Blood Telomere Length as Modifier of the Association between Long Term Exposure to Traffic Particles and Cognition in Aging Men

Name: Work Video:
Duration: 3 min 30 s
Elena Colicino; Maria Chiara Frisardi; Melinda C. Power; Mirjiam Hoxha; Laura Dioni; Pantel Vokonas; Avron Spiro; Marc G. Weisskopf; Joel Schwartz; Andrea Baccarelli
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'https://openalex.org/P4310316754'], 'host_organization_lineage_names': ['National Institute of Environmental Health Sciences', 'National Institutes of Health'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'display_name': 'Good health and well-being', 'score': 0.56}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 0, 'referenced_works': [], 'related_works': ['https://openalex.org/W4389568370', 'https://openalex.org/W3108674512', 'https://openalex.org/W3032375762', 'https://openalex.org/W3031052312', 'https://openalex.org/W2748952813', 'https://openalex.org/W2148612803', 'https://openalex.org/W2080531066', 'https://openalex.org/W1995515455', 'https://openalex.org/W1506200166', 'https://openalex.org/W1489783725'], 'abstract_inverted_index': {'Blood': [0], 'Telomere': [1], 'Length': [2], 'as': [3, 260, 306, 335], 'Modifier': [4], 'of': [5, 47, 62, 72, 85, 96, 117, 142, 158, 172, 187, 208, 237, 252, 263, 269, 274, 291, 309, 396, 420, 456, 464], 'the': [6, 212, 215, 250, 281, 288, 326, 332, 336, 358, 361, 364, 383, 447, 454], 'Association': [7], 'between': [8], 'Long': [9], 'Term': [10], 'Exposure': [11], 'to': [12, 199, 255, 437, 478, 486], 'Traffic': [13], 'Particles': [14], 'and': [15, 40, 113, 120, 138, 145, 182, 231, 239, 330, 376], 'Cognition': [16], 'in': [17, 211, 228, 280, 316, 339, 360, 380, 426, 461, 476, 490], 'Aging': [18, 108, 133, 295], 'MenAbstract': [19], 'Number:2198': [20], 'Elena': [21, 43], 'Colicino*,': [22], 'Maria': [23, 57], 'Chiara': [24, 58], 'Frisardi,': [25], 'Melinda': [26, 68], 'Power,': [27], 'Mirjiam': [28, 82], 'Hoxha,': [29], 'Laura': [30, 93], 'Dioni,': [31], 'Pantel': [32, 104], 'Vokonas,': [33], 'Avron': [34, 129], 'Spiro,': [35], 'Marc': [36, 154], 'Weisskopf,': [37], 'Joel': [38, 168], 'Schwartz,': [39], 'Andrea': [41, 183], 'Baccarelli': [42, 184], 'Colicino*': [44], 'Harvard': [45, 60, 70, 156, 170, 185], 'School': [46, 61, 71, 157, 171, 186], 'Public': [48, 63, 73, 118, 143, 159, 173, 188], 'Health,': [49, 64, 74, 160, 174, 189], 'United': [50, 65, 75, 122, 147, 161, 175, 190], 'States,': [51, 76, 123, 148, 162, 176, 191], 'E-mail': [52, 77, 88, 99, 124, 149, 163, 177, 192], 'Address:': [53, 78, 89, 100, 125, 150, 164, 178, 193], '[email': [54, 79, 90, 101, 126, 151, 165, 179, 194], 'protected]': [55, 80, 91, 102, 127, 152, 166, 180, 195], ',': [56, 67, 81, 92, 103, 128, 153, 167, 181], 'Frisardi': [59], 'States': [66], 'Power': [69], 'Hoxha': [83], 'University': [84, 95, 115, 140], 'Milan,': [86, 97], 'Italy,': [87, 98], 'Dioni': [94], 'Vokonas': [105], 'VA': [106, 131], 'Normative': [107, 132, 294], 'Study': [109, 134], 'Boston': [110, 114, 135, 139], 'Healthcare': [111, 136], 'System': [112, 137], 'Schools': [116, 141], 'Health': [119, 144], 'Medicine,': [121, 146], 'Spiro': [130], 'Weisskopf': [155], 'Schwartz': [169], 'AbstractBackground:': [196], 'Long-term': [197], 'exposure': [198, 254], 'ambient': [200], 'air': [201], 'pollution': [202], 'has': [203], 'been': [204], 'associated': [205, 387, 413], 'with': [206, 388, 406, 414, 430, 439, 468], 'loss': [207], 'cognitive': [209, 267, 314, 366, 459, 492], 'function': [210, 268, 460], 'elderly,': [213], 'but': [214, 410], 'pathways': [216], 'mediating': [217], 'this': [218], 'association': [219], 'are': [220, 484], 'still': [221], 'unclear.': [222], 'Telomeres': [223], 'have': [224], 'a': [225, 235, 261, 307, 353, 462], 'crucial': [226], 'role': [227], 'cellular': [229, 238], 'replication': [230], 'their': [232], 'shortening': [233], 'is': [234], 'biomarker': [236], 'biological': [240], 'aging.': [241], 'Aims:': [242], 'To': [243], 'assess': [244], 'whether': [245], 'telomere': [246], 'length': [247], '(TL)': [248], 'modifies': [249], 'effect': [251, 419, 455], 'long-term': [253], 'black': [256], 'carbon': [257], '(BC),': [258], 'taken': [259], 'marker': [262], 'traffic-related': [264], 'particles,': [265], 'on': [266, 322, 382, 422, 458], 'older': [270, 276, 465], 'men.Methods:': [271], 'A': [272], 'cohort': [273], '438': [275], 'men': [277], '(mean=73.3,': [278], 'SD=6.6)': [279], 'period': [282], '1999-': [283], '2007': [284], 'was': [285, 370, 386, 403, 411, 424], 'drawn': [286], 'from': [287], 'U.S.': [289], 'Department': [290], 'Veteran': [292], 'Affairs': [293], 'Study.': [296], 'We': [297, 318, 342], 'used': [298, 331], 'low': [299, 397, 415], '(≤25)': [300], 'Mini-Mental': [301], 'State': [302], 'Examination': [303], '(MMSE)': [304], 'score': [305], 'proxy': [308], 'relatively': [310], 'poor': [311], 'cognition': [312], '(1.4': [313], 'assessments': [315], 'average).': [317], 'divided': [319], 'participants': [320], 'based': [321], 'median': [323], 'TL': [324, 400, 432, 441, 451, 488], 'at': [325, 357], 'baseline': [327], 'visits': [328], '(median=1.2)': [329], 'longer-value': [333], 'category': [334], 'reference': [337], 'group': [338], 'all': [340], 'analyses.': [341], 'fitted': [343], 'repeated-': [344], 'measures': [345], 'logistic': [346], 'regression': [347], 'models': [348], 'using': [349], 'BC': [350, 381, 421, 457, 479], 'estimated': [351], 'through': [352], 'validated': [354], 'LUR': [355], 'model': [356, 369], "participants'address": [359], 'year': [362], 'before': [363], 'first': [365], 'assessment.': [367], 'Each': [368, 378], 'adjusted': [371], 'for': [372, 446], 'lifestyle,': [373], 'demographic': [374], 'factors': [375], 'diseases.Results:': [377], 'doubling': [379], 'natural': [384], 'scale': [385], '1.5': [389], '(95%CI:': [390], '1.2-2.0)': [391], 'times': [392], 'higher': [393], 'relative': [394], 'odds': [395], 'MMSE.': [398], 'Leukocyte': [399], '(mean=1.3,': [401], 'SD=0.5)': [402], 'negatively': [404], 'correlated': [405], 'age': [407], '(r:-0.2;': [408], 'p-value<0.0001),': [409], 'not': [412], 'MMSE': [416, 423], 'scores.': [417], 'The': [418], 'larger': [425], 'size': [427], 'among': [428], 'individuals': [429], 'longer': [431, 469], '(OR=2.1;': [433], '95%CI:': [434, 443], '1.4-3.1),': [435], 'compared': [436], 'those': [438], 'shorter': [440], '(OR=1.1;': [442], '0.8-1.5;': [444], 'p-value': [445], 'interaction': [448], '0.01).Conclusions:': [449], 'Longer': [450], 'showed': [452], 'worsened': [453], 'population': [463], 'men.': [466], 'Leukocytes': [467], 'telomeres': [470], 'could': [471], 'elicit': [472], 'stronger': [473], 'inflammatory': [474], 'responses': [475], 'response': [477], 'exposures.': [480], 'Further': [481], 'mechanistic': [482], 'studies': [483], 'warranted': [485], 'elucidate': [487], 'roles': [489], 'BC-associated': [491], 'decline.': [493]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2914492174', 'counts_by_year': [], 'updated_date': '2024-12-24T08:20:51.130493', 'created_date': '2019-02-21'}
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