Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2922018786', 'doi': 'https://doi.org/10.31631/2073-3046-2019-18-1-18-25', 'title': 'Experimental DNA-Launched Live-Attenuated Vaccines Against Yellow Fever', 'display_name': 'Experimental DNA-Launched Live-Attenuated Vaccines Against Yellow Fever', 'publication_year': 2019, 'publication_date': '2019-03-12', 'ids': {'openalex': 'https://openalex.org/W2922018786', 'doi': 'https://doi.org/10.31631/2073-3046-2019-18-1-18-25', 'mag': '2922018786'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31631/2073-3046-2019-18-1-18-25', 'pdf_url': 'https://www.epidemvac.ru/jour/article/download/657/501', 'source': {'id': 'https://openalex.org/S4210187282', 'display_name': 'Epidemiology and Vaccinal Prevention', 'issn_l': '2073-3046', 'issn': ['2073-3046', '2619-0494'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4310312789', 'host_organization_name': 'Numikom LLC', 'host_organization_lineage': ['https://openalex.org/P4310312789'], 'host_organization_lineage_names': ['Numikom LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://www.epidemvac.ru/jour/article/download/657/501', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5065607514', 'display_name': 'Peter Pushko', 'orcid': 'https://orcid.org/0000-0002-1073-6981'}, 'institutions': [{'id': 'https://openalex.org/I4210121007', 'display_name': 'Medigen (United States)', 'ror': 'https://ror.org/02gkj6c36', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I4210121007']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'P. Pushko', 'raw_affiliation_strings': ['Medigen, Inc., Frederick, MD'], 'affiliations': [{'raw_affiliation_string': 'Medigen, Inc., Frederick, MD', 'institution_ids': ['https://openalex.org/I4210121007']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023381881', 'display_name': 'Aydar A. Ishmukhametov', 'orcid': 'https://orcid.org/0000-0001-6130-4145'}, 'institutions': [{'id': 'https://openalex.org/I4210117042', 'display_name': 'Ministry of Health of the Russian Federation', 'ror': 'https://ror.org/01p8ehb87', 'country_code': 'RU', 'type': 'government', 'lineage': ['https://openalex.org/I4210117042']}], 'countries': ['RU'], 'is_corresponding': False, 'raw_author_name': 'А. А. Ishmukhametov', 'raw_affiliation_strings': ['Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences», Moscow; Sechenov First Moscow State Medical University, of the Ministry of Health of the Russian Federation, Moscow'], 'affiliations': [{'raw_affiliation_string': 'Federal State Budget Institution of Science «Chumakov Federal Scientific Center for Research and Development of Immune-andBiological Products of Russian Academy of Sciences», Moscow; Sechenov First Moscow State Medical University, of the Ministry of Health of the Russian Federation, Moscow', 'institution_ids': ['https://openalex.org/I4210117042']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111373931', 'display_name': 'Peter P. Bredenbeek', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2800006345', 'display_name': 'Leiden University Medical Center', 'ror': 'https://ror.org/05xvt9f17', 'country_code': 'NL', 'type': 'healthcare', 'lineage': ['https://openalex.org/I2800006345']}], 'countries': ['NL'], 'is_corresponding': False, 'raw_author_name': 'P. P. Bredenbeek', 'raw_affiliation_strings': ['Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden'], 'affiliations': [{'raw_affiliation_string': 'Department of Medical Microbiology, Center of Infectious Diseases, Leiden University Medical Center, Leiden', 'institution_ids': ['https://openalex.org/I2800006345']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5001748716', 'display_name': 'Igor S. Lukashevich', 'orcid': 'https://orcid.org/0000-0001-6523-5116'}, 'institutions': [{'id': 'https://openalex.org/I142740786', 'display_name': 'University of Louisville', 'ror': 'https://ror.org/01ckdn478', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I142740786']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'I. S. Lukashevich', 'raw_affiliation_strings': ['Department of Pharmacology and Toxicology, School of Medicine, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, NIH Regional Bio-containment Laboratory, University of Louisville'], 'affiliations': [{'raw_affiliation_string': 'Department of Pharmacology and Toxicology, School of Medicine, Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, NIH Regional Bio-containment Laboratory, University of Louisville', 'institution_ids': ['https://openalex.org/I142740786']}]}], 'institution_assertions': [], 'countries_distinct_count': 3, 'institutions_distinct_count': 4, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 0.235, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 2, 'citation_normalized_percentile': {'value': 0.671816, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 69, 'max': 74}, 'biblio': {'volume': '18', 'issue': '1', 'first_page': '18', 'last_page': '25'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9989, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11581', 'display_name': 'Viral Infections and Outbreaks Research', 'score': 0.9982, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10976', 'display_name': 'Viral gastroenteritis research and epidemiology', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/attenuated-vaccine', 'display_name': 'Attenuated vaccine', 'score': 0.6408088}], 'concepts': [{'id': 'https://openalex.org/C167508917', 'wikidata': 'https://www.wikidata.org/wiki/Q578537', 'display_name': 'DNA vaccination', 'level': 4, 'score': 0.83756953}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.8211671}, {'id': 'https://openalex.org/C54602769', 'wikidata': 'https://www.wikidata.org/wiki/Q1810913', 'display_name': 'Attenuated vaccine', 'level': 4, 'score': 0.6408088}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.58340967}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.565459}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.54162693}, {'id': 'https://openalex.org/C186852380', 'wikidata': 'https://www.wikidata.org/wiki/Q1142521', 'display_name': 'Electroporation', 'level': 3, 'score': 0.5075952}, {'id': 'https://openalex.org/C524204448', 'wikidata': 'https://www.wikidata.org/wiki/Q788926', 'display_name': 'Infectious disease (medical specialty)', 'level': 3, 'score': 0.48100695}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.4775506}, {'id': 'https://openalex.org/C2780801004', 'wikidata': 'https://www.wikidata.org/wiki/Q1415366', 'display_name': 'Immunization', 'level': 3, 'score': 0.37102178}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.25938827}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.21266365}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.194668}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.12531269}, {'id': 'https://openalex.org/C2779134260', 'wikidata': 'https://www.wikidata.org/wiki/Q12136', 'display_name': 'Disease', 'level': 2, 'score': 0.122587204}, {'id': 'https://openalex.org/C60987743', 'wikidata': 'https://www.wikidata.org/wiki/Q1460232', 'display_name': 'Virulence', 'level': 3, 'score': 0.121190935}, {'id': 'https://openalex.org/C142724271', 'wikidata': 'https://www.wikidata.org/wiki/Q7208', 'display_name': 'Pathology', 'level': 1, 'score': 0.0}], 'mesh': [], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.31631/2073-3046-2019-18-1-18-25', 'pdf_url': 'https://www.epidemvac.ru/jour/article/download/657/501', 'source': {'id': 'https://openalex.org/S4210187282', 'display_name': 'Epidemiology and Vaccinal Prevention', 'issn_l': '2073-3046', 'issn': ['2073-3046', '2619-0494'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4310312789', 'host_organization_name': 'Numikom LLC', 'host_organization_lineage': ['https://openalex.org/P4310312789'], 'host_organization_lineage_names': ['Numikom LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/2a97b58e0255470fb30a27d0a99e21c4', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.31631/2073-3046-2019-18-1-18-25', 'pdf_url': 'https://www.epidemvac.ru/jour/article/download/657/501', 'source': {'id': 'https://openalex.org/S4210187282', 'display_name': 'Epidemiology and Vaccinal Prevention', 'issn_l': '2073-3046', 'issn': ['2073-3046', '2619-0494'], 'is_oa': True, 'is_in_doaj': True, 'is_core': False, 'host_organization': 'https://openalex.org/P4310312789', 'host_organization_name': 'Numikom LLC', 'host_organization_lineage': ['https://openalex.org/P4310312789'], 'host_organization_lineage_names': ['Numikom LLC'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.72, 'display_name': 'Good health and well-being'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 31, 'referenced_works': ['https://openalex.org/W1963781218', 'https://openalex.org/W1977167249', 'https://openalex.org/W2000045275', 'https://openalex.org/W2000918486', 'https://openalex.org/W2007075040', 'https://openalex.org/W2008922519', 'https://openalex.org/W2014495927', 'https://openalex.org/W2016480047', 'https://openalex.org/W2023850524', 'https://openalex.org/W2027598863', 'https://openalex.org/W2030216544', 'https://openalex.org/W2038014675', 'https://openalex.org/W2041568306', 'https://openalex.org/W2053085788', 'https://openalex.org/W2060969557', 'https://openalex.org/W2064154023', 'https://openalex.org/W2064745838', 'https://openalex.org/W2065818546', 'https://openalex.org/W2072279843', 'https://openalex.org/W2089804305', 'https://openalex.org/W2096190714', 'https://openalex.org/W2097790240', 'https://openalex.org/W2105382692', 'https://openalex.org/W2112040693', 'https://openalex.org/W2123387190', 'https://openalex.org/W2147032208', 'https://openalex.org/W2151244977', 'https://openalex.org/W2163478597', 'https://openalex.org/W2181504763', 'https://openalex.org/W4211206146', 'https://openalex.org/W4285719527'], 'related_works': ['https://openalex.org/W2410451013', 'https://openalex.org/W2401727750', 'https://openalex.org/W2382184237', 'https://openalex.org/W2130202860', 'https://openalex.org/W2114269429', 'https://openalex.org/W2104395670', 'https://openalex.org/W2038014675', 'https://openalex.org/W2009072977', 'https://openalex.org/W1995850971', 'https://openalex.org/W1973081965'], 'abstract_inverted_index': {'Background': [0], 'DNA-launched': [1], 'vaccine': [2, 13, 31, 51, 94, 108, 141, 152], 'is': [3, 53], '“manufactured”': [4], 'in': [5, 70, 73, 96, 99, 111, 118, 157], 'vaccinated': [6], 'individuals': [7], 'and': [8, 16, 37, 72, 128, 150], 'does': [9], 'not': [10], 'require': [11], 'traditional': [12], 'manufacturing': [14], 'facility': [15], 'technology.': [17], 'Goals.': [18], 'Using': [19], 'yellow': [20, 46], 'fever': [21], '17D': [22], 'vaccine,': [23], 'we': [24, 135, 167], 'have': [25], 'provided': [26], 'proof-of-concept': [27], 'evidence': [28], 'that': [29], 'these': [30], 'can': [32, 162], 'be': [33], 'launched': [34], 'from': [35, 67], 'DNA': [36, 50, 69, 80, 140, 148], 'induce': [38], 'specific': [39, 122], 'immune': [40, 123], 'responses': [41, 124], 'against': [42, 125, 131], 'pathogenic': [43, 126], 'virus': [44, 66, 95, 127], 'causing': [45], 'fever.': [47], 'The': [48, 98], 'infectious': [49, 79, 139], 'technology': [52, 142, 161], 'based': [54], 'on': [55], 'the': [56, 59, 64, 82, 90, 93, 107, 165], 'transcription': [57], 'of': [58, 63, 78, 92, 106, 146], 'full-length': [60], 'genomic': [61, 84], 'RNA': [62, 85, 102], 'live-attenuated': [65, 151], 'plasmid': [68], 'vitro': [71], 'vivo.': [74], 'A': [75], 'few': [76], 'ng': [77], 'encoding': [81], 'fulllength': [83], 'are': [86], 'required': [87], 'to': [88, 114], 'initiate': [89], 'replication': [91, 105], 'vitro.': [97], 'vivo-generated': [100], 'viral': [101], 'initiates': [103], 'limited': [104], 'virus,': [109], 'which': [110, 143], 'turn': [112], 'leads': [113], 'efficient': [115], 'immunization.': [116], 'Electroporation': [117], 'vivo': [119], 'has': [120], 'induced': [121], 'protected': [129], 'mice': [130], 'fatal': [132], 'disease.': [133], 'Here': [134], 'describe': [136], 'a': [137], 'novel': [138], 'combines': [144], 'advantages': [145], 'naked': [147], 'vaccination': [149, 173], 'efficacy.': [153], 'Conclusions': [154], 'If': [155], 'successful': [156], 'further': [158], 'testing,': [159], 'this': [160], 'dramatically': [163], 'change': [164], 'way': [166], 'make': [168], 'vaccines': [169], 'as': [170, 172], 'well': [171], 'practice.': [174]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2922018786', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-20T04:03:10.358812', 'created_date': '2019-03-22'}