Publication Information

{'id': 'https://openalex.org/W2932111434', 'doi': 'https://doi.org/10.1038/s41467-019-09277-9', 'title': 'A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis', 'display_name': 'A GPX4-dependent cancer cell state underlies the clear-cell morphology and confers sensitivity to ferroptosis', 'publication_year': 2019, 'publication_date': '2019-04-08', 'ids': {'openalex': 'https://openalex.org/W2932111434', 'doi': 'https://doi.org/10.1038/s41467-019-09277-9', 'mag': '2932111434', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30962421', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6453886'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-09277-9', 'pdf_url': 'https://www.nature.com/articles/s41467-019-09277-9.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41467-019-09277-9.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5026532416', 'display_name': 'Yilong Zou', 'orcid': 'https://orcid.org/0000-0001-8198-6067'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yilong Zou', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5090707586', 'display_name': 'Michael J. Palte', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Michael J. Palte', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054590845', 'display_name': 'Amy Deik', 'orcid': 'https://orcid.org/0000-0002-9687-0953'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amy A. Deik', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101724921', 'display_name': 'Haoxin Li', 'orcid': 'https://orcid.org/0000-0002-0476-6201'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Haoxin Li', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058266150', 'display_name': 'John K. Eaton', 'orcid': 'https://orcid.org/0000-0003-4633-5546'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John K. Eaton', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100338161', 'display_name': 'Wenyu Wang', 'orcid': 'https://orcid.org/0000-0003-2816-9740'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Wenyu Wang', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066003459', 'display_name': 'Yuen‐Yi Tseng', 'orcid': 'https://orcid.org/0000-0002-8757-4087'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Yuen-Yi Tseng', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5067045094', 'display_name': 'Rebecca Deasy', 'orcid': 'https://orcid.org/0000-0001-9143-6296'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rebecca Deasy', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075457915', 'display_name': 'Maria Kost‐Alimova', 'orcid': 'https://orcid.org/0000-0002-5257-4909'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Maria Kost-Alimova', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015744482', 'display_name': 'Vlado Dančík', 'orcid': 'https://orcid.org/0000-0002-5970-6660'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vlado Dančík', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011402750', 'display_name': 'Elizaveta S. Leshchiner', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Elizaveta S. Leshchiner', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016174269', 'display_name': 'Vasanthi S. Viswanathan', 'orcid': 'https://orcid.org/0000-0001-9878-3629'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Vasanthi S. Viswanathan', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5046795494', 'display_name': 'Sabina Signoretti', 'orcid': 'https://orcid.org/0000-0002-5000-9105'}, 'institutions': [{'id': 'https://openalex.org/I4210161994', 'display_name': 'Dana-Farber Brigham Cancer Center', 'ror': 'https://ror.org/05rgrbr06', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Sabina Signoretti', 'raw_affiliation_strings': ['Department of Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncologic Pathology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA', 'institution_ids': ['https://openalex.org/I4210161994', 'https://openalex.org/I1283280774', 'https://openalex.org/I136199984', 'https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5052504518', 'display_name': 'Toni K. Choueiri', 'orcid': 'https://orcid.org/0000-0002-9201-3217'}, 'institutions': [{'id': 'https://openalex.org/I4210161994', 'display_name': 'Dana-Farber Brigham Cancer Center', 'ror': 'https://ror.org/05rgrbr06', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I4210117453', 'https://openalex.org/I4210161994', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I1283280774', 'display_name': "Brigham and Women's Hospital", 'ror': 'https://ror.org/04b6nzv94', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1283280774', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}, {'id': 'https://openalex.org/I4210117453', 'display_name': 'Dana-Farber Cancer Institute', 'ror': 'https://ror.org/02jzgtq86', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210117453']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Toni K. Choueiri', 'raw_affiliation_strings': ['Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Oncology, Dana-Farber Cancer Institute and Brigham and Women’s Hospital, Harvard Medical School, Boston, MA, 02215, USA', 'institution_ids': ['https://openalex.org/I4210161994', 'https://openalex.org/I1283280774', 'https://openalex.org/I136199984', 'https://openalex.org/I4210117453']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5019750129', 'display_name': 'Jesse S. Boehm', 'orcid': 'https://orcid.org/0000-0002-6795-6336'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jesse S. Boehm', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5075249814', 'display_name': 'Bridget K. Wagner', 'orcid': 'https://orcid.org/0000-0002-2629-361X'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bridget K. Wagner', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5051881453', 'display_name': 'John G. Doench', 'orcid': 'https://orcid.org/0000-0002-3707-9889'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'John G. Doench', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5057221073', 'display_name': 'Clary B. Clish', 'orcid': 'https://orcid.org/0000-0001-8259-9245'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Clary B. Clish', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021915671', 'display_name': 'Paul A. Clemons', 'orcid': 'https://orcid.org/0000-0002-1800-5112'}, 'institutions': [{'id': 'https://openalex.org/I107606265', 'display_name': 'Broad Institute', 'ror': 'https://ror.org/05a0ya142', 'country_code': 'US', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I107606265']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Paul A. Clemons', 'raw_affiliation_strings': ['The Broad Institute, Cambridge, MA, 02142, USA'], 'affiliations': [{'raw_affiliation_string': 'The Broad Institute, Cambridge, MA, 02142, USA', 'institution_ids': ['https://openalex.org/I107606265']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5035618234', 'display_name': 'Stuart L. Schreiber', 'orcid': 'https://orcid.org/0000-0003-1922-7558'}, 'institutions': [{'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Stuart L. Schreiber', 'raw_affiliation_strings': ['Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Chemistry and Chemical Biology, Harvard University, Cambridge, MA, 02138, USA', 'institution_ids': ['https://openalex.org/I136199984']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'apc_paid': {'value': 3920, 'currency': 'GBP', 'value_usd': 4808, 'provenance': 'doaj'}, 'fwci': 62.256, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 642, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '10', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11297', 'display_name': 'Ferroptosis and cancer prognosis', 'score': 0.9996, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12465', 'display_name': 'Cancer, Lipids, and Metabolism', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/1306', 'display_name': 'Cancer Research'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10269', 'display_name': 'Epigenetics and DNA Methylation', 'score': 0.9984, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gpx4', 'display_name': 'GPX4', 'score': 0.8357546}], 'concepts': [{'id': 'https://openalex.org/C158086472', 'wikidata': 'https://www.wikidata.org/wiki/Q21103287', 'display_name': 'GPX4', 'level': 5, 'score': 0.8357546}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5570435}, {'id': 'https://openalex.org/C2780829032', 'wikidata': 'https://www.wikidata.org/wiki/Q898539', 'display_name': 'Lipid peroxidation', 'level': 3, 'score': 0.5345411}, {'id': 'https://openalex.org/C1491633281', 'wikidata': 'https://www.wikidata.org/wiki/Q7868', 'display_name': 'Cell', 'level': 2, 'score': 0.46215537}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.46005508}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.43187878}, {'id': 'https://openalex.org/C538909803', 'wikidata': 'https://www.wikidata.org/wiki/Q116907', 'display_name': 'Glutathione', 'level': 3, 'score': 0.29874647}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.21776691}, {'id': 'https://openalex.org/C2778760513', 'wikidata': 'https://www.wikidata.org/wiki/Q24773045', 'display_name': 'Glutathione peroxidase', 'level': 4, 'score': 0.20680797}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.19879013}], 'mesh': [{'descriptor_ui': 'D000368', 'descriptor_name': 'Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017209', 'descriptor_name': 'Apoptosis', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D051792', 'descriptor_name': 'Basic Helix-Loop-Helix Transcription Factors', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D064113', 'descriptor_name': 'CRISPR-Cas Systems', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D002292', 'descriptor_name': 'Carcinoma, Renal Cell', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020869', 'descriptor_name': 'Gene Expression Profiling', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015972', 'descriptor_name': 'Gene Expression Regulation, Neoplastic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055786', 'descriptor_name': 'Gene Knockout Techniques', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005979', 'descriptor_name': 'Glutathione Peroxidase', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007501', 'descriptor_name': 'Iron', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D007680', 'descriptor_name': 'Kidney Neoplasms', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015227', 'descriptor_name': 'Lipid Peroxidation', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008875', 'descriptor_name': 'Middle Aged', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009363', 'descriptor_name': 'Neoplasm Proteins', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D000080662', 'descriptor_name': 'Phospholipid Hydroperoxide Glutathione Peroxidase', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D034622', 'descriptor_name': 'RNA Interference', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D023041', 'descriptor_name': 'Xenograft Model Antitumor Assays', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 5, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-09277-9', 'pdf_url': 'https://www.nature.com/articles/s41467-019-09277-9.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/30381869b6f34533b2be4a86cf0a583a', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6453886', 'pdf_url': 'https://europepmc.org/articles/pmc6453886?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453886', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30962421', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41467-019-09277-9', 'pdf_url': 'https://www.nature.com/articles/s41467-019-09277-9.pdf', 'source': {'id': 'https://openalex.org/S64187185', 'display_name': 'Nature Communications', 'issn_l': '2041-1723', 'issn': ['2041-1723'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.78}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 72, 'referenced_works': ['https://openalex.org/W1501532961', 'https://openalex.org/W1597517760', 'https://openalex.org/W1969174225', 'https://openalex.org/W1977580495', 'https://openalex.org/W1989040551', 'https://openalex.org/W1992412494', 'https://openalex.org/W1994720359', 'https://openalex.org/W1997685539', 'https://openalex.org/W1998914462', 'https://openalex.org/W2001877789', 'https://openalex.org/W2002490399', 'https://openalex.org/W2010224245', 'https://openalex.org/W2010819467', 'https://openalex.org/W2010826470', 'https://openalex.org/W2035898183', 'https://openalex.org/W2038005397', 'https://openalex.org/W2043398720', 'https://openalex.org/W2045171661', 'https://openalex.org/W2046422846', 'https://openalex.org/W2048395893', 'https://openalex.org/W2052446872', 'https://openalex.org/W2071006154', 'https://openalex.org/W2094242056', 'https://openalex.org/W2094518946', 'https://openalex.org/W2111867681', 'https://openalex.org/W2128865543', 'https://openalex.org/W2129299356', 'https://openalex.org/W2135546443', 'https://openalex.org/W2137465719', 'https://openalex.org/W2152883907', 'https://openalex.org/W2163005196', 'https://openalex.org/W2175970000', 'https://openalex.org/W2220553089', 'https://openalex.org/W2252568502', 'https://openalex.org/W2408722709', 'https://openalex.org/W2470530820', 'https://openalex.org/W2470889344', 'https://openalex.org/W2508296626', 'https://openalex.org/W2510079645', 'https://openalex.org/W2513249090', 'https://openalex.org/W2549188196', 'https://openalex.org/W2550324626', 'https://openalex.org/W2554098255', 'https://openalex.org/W2566405543', 'https://openalex.org/W2568082326', 'https://openalex.org/W2586265133', 'https://openalex.org/W2587925611', 'https://openalex.org/W2613084028', 'https://openalex.org/W2614480329', 'https://openalex.org/W2727828415', 'https://openalex.org/W2739942166', 'https://openalex.org/W2740317277', 'https://openalex.org/W2741508285', 'https://openalex.org/W2750899255', 'https://openalex.org/W2759112714', 'https://openalex.org/W2762087180', 'https://openalex.org/W2767055857', 'https://openalex.org/W2768079652', 'https://openalex.org/W2781417302', 'https://openalex.org/W2783776613', 'https://openalex.org/W2791106312', 'https://openalex.org/W2791879511', 'https://openalex.org/W2792487685', 'https://openalex.org/W2797906965', 'https://openalex.org/W2799862686', 'https://openalex.org/W2806219344', 'https://openalex.org/W2808190086', 'https://openalex.org/W2883811961', 'https://openalex.org/W2891967018', 'https://openalex.org/W2903107073', 'https://openalex.org/W2953135007', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W52860301', 'https://openalex.org/W4319310796', 'https://openalex.org/W4315864849', 'https://openalex.org/W3186143435', 'https://openalex.org/W2980161056', 'https://openalex.org/W2545003596', 'https://openalex.org/W2416835948', 'https://openalex.org/W2406748704', 'https://openalex.org/W2160733843', 'https://openalex.org/W1971820093'], 'abstract_inverted_index': {'Abstract': [0], 'Clear-cell': [1], 'carcinomas': [2], '(CCCs)': [3], 'are': [4, 20, 29], 'a': [5, 32, 87, 124], 'histological': [6], 'group': [7], 'of': [8, 35, 89, 110, 140], 'highly': [9], 'aggressive': [10], 'malignancies': [11], 'commonly': [12], 'originating': [13], 'in': [14, 52, 127, 149], 'the': [15, 48, 81, 100, 108, 138], 'kidney': [16], 'and': [17, 25, 28, 58, 61, 76, 129, 146], 'ovary.': [18], 'CCCs': [19], 'distinguished': [21], 'by': [22, 65, 106, 144], 'aberrant': [23], 'lipid': [24, 104, 112], 'glycogen': [26], 'accumulation': [27], 'refractory': [30], 'to': [31, 44], 'broad': [33], 'range': [34], 'anti-cancer': [36], 'therapies.': [37], 'Here': [38], 'we': [39, 79], 'identify': [40, 80], 'an': [41], 'intrinsic': [42], 'vulnerability': [43, 55], 'ferroptosis': [45], 'associated': [46], 'with': [47, 71], 'unique': [49], 'metabolic': [50, 147], 'state': [51], 'CCCs.': [53], 'This': [54], 'transcends': [56], 'lineage': [57], 'genetic': [59], 'landscape,': [60], 'can': [62, 134], 'be': [63, 135], 'exploited': [64], 'inhibiting': [66], 'glutathione': [67], 'peroxidase': [68], '4': [69], '(GPX4)': [70], 'small-molecules.': [72], 'Using': [73], 'CRISPR': [74], 'screening': [75], 'lipidomic': [77], 'profiling,': [78], 'hypoxia-inducible': [82], 'factor': [83], '(HIF)': [84], 'pathway': [85], 'as': [86, 123], 'driver': [88], 'this': [90], 'vulnerability.': [91], 'In': [92], 'renal': [93], 'CCCs,': [94, 128], 'HIF-2α': [95], 'selectively': [96], 'enriches': [97], 'polyunsaturated': [98], 'lipids,': [99], 'rate-limiting': [101], 'substrates': [102], 'for': [103], 'peroxidation,': [105], 'activating': [107], 'expression': [109], 'hypoxia-inducible,': [111], 'droplet-associated': [113], 'protein': [114], '(': [115], 'HILPDA': [116], ').': [117], 'Our': [118], 'study': [119], 'suggests': [120], 'targeting': [121], 'GPX4': [122], 'therapeutic': [125, 132], 'opportunity': [126], 'highlights': [130], 'that': [131], 'approaches': [133], 'identified': [136], 'on': [137], 'basis': [139], 'cell': [141], 'states': [142], 'manifested': [143], 'morphological': [145], 'features': [148], 'hard-to-treat': [150], 'cancers.': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2932111434', 'counts_by_year': [{'year': 2024, 'cited_by_count': 140}, {'year': 2023, 'cited_by_count': 166}, {'year': 2022, 'cited_by_count': 145}, {'year': 2021, 'cited_by_count': 97}, {'year': 2020, 'cited_by_count': 72}, {'year': 2019, 'cited_by_count': 11}, {'year': 2018, 'cited_by_count': 2}], 'updated_date': '2024-12-21T10:23:22.916929', 'created_date': '2019-04-11'}