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'studies': [143], 'for': [144, 162], 'QM/MM': [149], 'optimizations': [150], 'predict': [152], 'their': [153], 'mechanisms': [156], 'at': [157], 'level': [159], 'search': [161], 'correlations': [163], 'vitro': [167], 'results.': [168], 'found': [170], 'that': [171], 'ionized': [173], 'form': [174], '(5i)': [177], 'higher': [179], 'affinity': [180], 'stable': [183], 'binding': [184], 'catalytic': [187, 207], 'site': [188], 'its': [190], 'neutral': [191], 'form,': [192], 'while': [193], 'bound': [195], 'predicted': [198], 'allosteric': [199], 'sites': [200], 'enzyme': [203], 'better': [204], 'site.': [208]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2914582885', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 5}, {'year': 2021, 'cited_by_count': 4}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-11T23:01:48.400737', 'created_date': '2019-02-21'}