Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2916154476', 'doi': 'https://doi.org/10.1038/s41598-019-40339-6', 'title': 'DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates', 'display_name': 'DNA DSB Repair Dynamics following Irradiation with Laser-Driven Protons at Ultra-High Dose Rates', 'publication_year': 2019, 'publication_date': '2019-03-14', 'ids': {'openalex': 'https://openalex.org/W2916154476', 'doi': 'https://doi.org/10.1038/s41598-019-40339-6', 'mag': '2916154476', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30872656', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6418121'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-40339-6', 'pdf_url': 'https://www.nature.com/articles/s41598-019-40339-6.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://www.nature.com/articles/s41598-019-40339-6.pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5096245276', 'display_name': 'F. Hanton', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'F. Hanton', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073535477', 'display_name': 'Pankaj Chaudhary', 'orcid': 'https://orcid.org/0000-0002-0381-3635'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P. Chaudhary', 'raw_affiliation_strings': ["Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037948010', 'display_name': 'D. Doria', 'orcid': 'https://orcid.org/0000-0001-8776-5791'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. Doria', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080750320', 'display_name': 'D. Gwynne', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. Gwynne', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5062650346', 'display_name': 'C. Maiorino', 'orcid': 'https://orcid.org/0000-0002-3739-001X'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C. Maiorino', 'raw_affiliation_strings': ["Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5087897247', 'display_name': 'C. Scullion', 'orcid': 'https://orcid.org/0000-0003-1871-2447'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'C. Scullion', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029624782', 'display_name': 'H. Ahmed', 'orcid': 'https://orcid.org/0000-0002-2151-8971'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'H. Ahmed', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040051115', 'display_name': 'Thomas I. Marshall', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'T. Marshall', 'raw_affiliation_strings': ["Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040364128', 'display_name': 'K. Naughton', 'orcid': 'https://orcid.org/0000-0001-8629-2224'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'K. Naughton', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023329976', 'display_name': 'L. Romagnani', 'orcid': 'https://orcid.org/0000-0002-7053-3967'}, 'institutions': [{'id': 'https://openalex.org/I142476485', 'display_name': 'École Polytechnique', 'ror': 'https://ror.org/05hy3tk52', 'country_code': 'FR', 'type': 'education', 'lineage': ['https://openalex.org/I142476485', 'https://openalex.org/I4210145102']}, {'id': 'https://openalex.org/I4210087526', 'display_name': "Laboratoire pour l'utilisation des lasers intenses", 'ror': 'https://ror.org/002ty1h48', 'country_code': 'FR', 'type': 'facility', 'lineage': ['https://openalex.org/I1294671590', 'https://openalex.org/I142476485', 'https://openalex.org/I2738703131', 'https://openalex.org/I39804081', 'https://openalex.org/I4210087526', 'https://openalex.org/I4210145102']}], 'countries': ['FR'], 'is_corresponding': False, 'raw_author_name': 'L. Romagnani', 'raw_affiliation_strings': ["Laboratoire pour l' Utilisation des Lasers Intenses (LULI), Ecole Polytechnique, 91128, Palaiseau Cedex, France"], 'affiliations': [{'raw_affiliation_string': "Laboratoire pour l' Utilisation des Lasers Intenses (LULI), Ecole Polytechnique, 91128, Palaiseau Cedex, France", 'institution_ids': ['https://openalex.org/I142476485', 'https://openalex.org/I4210087526']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5082760513', 'display_name': 'O. Willi', 'orcid': 'https://orcid.org/0000-0002-9406-3103'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S. Kar', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037177884', 'display_name': 'Giuseppe Schettino', 'orcid': 'https://orcid.org/0000-0003-3284-3953'}, 'institutions': [{'id': 'https://openalex.org/I134421475', 'display_name': 'National Physical Laboratory', 'ror': 'https://ror.org/015w2mp89', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I134421475']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'G. Schettino', 'raw_affiliation_strings': ['National Physical Laboratory, Hampton Road, Teddington, TW11 0LW, UK'], 'affiliations': [{'raw_affiliation_string': 'National Physical Laboratory, Hampton Road, Teddington, TW11 0LW, UK', 'institution_ids': ['https://openalex.org/I134421475']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034347795', 'display_name': 'P. McKenna', 'orcid': 'https://orcid.org/0000-0001-8061-7091'}, 'institutions': [{'id': 'https://openalex.org/I181647926', 'display_name': 'University of Strathclyde', 'ror': 'https://ror.org/00n3w3b69', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I181647926']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P. McKenna', 'raw_affiliation_strings': ['Department of Physics, SUPA, University of Strathclyde, Glasgow, G4 0NG, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Physics, SUPA, University of Strathclyde, Glasgow, G4 0NG, UK', 'institution_ids': ['https://openalex.org/I181647926']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056249489', 'display_name': 'Stanley W. Botchway', 'orcid': 'https://orcid.org/0000-0002-3268-9303'}, 'institutions': [{'id': 'https://openalex.org/I1286704778', 'display_name': 'Rutherford Appleton Laboratory', 'ror': 'https://ror.org/03gq8fr08', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}, {'id': 'https://openalex.org/I162524378', 'display_name': 'Science and Technology Facilities Council', 'ror': 'https://ror.org/057g20z61', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'S. Botchway', 'raw_affiliation_strings': ['Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK', 'institution_ids': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5038121494', 'display_name': 'D. R. Symes', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I1286704778', 'display_name': 'Rutherford Appleton Laboratory', 'ror': 'https://ror.org/03gq8fr08', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}, {'id': 'https://openalex.org/I162524378', 'display_name': 'Science and Technology Facilities Council', 'ror': 'https://ror.org/057g20z61', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'D. R. Symes', 'raw_affiliation_strings': ['Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK', 'institution_ids': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037478085', 'display_name': 'P. P. Rajeev', 'orcid': 'https://orcid.org/0000-0002-7375-0000'}, 'institutions': [{'id': 'https://openalex.org/I1286704778', 'display_name': 'Rutherford Appleton Laboratory', 'ror': 'https://ror.org/03gq8fr08', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}, {'id': 'https://openalex.org/I162524378', 'display_name': 'Science and Technology Facilities Council', 'ror': 'https://ror.org/057g20z61', 'country_code': 'GB', 'type': 'government', 'lineage': ['https://openalex.org/I162524378', 'https://openalex.org/I4210087105']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'P. P. Rajeev', 'raw_affiliation_strings': ['Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK'], 'affiliations': [{'raw_affiliation_string': 'Central Laser Facility, Science and Technology Facilities Council, Rutherford Appleton Laboratory, Harwell Campus, Didcot, OX11 0QX, Oxford, UK', 'institution_ids': ['https://openalex.org/I1286704778', 'https://openalex.org/I162524378']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076875343', 'display_name': 'Kevin M. Prise', 'orcid': 'https://orcid.org/0000-0001-6134-7946'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'K. M. Prise', 'raw_affiliation_strings': ["Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Cancer Research & Cell Biology, Queen's University Belfast, Belfast, BT9 7AE, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5031742925', 'display_name': 'M. Borghesi', 'orcid': 'https://orcid.org/0000-0001-9165-0073'}, 'institutions': [{'id': 'https://openalex.org/I126231945', 'display_name': "Queen's University Belfast", 'ror': 'https://ror.org/00hswnk62', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I126231945']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'M. Borghesi', 'raw_affiliation_strings': ["Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK"], 'affiliations': [{'raw_affiliation_string': "Centre for Plasma Physics, School of Mathematics and Physics, Queen's University Belfast, Belfast, BT7 1NN, UK", 'institution_ids': ['https://openalex.org/I126231945']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 1890, 'currency': 'EUR', 'value_usd': 2190, 'provenance': 'doaj'}, 'apc_paid': {'value': 1775, 'currency': 'EUR', 'value_usd': 1914, 'provenance': 'openapc'}, 'fwci': 6.168, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 46, 'citation_normalized_percentile': {'value': 0.999975, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 96, 'max': 97}, 'biblio': {'volume': '9', 'issue': '1', 'first_page': None, 'last_page': None}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11176', 'display_name': 'Particle Therapy for Cancer Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11176', 'display_name': 'Particle Therapy for Cancer Treatment', 'score': 0.9988, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10384', 'display_name': 'Laser-Plasma Interactions and Particle Acceleration', 'score': 0.998, 'subfield': {'id': 'https://openalex.org/subfields/3106', 'display_name': 'Nuclear and High Energy Physics'}, 'field': {'id': 'https://openalex.org/fields/31', 'display_name': 'Physics and Astronomy'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T11359', 'display_name': 'Biological and Clinical Effects of Ionizing Radiation', 'score': 0.9952, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/proton-therapy', 'display_name': 'Proton Therapy', 'score': 0.599334}, {'id': 'https://openalex.org/keywords/radiotherapy', 'display_name': 'Radiotherapy', 'score': 0.545302}, {'id': 'https://openalex.org/keywords/high-power-lasers', 'display_name': 'High-Power Lasers', 'score': 0.530878}, {'id': 'https://openalex.org/keywords/dose-rate', 'display_name': 'Dose rate', 'score': 0.46739703}], 'concepts': [{'id': 'https://openalex.org/C2779343474', 'wikidata': 'https://www.wikidata.org/wiki/Q3109175', 'display_name': 'Context (archaeology)', 'level': 2, 'score': 0.68438184}, {'id': 'https://openalex.org/C111337013', 'wikidata': 'https://www.wikidata.org/wiki/Q2737837', 'display_name': 'Irradiation', 'level': 2, 'score': 0.68098944}, {'id': 'https://openalex.org/C54516573', 'wikidata': 'https://www.wikidata.org/wiki/Q2294', 'display_name': 'Proton', 'level': 2, 'score': 0.5256095}, {'id': 'https://openalex.org/C520434653', 'wikidata': 'https://www.wikidata.org/wiki/Q38867', 'display_name': 'Laser', 'level': 2, 'score': 0.51741946}, {'id': 'https://openalex.org/C3017588741', 'wikidata': 'https://www.wikidata.org/wiki/Q3042357', 'display_name': 'Dose rate', 'level': 2, 'score': 0.46739703}, {'id': 'https://openalex.org/C134935766', 'wikidata': 'https://www.wikidata.org/wiki/Q210538', 'display_name': 'DNA repair', 'level': 3, 'score': 0.4533212}, {'id': 'https://openalex.org/C148898269', 'wikidata': 'https://www.wikidata.org/wiki/Q1108792', 'display_name': 'Kinetics', 'level': 2, 'score': 0.44610208}, {'id': 'https://openalex.org/C143425029', 'wikidata': 'https://www.wikidata.org/wiki/Q5205747', 'display_name': 'DNA damage', 'level': 3, 'score': 0.41124666}, {'id': 'https://openalex.org/C2989005', 'wikidata': 'https://www.wikidata.org/wiki/Q214963', 'display_name': 'Nuclear medicine', 'level': 1, 'score': 0.40158582}, {'id': 'https://openalex.org/C552990157', 'wikidata': 'https://www.wikidata.org/wiki/Q7430', 'display_name': 'DNA', 'level': 2, 'score': 0.39375558}, {'id': 'https://openalex.org/C12554922', 'wikidata': 'https://www.wikidata.org/wiki/Q7100', 'display_name': 'Biophysics', 'level': 1, 'score': 0.36304152}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.3467301}, {'id': 'https://openalex.org/C121332964', 'wikidata': 'https://www.wikidata.org/wiki/Q413', 'display_name': 'Physics', 'level': 0, 'score': 0.3034217}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.28896773}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.2547347}, {'id': 'https://openalex.org/C177322064', 'wikidata': 'https://www.wikidata.org/wiki/Q750955', 'display_name': 'Radiochemistry', 'level': 1, 'score': 0.23312736}, {'id': 'https://openalex.org/C120665830', 'wikidata': 'https://www.wikidata.org/wiki/Q14620', 'display_name': 'Optics', 'level': 1, 'score': 0.18540648}, {'id': 'https://openalex.org/C185544564', 'wikidata': 'https://www.wikidata.org/wiki/Q81197', 'display_name': 'Nuclear physics', 'level': 1, 'score': 0.12448576}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12163386}, {'id': 'https://openalex.org/C62520636', 'wikidata': 'https://www.wikidata.org/wiki/Q944', 'display_name': 'Quantum mechanics', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C151730666', 'wikidata': 'https://www.wikidata.org/wiki/Q7205', 'display_name': 'Paleontology', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D053903', 'descriptor_name': 'DNA Breaks, Double-Stranded', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000528', 'qualifier_name': 'radiation effects', 'is_major_topic': True}, {'descriptor_ui': 'D061766', 'descriptor_name': 'Proton Therapy', 'qualifier_ui': 'Q000295', 'qualifier_name': 'instrumentation', 'is_major_topic': True}, {'descriptor_ui': 'D000071857', 'descriptor_name': 'Tumor Suppressor p53-Binding Protein 1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D002460', 'descriptor_name': 'Cell Line', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017357', 'descriptor_name': 'Cyclotrons', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017357', 'descriptor_name': 'Cyclotrons', 'qualifier_ui': 'Q000295', 'qualifier_name': 'instrumentation', 'is_major_topic': False}, {'descriptor_ui': 'D004307', 'descriptor_name': 'Dose-Response Relationship, Radiation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000166', 'qualifier_name': 'cytology', 'is_major_topic': False}, {'descriptor_ui': 'D005347', 'descriptor_name': 'Fibroblasts', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007834', 'descriptor_name': 'Lasers', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011446', 'descriptor_name': 'Prospective Studies', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061766', 'descriptor_name': 'Proton Therapy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061766', 'descriptor_name': 'Proton Therapy', 'qualifier_ui': 'Q000009', 'qualifier_name': 'adverse effects', 'is_major_topic': False}, {'descriptor_ui': 'D000071857', 'descriptor_name': 'Tumor Suppressor p53-Binding Protein 1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-40339-6', 'pdf_url': 'https://www.nature.com/articles/s41598-019-40339-6.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://hal.sorbonne-universite.fr/hal-02089385', 'pdf_url': 'https://hal.sorbonne-universite.fr/hal-02089385/document', 'source': {'id': 'https://openalex.org/S4306402512', 'display_name': 'HAL (Le Centre pour la Communication Scientifique Directe)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1294671590', 'host_organization_name': 'Centre National de la Recherche Scientifique', 'host_organization_lineage': ['https://openalex.org/I1294671590'], 'host_organization_lineage_names': ['Centre National de la Recherche Scientifique'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6418121', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30872656', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1038/s41598-019-40339-6', 'pdf_url': 'https://www.nature.com/articles/s41598-019-40339-6.pdf', 'source': {'id': 'https://openalex.org/S196734849', 'display_name': 'Scientific Reports', 'issn_l': '2045-2322', 'issn': ['2045-2322'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.55, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320334627', 'funder_display_name': 'Engineering and Physical Sciences Research Council', 'award_id': 'EP/K022415/1'}, {'funder': 'https://openalex.org/F4320334632', 'funder_display_name': 'Science and Technology Facilities Council', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 39, 'referenced_works': ['https://openalex.org/W1923055195', 'https://openalex.org/W1968042369', 'https://openalex.org/W1968685800', 'https://openalex.org/W1969960270', 'https://openalex.org/W1972199097', 'https://openalex.org/W1972373944', 'https://openalex.org/W1972613669', 'https://openalex.org/W1975052508', 'https://openalex.org/W1979663716', 'https://openalex.org/W1983531064', 'https://openalex.org/W1992386117', 'https://openalex.org/W2012018845', 'https://openalex.org/W2020611956', 'https://openalex.org/W2024215564', 'https://openalex.org/W2035757358', 'https://openalex.org/W2036417164', 'https://openalex.org/W2045869375', 'https://openalex.org/W2054827517', 'https://openalex.org/W2058925620', 'https://openalex.org/W2074301766', 'https://openalex.org/W2079693984', 'https://openalex.org/W2090112435', 'https://openalex.org/W2090364493', 'https://openalex.org/W2099540110', 'https://openalex.org/W2104009336', 'https://openalex.org/W2120829690', 'https://openalex.org/W2123538201', 'https://openalex.org/W2135419037', 'https://openalex.org/W2152042169', 'https://openalex.org/W2163726032', 'https://openalex.org/W2166220537', 'https://openalex.org/W2167525648', 'https://openalex.org/W2225135041', 'https://openalex.org/W2320495103', 'https://openalex.org/W2509964283', 'https://openalex.org/W255240917', 'https://openalex.org/W2603287690', 'https://openalex.org/W3118117235', 'https://openalex.org/W981584252'], 'related_works': ['https://openalex.org/W3125757075', 'https://openalex.org/W2760815521', 'https://openalex.org/W2747101336', 'https://openalex.org/W2108718931', 'https://openalex.org/W2107516157', 'https://openalex.org/W2055890925', 'https://openalex.org/W2033918102', 'https://openalex.org/W2004480716', 'https://openalex.org/W1991644354', 'https://openalex.org/W1972094156'], 'abstract_inverted_index': {'Abstract': [0], 'Protontherapy': [1], 'has': [2, 28, 54], 'emerged': [3], 'as': [4, 57], 'more': [5], 'effective': [6], 'in': [7, 31, 37, 135, 141, 182], 'the': [8, 40, 46, 65, 103, 108, 123, 136, 142, 156, 161, 175, 183, 191, 196], 'treatment': [9], 'of': [10, 42, 48, 64, 78, 97, 190], 'certain': [11], 'tumors': [12], 'than': [13], 'photon': [14], 'based': [15], 'therapies.': [16], 'However,': [17], 'significant': [18], 'capital': [19], 'and': [20, 36, 130, 149, 177, 187], 'operational': [21], 'costs': [22], 'make': [23], 'protontherapy': [24], 'less': [25], 'accessible.': [26], 'This': [27], 'stimulated': [29], 'interest': [30], 'alternative': [32], 'proton': [33], 'delivery': [34], 'approaches,': [35], 'this': [38, 79, 82], 'context': [39], 'use': [41], 'laser-based': [43], 'technologies': [44], 'for': [45, 73, 155], 'generation': [47], 'ultra-high': [49, 69], 'dose': [50, 95, 152, 197], 'rate': [51, 96, 153], 'ion': [52], 'beams': [53], 'been': [55], 'proposed': [56], 'a': [58, 94, 132, 171], 'prospective': [59], 'route.': [60], 'A': [61], 'better': [62], 'understanding': [63], 'radiobiological': [66], 'effects': [67], 'at': [68, 93, 107], 'dose-rates': [70], 'is': [71], 'important': [72], 'any': [74], 'future': [75], 'clinical': [76], 'adoption': [77], 'technology.': [80], 'In': [81], 'study,': [83], 'we': [84], 'irradiated': [85, 144], 'human': [86], 'skin': [87], 'fibroblasts-AG01522B': [88], 'cells': [89, 143], 'with': [90, 145], 'laser-accelerated': [91], 'protons': [92, 154, 179], '10': [98], '9': [99], 'Gy/s,': [100], 'generated': [101], 'using': [102, 122], 'Gemini': [104], 'laser': [105, 176], 'system': [106], 'Rutherford': [109], 'Appleton': [110], 'Laboratory,': [111], 'UK.': [112], 'We': [113], 'studied': [114], 'DNA': [115, 184], 'double': [116], 'strand': [117], 'break': [118], '(DSB)': [119], 'repair': [120, 139], 'kinetics': [121, 140], 'p53': [124], 'binding': [125], 'protein-1(53BP1)': [126], 'foci': [127, 138, 164], 'formation': [128], 'assay': [129], 'observed': [131], 'close': [133], 'similarity': [134, 181], '53BP1': [137], '225': [146], 'kVp': [147], 'X-rays': [148], 'ultra-': [150], 'high': [151], 'initial': [157], 'time': [158, 192], 'points.': [159], 'At': [160], 'microdosimetric': [162], 'scale,': [163], 'per': [165, 167], 'cell': [166], 'track': [168], 'values': [169], 'showed': [170], 'good': [172], 'correlation': [173], 'between': [174], 'cyclotron-accelerated': [178], 'indicating': [180], 'DSB': [185], 'induction': [186], 'repair,': [188], 'independent': [189], 'duration': [193], 'over': [194], 'which': [195], 'was': [198], 'delivered.': [199]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2916154476', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 10}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 4}, {'year': 2019, 'cited_by_count': 6}], 'updated_date': '2024-09-19T02:05:49.179205', 'created_date': '2019-03-02'}