Clinical Course and Significance of Hypertrophic Cardiomyopathy Without Left Ventricular Hypertrophy

Name: Work Video:
Duration: 3 min 30 s
Niccolò Maurizi; Michelle Michels; Ethan J. Rowin; Christopher Semsarian; Francesca Girolami; Benedetta Tomberli; Franco Cecchi; Martin S. Maron; Iacopo Olivotto; Barry J. Maron
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'convert': [843, 1246], 'LVH.': [845], 'At': [846, 927], 'recent': [848, 930], '37±16': [852], 'old;': [854, 936], '37': [855], '(18%)': [857], '>50': [859, 940, 1144], '>60': [864, 945, 1151], 'old': [866, 1146], '(range': [867], '69).': [869], 'For': [870], 'group,': [872], 'increased': [876], '1±2': [877], 'mm': [878], 'but': [879, 919], 'remained': [880], 'mm;': [882], '22': [883], '182': [885], '(12%)': [886], 'developed': [888], 'ECG': [889, 1026, 1190], 'abnormalities.Over': [890], '21': [893], '(10%)': [895], '(converters)': [896], 'converted': [897, 1176], 'phenotype,': [901, 1180], 'defined': [902], 'as': [903, 1199, 2121], '≥13': [908], 'mm,': [909, 961], 'usually': [910], 'anterior': [913], 'septum': [915], '(mean': [916], '15±2;': [917], '13–17),': [918], 'hypertension;': [921], 'rate': [924], '0.3%/y.': [926], '39±10': [934], '43': [937], '(21%)': [938], '16': [943], '(8%)': [944], 'years.LVH': [946], 'nonconverters': [949, 1020], 'differ': [952], 'entry': [957], '(10±2': [958], 'P=0.28).': [962], 'Based': [963], 'serial': [965], 'echocardiograms,': [966], 'conversions': [968], 'similar': [971, 1183], 'frequency': [972, 1184], 'decade': [974], '(7%–13%;': [975], 'average,': [976], '10)': [977], 'although': [978], 'delayed': [979], '≥50': [981], '40': [988], '49': [990], 'others': [994], '(P=0.76).ECG': [995], 'results': [996], 'abnormal': [998, 1015], '24': [1000], '(21%),': [1001], 'pathological': [1004, 1050], 'waves': [1006, 1052], '(n=17)': [1007], 'abnormalities': [1010, 1027, 2129], '(n=11).': [1011], 'had': [1014], 'ECGs': [1016], 'more': [1017], 'than': [1019], '(48%': [1021], '8%;': [1023], 'P<0.01)': [1024], 'preceding': [1028], 'imaging': [1031], '4±2': [1033], '9': [1036, 1770, 2212], 'patients.': [1037, 1189], 'Multivariable': [1038], 'analysis': [1039], 'showed': [1040], '2-fold': [1042], 'increase': [1043], '(hazard': [1056], 'ratio,': [1057], '2.1;': [1058], '95%': [1059], 'CI,': [1060], '1.3–5.1;': [1061], 'P=0.01).There': [1062], 'few': [1064], 'long-term': [1065], 'addressing': [1068], 'consequences': [1071, 1091], 'status.3': [1074], 'In': [1075], 'our': [1076], 'prospectively': [1077], 'cohort': [1080, 1216, 1521], '>200': [1082], 'patients,': [1083], 'found': [1085], 'evidence': [1087], 'disease': [1090, 1335, 1439], 'patient.': [1094], 'This': [1095, 1299], 'important': [1096], 'observation': [1097, 1300], 'should': [1098], 'represent': [1099], 'source': [1101], 'reassurance': [1103], 'clinicians.However,': [1108], 'cannot': [1110], 'exclude': [1111], 'possibility': [1113], 'that,': [1114], 'extended': [1116], 'surveillance,': [1117], 'disease-related': [1118, 1287], 'complications': [1119, 1165], 'could': [1124, 1232, 1244], 'occur': [1125], 'additional': [1127], 'patients.2,5': [1128], 'Nevertheless,': [1129], 'average': [1131], 'population': [1136], 'is': [1137, 1320], '39': [1138], '≈20%': [1141], 'already': [1143, 1294], '(including': [1147], '5%': [1148], 'who': [1149, 1243, 1292], 'old),': [1153], 'suggesting': [1154], 'many': [1156, 1310], 'will': [1159], 'achieve': [1160], 'longevity': [1162], 'development': [1167], 'LVH.Ten': [1169], 'percent': [1170], 'group': [1174], 'younger': [1186], 'older': [1188], 'abnormalities,': [1191], 'particularly': [1192], 'waves,': [1194], 'often': [1195], 'preceded': [1196], 'serving': [1198], 'predictor': [1201], 'phenotypic': [1203], 'some': [1206], 'patients.2,3,5': [1207], 'need': [1210], 'be': [1212, 1233], 'confirmed': [1213], 'larger': [1215], 'studies,': [1217], 'given': [1218], 'relatively': [1220, 1296], 'small': [1221], 'number': [1222, 1238], 'cohort.': [1227], 'Present': [1228], 'underrecognition': [1229], 'related': [1234], '<18': [1241], 'yet': [1245], 'HCM,2,3': [1248], 'exclusion': [1249], 'CMR': [1258], 'being': [1260], 'routine': [1262], 'part': [1263], 'design.2In': [1267], 'conclusion,': [1268], 'present': [1271], 'cohort,': [1273], 'demonstrated': [1276], 'benign': [1278], 'course': [1280], 'virtually': [1282], 'demonstrable': [1284], 'morbidity/mortality,': [1288], 'almost': [1290], '20%': [1291], 'achieved': [1295], 'advanced': [1297], 'age.': [1298], 'uncommon': [1302], 'phenotype': [1307], 'suggest': [1308], 'can': [1313], 'anticipate': [1314], 'longevity.Sources': [1316], 'FundingDr': [1318], 'supported': [1321], 'Italian': [1324], 'Ministry': [1325], 'Health:': [1327], 'RF-2013-02356787': [1328], '(Left': [1329], 'aortic': [1333], 'valve': [1334], 'cardiomyopathy:': [1338, 2352, 2971], 'basis,': [1340], 'biophysical': [1341], 'correlates': [1342], 'viral': [1344], 'therapy': [1345], 'models),': [1346], 'NET-2011-02347173': [1347], '(Mechanisms': [1348], 'treatment': [1350, 2314], 'coronary': [1352], 'microvascular': [1353], 'dysfunction': [1354], 'secondary': [1360], 'hypertrophy),': [1363], '"Monitoraggio': [1365], 'e': [1366], 'prevenzione': [1367], 'delle': [1368], 'morti': [1369], 'improvvisecardiache': [1370], 'giovanili': [1371], 'Regione': [1373], 'Toscana"': [1374], 'Acronimo': [1375], 'ToRSADE': [1376, 1763], '(Tuscany': [1377], 'Registry': [1378], 'Sudden': [1380], 'cArdiac': [1381], 'Death)': [1382], '(Bando': [1383], 'FAS': [1384], 'Salute': [1385], '2014).DisclosuresNone.Footnoteshttps://www.ahajournals.org/journal/circData': [1386], 'sharing:': [1387], 'Data': [1388], 'online.': [1392], 'request.Niccolò': [1410], 'niccolo.[email': [1425], 'protected]comReferences1.': [1426], 'BJ,': [1428], 'C.': [1430, 1547], 'Emergence': [1431], 'mutation': [1434, 1527], 'expanding': [1438], 'spectrum': [1440], 'cardiomyopathy.Eur': [1443], '2010;': [1446], '31:1551–1553.': [1447], 'doi:': [1448, 1539, 1562, 1625, 1657], '10.1093/eurheartj/ehq111CrossrefMedlineGoogle': [1449], 'Scholar2.': [1450], 'Christiaans': [1451], 'Birnie': [1453], 'E,': [1454, 1582, 1584, 1958, 2064, 2147, 2433, 2470, 2798, 2919, 2958], 'Bonsel': [1455], 'GJ,': [1456], 'Mannens': [1457], 'MM,': [1458], 'M,': [1460, 1580, 1678, 1728, 1740, 1819, 1858, 1870, 1916, 1920, 1948, 2060, 2062, 2093, 2099, 2218, 2236, 2238, 2240, 2242, 2286, 2298, 2375, 2417, 2472, 2531, 2549, 2551, 2553, 2555, 2592, 2610, 2612, 2614, 2616, 2652, 2670, 2672, 2674, 2676, 2719, 2737, 2739, 2741, 2743, 2794, 2802, 2804, 2915, 2917, 2946, 2992], 'Majoor-Krakauer': [1461], 'D,': [1462, 1464, 1572, 1880, 1890, 1914, 2266, 2294, 2373, 2431, 2478], 'Dooijes': [1463], 'van': [1465, 1468, 1476, 1491, 1501, 1628, 1639], 'Tintelen': [1466], 'JP,': [1467], 'den': [1469, 1477, 1483], 'Berg': [1470], 'MP,': [1471], 'Volders': [1472], 'PG,': [1473], 'Arens': [1474], 'YH,': [1475], 'Wijngaard': [1478], 'A,': [1479, 1676, 1813, 2222, 2260, 2272, 2284, 2379, 2413, 2484, 2494, 2496, 2535, 2596, 2656, 2723, 2841, 2883, 2921], 'Atsma': [1480], 'DE,': [1481], 'Helderman-van': [1482], 'Enden': [1484], 'AT,': [1485], 'Houweling': [1486], 'AC,': [1487], 'de': [1488, 2267], 'Boer': [1489], 'K,': [1490, 1586, 1854, 2262, 2954], 'der': [1492], 'Smagt': [1493], 'JJ,': [1494], 'Hauer': [1495], 'RN,': [1496], 'Marcelis': [1497], 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2152, 2197, 2438, 2810, 2856, 2892, 2997], 'Cardiol.': [1559], '152:258–259.': [1561], '10.1016/j.ijcard.2011.07.095CrossrefMedlineGoogle': [1563], 'Scholar4.': [1564], 'Richards': [1565], 'S,': [1566, 1570, 1574, 1744, 1815, 1856, 2095, 2101, 2214, 2216, 2220, 2258, 2423, 2429, 2466, 2482, 2488, 2492, 2527, 2529, 2533, 2588, 2590, 2594, 2648, 2650, 2654, 2715, 2717, 2721], 'Aziz': [1567], 'N,': [1568, 1668, 1686, 1726, 1817, 1872, 2091, 2107, 2282, 2419, 2462], 'Bale': [1569], 'Bick': [1571], 'Das': [1573], 'Gastier-Foster': [1575], 'Grody': [1577], 'WW,': [1578], 'Hegde': [1579], 'Lyon': [1581], 'Spector': [1583], 'Voelkerding': [1585], 'Rehm': [1587], 'HL;': [1588], 'ACMG': [1589], 'Laboratory': [1590], 'Quality': [1591], 'Assurance': [1592], 'Committee.': [1593], 'Standards': [1594], 'guidelines': [1596], 'interpretation': [1599], 'sequence': [1601], 'variants:': [1602], 'joint': [1604], 'consensus': [1605], 'recommendation': [1606], 'American': [1609, 1974, 2082, 2703, 2772, 2827, 3012, 3034], 'College': [1610, 1975, 2704, 2773, 2828, 3013], 'Genetics': [1613], 'Genomics': [1615], 'Association': [1618], 'Molecular': [1620, 2164, 2186], 'Pathology.Genet': [1621], 'Med.': [1622, 1654], '2015;': [1623], '17:405–424.': [1624], '10.1038/gim.2015.30CrossrefMedlineGoogle': [1626], 'Scholar5.': [1627], 'Velzen': [1629], 'HG,': [1630], 'Schinkel': [1631], 'AFL,': [1632], 'Baart': [1633], 'SJ,': [1634], 'Oldenburg': [1635], 'RA,': [1636], 'Frohn-Mulder': [1637], 'IME,': [1638], 'Slegtenhorst': [1640], 'MA,': [1641], 'M.': [1643], 'Outcomes': [1644, 2513], 'contemporary': [1646], 'cardiomyopathy.Circ': [1651], 'Genom': [1652], 'Precis': [1653], '2018;': [1655], '11:e001896.': [1656], '10.1161/CIRCGEN.117.001896LinkGoogle': [1658], 'Scholar': [1659], 'Previous': [1660], 'Back': [1661], 'top': [1663], 'Next': [1664], 'FiguresReferencesRelatedDetailsCited': [1665], 'By': [1666], 'Fumagalli': [1669, 2104, 2911], 'C,': [1670, 1874, 2097, 2105, 2234, 2244, 2248, 2381, 2421, 2425, 2476, 2547, 2557, 2608, 2618, 2668, 2678, 2735, 2745, 2912, 2923], 'Skalidis': [1671], 'Imberti': [1673], 'Faragli': [1675], 'Targetti': [1677, 1739], 'Lu': [1679, 1869], 'H,': [1680, 1864, 1876, 1954, 2246, 2559, 2620, 2680, 2747], 'Monney': [1681], 'P,': [1682, 1892, 1952, 2224, 2232, 2250, 2252, 2537, 2545, 2598, 2606, 2658, 2666, 2725, 2733, 2806, 2845, 2847], 'Muller': [1683], 'O,': [1684], 'Marchionni': [1685], 'F': [1688, 1821, 2114], 'I': [1691, 1746, 2111, 2928], '(2023)': [1692], 'Validation': [1693], 'multiple‑lead': [1696], 'smartphone-based': [1697], 'electrocardiograph': [1698], 'automated': [1700], 'lead': [1701], 'placement': [1702], 'layman': [1704], 'use': [1705], 'cardiomyopathy,': [1710, 1938, 2319], 'Journal': [1711, 1798, 1840, 1971, 2079, 2133, 2162, 2184, 2321, 2401, 2700, 2769, 2824, 3009], 'Electrocardiology,': [1713], '10.1016/j.jelectrocard.2023.02.006,': [1714], '79,': [1715], '(1-7),': [1716], 'Online': [1717, 1806, 1981, 2006, 2025, 2053, 2086, 2140, 2330, 2364, 2457, 2523, 2584, 2643, 2710, 2779, 2789, 2834, 2876, 2907, 2941, 2985, 3019], 'publication': [1718, 1807, 1982, 2007, 2026, 2054, 2087, 2141, 2331, 2365, 2458, 2524, 2585, 2644, 2711, 2780, 2790, 2835, 2877, 2908, 2942, 2986, 3020], 'date:': [1719, 1808, 1983, 2008, 2027, 2055, 2088, 2142, 2332, 2366, 2459, 2525, 2586, 2645, 2712, 2781, 2791, 2836, 2878, 2909, 2943, 2987, 3021], '1-Jul-2023.': [1720], 'F,': [1722, 2030, 2103, 2276, 2377, 2383], 'Spinelli': [1723], 'V,': [1724, 1732, 2843], 'Focardi': [1727], 'Nesi': [1729], 'G,': [1730, 1736, 1868, 1918, 2109, 2192, 2256, 2371, 2409, 2796], 'Maio': [1731], 'Grifoni': [1733], 'R,': [1734, 1742, 1950], 'Albora': [1735], 'Bertaccini': [1737], 'Coppini': [1741], 'Favilli': [1743], 'Cerbai': [1748], 'E': [1749, 1988, 2011, 2194, 2337], '(2022)': [1750, 1782, 1825, 1898, 1964, 1992, 2015, 2040], 'Genetic': [1751, 2154], 'characterization': [1752, 1900], 'juvenile': [1754], 'arrest': [1757], 'Tuscany:': [1761], 'registry,': [1764], 'Frontiers': [1765, 2208], 'Cardiovascular': [1767, 1842, 1908, 2071, 2135, 2325], 'Medicine,': [1768, 1802, 2002, 2136, 2404, 2521], '10.3389/fcvm.2022.1080608,': [1769], 'Novo': [1771], 'Matos': [1772], 'Payne': [1774], 'Seo': [1776], 'Luis': [1779], 'Fuentes': [1780, 2269], 'V': [1781, 2149], 'cats': [1789], 'rehoming': [1791], 'centers:': [1792], 'CatScan': [1794], 'II': [1795], 'Veterinary': [1800], 'Internal': [1801], '10.1111/jvim.16576,': [1803], '36:6,': [1804], '(1900-1912),': [1805], '1-Nov-2022.': [1809], 'Kitai': [1810], 'T,': [1811, 1882, 2032], 'Xanthopoulos': [1812], 'Nakagawa': [1814], 'Ishii': [1816], 'Amano': [1818], 'Triposkiadis': [1820], 'Izumi': [1823], 'C': [1824, 1929, 2170, 2388, 2435, 2500, 2503, 2561, 2622, 2682, 2749, 2962], 'Contemporary': [1826], 'Diagnosis': [1827, 1965, 2571, 2632, 2692, 2759], 'Management': [1829], 'Cardiomyopathy:': [1832, 1994, 2201, 2395, 2578, 2766, 2895], 'Role': [1834], 'Multimodality': [1838], 'Imaging,': [1839], 'Development': [1843], 'Disease,': [1845], '10.3390/jcdd9060169,': [1846], '9:6,': [1847], '(169)': [1848], 'Wang': [1849, 1851, 1855, 1861], 'W,': [1850, 2290], 'Yao': [1853], 'Nie': [1857], 'Zhao': [1859], 'Y,': [1860, 1888, 2411, 2948], 'Pang': [1863], 'Xu': [1865], 'Wu': [1867], 'Tang': [1871], 'Qi': [1873], 'Pei': [1875], 'Luo': [1877], 'X,': [1878, 1886], 'Li': [1879, 1887, 1891], 'Yang': [1881], 'Sun': [1883], 'Q,': [1884], 'Wei': [1885], 'Jiang': [1889], 'Song': [1893], 'L': [1894], 'Hu': [1896], 'Z': [1897], 'Metabolic': [1899], 'human': [1905], 'heart,': [1906], 'Nature': [1907], 'Research,': [1909], '10.1038/s44161-022-00057-1,': [1910], '1:5,': [1911], '(445-461)': [1912], 'RUSSO': [1913], 'SCLAFANI': [1915], 'TINI': [1917], 'MUSUMECI': [1919], 'ARCARI': [1921], 'L,': [1922, 1924, 2034, 2226, 2270, 2274, 2296, 2468, 2498, 2539, 2600, 2660, 2727, 2808, 2885, 2950, 2960], 'LIMITE': [1923], 'FRANCIA': [1925], 'P': [1926, 2385, 2564, 2625, 2685, 2752, 2813], 'AUTORE': [1928], 'Prognostic': [1930], 'implications': [1931], 'different': [1933], 'Minerva': [1939], 'Cardiology': [1940, 2937], 'Angiology,': [1942], '10.23736/S2724-5683.21.05752-5,': [1943], '70:2': [1944], 'Desai': [1947], 'Nishimura': [1949], 'Spirito': [1951], 'Rakowski': [1953], 'Towbin': [1955], 'M': [1960, 1963, 1991, 2014, 2173, 2340, 2853], 'Sherrid': [1962], 'Evaluation': [1967], 'Cardiomyopathy,': [1970, 2160, 2516, 2639, 2699, 2935, 3008], 'Cardiology,': [1977, 2706, 2775, 2830, 3015], '10.1016/j.jacc.2021.12.002,': [1978], '79:4,': [1979], '(372-389),': [1980], '1-Feb-2022.': [1984], 'Concepts': [1996], 'Therapies,': [1998], 'Annual': [1999], 'Review': [2000], '10.1146/annurev-med-042220-021539,': [2003], '73:1,': [2004], '(363-375),': [2005], '27-Jan-2022.': [2009], 'Winter': [2016], 'Is': [2017, 2972], 'Coming,': [2018], 'JACC:': [2019, 2047], 'Case': [2020, 2048], 'Reports,': [2021, 2049, 2938], '10.1016/j.jaccas.2021.12.001,': [2022], '4:2,': [2023, 2051], '(99-101),': [2024], '1-Jan-2022.': [2028, 2056], 'Chan': [2029], 'Lockie': [2031], 'Monserrat': [2033], 'Moon': [2035], 'Captur': [2038], 'G': [2039], 'Subclinical': [2041], 'Elite': [2045], 'Athletes,': [2046], '10.1016/j.jaccas.2021.11.004,': [2050], '(94-98),': [2052], 'Maurer': [2061], 'B': [2066, 2994], 'Galiè': [2068], 'N': [2069], '(2021)': [2070, 2115, 2153, 2174, 2198, 2306, 2341, 2389, 2439], 'Diseases': [2072], 'That': [2073], 'Have': [2074], 'Emerged': [2075], 'From': [2076], 'Darkness,': [2078], 'Association,': [2084, 3036], '10:20,': [2085], '19-Oct-2021.': [2089], 'Baldi': [2092], 'Castelletti': [2094], 'Lisi': [2096], 'Galli': [2098], 'Bianchi': [2100], 'Panzera': [2102], 'Mochi': [2106], 'Parati': [2108], 'Age-dependent': [2116], 'diagnostic': [2117, 2124], 'yield': [2118], 'echocardiography': [2120], 'second-line': [2123], 'investigation': [2125], 'athletes': [2127], 'preparticipation': [2131], 'screening,': [2132], '10.2459/JCM.0000000000001215,': [2137], '22:10,': [2138], '(759-766),': [2139], '1-Oct-2021.': [2143], 'Bonaventura': [2144, 2838], 'Polakova': [2146], 'Vejtasova': [2148], 'Veselka': [2151, 2855], 'Testing': [2155], 'Patients': [2157, 2575, 2636, 2696, 2763], 'International': [2161, 2183], 'Sciences,': [2165, 2187, 2454], '10.3390/ijms221910401,': [2166], '22:19,': [2167], '(10401)': [2168], 'Chou': [2169], 'Chin': [2172], 'Pathogenic': [2175], 'Mechanisms': [2176], 'beyond': [2180], 'Sarcomere': [2181, 2509, 2820, 3002], 'Dysfunction,': [2182], '10.3390/ijms22168933,': [2188], '22:16,': [2189], '(8933)': [2190], 'Norrish': [2191, 2795], 'Field': [2193, 2797], 'Kaski': [2196, 2809], 'Childhood': [2199], 'A': [2202, 2925], 'Disease': [2203], 'Cardiac': [2206], 'Sarcomere,': [2207], 'Pediatrics,': [2210], '10.3389/fped.2021.708679,': [2211], 'Ommen': [2213, 2647, 2714], 'Mital': [2215, 2528, 2589, 2649, 2716, 2964], 'Burke': [2217, 2530, 2591, 2651, 2718], 'Day': [2219, 2422, 2465, 2532, 2593, 2653, 2720], 'Deswal': [2221, 2271, 2534, 2595, 2655, 2722], 'Elliott': [2223, 2536, 2597, 2657, 2724, 2812], 'Evanovich': [2225, 2538, 2599, 2659, 2726], 'Hung': [2227, 2540, 2601, 2661, 2728], 'Joglar': [2229, 2287, 2542, 2603, 2663, 2730], 'Kantor': [2231, 2544, 2605, 2665, 2732], 'Kimmelstiel': [2233, 2546, 2607, 2667, 2734], 'Kittleson': [2235, 2548, 2609, 2669, 2736], 'Link': [2237, 2550, 2611, 2671, 2738], 'Martinez': [2241, 2554, 2615, 2675, 2742], 'Miyake': [2243, 2556, 2617, 2677, 2744], 'Schaff': [2245, 2558, 2619, 2679, 2746], 'Sorajja': [2249, 2563, 2624, 2684, 2751], "O'Gara": [2251], 'Beckman': [2253], 'Levine': [2255], 'Al-Khatib': [2257], 'Armbruster': [2259], 'Birtcher': [2261], 'Ciggaroa': [2263], 'Dixon': [2265], 'las': [2268], 'Fleisher': [2273], 'Gentile': [2275], 'Goldberger': [2277], 'Z,': [2278], 'Gorenek': [2279], 'Haynes': [2281], 'Hernandez': [2283], 'Hlatky': [2285], 'Jones': [2289], 'Marine': [2291], 'Mark': [2293], 'Palaniappan': [2295], 'Piano': [2297], 'Tamis-Holland': [2299], 'Wijeysundera': [2301], 'D': [2302], 'Woo': [2304], 'Y': [2305], '2020': [2307, 2566, 2627, 2687, 2754], 'AHA/ACC': [2308, 2567, 2628, 2688, 2755], 'guideline': [2309], 'diagnosis': [2312], 'Thoracic': [2323], 'Surgery,': [2326], '10.1016/j.jtcvs.2021.04.001,': [2327], '162:1,': [2328], '(e23-e106),': [2329], '1-Jul-2021.': [2333], 'Evolution': [2342], 'stratification': [2345], 'prevention': [2349], 'Twenty': [2353], 'implantable': [2357], 'cardioverter-defibrillator,': [2358], 'Rhythm,': [2360], '10.1016/j.hrthm.2021.01.019,': [2361], '18:6,': [2362], '(1012-1023),': [2363], '1-Jun-2021.': [2367], 'Musumeci': [2368], 'Tini': [2370], 'Russo': [2372], 'Sclafani': [2374], 'Cava': [2376], 'Tropea': [2378], 'Adduci': [2380], 'Palano': [2382], 'Francia': [2384], 'Autore': [2387], 'Remodeling': [2392], 'An': [2396], 'Overview': [2397], 'Current': [2399, 2936], 'Knowledge,': [2400], 'Clinical': [2403, 2512], '10.3390/jcm10081547,': [2405], '10:8,': [2406], '(1547)': [2407], 'Repetti': [2408], 'Kim': [2410], 'Pereira': [2412, 2483], 'Russell': [2416], 'Lakdawala': [2418, 2461], 'Ho': [2420, 2502], 'McDonough': [2426], 'DePalma': [2428], 'Quiat': [2430], 'Green': [2432], 'Seidman': [2434, 2437, 2499], 'Discordant': [2440], 'features': [2442], 'identical': [2444], 'twins,': [2447], 'Proceedings': [2448], 'National': [2451], 'Academy': [2452], '10.1073/pnas.2021717118,': [2455], '118:10,': [2456], '9-Mar-2021.': [2460], 'Han': [2467], 'Ashley': [2469], 'Jacoby': [2477], 'Jefferies': [2479], 'Colan': [2481], 'Rossano': [2485], 'Wittekind': [2487], 'Ware': [2489], 'Saberi': [2491], 'Helms': [2493], 'Cirino': [2495], 'Leinwand': [2497], '(2020)': [2504, 2565, 2626, 2686, 2753, 2783, 2814, 2857, 2893, 2929], 'Associations': [2505], 'Between': [2506], 'Female': [2507], 'Sex,': [2508], 'Variants,': [2510], 'Circulation:': [2517], 'Genomic': [2518], 'Precision': [2520], '14:1,': [2522], '1-Feb-2021.Ommen': [2526], 'Guideline': [2568, 2629, 2689, 2756], 'Treatment': [2573, 2634, 2694, 2761], 'With': [2576, 2637, 2697, 2764], 'Executive': [2579, 2767], 'Summary,': [2580, 2768], 'Circulation,': [2581, 2640, 2786, 2903], '142:25,': [2582, 2641], '(e533-e557),': [2583], '22-Dec-2020.Ommen': [2587], '(e558-e631),': [2642], '22-Dec-2020.': [2646], '10.1016/j.jacc.2020.08.045,': [2707], '76:25,': [2708, 2777], '(e159-e240),': [2709], '1-Dec-2020.': [2713, 2782], '10.1016/j.jacc.2020.08.044,': [2776], '(3022-3055),': [2778], 'Joint': [2784], 'Statement,': [2785], '142:3,': [2787], '(1-33),': [2788], '1-Aug-2020.': [2792, 2837], 'Lorenzini': [2793], 'Ochoa': [2799], 'Cicerchia': [2801], 'Akhtar': [2803], 'Syrris': [2805], 'Lopes': [2807], 'Penetrance': [2815], 'Protein': [2821], 'Mutation': [2822], 'Carriers,': [2823], '10.1016/j.jacc.2020.06.011,': [2831], '76:5,': [2832], '(550-559),': [2833], 'Krebsová': [2840], 'Zoubková': [2842], 'Votýpka': [2844], 'Peldová': [2846], 'Petřková': [2848], 'Kautzner': [2850], 'Macek': [2852], '(Complex': [2858], 'approach': [2859], 'towards': [2860], 'indications': [2866], 'testing),': [2869], 'Cor': [2870], 'et': [2871], 'Vasa,': [2872], '10.33678/cor.2020.023,': [2873], '62:3,': [2874], '(272-278),': [2875], '29-Jul-2020.': [2879], 'Younger': [2880], 'Lo': [2882], 'McCormack': [2884], 'McGaughran': [2886], 'Prasad': [2888], 'S': [2889, 2965], 'Atherton': [2891], 'Challenging': [2896], 'Status': [2898], 'Quo?,': [2899], 'Heart,': [2900], 'Lung': [2901], '10.1016/j.hlc.2019.12.005,': [2904], '29:4,': [2905], '(556-565),': [2906], '1-Apr-2020.': [2910], 'De': [2913], 'Gregorio': [2914], 'Zampieri': [2916], 'Fedele': [2918], 'Chiriatti': [2922], 'Marchi': [2924], 'Targeted': [2930], 'Therapies': [2932], '10.1007/s11886-020-1258-x,': [2939], '22:2,': [2940], '1-Feb-2020.': [2944], 'Lafreniere-Roula': [2945], 'Bolkier': [2947], 'Zahavich': [2949], 'Mathew': [2951], 'George': [2953], 'Wilson': [2955], 'Stephenson': [2957], 'Benson': [2959], 'Manlhiot': [2961], '(2019)': [2966, 2998], 'it': [2973], 'time': [2974], 'change': [2976], 'practice': [2977], 'guidelines?,': [2978], 'European': [2979], 'Journal,': [2981], '10.1093/eurheartj/ehz396,': [2982], '40:45,': [2983], '(3672-3681),': [2984], '1-Dec-2019.': [2988], 'Loscalzo': [2996], 'Moving': [2999], 'Beyond': [3000], 'Explain': [3004], 'Heterogeneity': [3005], '10.1016/j.jacc.2019.01.061,': [3016], '73:15,': [3017], '(1978-1986),': [3018], '1-Apr-2019.': [3022], 'February': [3023], '5,': [3024], '2019Vol': [3025], 'Issue': [3027], '6': [3028], 'Advertisement': [3029, 3048], 'Article': [3030], 'InformationMetrics': [3031], '©': [3032], '2019': [3033, 3042], 'Inc.https://doi.org/10.1161/CIRCULATIONAHA.118.037264PMID:': [3037], '30715937': [3038], 'publishedFebruary': [3040], '4,': [3041], 'Keywordselectrocardiographyhypertrophy,': [3043], 'ventricularcardiomyopathy,': [3045], 'hypertrophicgeneticsechocardiographymortalityPDF': [3046], 'download': [3047], 'SubjectsCardiomyopathyGeneticsMortality/Survival': [3049]}, 'cited_by_api_url': 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