Nocturnal asthma is affected by genetic interactions between <i>RORA</i> and <i>NPSR1</i>

Name: Work Video:
Duration: 3 min 30 s
Vincent D. Gaertner; Sven Michel; John A. Curtin; Ville Pulkkinen; Nathalie Acevedo; Cilla Söderhäll; Andrea von Berg; Albrecht Bufe; Otto Laub; Ernst Rietschel; Andrea Heinzmann; Burkhard Simma; Christian Vogelberg; Göran Pershagen; Erik Melén; Angela Simpson; Adnan Ćustović; Juha Kere; Michael Kabesch
{'id': 'https://openalex.org/W2934778819', 'doi': 'https://doi.org/10.1002/ppul.24292', 'title': 'Nocturnal asthma is affected by genetic interactions between <i>RORA</i> and <i>NPSR1</i>', 'display_name': 'Nocturnal asthma is affected by genetic interactions between <i>RORA</i> and <i>NPSR1</i>', 'publication_year': 2019, 'publication_date': '2019-03-29', 'ids': {'openalex': 'https://openalex.org/W2934778819', 'doi': 'https://doi.org/10.1002/ppul.24292', 'mag': '2934778819', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30927345'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ppul.24292', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144578311', 'display_name': 'Pediatric Pulmonology', 'issn_l': '1099-0496', 'issn': ['1099-0496', '8755-6863'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://pure.manchester.ac.uk/ws/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5057520324', 'display_name': 'Vincent D. Gaertner', 'orcid': 'https://orcid.org/0000-0001-5330-652X'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Vincent D. Gaertner', 'raw_affiliation_strings': ["Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5013505557', 'display_name': 'Sven Michel', 'orcid': 'https://orcid.org/0000-0003-3604-3187'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Sven Michel', 'raw_affiliation_strings': ["Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038384580', 'display_name': 'John A. Curtin', 'orcid': 'https://orcid.org/0000-0001-6299-9110'}, 'institutions': [{'id': 'https://openalex.org/I2799725268', 'display_name': 'Manchester Academic Health Science Centre', 'ror': 'https://ror.org/04rrkhs81', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799725268']}, {'id': 'https://openalex.org/I4210092852', 'display_name': 'Manchester University NHS Foundation Trust', 'ror': 'https://ror.org/00he80998', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092852']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'John A. Curtin', 'raw_affiliation_strings': ['Division of Infection Immunity and Respiratory Medicine School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust Manchester UK'], 'affiliations': [{'raw_affiliation_string': 'Division of Infection Immunity and Respiratory Medicine School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust Manchester UK', 'institution_ids': ['https://openalex.org/I2799725268', 'https://openalex.org/I4210092852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057906633', 'display_name': 'Ville Pulkkinen', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'funder', 'lineage': ['https://openalex.org/I133731052']}, {'id': 'https://openalex.org/I2800394112', 'display_name': 'Helsinki University Hospital', 'ror': 'https://ror.org/02e8hzf44', 'country_code': 'FI', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800394112', 'https://openalex.org/I4210166427']}], 'countries': ['FI'], 'is_corresponding': True, 'raw_author_name': 'Ville Pulkkinen', 'raw_affiliation_strings': ['Heart and Lung Center, Division of Pulmonary Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland'], 'affiliations': [{'raw_affiliation_string': 'Heart and Lung Center, Division of Pulmonary Medicine University of Helsinki and Helsinki University Central Hospital Helsinki Finland', 'institution_ids': ['https://openalex.org/I133731052', 'https://openalex.org/I2800394112']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056815373', 'display_name': 'Nathalie Acevedo', 'orcid': 'https://orcid.org/0000-0002-5154-2964'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'funder', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I153390918', 'display_name': 'University of Cartagena', 'ror': 'https://ror.org/0409zd934', 'country_code': 'CO', 'type': 'education', 'lineage': ['https://openalex.org/I153390918']}], 'countries': ['CO', 'SE'], 'is_corresponding': True, 'raw_author_name': 'Nathalie Acevedo', 'raw_affiliation_strings': ['Department of Clinical Science and Education Karolinska Institutet Stockholm Sweden', 'Institute for Immunological Research University of Cartagena Cartagena Colombia'], 'affiliations': [{'raw_affiliation_string': 'Department of Clinical Science and Education Karolinska Institutet Stockholm Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Institute for Immunological Research University of Cartagena Cartagena Colombia', 'institution_ids': ['https://openalex.org/I153390918']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040807511', 'display_name': 'Cilla Söderhäll', 'orcid': 'https://orcid.org/0000-0002-8397-3080'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'funder', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Cilla Söderhäll', 'raw_affiliation_strings': ['Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden', 'Department of Women´s and Children’s Health Karolinska Institutet Stockholm Sweden'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Department of Women´s and Children’s Health Karolinska Institutet Stockholm Sweden', 'institution_ids': ['https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102784895', 'display_name': 'Andrea von Berg', 'orcid': 'https://orcid.org/0000-0003-0168-1541'}, 'institutions': [{'id': 'https://openalex.org/I4210110904', 'display_name': 'Marien Hospital Wesel', 'ror': 'https://ror.org/016j3vn58', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210110904']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Andrea von Berg', 'raw_affiliation_strings': ["Children's Department Research Institute for the Prevention of Allergic Diseases, Marien-Hospital Wesel Germany"], 'affiliations': [{'raw_affiliation_string': "Children's Department Research Institute for the Prevention of Allergic Diseases, Marien-Hospital Wesel Germany", 'institution_ids': ['https://openalex.org/I4210110904']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5088875589', 'display_name': 'Albrecht Bufe', 'orcid': 'https://orcid.org/0000-0001-7335-9362'}, 'institutions': [{'id': 'https://openalex.org/I904495901', 'display_name': 'Ruhr University Bochum', 'ror': 'https://ror.org/04tsk2644', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I904495901']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Albrecht Bufe', 'raw_affiliation_strings': ['Department of Experimental Pneumology Ruhr-University Bochum Germany'], 'affiliations': [{'raw_affiliation_string': 'Department of Experimental Pneumology Ruhr-University Bochum Germany', 'institution_ids': ['https://openalex.org/I904495901']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5079367979', 'display_name': 'Otto Laub', 'orcid': None}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Otto Laub', 'raw_affiliation_strings': ['Kinder- und Jugendarztpraxis Laub Rosenheim Germany'], 'affiliations': [{'raw_affiliation_string': 'Kinder- und Jugendarztpraxis Laub Rosenheim Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111559569', 'display_name': 'Ernst Rietschel', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210153755', 'display_name': 'University Hospital Cologne', 'ror': 'https://ror.org/05mxhda18', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210153755']}, {'id': 'https://openalex.org/I180923762', 'display_name': 'University of Cologne', 'ror': 'https://ror.org/00rcxh774', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I180923762']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Ernst Rietschel', 'raw_affiliation_strings': ["Faculty of Medicine University Children's Hospital, University of Cologne Cologne Germany"], 'affiliations': [{'raw_affiliation_string': "Faculty of Medicine University Children's Hospital, University of Cologne Cologne Germany", 'institution_ids': ['https://openalex.org/I4210153755', 'https://openalex.org/I180923762']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069880249', 'display_name': 'Andrea Heinzmann', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801240073', 'display_name': 'University Medical Center Freiburg', 'ror': 'https://ror.org/03vzbgh69', 'country_code': 'DE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2801240073']}, {'id': 'https://openalex.org/I161046081', 'display_name': 'University of Freiburg', 'ror': 'https://ror.org/0245cg223', 'country_code': 'DE', 'type': 'funder', 'lineage': ['https://openalex.org/I161046081']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Andrea Heinzmann', 'raw_affiliation_strings': ['Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology Faculty of Medicine, Medical Center – University of Freiburg, University of Freiburg Freiburg im Breisgau Germany'], 'affiliations': [{'raw_affiliation_string': 'Center for Pediatrics, Department of General Pediatrics, Adolescent Medicine and Neonatology Faculty of Medicine, Medical Center – University of Freiburg, University of Freiburg Freiburg im Breisgau Germany', 'institution_ids': ['https://openalex.org/I2801240073', 'https://openalex.org/I161046081']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053266244', 'display_name': 'Burkhard Simma', 'orcid': 'https://orcid.org/0000-0002-3915-8409'}, 'institutions': [{'id': 'https://openalex.org/I4210087533', 'display_name': 'Landeskrankenhaus Feldkirch', 'ror': 'https://ror.org/004gqpt18', 'country_code': 'AT', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087533']}], 'countries': ['AT'], 'is_corresponding': True, 'raw_author_name': 'Burkhard Simma', 'raw_affiliation_strings': ["Children's Department University Teaching Hospital, Landeskrankenhaus Feldkirch Feldkirch Austria"], 'affiliations': [{'raw_affiliation_string': "Children's Department University Teaching Hospital, Landeskrankenhaus Feldkirch Feldkirch Austria", 'institution_ids': ['https://openalex.org/I4210087533']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5091863505', 'display_name': 'Christian Vogelberg', 'orcid': 'https://orcid.org/0000-0002-4881-8368'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Christian Vogelberg', 'raw_affiliation_strings': ["University Children's Hospital Technical University Dresden Dresden Germany"], 'affiliations': [{'raw_affiliation_string': "University Children's Hospital Technical University Dresden Dresden Germany", 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5107409408', 'display_name': 'Göran Pershagen', 'orcid': 'https://orcid.org/0000-0002-9701-1130'}, 'institutions': [{'id': 'https://openalex.org/I2801939835', 'display_name': 'Stockholm County Council', 'ror': 'https://ror.org/02zrae794', 'country_code': 'SE', 'type': 'government', 'lineage': ['https://openalex.org/I2801939835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'funder', 'lineage': ['https://openalex.org/I28166907']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Göran Pershagen', 'raw_affiliation_strings': ['Institute of Environmental Medicine Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council Stockholm Sweden'], 'affiliations': [{'raw_affiliation_string': 'Institute of Environmental Medicine Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council Stockholm Sweden', 'institution_ids': ['https://openalex.org/I2801939835', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5049025189', 'display_name': 'Erik Melén', 'orcid': 'https://orcid.org/0000-0002-8248-0663'}, 'institutions': [{'id': 'https://openalex.org/I4210127661', 'display_name': "Sachs' Children and Youth Hospital", 'ror': 'https://ror.org/03tqnz817', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210127661']}, {'id': 'https://openalex.org/I2801939835', 'display_name': 'Stockholm County Council', 'ror': 'https://ror.org/02zrae794', 'country_code': 'SE', 'type': 'government', 'lineage': ['https://openalex.org/I2801939835']}, {'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'funder', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I4210094988', 'display_name': 'Stockholm South General Hospital', 'ror': 'https://ror.org/00ncfk576', 'country_code': 'SE', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210094988']}], 'countries': ['SE'], 'is_corresponding': True, 'raw_author_name': 'Erik Melén', 'raw_affiliation_strings': ['Institute of Environmental Medicine Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council Stockholm Sweden', 'Sachs’ Children and Youth Hospital Södersjukhuset Stockholm Sweden'], 'affiliations': [{'raw_affiliation_string': 'Sachs’ Children and Youth Hospital Södersjukhuset Stockholm Sweden', 'institution_ids': ['https://openalex.org/I4210127661', 'https://openalex.org/I4210094988']}, {'raw_affiliation_string': 'Institute of Environmental Medicine Karolinska Institutet and Centre for Occupational and Environmental Medicine, Stockholm County Council Stockholm Sweden', 'institution_ids': ['https://openalex.org/I2801939835', 'https://openalex.org/I28166907']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5006644007', 'display_name': 'Angela Simpson', 'orcid': 'https://orcid.org/0000-0003-2733-6666'}, 'institutions': [{'id': 'https://openalex.org/I2799725268', 'display_name': 'Manchester Academic Health Science Centre', 'ror': 'https://ror.org/04rrkhs81', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2799725268']}, {'id': 'https://openalex.org/I4210092852', 'display_name': 'Manchester University NHS Foundation Trust', 'ror': 'https://ror.org/00he80998', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210092852']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Angela Simpson', 'raw_affiliation_strings': ['Division of Infection Immunity and Respiratory Medicine School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust Manchester UK'], 'affiliations': [{'raw_affiliation_string': 'Division of Infection Immunity and Respiratory Medicine School of Biological Sciences, The University of Manchester, Manchester Academic Health Science Centre, and Manchester University NHS Foundation Trust Manchester UK', 'institution_ids': ['https://openalex.org/I2799725268', 'https://openalex.org/I4210092852']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021298553', 'display_name': 'Adnan Ćustović', 'orcid': 'https://orcid.org/0000-0001-5218-7071'}, 'institutions': [{'id': 'https://openalex.org/I47508984', 'display_name': 'Imperial College London', 'ror': 'https://ror.org/041kmwe10', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I47508984']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Adnan Custovic', 'raw_affiliation_strings': ['Department of Paediatrics Imperial College London UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Paediatrics Imperial College London UK', 'institution_ids': ['https://openalex.org/I47508984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100712980', 'display_name': 'Juha Kere', 'orcid': 'https://orcid.org/0000-0003-1974-0271'}, 'institutions': [{'id': 'https://openalex.org/I28166907', 'display_name': 'Karolinska Institutet', 'ror': 'https://ror.org/056d84691', 'country_code': 'SE', 'type': 'funder', 'lineage': ['https://openalex.org/I28166907']}, {'id': 'https://openalex.org/I133731052', 'display_name': 'University of Helsinki', 'ror': 'https://ror.org/040af2s02', 'country_code': 'FI', 'type': 'funder', 'lineage': ['https://openalex.org/I133731052']}], 'countries': ['FI', 'SE'], 'is_corresponding': True, 'raw_author_name': 'Juha Kere', 'raw_affiliation_strings': ['Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden', 'Research Programs Unit, Program for Molecular Neurology University of Helsinki, Folkhälsän Institute of Genetics Helsinki Finland'], 'affiliations': [{'raw_affiliation_string': 'Department of Biosciences and Nutrition Karolinska Institutet Huddinge Sweden', 'institution_ids': ['https://openalex.org/I28166907']}, {'raw_affiliation_string': 'Research Programs Unit, Program for Molecular Neurology University of Helsinki, Folkhälsän Institute of Genetics Helsinki Finland', 'institution_ids': ['https://openalex.org/I133731052']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5064160876', 'display_name': 'Michael Kabesch', 'orcid': 'https://orcid.org/0000-0003-0697-1871'}, 'institutions': [{'id': 'https://openalex.org/I183935753', 'display_name': "King's College London", 'ror': 'https://ror.org/0220mzb33', 'country_code': 'GB', 'type': 'funder', 'lineage': ['https://openalex.org/I124357947', 'https://openalex.org/I183935753']}], 'countries': ['GB'], 'is_corresponding': True, 'raw_author_name': 'Michael Kabesch', 'raw_affiliation_strings': ["Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany", "School of Basic &amp; Medical Biosciences, King's College London London England"], 'affiliations': [{'raw_affiliation_string': "Department of Pediatric Pneumology and Allergy University Children's Hospital Regensburg (KUNO) Regensburg Germany", 'institution_ids': []}, {'raw_affiliation_string': "School of Basic &amp; Medical Biosciences, King's College London London England", 'institution_ids': ['https://openalex.org/I183935753']}]}], 'institution_assertions': [], 'countries_distinct_count': 6, 'institutions_distinct_count': 18, 'corresponding_author_ids': ['https://openalex.org/A5057520324', 'https://openalex.org/A5013505557', 'https://openalex.org/A5038384580', 'https://openalex.org/A5057906633', 'https://openalex.org/A5056815373', 'https://openalex.org/A5040807511', 'https://openalex.org/A5102784895', 'https://openalex.org/A5088875589', 'https://openalex.org/A5079367979', 'https://openalex.org/A5111559569', 'https://openalex.org/A5069880249', 'https://openalex.org/A5053266244', 'https://openalex.org/A5091863505', 'https://openalex.org/A5107409408', 'https://openalex.org/A5049025189', 'https://openalex.org/A5006644007', 'https://openalex.org/A5021298553', 'https://openalex.org/A5100712980', 'https://openalex.org/A5064160876'], 'corresponding_institution_ids': ['https://openalex.org/I2799725268', 'https://openalex.org/I4210092852', 'https://openalex.org/I133731052', 'https://openalex.org/I2800394112', 'https://openalex.org/I28166907', 'https://openalex.org/I153390918', 'https://openalex.org/I28166907', 'https://openalex.org/I4210110904', 'https://openalex.org/I904495901', 'https://openalex.org/I4210153755', 'https://openalex.org/I180923762', 'https://openalex.org/I2801240073', 'https://openalex.org/I161046081', 'https://openalex.org/I4210087533', 'https://openalex.org/I2801939835', 'https://openalex.org/I28166907', 'https://openalex.org/I4210127661', 'https://openalex.org/I2801939835', 'https://openalex.org/I28166907', 'https://openalex.org/I4210094988', 'https://openalex.org/I2799725268', 'https://openalex.org/I4210092852', 'https://openalex.org/I47508984', 'https://openalex.org/I28166907', 'https://openalex.org/I133731052', 'https://openalex.org/I183935753'], 'apc_list': {'value': 4740, 'currency': 'USD', 'value_usd': 4740, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.073, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 9, 'citation_normalized_percentile': {'value': 0.608094, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 84, 'max': 85}, 'biblio': {'volume': '54', 'issue': '6', 'first_page': '847', 'last_page': '857'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma and respiratory diseases', 'score': 0.9999, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10342', 'display_name': 'Circadian rhythm and melatonin', 'score': 0.9964, 'subfield': {'id': 'https://openalex.org/subfields/2807', 'display_name': 'Endocrine and Autonomic Systems'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10814', 'display_name': 'Neuropeptides and Animal Physiology', 'score': 0.969, 'subfield': {'id': 'https://openalex.org/subfields/2804', 'display_name': 'Cellular and Molecular Neuroscience'}, 'field': {'id': 'https://openalex.org/fields/28', 'display_name': 'Neuroscience'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2776042228', 'wikidata': 'https://www.wikidata.org/wiki/Q35869', 'display_name': 'Asthma', 'level': 2, 'score': 0.8286831}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.69305515}, {'id': 'https://openalex.org/C2777334680', 'wikidata': 'https://www.wikidata.org/wiki/Q1607611', 'display_name': 'Nocturnal', 'level': 2, 'score': 0.57014155}, {'id': 'https://openalex.org/C207480886', 'wikidata': 'https://www.wikidata.org/wiki/Q42982', 'display_name': 'Allergy', 'level': 2, 'score': 0.48647925}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.2959458}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.26100963}], 'mesh': [{'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D002940', 'descriptor_name': 'Circadian Rhythm', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D020022', 'descriptor_name': 'Genetic Predisposition to Disease', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D006967', 'descriptor_name': 'Hypersensitivity', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D057094', 'descriptor_name': 'Nuclear Receptor Subfamily 1, Group F, Member 1', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D000293', 'descriptor_name': 'Adolescent', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001249', 'descriptor_name': 'Asthma', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D002648', 'descriptor_name': 'Child', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015331', 'descriptor_name': 'Cohort Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D003430', 'descriptor_name': 'Cross-Sectional Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D030541', 'descriptor_name': 'Databases, Genetic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006967', 'descriptor_name': 'Hypersensitivity', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057094', 'descriptor_name': 'Nuclear Receptor Subfamily 1, Group F, Member 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D057094', 'descriptor_name': 'Nuclear Receptor Subfamily 1, Group F, Member 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010641', 'descriptor_name': 'Phenotype', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020641', 'descriptor_name': 'Polymorphism, Single Nucleotide', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D043562', 'descriptor_name': 'Receptors, G-Protein-Coupled', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012307', 'descriptor_name': 'Risk Factors', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1002/ppul.24292', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S144578311', 'display_name': 'Pediatric Pulmonology', 'issn_l': '1099-0496', 'issn': ['1099-0496', '8755-6863'], 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://pure.manchester.ac.uk/ws/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'pdf_url': 'https://pure.manchester.ac.uk/ws/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'source': {'id': 'https://openalex.org/S4306400662', 'display_name': 'Research Explorer (The University of Manchester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I28407311', 'host_organization_name': 'University of Manchester', 'host_organization_lineage': ['https://openalex.org/I28407311'], 'host_organization_lineage_names': ['University of Manchester'], 'type': 'repository'}, 'license': 'mit', 'license_id': 'https://openalex.org/licenses/mit', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.research.manchester.ac.uk/portal/en/publications/nocturnal-asthma-is-affected-by-genetic-interactions-between-rora-and-npsr1(aaab0716-2565-4a5e-95d3-990df800692d).html', 'pdf_url': 'https://research.manchester.ac.uk/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'source': {'id': 'https://openalex.org/S4306400662', 'display_name': 'Research Explorer (The University of Manchester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I28407311', 'host_organization_name': 'University of Manchester', 'host_organization_lineage': ['https://openalex.org/I28407311'], 'host_organization_lineage_names': ['University of Manchester'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30927345', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://pure.manchester.ac.uk/ws/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'pdf_url': 'https://pure.manchester.ac.uk/ws/files/85879071/Proof_RORAxNPSR1_Gaertner_FinalVersion.pdf', 'source': {'id': 'https://openalex.org/S4306400662', 'display_name': 'Research Explorer (The University of Manchester)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_indexed_in_scopus': False, 'is_core': False, 'host_organization': 'https://openalex.org/I28407311', 'host_organization_name': 'University of Manchester', 'host_organization_lineage': ['https://openalex.org/I28407311'], 'host_organization_lineage_names': ['University of Manchester'], 'type': 'repository'}, 'license': 'mit', 'license_id': 'https://openalex.org/licenses/mit', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.8}], 'grants': [{'funder': 'https://openalex.org/F4320322169', 'funder_display_name': 'Hjärt-Lungfonden', 'award_id': None}, {'funder': 'https://openalex.org/F4320322581', 'funder_display_name': 'Vetenskapsrådet', 'award_id': None}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': 'MR/L012693/1'}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': 'MR/K002449/1'}, {'funder': 'https://openalex.org/F4320334626', 'funder_display_name': 'Medical Research Council', 'award_id': 'G0601361'}], 'datasets': [], 'versions': [], 'referenced_works_count': 43, 'referenced_works': ['https://openalex.org/W1574177110', 'https://openalex.org/W164280636', 'https://openalex.org/W1747499909', 'https://openalex.org/W1953582488', 'https://openalex.org/W1967567932', 'https://openalex.org/W1972625414', 'https://openalex.org/W1988348542', 'https://openalex.org/W1990265358', 'https://openalex.org/W1998438854', 'https://openalex.org/W2000416469', 'https://openalex.org/W2008599922', 'https://openalex.org/W2009819386', 'https://openalex.org/W2013763645', 'https://openalex.org/W2015371796', 'https://openalex.org/W2017064315', 'https://openalex.org/W2019796661', 'https://openalex.org/W2030310734', 'https://openalex.org/W2033370173', 'https://openalex.org/W2034238685', 'https://openalex.org/W2051159483', 'https://openalex.org/W2053559093', 'https://openalex.org/W2063575312', 'https://openalex.org/W2064693528', 'https://openalex.org/W2093505571', 'https://openalex.org/W2096118746', 'https://openalex.org/W2134532077', 'https://openalex.org/W2139762530', 'https://openalex.org/W2140297113', 'https://openalex.org/W2145966572', 'https://openalex.org/W2150825072', 'https://openalex.org/W2157087957', 'https://openalex.org/W2161633633', 'https://openalex.org/W2162530578', 'https://openalex.org/W2162647412', 'https://openalex.org/W2165277651', 'https://openalex.org/W2168271199', 'https://openalex.org/W2195359644', 'https://openalex.org/W242058159', 'https://openalex.org/W2808821270', 'https://openalex.org/W2811099953', 'https://openalex.org/W4233171220', 'https://openalex.org/W4236393349', 'https://openalex.org/W4249713142'], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2586801360', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Neuropeptide': [0], 'S': [1], 'Receptor': [2, 11], '1': [3], '(': [4], 'NPSR1)': [5], 'and': [6, 24, 39, 47, 65, 72, 100, 109, 117, 123, 129, 142, 154, 171], 'Retinoid': [7], 'Acid': [8], 'Receptor-Related': [9], 'Orphan': [10], 'Alpha': [12], '(RORA': [13], ')': [14], 'interact': [15], 'biologically,': [16], 'are': [17, 25, 228], 'both': [18, 140], 'known': [19], 'candidate': [20], 'genes': [21], 'for': [22, 189], 'asthma,': [23], 'involved': [26, 185], 'in': [27, 63, 68, 78, 95, 102, 111, 167, 186, 206, 217, 224], 'controlling': [28], 'circadian': [29, 225], 'rhythm.': [30], 'Thus,': [31], 'we': [32], 'assessed': [33], '(1)': [34], 'whether': [35], 'interactions': [36, 136, 149, 181], 'between': [37, 58], 'RORA': [38, 64], 'NPSR1': [40, 69, 135, 180], 'specifically': [41], 'affect': [42, 139], 'the': [43, 91, 114, 124, 199], 'nocturnal': [44, 73, 85, 143, 152, 159, 190, 207], 'asthma': [45, 55, 71, 74, 86, 141, 153, 157, 162, 208, 213, 232], 'phenotype': [46], '(2)': [48], 'how': [49], 'this': [50], 'may': [51], 'differ': [52], 'from': [53, 90, 113], 'other': [54], 'phenotypes.Interaction': [56], 'effects': [57], '24': [59], 'single-nucleotide': [60], 'polymorphisms': [61, 205], '(SNPs)': [62], '35': [66], 'SNPs': [67], 'on': [70, 198], 'symptoms': [75, 160], 'were': [76, 107, 165], 'determined': [77], '1432': [79], 'subjects': [80], '(763': [81], 'asthmatics': [82], '[192': [83], 'with': [84, 230], 'symptoms];': [87], '669': [88], 'controls)': [89], 'Multicenter': [92], 'Asthma': [93, 99, 116], 'Genetic': [94], 'Childhood/International': [96], 'Study': [97, 119], 'of': [98, 201, 212], 'Allergies': [101], 'Childhood': [103], 'studies.': [104], 'The': [105], 'results': [106], 'validated': [108], 'extended': [110], 'children': [112], 'Manchester': [115], 'Allergy': [118, 126], '(N': [120, 132], '=': [121, 133], '723)': [122], 'Children': [125], 'Milieu': [127], 'Stockholm': [128], 'Epidemiological': [130], 'cohort': [131], '1646).RORA*': [134], 'seemed': [137, 172], 'to': [138, 173, 183, 194], 'asthma.': [144, 191], 'In': [145, 192], 'stratified': [146], 'analyses,': [147], 'however,': [148], 'mainly': [150], 'affected': [151], 'less': [155], 'so': [156], 'without': [158], 'or': [161, 215], 'severity.': [163], 'Results': [164], 'replicated': [166], 'two': [168], 'independent': [169], 'cohorts': [170], 'remain': [174], 'constant': [175], 'over': [176], 'time': [177], 'throughout': [178], 'youth.RORA*': [179], 'appear': [182], 'be': [184], 'mechanisms': [187], 'specific': [188], 'contrast': [193], 'previous': [195], 'studies': [196], 'focusing': [197], 'role': [200], 'beta': [202], '2': [203], 'receptor': [204], 'as': [209], 'a': [210], 'feature': [211], 'control': [214, 227], 'severity': [216], 'general,': [218], 'our': [219], 'data': [220], 'suggest': [221], 'that': [222], 'changes': [223], 'rhythm': [226], 'associated': [229], 'nighttime': [231], 'symptoms.': [233]}, 'abstract_inverted_index_v3': None, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2934778819', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 4}, {'year': 2021, 'cited_by_count': 3}], 'updated_date': '2025-01-24T17:23:39.909694', 'created_date': '2019-04-11'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
