Abstract: Advanced MaterialsVolume 31, Issue 12 1970083 Inside Front CoverFree Access Biomaterials: Phytochrome-Based Extracellular Matrix with Reversibly Tunable Mechanical Properties (Adv. Mater. 12/2019) Maximilian Hörner, Maximilian Hörner Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorKatrin Raute, Katrin Raute Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorBarbara Hummel, Barbara Hummel Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, GermanySearch for more papers by this authorJosef Madl, Josef Madl Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorGuido Creusen, Guido Creusen Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorOliver S. Thomas, Oliver S. Thomas Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorErik H. Christen, Erik H. Christen Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorNatascha Hotz, Natascha Hotz Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRaphael J. Gübeli, Raphael J. Gübeli Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRaphael Engesser, Raphael Engesser Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Institute of Physics, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorBalder Rebmann, Balder Rebmann Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorJasmin Lauer, Jasmin Lauer Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany G.E.R.N. Tissue Replacement, Regeneration and Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanySearch for more papers by this authorBernd Rolauffs, Bernd Rolauffs G.E.R.N. Tissue Replacement, Regeneration and Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanySearch for more papers by this authorJens Timmer, Jens Timmer Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Institute of Physics, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWolfgang W. A. Schamel, Wolfgang W. A. Schamel Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Centre for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorJan Pruszak, Jan Pruszak Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWinfried Römer, Winfried Römer Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorMatias D. Zurbriggen, Matias D. Zurbriggen Institute of Synthetic Biology and CEPLAS, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, GermanySearch for more papers by this authorChristian Friedrich, Christian Friedrich Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorAndreas Walther, Andreas Walther Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, Germany Cluster of Excellence Living, Adaptive and Energy-Autonomous Materials Systems (livMatS), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorSusana Minguet, Susana Minguet Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Centre for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRitwick Sawarkar, Ritwick Sawarkar Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWilfried Weber, Wilfried Weber Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this author Maximilian Hörner, Maximilian Hörner Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorKatrin Raute, Katrin Raute Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorBarbara Hummel, Barbara Hummel Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, GermanySearch for more papers by this authorJosef Madl, Josef Madl Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorGuido Creusen, Guido Creusen Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorOliver S. Thomas, Oliver S. Thomas Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorErik H. Christen, Erik H. Christen Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorNatascha Hotz, Natascha Hotz Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRaphael J. Gübeli, Raphael J. Gübeli Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRaphael Engesser, Raphael Engesser Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Institute of Physics, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorBalder Rebmann, Balder Rebmann Faculty of Biology, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorJasmin Lauer, Jasmin Lauer Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany G.E.R.N. Tissue Replacement, Regeneration and Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanySearch for more papers by this authorBernd Rolauffs, Bernd Rolauffs G.E.R.N. Tissue Replacement, Regeneration and Neogenesis, Department of Orthopedics and Trauma Surgery, Medical Center, Faculty of Medicine, University of Freiburg, 79085 Freiburg, GermanySearch for more papers by this authorJens Timmer, Jens Timmer Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Institute of Physics, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWolfgang W. A. Schamel, Wolfgang W. A. Schamel Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Centre for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorJan Pruszak, Jan Pruszak Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Institute of Anatomy and Cell Biology, Department of Molecular Embryology, Faculty of Medicine, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWinfried Römer, Winfried Römer Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorMatias D. Zurbriggen, Matias D. Zurbriggen Institute of Synthetic Biology and CEPLAS, Heinrich Heine University Düsseldorf, 40204 Düsseldorf, GermanySearch for more papers by this authorChristian Friedrich, Christian Friedrich Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorAndreas Walther, Andreas Walther Institute for Macromolecular Chemistry, FMF Freiburg Materials Research Center, University of Freiburg, 79104 Freiburg, Germany Freiburg Center for Interactive Materials and Bioinspired Technology (FIT), University of Freiburg, 79110 Freiburg, Germany Cluster of Excellence Living, Adaptive and Energy-Autonomous Materials Systems (livMatS), University of Freiburg, 79110 Freiburg, GermanySearch for more papers by this authorSusana Minguet, Susana Minguet Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, Germany Centre for Chronic Immunodeficiency (CCI), Medical Center, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorRitwick Sawarkar, Ritwick Sawarkar Max Planck Institute of Immunobiology and Epigenetics, 79108 Freiburg, Germany CIBSS - Centre for Integrative Biological Signalling Studies, University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this authorWilfried Weber, Wilfried Weber Signalling Research Centres BIOSS and CIBSS, University of Freiburg, 79104 Freiburg, Germany Faculty of Biology, University of Freiburg, 79104 Freiburg, Germany Spemann Graduate School of Biology and Medicine (SGBM), University of Freiburg, 79104 Freiburg, GermanySearch for more papers by this author First published: 19 March 2019 https://doi.org/10.1002/adma.201970083AboutPDF ToolsRequest permissionExport citationAdd to favoritesTrack citation ShareShare Give accessShare full text accessShare full-text accessPlease review our Terms and Conditions of Use and check box below to share full-text version of article.I have read and accept the Wiley Online Library Terms and Conditions of UseShareable LinkUse the link below to share a full-text version of this article with your friends and colleagues. Learn more.Copy URL Share a linkShare onFacebookTwitterLinkedInRedditWechat Graphical Abstract In article number 1806727, Wilfried Weber and co-workers present a synthetic extracellular matrix, the mechanical properties of which can be tuned in a fast and reversible manner by light in the red spectrum. They apply this matrix to optically control the migration of primary T lymphocytes and to analyze mechanosignalling in mesenchymal stem cells in response to dynamic mechanical cues. Cover image designed by Jo Richers (www.jorichers.com). Volume31, Issue12March 22, 20191970083 RelatedInformation