Title: 03:00 PM Abstract No. 316 Morphology, loadability, and releasing profiles of CalliSpheres microspheres in delivering oxaliplatin: an in vitro study
Abstract: This study aimed to explore the morphology, loadability and releasing profiles of CalliSpheres microspheres (CMS) in delivering oxaliplatin. Varied amount (20, 40, 60 and 80 mg oxaliplatin) and concentration (1.25, 2.5, 5.0 mg/ml oxaliplatin) of oxaliplatin was mixed with CSM with three sizes (50-150 μm, 100-300 μm and 300-500 μm) to measure the loadability. 20 mg oxaliplatin loaded CSM with three sizes was prepared to measure the releasing profiles, meanwhile, fetal bovine serum (FBS) was added to determine the effect of serum on oxaliplatin releasing. The morphology and size distribution of CSM with three sizes before and after 20 mg oxaliplatin loading were detected. Oxaliplatin amount was negatively correlated with loading efficiency with highest loadability in 20 mg oxaliplatin group (Maximum 40% in 50-100 μm CSM, 52% in 100-300 μm CSM, and 52% in 300-500 μm CSM), while oxaliplatin concentration was positively associated with loading efficiency. Similar drug-releasing profiles were observed among oxaliplatin loaded CSM with three sizes, and a rapid drug release was discovered in CSM with three sizes as well. We also found that FBS did not affect the drug-releasing profiles of oxaliplatin loaded CSM. In addition, CSM was modified a little to ellipse shape and less smooth after oxaliplatin loading, and it was enlarged to some extent. This study discloses drug loadability, releasing profiles and morphology change of CSM for delivering oxaliplatin, which provides potential evidences for application of oxaliplatin-loaded DEB in clinical practice.TableDiameters of Unloaded and Oxaliplatin-Loaded CalliSpheresSize of CalliSpheres (μm)Mean Diameter (μm)Increase Ratio (%)Unloaded20-mg Oxaliplatin Loaded50-1501191211.7100-3002572642.7300-50048161628.1 Open table in a new tab
Publication Year: 2019
Publication Date: 2019-02-23
Language: en
Type: article
Indexed In: ['crossref']
Access and Citation
AI Researcher Chatbot
Get quick answers to your questions about the article from our AI researcher chatbot