Samani': [2145], 'NJ,': [2146], 'Bakker': [2148], 'PIW.': [2149], '52': [2150], 'Genetic': [2151, 2474, 2533], 'loci': [2152], 'influencing': [2153], 'mass.J': [2155], 'Am': [2156], 'Coll': [2157], 'Cardiol.': [2158], '2016;': [2159], '68:1435–1448.': [2160], '10.1016/j.jacc.2016.07.729CrossrefMedlineGoogle': [2162], 'Scholar4.': [2163], 'Demissie': [2170], 'Glazer': [2172], 'Loehr': [2174], 'LR,': [2175], 'Cupples': [2176], 'Dehghan': [2178], 'Lumley': [2180], 'Rosamond': [2182], 'WD,': [2183], 'Folsom': [2190], 'AR,': [2191], 'Aulchenko': [2194], 'YS,': [2195], 'Haritunians': [2196], 'Couper': [2198], 'Murabito': [2200], 'YA,': [2203], 'Gottdiener': [2206], 'Chang': [2208], 'TJ,': [2211], "O'Donnell": [2220], 'CJ,': [2221], 'Willerson': [2226], 'JT,': [2227], 'Witteman': [2235], 'Boerwinkle': [2237], 'RS.': [2240], 'variation': [2244], 'incident': [2249], 'adults': [2253], 'African': [2257], 'ancestry:': [2258], 'prospective': [2260], 'meta-analysis': [2261], 'cohorts': [2264], 'aging': [2268], 'epidemiology': [2272], '(CHARGE)': [2273], 'consortium.Circ': [2274], 'Cardiovasc': [2275], '2010;': [2277, 2309], '3:256–266.': [2278], '10.1161/CIRCGENETICS.109.895763LinkGoogle': [2280], 'Scholar5.': [2281], 'Xia': [2282, 2378], 'Li': [2284, 2292], 'Johnson': [2286], 'Seidel': [2288], 'Wallace': [2290], 'DP,': [2291], 'Polycystin-dependent': [2294], 'fluid': [2295], 'flow': [2296], 'sensing': [2297], 'targets': [2298], 'histone': [2299], 'deacetylase': [2300], '5': [2301], 'prevent': [2303], 'renal': [2307], 'cysts.Development.': [2308], '137:1075–1084.': [2310], '10.1242/dev.049437CrossrefMedlineGoogle': [2312], 'Scholar': [2313], 'Previous': [2314], 'Back': [2315], 'top': [2317], 'Next': [2318], 'FiguresReferencesRelatedDetailsCited': [2319], 'By': [2320], 'Anene-Nzelu': [2321, 2406], 'Lee': [2323, 2410, 2426], 'Dashi': [2327], 'A': [2328], 'Foo': [2330, 2448], 'R': [2331, 2466], '(2021)': [2332], 'Genomic': [2333], 'enhancers': [2334], 'disease,': [2339], 'Nature': [2340], 'Reviews': [2341], '10.1038/s41569-021-00597-2,': [2343], '19:1,': [2344], '(7-25),': [2345], 'Online': [2346, 2370, 2400, 2486, 2548], 'publication': [2347, 2371, 2401, 2487, 2549], 'date:': [2348, 2372, 2402, 2488, 2550], '1-Jan-2022.': [2349], 'T': [2351], 'Burke': [2353], '(2020)': [2355, 2387, 2467, 2532], 'Studying': [2356], 'Heart': [2357, 2366, 2564], 'Failure': [2358], 'Through': [2359], 'Lens': [2361], 'Gene': [2363], 'Regulation,': [2364], 'Circulation:': [2365], 'Failure,': [2367], '13:10,': [2368], '(e007647),': [2369], '1-Oct-2020.': [2373], 'Xu': [2374], 'Xiong': [2380], 'W': [2383], 'Annotation': [2388], 'susceptibility': [2390], 'SNPs': [2391], 'atrial': [2394], 'fibrillation,': [2395], 'Aging,': [2396], '10.18632/aging.103615,': [2397], '12:17,': [2398], '(16981-16998),': [2399], '9-Sep-2020.': [2403], 'Wong': [2408], 'Tang': [2414], 'Perrin': [2416], 'Wu': [2418], 'Zheng': [2420], 'Ashburn': [2422], 'Pan': [2424], 'Autio': [2428], 'Tam': [2432], 'Cheung': [2434], 'Loh': [2442], 'Prabhakar': [2446], 'Assa': [2450], 'Meder': [2460], 'G': [2463], 'Tappu': [2465], 'Epigenomes': [2468], 'Human': [2470], 'Reveal': [2472], 'New': [2473], 'Relevant': [2476], 'Cardiac': [2478], 'Disease': [2479], 'Phenotype,': [2481], 'Circulation': [2482], 'Research,': [2483], '127:6,': [2484], '(761-777),': [2485], '28-Aug-2020.': [2489], 'Meyer': [2490], 'Dawes': [2492], 'Serrani': [2494], 'Bai': [2496], 'Tokarczuk': [2498], 'Cai': [2500], 'Marvao': [2503], 'Henry': [2505], 'Lumbers': [2507], 'Gierten': [2509], 'Thumberger': [2511], 'Wittbrodt': [2513], 'Ware': [2515], 'Rueckert': [2517], 'Matthews': [2519], 'Prasad': [2521], 'Costantino': [2523], 'Cook': [2525], 'Birney': [2527], 'E': [2528], "O'Regan": [2530], 'D': [2531], 'functional': [2535], 'insights': [2536], 'fractal': [2539], 'Nature,': [2544], '10.1038/s41586-020-2635-8,': [2545], '584:7822,': [2546], '(589-594),': [2547], '27-Aug-2020.': [2551], 'April': [2552], '23,': [2553, 2570], '2019Vol': [2554], 'Issue': [2556], '17': [2557], 'Advertisement': [2558, 2580], 'Article': [2559], 'InformationMetrics': [2560], '©': [2561], '2019': [2562, 2571], 'American': [2563], 'Association,': [2565], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.118.037939PMID:': [2566], '31070942': [2567], 'publishedApril': [2569], 'Keywordstranslational': [2572], 'studiesgene': [2573], 'regulationmyocardial': [2576], 'biologycardiomyopathygenomicsheart': [2577], 'failuregeneticsPDF': [2578], 'download': [2579], 'SubjectsGene': [2581], 'RegulationGenetic,': [2584], 'StudiesHeart': [2586], 'FailureMyocardial': [2587], 'BiologyOmics': [2588]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2941001171', 'counts_by_year': [{'year': 2024, 'cited_by_count': 6}, {'year': 2023, 'cited_by_count': 3}, {'year': 2022, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 4}], 'updated_date': '2024-12-17T05:23:27.668709', 'created_date': '2019-05-03'}