Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2937722798', 'doi': 'https://doi.org/10.1088/2053-1591/ab16bf', 'title': 'Electrospun Zein nanofibers as drug carriers for controlled delivery of Levodopa in Parkinson syndrome', 'display_name': 'Electrospun Zein nanofibers as drug carriers for controlled delivery of Levodopa in Parkinson syndrome', 'publication_year': 2019, 'publication_date': '2019-04-08', 'ids': {'openalex': 'https://openalex.org/W2937722798', 'doi': 'https://doi.org/10.1088/2053-1591/ab16bf', 'mag': '2937722798'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1088/2053-1591/ab16bf', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210216311', 'display_name': 'Materials Research Express', 'issn_l': '2053-1591', 'issn': ['2053-1591'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320083', 'host_organization_name': 'IOP Publishing', 'host_organization_lineage': ['https://openalex.org/P4310311669', 'https://openalex.org/P4310320083'], 'host_organization_lineage_names': ['Institute of Physics', 'IOP Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5029931471', 'display_name': 'Abdul Quaiyum Ansari', 'orcid': 'https://orcid.org/0000-0003-0153-4381'}, 'institutions': [{'id': 'https://openalex.org/I180291457', 'display_name': 'Mehran University of Engineering and Technology', 'ror': 'https://ror.org/0575ttm03', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I180291457']}], 'countries': ['PK'], 'is_corresponding': True, 'raw_author_name': 'Abdul Q Ansari', 'raw_affiliation_strings': ['Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'Department of Biomedical Engineering, Mehran UET, Pakistan'], 'affiliations': [{'raw_affiliation_string': 'Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'institution_ids': ['https://openalex.org/I180291457']}, {'raw_affiliation_string': 'Department of Biomedical Engineering, Mehran UET, Pakistan', 'institution_ids': ['https://openalex.org/I180291457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049769166', 'display_name': 'Shafaq J Ansari', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801020214', 'display_name': 'College of Physicians and Surgeons Pakistan', 'ror': 'https://ror.org/0039pbm21', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I2801020214']}], 'countries': ['PK'], 'is_corresponding': False, 'raw_author_name': 'Shafaq J Ansari', 'raw_affiliation_strings': ['Fellow College of Physicians and Surgeons Pakistan'], 'affiliations': [{'raw_affiliation_string': 'Fellow College of Physicians and Surgeons Pakistan', 'institution_ids': ['https://openalex.org/I2801020214']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009128881', 'display_name': 'Muhammad Qamar Khan', 'orcid': 'https://orcid.org/0000-0002-1680-1588'}, 'institutions': [{'id': 'https://openalex.org/I137975476', 'display_name': 'Shinshu University', 'ror': 'https://ror.org/0244rem06', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137975476']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'M Qamar Khan', 'raw_affiliation_strings': ['Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan', 'institution_ids': ['https://openalex.org/I137975476']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5060730885', 'display_name': 'Faraz Khan Mahar', 'orcid': 'https://orcid.org/0000-0002-4417-3339'}, 'institutions': [{'id': 'https://openalex.org/I3923682', 'display_name': 'Soochow University', 'ror': 'https://ror.org/05t8y2r12', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I3923682']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'M Faraz Khan', 'raw_affiliation_strings': ["National Engineering Laboratory for Modern Silk, Soochow University, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "National Engineering Laboratory for Modern Silk, Soochow University, People's Republic of China", 'institution_ids': ['https://openalex.org/I3923682']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5026604744', 'display_name': 'Umair Ahmed Qureshi', 'orcid': 'https://orcid.org/0000-0003-0676-0353'}, 'institutions': [{'id': 'https://openalex.org/I180291457', 'display_name': 'Mehran University of Engineering and Technology', 'ror': 'https://ror.org/0575ttm03', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I180291457']}], 'countries': ['PK'], 'is_corresponding': True, 'raw_author_name': 'Umair A Qureshi', 'raw_affiliation_strings': ['Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan'], 'affiliations': [{'raw_affiliation_string': 'Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'institution_ids': ['https://openalex.org/I180291457']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057444726', 'display_name': 'Zeeshan Khatri', 'orcid': 'https://orcid.org/0000-0001-8779-3805'}, 'institutions': [{'id': 'https://openalex.org/I180291457', 'display_name': 'Mehran University of Engineering and Technology', 'ror': 'https://ror.org/0575ttm03', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I180291457']}, {'id': 'https://openalex.org/I137975476', 'display_name': 'Shinshu University', 'ror': 'https://ror.org/0244rem06', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137975476']}], 'countries': ['JP', 'PK'], 'is_corresponding': True, 'raw_author_name': 'Zeeshan Khatri', 'raw_affiliation_strings': ['Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'institution_ids': ['https://openalex.org/I180291457']}, {'raw_affiliation_string': 'Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan', 'institution_ids': ['https://openalex.org/I137975476']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091708610', 'display_name': 'Farooq Ahmed', 'orcid': 'https://orcid.org/0000-0002-8444-2038'}, 'institutions': [{'id': 'https://openalex.org/I180291457', 'display_name': 'Mehran University of Engineering and Technology', 'ror': 'https://ror.org/0575ttm03', 'country_code': 'PK', 'type': 'education', 'lineage': ['https://openalex.org/I180291457']}], 'countries': ['PK'], 'is_corresponding': True, 'raw_author_name': 'Farooq Ahmed', 'raw_affiliation_strings': ['Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan'], 'affiliations': [{'raw_affiliation_string': 'Center of Excellence in Nanotechnology & Materials, Mehran UET, Pakistan', 'institution_ids': ['https://openalex.org/I180291457']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5059896592', 'display_name': 'Ick Soo Kim', 'orcid': 'https://orcid.org/0000-0003-2126-0381'}, 'institutions': [{'id': 'https://openalex.org/I137975476', 'display_name': 'Shinshu University', 'ror': 'https://ror.org/0244rem06', 'country_code': 'JP', 'type': 'education', 'lineage': ['https://openalex.org/I137975476']}], 'countries': ['JP'], 'is_corresponding': True, 'raw_author_name': 'Ick Soo Kim', 'raw_affiliation_strings': ['Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan'], 'affiliations': [{'raw_affiliation_string': 'Nano Fusion Technology Research Lab, Institute for Fiber Engineering (IFES), Interdisciplinary Cluster for Cutting Edge Research (ICCER), Shinshu University, Japan', 'institution_ids': ['https://openalex.org/I137975476']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5029931471', 'https://openalex.org/A5009128881', 'https://openalex.org/A5060730885', 'https://openalex.org/A5026604744', 'https://openalex.org/A5057444726', 'https://openalex.org/A5091708610', 'https://openalex.org/A5059896592'], 'corresponding_institution_ids': ['https://openalex.org/I180291457', 'https://openalex.org/I137975476', 'https://openalex.org/I3923682', 'https://openalex.org/I180291457', 'https://openalex.org/I180291457', 'https://openalex.org/I137975476', 'https://openalex.org/I180291457', 'https://openalex.org/I137975476'], 'apc_list': {'value': 1100, 'currency': 'GBP', 'value_usd': 1349, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.545, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 32, 'citation_normalized_percentile': {'value': 0.99988, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '6', 'issue': '7', 'first_page': '075405', 'last_page': '075405'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10729', 'display_name': 'Electrospun Nanofibers in Biomedical Applications', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2502', 'display_name': 'Biomaterials'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10085', 'display_name': "Parkinson's Disease Mechanisms and Treatments", 'score': 0.9909, 'subfield': {'id': 'https://openalex.org/subfields/2728', 'display_name': 'Neurology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10660', 'display_name': 'Conducting polymers and applications', 'score': 0.9814, 'subfield': {'id': 'https://openalex.org/subfields/2507', 'display_name': 'Polymers and Plastics'}, 'field': {'id': 'https://openalex.org/fields/25', 'display_name': 'Materials Science'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C91129048', 'wikidata': 'https://www.wikidata.org/wiki/Q594196', 'display_name': 'Nanofiber', 'level': 2, 'score': 0.77862316}, {'id': 'https://openalex.org/C181389837', 'wikidata': 'https://www.wikidata.org/wiki/Q461809', 'display_name': 'Bioavailability', 'level': 2, 'score': 0.54450196}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.5130664}, {'id': 'https://openalex.org/C2779820397', 'wikidata': 'https://www.wikidata.org/wiki/Q1392806', 'display_name': 'Drug delivery', 'level': 2, 'score': 0.48536098}, {'id': 'https://openalex.org/C2780035454', 'wikidata': 'https://www.wikidata.org/wiki/Q8386', 'display_name': 'Drug', 'level': 2, 'score': 0.48416573}, {'id': 'https://openalex.org/C513476851', 'wikidata': 'https://www.wikidata.org/wiki/Q170304', 'display_name': 'Dopamine', 'level': 2, 'score': 0.46192855}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.4554699}, {'id': 'https://openalex.org/C13245373', 'wikidata': 'https://www.wikidata.org/wiki/Q3715494', 'display_name': 'Drug carrier', 'level': 3, 'score': 0.4229424}, {'id': 'https://openalex.org/C137183658', 'wikidata': 'https://www.wikidata.org/wiki/Q461076', 'display_name': 'Dopaminergic', 'level': 3, 'score': 0.421207}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.37218294}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.35073644}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.2683016}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.18387109}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.14275396}, {'id': 'https://openalex.org/C178790620', 'wikidata': 'https://www.wikidata.org/wiki/Q11351', 'display_name': 'Organic chemistry', 'level': 1, 'score': 0.107233286}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.0}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 1, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1088/2053-1591/ab16bf', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210216311', 'display_name': 'Materials Research Express', 'issn_l': '2053-1591', 'issn': ['2053-1591'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320083', 'host_organization_name': 'IOP Publishing', 'host_organization_lineage': ['https://openalex.org/P4310311669', 'https://openalex.org/P4310320083'], 'host_organization_lineage_names': ['Institute of Physics', 'IOP Publishing'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.72}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 25, 'referenced_works': ['https://openalex.org/W1524961740', 'https://openalex.org/W1964983681', 'https://openalex.org/W2027999712', 'https://openalex.org/W2041476316', 'https://openalex.org/W2050805075', 'https://openalex.org/W2075242633', 'https://openalex.org/W2079407952', 'https://openalex.org/W2084146115', 'https://openalex.org/W2107696226', 'https://openalex.org/W2125221540', 'https://openalex.org/W2129929316', 'https://openalex.org/W2130073749', 'https://openalex.org/W2331761688', 'https://openalex.org/W2513655122', 'https://openalex.org/W2574472787', 'https://openalex.org/W2739701749', 'https://openalex.org/W2744570396', 'https://openalex.org/W2751469159', 'https://openalex.org/W2755751245', 'https://openalex.org/W2802586967', 'https://openalex.org/W2808750237', 'https://openalex.org/W2888110725', 'https://openalex.org/W2895561333', 'https://openalex.org/W44078951', 'https://openalex.org/W609458180'], 'related_works': ['https://openalex.org/W655501494', 'https://openalex.org/W4200433715', 'https://openalex.org/W3201778902', 'https://openalex.org/W2741112897', 'https://openalex.org/W2597042212', 'https://openalex.org/W2188963719', 'https://openalex.org/W2188649487', 'https://openalex.org/W2080630976', 'https://openalex.org/W2057314137', 'https://openalex.org/W2010173644'], 'abstract_inverted_index': {'Levodopa': [0], '(LD),': [1], 'a': [2], 'dopamine': [3], 'precursor,': [4], 'is': [5, 64, 114, 128], 'one': [6], 'of': [7, 17, 23, 61, 88, 91, 98, 121, 133, 140], 'the': [8, 14, 53], 'most': [9], 'in': [10, 29, 34, 94, 112, 116], 'effect': [11], 'drug': [12, 76], 'for': [13, 78, 83], 'indicative': [15], 'management': [16], "Parkinson's": [18], 'syndrome.': [19], 'Variable': [20], 'plasmatic': [21], 'levels': [22], 'LD': [24, 79, 93, 99, 105, 122, 141], 'cause': [25], 'pulsatile': [26], 'dopaminergic': [27], 'stimulus': [28], 'Parkinsonian': [30], 'patients': [31, 45], 'that': [32], 'results': [33], 'uninhibited': [35], 'motor': [36], 'and': [37, 104, 135, 149], 'other': [38], 'associated': [39], 'deactivations.': [40], 'The': [41, 59, 119, 137], 'wearing': [42], 'off': [43], 'PD': [44], 'between': [46], 'doses': [47], 'can': [48], 'be': [49], 'rationally': [50], 'linked': [51], 'to': [52, 65, 80], "drug's": [54], 'peripheral': [55], 'pharmacokinetic': [56], '(PK)': [57], 'profile.': [58], 'purpose': [60], 'this': [62, 117], 'research': [63], 'appraise': [66], 'Zein': [67, 95, 101, 109, 125], 'Nanofiber': [68, 102, 110, 126], 'films': [69, 111, 127], 'prepared': [70], 'by': [71], 'electrospinning': [72], 'as': [73], 'sustained': [74], 'release': [75, 106, 123, 142], 'carriers': [77], 'increase': [81], 'bioavailability': [82], 'stable': [84], 'blood': [85], 'plasma': [86], 'level': [87], 'LD.': [89], 'Process': [90], 'encapsulating': [92], 'Nanofibers,': [96], 'characterization': [97], 'loaded': [100], 'films,': [103], 'behavior': [107], 'from': [108, 124], 'vitro': [113], 'detailed': [115], 'article.': [118], 'kinetics': [120], 'assessed': [129], 'using': [130], 'mathematical': [131], 'models': [132], "Higuchi's": [134, 147], 'Korsmeyer-Pappas.': [136], 'cumulative': [138], '%': [139], 'over': [143], 'time': [144], 'levelheadedly': [145], 'followed': [146], 'model': [148], 'also': [150], 'exhibited': [151], 'diffusion': [152], 'based': [153], 'release.': [154]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2937722798', 'counts_by_year': [{'year': 2024, 'cited_by_count': 8}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 9}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2025-01-08T10:31:24.627437', 'created_date': '2019-04-25'}