Publication Information

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1284, 1339, 1507, 1574, 1639, 1679, 1914, 1923, 1976], 'suspected': [190, 528, 799, 1575, 1640], 'acute': [191, 529, 800, 1086, 1576, 1918], 'coronary': [192, 421, 432, 459, 499, 518, 530, 630, 695, 801, 892, 919, 928, 971, 1030, 1052, 1064, 1076, 1123, 1131, 1185, 1209, 1577, 1634, 1695], 'syndromes': [193], 'led': [195], 'a': [197, 278, 335, 381, 650, 653, 1163, 1232, 1241, 1294, 1298, 1389, 1579, 1802], 'new': [198], 'taxonomy': [199], 'define': [201, 1319], 'classify': [203], 'myocardial': [204, 238, 275, 303, 348, 356, 580, 677, 814, 1091, 1160, 1278, 1373, 1750, 1919], 'infarction.': [205, 239, 349, 815], 'Improvements': [206], 'assay': [208, 221, 1692, 1800], 'sensitivity': [209, 1509], 'now': [210, 1346], 'permit': [211], 'reliable': [213], 'measurement': [214], 'levels': [218, 1013], 'above': [219, 950], 'detection': [222], 'threshold': [223, 271, 318, 337], 'majority': [226], 'presenting': [229], 'emergency': [232, 296, 525, 1021, 1504], 'department,': [233], 'including': [234], 'those': [236, 388, 504, 522, 568, 700, 812, 898, 915, 962, 1060, 1213, 1459], 'without': [237, 355, 619, 813, 1159, 1214, 1277, 1372], 'Increasingly,': [240], 'we': [241, 682], 'understand': [242], 'value': [244], 'these': [246, 410, 757, 788, 1171, 1350], 'measures': [247], 'developing': [250], 'ways': [251], 'harness': [253], 'information': [255, 1146], 'guide': [258, 1152, 1364], 'our': [259, 1167], 'decisions.1A': [261], 'measurable': [262], 'high-sensitivity': [263, 804], '(hs-cTn)': [266, 807], 'concentration': [267, 1116], 'well': [268], 'below': [269, 392, 539, 1117, 1967], 'used': [272, 689], 'diagnose': [274], 'infarction': [276, 304, 357, 581, 678, 1092, 1161, 1279, 1920], 'is': [277, 597, 643, 859, 924, 981, 1126, 1162, 1238, 1245, 1280, 1345, 1378, 2143, 2159, 2187], 'powerful': [279], 'independent': [280], 'predictor': [281], 'future': [283], 'cardiovascular': [284, 384, 473, 555, 735, 833, 901, 1299], 'events.1,2': [285], 'hs-cTn': [288, 360, 390, 448, 483, 506, 685, 822, 872, 948, 967, 987, 1003, 1115, 1148, 1292], 'concentrations': [289, 361, 391, 484, 507, 535, 561, 686, 823, 873, 949, 1004, 1513], '<5': [290, 508, 824], 'ng/L': [291, 364, 487, 537, 825, 876, 1007], 'at': [292, 299, 338, 404, 999, 1570], 'presentation': [293, 1571], 'department': [297, 526, 1022, 1505], 'low': [300, 330, 711, 819], 'risk': [301, 316, 331, 394, 474, 549, 712, 736, 820, 834, 869, 902, 946, 1300, 1335, 1748], 'or': [305, 633, 697, 745, 767, 843, 1187, 1463], 'death': [307], 'up': [308], 'days': [311], 'later.2': [312], 'Incorporation': [313], 'stratification': [317, 395], 'into': [319, 444, 1297, 1352], 'an': [320, 547, 1322, 2160], 'early-rule-out': [321], 'pathway': [322], 'reduces': [323], 'number': [325], 'misclassified': [328], 'as': [329, 494, 649, 739, 818, 867, 944, 998, 1223, 1293], 'compared': [332, 386, 502], 'using': [334, 803, 1315], 'single': [336], '99th': [340, 367, 490, 541, 879, 952, 1010, 1119, 1969], 'percentile': [341, 368, 491, 542, 880, 953, 1120], 'rule': [343, 346], 'out': [347, 585, 1128], 'However,': [350, 637, 1173], '1': [351, 405, 992], '3': [353, 994], 'intermediate': [359, 868, 1000], 'between': [362, 485, 874, 1005], '5': [363, 375, 486, 875, 1006], 'upper': [369], 'reference': [370, 1517], 'limit.': [371], 'These': [372], 'times': [376], 'more': [377, 1070, 1192, 1304, 1795], 'likely': [378, 495, 704, 1100], 'have': [380, 497, 628, 918], 'major': [382], 'adverse': [383], 'event': [385, 398], 'threshold,': [396], 'rates': [399], '3.3%': [401], '0.6%': [403], 'year,': [406], 'respectively.2Mechanisms': [407], 'explain': [409], 'associations': [411], 'emerging': [413, 2012], 'through': [414], 'imaging': [415, 932, 1106], 'studies': [416], 'stable': [420, 517, 559, 862, 871, 1047, 1112, 1341, 1694], 'heart': [422, 519, 552, 573, 635, 1189], 'disease.3': [423], 'A': [424, 624, 1687, 1847, 2000, 2085], '5-fold': [425], 'gradient': [426], 'prevalence': [429], 'obstructive': [431, 458, 498], 'artery': [433, 460, 500, 631, 920, 929, 1065, 1124, 1186, 1210, 1635, 1696, 2196], 'disease': [434, 461, 501, 520, 632, 1066, 1125, 1190, 1211, 1636], 'from': [435, 657, 782, 1034, 1268, 1394, 1409, 1417, 1428, 1442], '9%': [436], '48%': [438], 'was': [439], 'observed': [440], 'across': [441], 'grouped': [443], 'quintiles': [445], 'according': [446], 'concentration.': [449], 'For': [450], 'every': [451], 'doubling': [452], 'hs-cTn,': [454], 'likelihood': [456], 'increased': [462, 548], 'by': [463, 1058, 1201, 1380, 2153], 'one-third': [464], 'after': [465, 579, 894], 'adjustment': [466], 'age,': [468], 'sex,': [469], 'chest': [470, 762, 1087], 'pain': [471, 1088], 'characteristics,': [472], 'factors,': [475, 835], 'noninvasive': [477, 1365], 'test': [478], 'results.': [479], 'Those': [480, 864], 'were': [492, 1107], 'twice': [493], 'ng/L.': [509], 'At': [510], 'same': [512], 'time,': [513], 'attending': [523], 'syndrome,': [531], 'serial': [532, 717, 1017], '>5': [536], 'but': [538, 1310, 1921], 'also': [544, 566], 'associated': [545, 1283], 'incident': [551], 'failure': [553], 'death,4': [556], 'suggesting': [557], 'that': [558, 595, 684, 1050, 1074, 1147, 1272, 1290, 2183], 'range': [564], 'may': [565, 721, 1302], 'identify': [567], 'unrecognized': [571, 629, 1183], 'structural': [572, 634, 1188], 'disease.The': [574], 'use': [575, 776, 1169, 1237, 1359], 'secondary': [577, 783, 1253], 'investigations': [578, 789], 'been': [583, 680, 1094, 1326], 'ruled': [584, 1127], 'varies': [586, 647], 'widely': [587, 648], 'among': [588, 777], 'centers': [589, 786], 'physicians,': [591], 'little': [593], 'evidence': [594, 656, 926, 1033, 1267], 'proportional': [598], 'objective': [600], 'risk.': [601, 1320], 'In': [602], 'some': [603], 'centers,': [604, 614], 'even': [605], 'very-low-risk': [606], 'individuals': [607, 778], 'undergo': [608], 'routine': [609], 'testing,': [610], 'whereas': [611], 'other': [613, 725], 'discharged': [618, 829, 1922], 'further': [620, 886, 931, 1135], 'investigation': [621, 724, 751, 810, 848, 887, 1154, 1274], 'treatment.': [623], 'significant': [625, 1184], 'proportion': [626], 'will': [627, 1264], 'disease.': [636, 921], 'optimal': [639], 'subsequent': [640], 'management': [641], 'strategy': [642], 'unclear,': [644], 'result': [651], 'lack': [654], 'prospective': [658, 1269], 'trials.': [660], 'Consequently,': [661], 'current': [662, 1168, 1308], 'guidelines': [663], 'do': [664], 'not': [665, 722, 1457], 'recommend': [666], 'any': [667, 2180], 'particular': [668], 'investigative': [669], 'approach': [670, 772, 1244, 1313, 1323], 'large': [673], 'group': [674], 'patients.Once': [676], 'excluded,': [681], 'propose': [683], 'could': [687, 827, 852, 939, 1023, 1198], 'be': [688, 753, 828, 853, 883, 905, 912, 940, 990, 1024, 1079, 1098, 1142, 1199, 1303], 'target': [691, 809], 'computed': [692, 889], 'tomography': [693, 890], '(CT)': [694, 891], 'angiography': [696, 893, 1053, 1077, 1745], 'echocardiography': [698, 1133], 'who': [701, 709], 'benefit': [706, 781, 1082], '(Figure).': [707], 'on': [713, 1016, 1129, 2145], 'basis': [715], 'measurements': [720], 'require': [723, 955], 'than': [726, 1306], 'follow-up': [727], 'their': [729, 985], 'primary': [730], 'care': [731, 1369], 'physician': [732], 'assess': [734, 1136], 'factors': [737, 903], 'such': [738], 'blood': [740], 'pressure': [741], 'lipid': [743], 'profile': [744], 'screening': [746, 831], 'diabetes': [748, 844], 'mellitus.': [749], 'Further': [750, 847], 'would': [752, 773, 1078, 1097, 1141], 'considered': [754, 854, 884], 'only': [755], 'if': [756, 855, 1105], 'low-risk': [758, 850], 'report': [760], 'ongoing': [761], 'pains': [763], 'consistent': [764, 860], 'typical': [766], 'atypical': [768], 'angina': [769, 1048, 1342, 1641], 'pectoris.': [770], 'This': [771, 2158], 'reduce': [774], 'resource': [775, 1236], 'unlikely': [779], 'where': [787], 'performed': [791], 'widely.Download': [792], 'figureDownload': [793], 'PowerPointFigure.': [794], 'Pathway': 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'presentation,': [986], 'repeated': [991], 'later.Patients': [996], 'risk,': [1001], 'percentile,': [1011], 'whose': [1012], 'unchanged': [1015], 'tests': [1018], 'triaged': [1025], 'early': [1027], 'outpatient': [1028], 'CT': [1029, 1051, 1075, 1130, 1744], 'Recent': [1032, 2002], 'SCOT-HEART': [1035, 1741], '(Scottish': [1036], 'Computed': [1037, 1854], 'Tomography': [1038], 'Heart': [1041, 1397, 1467, 2150], 'Trial)': [1042], 'possible': [1046, 1340], 'suggests': [1049], 'can': [1054, 1367], 'improve': [1055, 1102, 1329, 1368], 'long-term': [1056, 1103], 'outcomes': [1057, 1104, 1502], 'identifying': [1059], 'underlying': [1063], 'targeting': [1068, 1194], 'therapy': [1069], 'effectively.5': [1071], 'We': [1072], 'anticipate': [1073], 'similar': [1081], 'excluded': [1095], 'targeted': [1108], 'increases': [1113], 'range.': [1121], 'When': [1122], 'angiography,': [1132], 'indicated.Harnessing': [1143], 'prognostic': [1145], 'assays': [1149], 'offer': [1150], 'logical': [1164], 'extension': [1165], 'tests.': [1172], 'potential': [1175, 1203, 1219], 'benefits': [1176], 'identification': [1179], 'effective': [1193, 1281, 1305], 'treatments': [1197], 'offset': [1200], 'harm.': [1205], 'diagnosis': [1207, 1632], 'ischemic': [1215], 'cause': [1221], 'confusion': [1222], 'nature': [1226], "patients'": [1229], 'symptoms.': [1230], 'Thus,': [1231], 'careful': [1233], 'required': [1239], 'when': [1240], 'troponin–guided': [1243], 'introduced': [1246], 'selection': [1249], 'practice.Future': [1256], 'research': [1257, 1401, 1436], 'address': [1259], 'areas': [1260], 'uncertainty': [1262], 'ideally': [1265], 'provide': [1266], 'randomized': [1270], 'trials': [1271], 'hs-cTn–guided': [1273], 'better': [1285], 'outcomes.': [1286], 'Likewise,': [1287], 'innovative': [1288], 'approaches': [1289], 'incorporate': [1291], 'continuous': [1295], 'measure': [1296], 'score': [1301], 'practical,': [1309], 'perhaps': [1311], 'simplistic,': [1312], 'binary': [1316], 'thresholds': 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'Hospital': [1441], 'Novartis,': [1445], 'Singulex,': [1448], 'SomaLogic.FootnotesThe': [1450], 'opinions': [1451], 'expressed': [1452], 'article': [1455, 2163], 'necessarily': [1458], 'editors': [1462], 'American': [1466, 1865, 2149], 'Association.https://www.ahajournals.org/journal/circTorbjørn': [1468], 'torbjorn.[email': [1485], 'protected]uio.noReferences1.': [1486], 'Sandoval': [1487, 1528], 'Y,': [1488, 1529], 'Smith': [1489, 1532], 'SW,': [1490, 1533], 'Sexter': [1491], 'A,': [1492, 1527, 1543, 1547, 1551, 1590, 1721, 1774, 1776, 1820, 1824, 1891, 1938, 1946, 1948, 2056, 2062, 2064, 2070, 2078], 'Gunsolus': [1493], 'IL,': [1494], 'Schulz': [1495], 'K,': [1496, 1770, 1778, 1818, 2058], 'Apple': [1497, 1558], 'FS.': [1498], 'features': [1500], 'high-': [1508], 'I': [1512, 1569, 1629], 'within': [1514], 'normal': [1515], 'sex-specific': [1516], 'intervals.Circulation.': [1518], '2019;': [1519], '139:1753–1755.': [1520], 'doi:': [1521, 1584, 1648, 1703, 1757], 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