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[16], 'the': [17, 31, 72, 79, 92, 107, 153, 177, 181, 194, 223, 250, 258, 263, 283, 288, 291, 294, 301, 312], 'MAINRITSAN': [18], 'trial.': [19], 'MAINRITSAN2': [20], 'a': [22, 38, 46, 54, 61, 83, 86, 102, 117, 132, 160, 189, 218], 'randomised,': [23], 'open-label,': [24], 'multicentre': [25], 'phase': [26], 'III': [27], 'trial': [28], 'which': [29], 'evaluated': [30], 'difference': [32], 'between': [33, 82], 'an': [34, 111, 135], 'individually': [35, 112, 208], 'tailored': [36, 113, 209], 'and': [37, 85, 128, 148, 203, 240, 243, 327, 342], 'fixed-schedule': [39, 87, 118, 224], 'therapy': [41, 114, 119, 211, 225], 'with': [42, 89, 120, 166, 172, 212, 319], 'rituximab.': [43], 'We': [44, 130, 158], 'found': [45], 'large': [47], 'number': [48, 161, 252], 'studies': [50, 309], 'evaluating': [51], 'in': [57, 257, 269, 278, 282, 304], 'AAVs,': [58], 'but': [59], 'only': [60], 'few': [62], 'looked': [63], 'at': [64], 'economic': [65], 'considerations.': [66], 'This': [67, 274], 'cost-minimisation': [68, 103], 'analysis': [69], '(CMA)': [70], 'provides': [71], 'best': [73], 'data': [74], 'available': [75], 'to': [76, 105, 116, 216, 222, 249, 299, 315, 323], 'date': [77], 'on': [78], 'cost-saving': [80, 219], 'option': [81, 303], 'tailored-therapy': [84, 295], 'regimen': [88, 265, 296], 'for': [91, 122, 169, 346], 'AAVs.': [96, 126], '<h3>Purpose</h3>': [97], 'present': [99], 'study': [100], 'used': [101], 'approach': [104], 'examine': [106], 'real-world': [108], 'costs': [109, 142, 150, 236, 245, 268, 313], 'compared': [115, 221], 'remission': [123], '<h3>Material': [127], 'methods</h3>': [129], 'performed': [131], 'CMA': [133], 'over': [134], '18': [136], 'month': [137], 'time': [138], 'period,': [139], 'estimating': [140], 'direct': [141], '–': [143, 151], 'drug': [144, 234], 'acquisition,': [145], 'preparation,': [146], 'administration': [147, 244], 'monitoring': [149, 270], 'from': [152, 232], 'National': [154], 'Health': [155], 'Service': [156], 'perspective.': [157], 'conducted': [159], 'additional': [163], 'sensitivity': [164, 284], 'analyses': [165], 'different': [167], 'assumptions': [168, 280], 'unit': [170], 'costs,': [171], 'two': [173], 'further': [174], 'scenarios': [175], 'including': [176], 'interquartile': [178], 'range': [179], 'tailored-infusion': [182, 259, 264], 'group.': [183], 'In': [184, 261], 'this': [185], 'analysis,': [186], 'we': [187], 'established': [188], 'point': [190], 'view': [192], 'health': [195, 292], 'system': [196], 'without': [197], 'considering': [198], "patients'": [199], 'preferences,': [200], 'or': [201], 'indirect': [202], 'intangible': [204], 'costs.': [205, 307], '<h3>Results</h3>': [206], 'shown': [215], 'be': [217, 300], '(€6,048.36': [226], 'vs.': [227, 238, 272], '€7,850.52).': [228], 'Savings': [229], 'resulted': [230], 'primarily': [231], 'lower': [233, 241, 251], 'acquisition': [235], '(€2,861.01': [237], '€4,768.35)': [239], 'preparation': [242], '(€891.81vs.': [246], '€1,486.35),': [247], 'due': [248], 'infusions': [254], 'per': [255], 'patient': [256], 'regimen.': [260], 'contrast,': [262], 'presented': [266], 'higher': [267], '(€2,295.54': [271], '€1,886.70).': [273], 'result': [275], 'replicated': [277], 'all': [279, 311], 'considered': [281], 'analysis.': [285], '<h3>Conclusion</h3>': [286], 'From': [287], 'perspective': [289], 'system,': [293], 'would': [297], 'seem': [298], 'preferable': [302], 'terms': [305], 'Further': [308], 'assessing': [310], 'associated': [314], 'AAVs': [316], 'are': [321], 'needed': [322], 'support': [324], 'clinical': [325], 'management': [326], 'healthcare': [328], 'planning.': [329], '<h3>References': [330], 'and/or': [331], 'acknowledgements</h3>': [332], 'authors': [334], 'thank': [335], 'Eduardo': [336], 'López': [337], 'Briz,': [338], 'Ana': [339], 'Ortega': [340], 'Eslava': [341], 'Oblikue': [343], 'Consulting,': [344], 'S.L': [345], 'their': [347], 'participation.': [348], 'No': [349], 'conflict': [350], 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