Publication Information

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622, 653, 685, 716, 750, 782, 811, 836, 873, 912, 957, 980, 1016, 1051, 1084, 1115, 1158, 1195, 1229, 1260, 1277, 1317, 1352, 1397, 1427, 1471, 1514, 1556, 1609, 1647, 1685, 1720, 1752, 1775, 1807, 1832, 1865, 1895, 1934, 1969, 2001, 2034, 2066, 2097, 2126, 2165, 2200, 2226, 2247, 2280, 2297, 2339, 2371, 2401, 2428, 2459, 2491, 2508, 2537, 2555, 2581, 2619, 2656, 2689, 2723, 2754, 2790, 2825, 2863, 2906, 2954, 3013, 3043, 3079, 3111, 3148], '6375662]': [166], 'CrossrefMedlineGoogle': [167, 200, 258, 303, 331, 365, 413, 446, 474, 500, 515, 547, 590, 624, 655, 687, 718, 752, 784, 813, 838, 875, 914, 959, 982, 1018, 1053, 1086, 1117, 1160, 1197, 1231, 1262, 1279, 1319, 1354, 1399, 1429, 1473, 1516, 1558, 1611, 1649, 1687, 1722, 1754, 1777, 1809, 1834, 1867, 1897, 1936, 1971, 2003, 2036, 2068, 2099, 2128, 2167, 2202, 2228, 2249, 2282, 2299, 2341, 2373, 2403, 2430, 2461, 2493, 2510, 2539, 2557, 2583, 2621, 2658, 2691, 2725, 2756, 2792, 2827, 2865, 2908, 2956, 3015, 3045, 3081, 3113, 3150], 'Scholar2.': [168], 'Kang': [169], 'J,': [170, 334, 416, 662, 925, 1097, 1402, 1486, 1660, 1812, 1902, 2016, 2213, 2464, 2761, 2763, 2805, 3024], 'Lemaire': [171], 'HG,': [172], 'Unterbeck': [173], 'A,': [174, 263, 635, 884, 1171, 1404, 2043, 2406, 2472, 3026, 3052, 3054], 'Salbaum': [175], 'JM,': [176], 'Masters': [177], 'CL,': [178, 1202, 1658, 1943, 1982], 'Grzeschik': [179], 'KH,': [180, 1438], 'et': [181, 345, 427, 529, 638, 669, 701, 732, 766, 798, 889, 928, 996, 1032, 1067, 1100, 1131, 1211, 1245, 1334, 1368, 1487, 1530, 1572, 1625, 1663, 1701, 1736, 1792, 1849, 1950, 1985, 2017, 2142, 2181, 2216, 2313, 2475, 2597, 2672, 2705, 2739, 2770, 2806, 2841, 2879, 3029, 3062, 3095, 3127], 'al': [182, 346, 428, 530, 639, 670, 702, 733, 767, 799, 890, 929, 997, 1033, 1068, 1101, 1132, 1212, 1246, 1335, 1369, 1488, 1531, 1573, 1626, 1664, 1702, 1737, 1793, 1850, 1951, 1986, 2018, 2143, 2182, 2217, 2314, 2476, 2598, 2673, 2706, 2740, 2771, 2807, 2842, 2880, 3030, 3063, 3096, 3128], '.': [183, 347, 429, 531, 640, 671, 703, 734, 768, 800, 891, 930, 998, 1034, 1069, 1102, 1133, 1213, 1247, 1336, 1370, 1489, 1532, 1574, 1627, 1665, 1703, 1738, 1794, 1851, 1952, 1987, 2019, 2144, 2183, 2218, 2315, 2477, 2599, 2674, 2707, 2741, 2772, 2808, 2843, 2881, 3031, 3097, 3129], 'The': [184, 430, 848, 963, 999, 1666, 2111, 2286, 2329, 3177, 3416], 'precursor': [185, 533, 615, 740, 774, 854, 897, 1638, 1861, 1912, 2053, 3779], 'A4': [190], 'protein': [191, 570, 578, 616, 678, 741, 775, 855, 898, 1639, 1706, 1913, 2054, 2086, 2190, 2243, 2639, 3780, 3849], 'resembles': [192], 'cell-surface': [194], 'receptor.': [195], 'Nature.': [196, 651, 714, 780, 809, 1082, 1156, 1227, 1425, 1773, 1805, 1863, 1893, 2032, 2198, 2457, 2752, 2788, 2823, 3109], '1987;325:733-6.': [197], '2881207]': [199], 'Scholar3.': [201], 'Yamaguchi': [202, 1285], 'H,': [203, 267, 420, 518, 698, 793, 880, 1210, 1286, 1844, 2205, 2694, 2700, 2736, 2878], 'Hirai': [204], 'S,': [205, 666, 725, 727, 755, 1208, 1408, 1622, 2207, 2209, 2441, 2667, 2669, 3084], 'Morimatsu': [206], 'M,': [207, 209, 392, 426, 520, 554, 658, 696, 878, 923, 1066, 1128, 1167, 1200, 1206, 1234, 1265, 1527, 1565, 1569, 2008, 2141, 2302, 2312, 2437, 2515, 2588], 'Shoji': [208, 657], 'Harigaya': [210], 'Y.': [211, 271], 'Diffuse': [212], 'type': [213, 941, 1153], 'senile': [215, 282, 1583], 'plaques': [216, 283, 1584, 2605, 2781, 3823], 'brains': [219, 3376], 'Alzheimer-type': [221, 1629], 'dementia.': [222, 1186, 2549], 'Acta': [223], 'Neuropathol': [224], '(Berl).': [225], '1988;77:113-9.': [226], '2465658]': [228], 'MedlineGoogle': [229], 'Scholar4.': [230], 'Tagliavini': [231], 'F,': [232, 694, 1654, 2868], 'Giaccone': [233], 'G,': [234, 595, 886, 993, 1064, 1126, 1725, 1735, 1846, 2474, 2519, 2663, 2734], 'Frangione': [235], 'B,': [236, 1781, 1838, 1947, 2211, 2346, 3028], 'Bugiani': [237], 'O.': [238], 'Preamyloid': [239], 'deposits': [240], 'cerebral': [243, 1346, 1376, 2850], 'cortex': [244, 1377], 'nondemented': [251], 'individuals.': [252], 'Neurosci': [253], 'Lett.': [254], '1988;93:191-6.': [255], '3241644]': [257], 'Scholar5.': [259], 'Iwatsubo': [260, 1691], 'T,': [261, 418, 1288, 1478, 1523, 1692, 1949, 2738], 'Odaka': [262], 'Suzuki': [264, 1570], 'N,': [265, 269, 1571, 2045], 'Mizusawa': [266], 'Nukina': [268], 'Ihara': [270], 'Visualization': [272], 'A': [274, 278, 286, 296, 819, 1674, 1795, 2316, 2773, 2809, 2930, 2936, 3098, 3472, 3487, 3562], 'beta': [275, 279, 287, 297, 577, 677, 1675, 1705, 2085, 2189, 2242, 2774, 2810, 2924, 2931, 2937, 3840], '42(43)': [276], '40': [280], 'end-specific': [285], 'monoclonals:': [288], 'evidence': [289, 2262], 'an': [291, 1963, 2817, 3274], 'initially': [292], 'deposited': [293], 'species': [294], 'is': [295, 435, 643, 856, 1443, 1492, 1588, 1962, 2415, 2636, 2709, 3205], '42(43).': [298], 'Neuron.': [299, 442, 1275, 1750, 3041, 3146], '1994;13:45-53.': [300], '8043280]': [302], 'Scholar6.': [304], 'Cummings': [305], 'BJ,': [306, 451, 1363], 'Pike': [307, 2375], 'CJ,': [308, 2376], 'Shankle': [309], 'R,': [310, 338, 424, 526, 721, 759, 763, 787, 1056, 1122, 1904, 2139, 2178, 2235, 2496, 2730, 2834, 2872, 3092], 'Cotman': [311, 2383], 'Beta-amyloid': [313, 2409], 'deposition': [314, 1295, 1374, 1496, 1537, 1677, 1708, 2602], 'other': [316], 'measures': [317], 'neuropathology': [319], 'predict': [320], 'status': [322, 3326, 3403], 'disease.': [325, 406, 948, 1048, 1081, 1388, 1462, 1505, 1547, 1605, 1925, 2222, 2293, 2328, 2502, 2616, 2787, 2822, 2859, 2902, 2945, 3040, 3073], 'Neurobiol': [326, 1314, 2223], 'Aging.': [327, 2224], '1996;17:921-33.': [328], '9363804]': [330], 'Scholar7.': [332], 'Naslund': [333], 'Haroutunian': [335], 'V,': [336, 1236, 1238], 'Mohs': [337], 'Davis': [339, 699, 764, 2232, 2347], 'KL,': [340], 'Davies': [341], 'P,': [342, 344, 690, 731, 1093, 1204, 1624, 1785, 1787, 1840, 2443, 3088], 'Greengard': [343], 'Correlation': [348], 'between': [349, 1910, 3843], 'elevated': [350], 'levels': [351, 3850], 'beta-peptide': [354, 642, 710, 1373, 2887], 'brain': [357, 565, 2935, 3344, 3777], 'decline.': [360], 'JAMA.': [361], '2000;283:1571-7.': [362], '10735393]': [364], 'Scholar8.': [366], 'Verbeek': [367], 'MM,': [368, 888], 'de': [369, 2438], 'Waal': [370], 'RM,': [371], 'Vinters': [372], 'HV.': [373], 'Cerebral': [374, 2600], 'Amyloid': [375, 641, 1704, 3439, 3446, 3571, 3619, 3702, 3839], 'Angiopathy': [376], 'Disease': [379, 2331, 3539], 'Related': [381], 'Disorders.': [382], 'Dordrecht,': [383], 'Netherlands:': [385], 'Kluwer': [386], 'Academic;': [387], '2000:357.': [388], 'Google': [389, 2995], 'Scholar9.': [390], 'Goedert': [391, 1166, 1264], 'Spillantini': [393, 1162, 1268], 'MG.': [394, 1269], 'Tau': [395, 1270, 3449, 3586], 'mutations': [396, 1076, 1141, 1219, 1271, 1600], 'frontotemporal': [398, 1273], 'dementia': [399, 1225], 'FTDP-17': [400], 'their': [402], 'relevance': [403], 'Biochim': [407], 'Acta.': [409], '2000;1502:110-21.': [410], '10899436]': [412], 'Scholar10.': [414], 'Kondo': [415], 'Honda': [417], 'Mori': [419, 2839], 'Hamada': [421], 'Y,': [422, 1060, 1130, 1482, 2696, 2767], 'Miura': [423], 'Ogawara': [425], 'carboxyl': [431], 'third': [432], 'tau': [434, 1177, 1221, 1253, 2486], 'tightly': [436], 'bound': [437], 'paired': [439, 461], 'helical': [440, 462], 'filaments.': [441, 1424], '1988;1:827-34.': [443], '2483105]': [445], 'Scholar11.': [447], 'Lee': [448, 695, 990, 1728, 2074], 'VM,': [449], 'Balin': [450], 'Otvos': [452], 'L,': [453, 1242, 1614, 1733, 2435, 2470, 2661], 'Trojanowski': [454], 'JQ.': [455], 'A68:': [456], 'major': [458, 2711], 'subunit': [459], 'filaments': [463], 'derivatized': [465], 'forms': [466], 'Tau.': [469], 'Science.': [470, 683, 748, 834, 1113, 1258, 1350, 2489, 2687], '1991;251:675-8.': [471], '1899488]': [473], 'Scholar12.': [475], "Down's": [483], 'syndrome:': [484, 1305], 'sharing': [485], 'unique': [488], 'fibril': [491, 2412], '1984;122:1131-5.': [497], '6236805]': [499], 'Scholar13.': [501], 'Selkoe': [502, 846, 961, 1291, 1819, 1879, 1907, 2109, 2633, 2958, 2997, 3204], 'DJ.': [503, 847, 962, 1292, 1880, 1908, 2110, 2634], 'genes,': [506], 'proteins,': [507], 'therapy.': [509], 'Physiol': [510], 'Rev.': [511], '2001;81:741-66.': [512], '11274343]': [514], 'Scholar14.': [516], 'Zheng': [517, 842], 'Jiang': [519, 2766], 'Trumbauer': [521], 'ME,': [522, 791, 2252, 3120], 'Sirinathsinghji': [523], 'DJ,': [524, 1480, 1820, 2915, 2959, 2998], 'Hopkins': [525], 'Smith': [527, 2561], 'DW,': [528, 995, 2466, 2590], 'beta-Amyloid': [532, 2355], 'protein-deficient': [534], 'mice': [535, 1633, 2483, 3739], 'show': [536], 'reactive': [537], 'gliosis': [538], 'decreased': [540], 'locomotor': [541], 'activity.': [542, 808, 1892, 3108], 'Cell.': [543, 1830, 2245], '1995;81:525-31.': [544], '7758106]': [546], 'Scholar15.': [548], 'Wasco': [549, 1090], 'W,': [550, 1091, 1783, 1818, 1848, 1872, 1900, 1941, 2513, 2521, 2630, 2732], 'Bupp': [551], 'K,': [552, 882, 1789, 1842, 2254, 2310, 2350], 'Magendantz': [553], 'Gusella': [555], 'JF,': [556], 'Tanzi': [557, 601], 'RE,': [558, 602, 2106], 'Solomon': [559], 'F.': [560], 'Identification': [561], 'mouse': [564, 613, 1501, 1543, 2855, 2898, 2941, 3277, 3829], 'cDNA': [566], 'encodes': [568], 'related': [571, 1148], 'disease-associated': [575], 'precursor.': [579], 'Proc': [580, 949, 1187, 1389, 1463, 1506, 1548, 1926, 2157, 2420, 2648, 2946], 'Natl': [581, 950, 1188, 1390, 1464, 1507, 1549, 1927, 2158, 2421, 2649, 2947], 'Acad': [582, 951, 1013, 1189, 1391, 1465, 1508, 1550, 1928, 2159, 2422, 2650, 2948], 'Sci': [583, 952, 1190, 1392, 1466, 1509, 1551, 1929, 2160, 2423, 2651, 2949], 'U': [584, 953, 1191, 1393, 1467, 1510, 1552, 1930, 2161, 2424, 2652, 2950], 'S': [585, 954, 1192, 1394, 1468, 1511, 1553, 1931, 2162, 2425, 2653, 2951], 'A.': [586, 955, 1193, 1395, 1469, 1512, 1554, 1932, 2163, 2426, 2654, 2952], '1992;89:10758-62.': [587], '1279693]': [589], 'Scholar16.': [591], 'Slunt': [592, 1730], 'HH,': [593, 1731], 'Thinakaran': [594, 1724], 'Von': [596], 'Koch': [597], 'C,': [598, 627, 633, 692, 1563, 2041, 2137, 2231, 2304, 2759, 2803, 2840, 2870, 3018], 'Lo': [599], 'AC,': [600], 'Sisodia': [603], 'SS.': [604], 'Expression': [605], 'ubiquitous,': [608], 'cross-reactive': [609], 'homologue': [610], 'beta-amyloid': [614, 853, 896, 936, 2270, 2388, 3034, 3139], '(APP).': [617], 'J': [618, 869, 2062, 2093, 2336, 2368, 2398, 2505, 3076], 'Biol': [619, 870, 2063], 'Chem.': [620, 871, 2064], '1994;269:2637-44.': [621], '8300594]': [623], 'Scholar17.': [625], 'Haass': [626], 'Schlossmacher': [628], 'MG,': [629, 1163], 'Hung': [630], 'AY,': [631], 'Vigo-Pelfrey': [632, 691], 'Mellon': [634], 'Ostaszewski': [636, 1873, 1946, 1977, 2627], 'BL,': [637, 1874, 1978, 2628], 'produced': [644, 2266], 'by': [645, 679, 742, 858, 1592, 1764, 2267, 2387, 2417, 2718, 3280, 3426, 3499, 3589], 'cultured': [646, 2274], 'cells': [647, 2119], 'during': [648], 'metabolism.': [650], '1992;359:322-5.': [652], '1383826]': [654], 'Scholar18.': [656], 'Golde': [659], 'TE,': [660], 'Ghiso': [661], 'Cheung': [663], 'TT,': [664], 'Estus': [665], 'Shaffer': [667], 'LM,': [668], 'Production': [672], 'proteolytic': [681], 'processing.': [682], '1992;258:126-9.': [684], '1439760]': [686], 'Scholar19.': [688], 'Seubert': [689], 'Esch': [693], 'Dovey': [697], 'D,': [700, 765, 921, 1025, 1561, 1698, 1757, 2348, 2378, 2698, 2728, 2795, 2876], 'Isolation': [704], 'quantification': [706], 'soluble': [708], 'from': [711, 777, 2121, 2149, 3305, 3382, 3445, 3537], 'biological': [712, 3805], 'fluids.': [713], '1992;359:325-7.': [715], '1406936]': [717], 'Scholar20.': [719], 'Vassar': [720], 'Bennett': [722], 'BD,': [723], 'Babu-Khan': [724], 'Kahn': [726], 'Mendiaz': [728], 'EA,': [729, 1062, 1124, 2596], 'Denis': [730], 'Beta-secretase': [735], 'cleavage': [736, 906, 1858], 'transmembrane': [744, 1882], 'aspartic': [745], 'protease': [746, 803, 1798, 2678], 'BACE.': [747], '1999;286:735-41.': [749], '10531052]': [751], 'Scholar21.': [753], 'Sinha': [754], 'Anderson': [756], 'JP,': [757], 'Barbour': [758, 2729, 2871], 'Basi': [760], 'GS,': [761, 927], 'Caccavello': [762], 'Purification': [769], 'cloning': [771], 'beta-secretase': [776, 807, 2712], 'human': [778, 2122, 2362], 'brain.': [779, 2123], '1999;402:537-40.': [781], '10591214]': [783], 'Scholar22.': [785], 'Yan': [786], 'Bienkowski': [788], 'MJ,': [789, 2626], 'Shuck': [790], 'Miao': [792], 'Tory': [794], 'MC,': [795], 'Pauley': [796], 'AM,': [797, 919, 1021, 1359, 1525], 'Membrane-anchored': [801], 'aspartyl': [802, 1965], '1999;402:533-7.': [810], '10591213]': [812], 'Scholar23.': [814], 'Cao': [815], 'X,': [816, 1567, 1620, 2665], 'Sudhof': [817], 'TC.': [818], 'transcriptionally': [820], '[correction': [821], 'transcriptively]': [823], 'active': [824, 2026], 'complex': [825, 2640], 'APP': [827, 1599], 'Fe65': [829, 859], 'histone': [831], 'acetyltransferase': [832], 'Tip60.': [833], '2001;293:115-20.': [835], '11441186]': [837], 'Scholar24.': [839], 'Kimberly': [840, 1877, 1975, 2623], 'WT,': [841, 1878, 1976, 2624], 'JB,': [843, 2233], 'Guenette': [844], 'SY,': [845], 'intracellular': [849, 1803], 'domain': [850, 2679], 'stabilized': [857], 'translocates': [861], 'nucleus': [864], 'notch-like': [867], 'manner.': [868], '2001;276:40288-92.': [872], '11544248]': [874], 'Scholar25.': [876], 'Sastre': [877], 'Steiner': [879], 'Fuchs': [881], 'Capell': [883], 'Multhaup': [885], 'Condron': [887], 'Presenilin-dependent': [892], 'gamma-secretase': [893, 1891, 1961, 1992, 2021, 2060], 'processing': [894], 'at': [899, 2993, 3387], 'site': [901, 2027], 'corresponding': [902], 'S3': [905], 'Notch.': [908], 'EMBO': [909], 'Rep.': [910], '2001;2:835-41.': [911], '11520861]': [913], 'Scholar26.': [915], 'Strittmatter': [916, 1022, 1360], 'WJ,': [917, 1023, 1361], 'Saunders': [918, 1020, 1358], 'Schmechel': [920, 1024, 1356], 'Pericak-Vance': [922, 1028], 'Enghild': [924], 'Salvesen': [926], 'Apolipoprotein': [931, 1441, 1490, 1533], 'E:': [932], 'high-avidity': [933], 'binding': [934], 'increased': [938, 1589, 1673], 'frequency': [939], '4': [942, 1041], 'allele': [943, 1039], 'late-onset': [945, 1043, 1386], 'familial': [946, 1044, 1079, 1109, 1180, 1603], '1993;90:1977-81.': [956], '8446617]': [958], 'Scholar27.': [960], 'genetics': [964], 'molecular': [966, 1956, 3003], 'pathology': [967, 2747, 2895], 'roles': [971], 'presenilins.': [976], 'Neurol': [977], 'Clin.': [978], '2000;18:903-22.': [979], '11072267]': [981], 'Scholar28.': [983], 'Price': [984, 2593, 2703], 'DL,': [985, 2704], 'PC,': [987], 'Markowska': [988], 'AL,': [989], 'MK,': [991, 1729], 'Thinakaren': [992], 'Cleveland': [994], 'value': [1000], 'transgenic': [1002, 1500, 1632, 2482, 3144, 3738], 'models': [1003], 'study': [1006], 'neurodegenerative': [1008, 3396], 'diseases.': [1009], 'Ann': [1010, 1717, 2860], 'N': [1011, 2334, 2503, 3074], 'Y': [1012], 'Sci.': [1014], '2000;920:179-91.': [1015], '11193148]': [1017], 'Scholar29.': [1019], 'George-Hyslop': [1026], 'PH,': [1027], 'MA,': [1029], 'Joo': [1030, 1366], 'SH,': [1031, 1367], 'Association': [1035, 1214], 'apolipoprotein': [1037, 1382, 1416], 'E': [1038, 1302, 1383, 1417, 1442, 1491, 1534], 'epsilon': [1040], 'sporadic': [1046], 'Neurology.': [1049, 2617], '1993;43:1467-72.': [1050], '8350998]': [1052], 'Scholar30.': [1054], 'Sherrington': [1055, 1121], 'Rogaev': [1057, 1119], 'EI,': [1058, 1120], 'Liang': [1059, 1129], 'Rogaeva': [1061, 1123], 'Levesque': [1063, 1125], 'Ikeda': [1065, 1127], 'Cloning': [1070], 'gene': [1073, 1104, 1144, 1178, 1343], 'bearing': [1074], 'missense': [1075, 1140, 1216], 'early-onset': [1078], '1995;375:754-60.': [1083], '7596406]': [1085], 'Scholar31.': [1087], 'Levy-Lahad': [1088], 'E,': [1089, 1322, 1618, 2517], 'Poorkaj': [1092], 'Romano': [1094], 'DM,': [1095, 1519, 1690, 2071, 2102, 2170, 2797], 'Oshima': [1096], 'Pettingell': [1098], 'WH,': [1099], 'Candidate': [1103, 3542], 'chromosome': [1107, 1146, 1710], '1': [1108, 1147, 1595, 1642, 1669, 1742, 3596, 3623], 'locus.': [1112], '1995;269:973-7.': [1114], '7638622]': [1116], 'Scholar32.': [1118], 'Familial': [1134], 'kindreds': [1138], 'on': [1145, 3733, 3871], '3': [1154], 'gene.': [1155, 1772], '1995;376:775-8.': [1157], '7651536]': [1159], 'Scholar33.': [1161], 'Murrell': [1164], 'JR,': [1165, 3022], 'Farlow': [1168], 'MR,': [1169, 2308], 'Klug': [1170], 'Ghetti': [1172], 'B.': [1173], 'Mutation': [1174, 1337], 'multiple': [1181], 'system': [1182, 2155, 2892], 'tauopathy': [1183], 'presenile': [1185], '1998;95:7737-41.': [1194], '9636220]': [1196], 'Scholar34.': [1198], 'Hutton': [1199], 'Lendon': [1201, 1657], 'Rizzu': [1203], 'Baker': [1205], 'Froelich': [1207], 'Houlden': [1209], "5'-splice-site": [1218], 'inherited': [1224], 'FTDP-17.': [1226, 1257], '1998;393:702-5.': [1228], '9641683]': [1230], 'Scholar35.': [1232], 'Hong': [1233, 2660], 'Zhukareva': [1235], 'Vogelsberg-Ragaglia': [1237], 'Wszolek': [1239], 'Z,': [1240], 'Reed': [1241], 'Miller': [1243], 'BI,': [1244], 'Mutation-specific': [1248], 'functional': [1249, 3662], 'impairments': [1250], 'distinct': [1252], 'isoforms': [1254], 'hereditary': [1256, 1345], '1998;282:1914-7.': [1259], '9836646]': [1261], 'Scholar36.': [1263], 'Crowther': [1266], 'RA,': [1267, 2258, 3116], 'cause': [1272], 'dementias.': [1274], '1998;21:955-8.': [1276], '9856453]': [1278], 'Scholar37.': [1280], 'Lemere': [1281, 1651, 2831], 'CA,': [1282, 1652, 2832, 3126], 'Blusztajn': [1283], 'JK,': [1284], 'Wisniewski': [1287], 'Saido': [1289, 1661], 'TC,': [1290, 1662], 'Sequence': [1293, 3304], 'heterogeneous': [1297], 'beta-peptides': [1299], 'APO': [1301], 'Down': [1304], 'implications': [1306, 1454, 1919], 'events': [1309], 'plaque': [1312], 'formation.': [1313], 'Dis.': [1315], '1996;3:16-32.': [1316], '9173910]': [1318], 'Scholar38.': [1320], 'Levy': [1321], 'Carman': [1323], 'MD,': [1324, 1328, 3224], 'Fernandez-Madrid': [1325], 'IJ,': [1326], 'Power': [1327], 'Lieberburg': [1329, 2351], 'I,': [1330, 2172, 2352], 'van': [1331, 3057], 'Duinen': [1332], 'SG,': [1333], 'hemorrhage,': [1347], 'Dutch': [1348], 'type.': [1349], '1990;248:1124-6.': [1351], '2111584]': [1353], 'Scholar39.': [1355], 'DE,': [1357], 'Crain': [1362], 'Hulette': [1364], 'CM,': [1365, 3059], 'Increased': [1371], 'consequence': [1380], 'genotype': [1384], '1993;90:9649-53.': [1396], '8415756]': [1398], 'Scholar40.': [1400], 'Ma': [1401], 'Yee': [1403], 'Brewer': [1405], 'HB,': [1406], 'Das': [1407, 3087], 'Potter': [1409], 'H.': [1410], 'Amyloid-associated': [1411], 'proteins': [1412], 'alpha': [1413], '1-antichymotrypsin': [1414], 'promote': [1418], 'assembly': [1419, 2396], 'beta-protein': [1422, 1577, 2115], 'into': [1423, 3547, 3661], '1994;372:92-4.': [1426], '7969426]': [1428], 'Scholar41.': [1430], 'Evans': [1431], 'KC,': [1432], 'Berger': [1433], 'EP,': [1434], 'Cho': [1435], 'CG,': [1436, 2382], 'Weisgraber': [1437], 'Lansbury': [1439], 'PT.': [1440], 'kinetic': [1445], 'thermodynamic': [1449], 'inhibitor': [1450], 'formation:': [1453], 'pathogenesis': [1457, 1922], 'treatment': [1459, 2325], '1995;92:763-7.': [1470], '7846048]': [1472], 'Scholar42.': [1474], 'Bales': [1475, 1520, 2912], 'KR,': [1476, 1521, 2913], 'Verina': [1477], 'Cummins': [1479, 2914], 'Du': [1481], 'Dodel': [1483], 'RC,': [1484, 2560], 'Saura': [1485], 'essential': [1493], 'APP(V717F)': [1499], 'model': [1502, 1544, 2784, 2819, 2856, 2899, 2942, 3278, 3434, 3830], '1999;96:15233-8.': [1513], '10611368]': [1515], 'Scholar43.': [1517], 'Holtzman': [1518, 2920], 'Tenkova': [1522], 'Fagan': [1524], 'Parsadanian': [1526], 'Sartorius': [1528], 'LJ,': [1529, 3056], 'isoform-dependent': [1535], 'neuritic': [1539, 3876], 'degeneration': [1540, 2480, 3696], '2000;97:2892-7.': [1555], '10694577]': [1557], 'Scholar44.': [1559], 'Scheuner': [1560], 'Eckman': [1562], 'Jensen': [1564], 'Song': [1566], 'Citron': [1568], 'Secreted': [1575], 'similar': [1578], 'vivo': [1591], 'presenilin': [1594, 1641, 1668, 1741, 1888, 2030], '2': [1597, 2682, 3366], 'linked': [1601], 'Nat': [1606, 1644, 1682, 1997, 2720, 2903], 'Med.': [1607, 1645, 1683, 2337, 2506, 2904, 3077], '1996;2:864-70.': [1608], '8705854]': [1610], 'Scholar45.': [1612], 'Holcomb': [1613], 'Gordon': [1615, 2733], 'MN,': [1616], 'McGowan': [1617], 'Yu': [1619], 'Benkovic': [1621], 'Jantzen': [1623], 'Accelerated': [1628], 'phenotype': [1630], 'carrying': [1634], 'both': [1635, 2323], 'mutant': [1636, 2485], 'transgenes.': [1643], '1998;4:97-100.': [1646], '9427614]': [1648], 'Scholar46.': [1650], 'Lopera': [1653], 'Kosik': [1655], 'KS,': [1656], 'Ossa': [1659], 'E280A': [1667], 'mutation': [1671], 'produces': [1672], '42': [1676], 'severe': [1679], 'cerebellar': [1680], 'pathology.': [1681], '1996;2:1146-50.': [1684], '8837617]': [1686], 'Scholar47.': [1688], 'Mann': [1689], 'Cairns': [1693], 'NJ,': [1694], 'Lantos': [1695], 'PL,': [1696], 'Nochlin': [1697], 'Sumi': [1699], 'SM,': [1700, 2919], '(Abeta)': [1707], '14-linked': [1711], 'predominance': [1714], 'Abeta42(43).': [1716], 'Neurol.': [1718, 2278, 2295, 2579, 2861], '1996;40:149-56.': [1719], '8773595]': [1721], 'Scholar48.': [1723], 'Borchelt': [1726, 2701], 'DR,': [1727, 2702], 'Spitzer': [1732], 'Kim': [1734], 'Endoproteolysis': [1739], 'accumulation': [1744, 3140], 'processed': [1746], 'derivatives': [1747], 'vivo.': [1749, 2197], '1996;17:181-90.': [1751], '8755489]': [1753], 'Scholar49.': [1755], 'Levitan': [1756], 'Greenwald': [1758], 'I.': [1759], 'Facilitation': [1760], 'lin-12-mediated': [1762], 'signalling': [1763], 'sel-12,': [1765], 'Caenorhabditis': [1767], 'elegans': [1768], 'S182': [1769], '1995;377:351-4.': [1774], '7566091]': [1776], 'Scholar50.': [1778], 'De': [1779, 1836], 'Strooper': [1780, 1837], 'Annaert': [1782, 1847], 'Cupers': [1784], 'Saftig': [1786, 1839], 'Craessaerts': [1788, 1841], 'Mumm': [1790], 'JS,': [1791], 'presenilin-1-dependent': [1796], 'gamma-secretase-like': [1797], 'mediates': [1799, 2240], 'release': [1800], 'Notch': [1802], 'domain.': [1804], '1999;398:518-22.': [1806], '10206645]': [1808], 'Scholar51.': [1810], 'Shen': [1811], 'Bronson': [1813], 'RT,': [1814], 'Chen': [1815], 'DF,': [1816], 'Xia': [1817, 1871, 1899, 1940], 'Tonegawa': [1821], 'S.': [1822], 'Skeletal': [1823], 'CNS': [1825, 2927], 'defects': [1826], 'Presenilin-1-deficient': [1828], 'mice.': [1829, 3145], '1997;89:629-39.': [1831], '9160754]': [1833], 'Scholar52.': [1835], 'Vanderstichele': [1843], 'Guhde': [1845], 'Deficiency': [1852], 'presenilin-1': [1854, 1885], 'inhibits': [1855, 3138], '1998;391:387-90.': [1864], '9450754]': [1866], 'Scholar53.': [1868], 'Wolfe': [1869, 1938, 2179, 2631], 'MS,': [1870, 1939, 2180, 2632], 'Diehl': [1875, 1979], 'TS,': [1876, 1980], 'Two': [1881], 'aspartates': [1883], 'required': [1886], 'endoproteolysis': [1889], '1999;398:513-7.': [1894], '10206644]': [1896], 'Scholar54.': [1898], 'Zhang': [1901], 'Perez': [1903], 'Koo': [1905], 'EH,': [1906, 2592], 'Interaction': [1909], 'presenilins': [1915], 'mammalian': [1917], 'cells:': [1918], '1997;94:8208-13.': [1933], '9223340]': [1935], 'Scholar55.': [1937], 'Moore': [1942, 1981], 'Leatherwood': [1944], 'DD,': [1945], 'Rahmati': [1948], 'Peptidomimetic': [1953], 'probes': [1954], 'modeling': [1957], 'intramembrane-cleaving': [1964], 'protease.': [1966], 'Biochemistry.': [1967, 2124], '1999;38:4720-7.': [1968], '10200159]': [1970], 'Scholar56.': [1972], 'Esler': [1973], 'WP,': [1974], 'Tsai': [1983, 2444], 'JY,': [1984], 'Transition-state': [1988], 'analogue': [1989], 'bind': [1993], 'directly': [1994], 'presenilin-1.': [1996], 'Cell': [1998, 2094, 3492], 'Biol.': [1999, 2095], '2000;2:428-34.': [2000], '10878808]': [2002], 'Scholar57.': [2004], 'Li': [2005], 'YM,': [2006], 'Xu': [2007], 'Lai': [2009], 'MT,': [2010], 'Huang': [2011], 'Q,': [2012], 'Castro': [2013], 'JL,': [2014, 2594, 3086], 'DiMuzio-Mower': [2015], 'Photoactivated': [2020], 'directed': [2023], 'covalently': [2028], 'label': [2029], '1.': [2031], '2000;405:689-94.': [2033], '10864326]': [2035], 'Scholar58.': [2037], 'Berezovska': [2038], 'O,': [2039], 'Jack': [2040], 'Deng': [2042], 'Gastineau': [2044], 'Rebeck': [2046], 'GW,': [2047], 'Hyman': [2048], 'BT.': [2049], 'Notch1': [2050], 'are': [2055, 2151], 'competitive': [2056], 'substrates': [2057], 'presenilin1-dependent': [2059], 'cleavage.': [2061], '2001;276:30018-23.': [2065], '11408475]': [2067], 'Scholar59.': [2069], 'Skovronsky': [2070], 'Doms': [2072], 'RW,': [2073], 'VM.': [2075], 'Detection': [2076], 'intraneuronal': [2080], 'pool': [2081], 'insoluble': [2083], 'accumulates': [2088], 'time': [2090], 'culture.': [2092], '1998;141:1031-9.': [2096], '9585420]': [2098], 'Scholar60.': [2100], 'Walsh': [2101, 2169, 2964], 'Tseng': [2103], 'BP,': [2104], 'Rydel': [2105, 2353], 'Podlisny': [2107], 'MB,': [2108], 'oligomerization': [2112], 'intracellularly': [2117], 'derived': [2120, 2148], '2000;39:10831-9.': [2125], '10978169]': [2127], 'Scholar61.': [2129], 'Lambert': [2130], 'MP,': [2131, 2344], 'Barlow': [2132], 'AK,': [2133, 2671], 'Chromy': [2134], 'BA,': [2135, 3050], 'Edwards': [2136], 'Freed': [2138], 'Liosatos': [2140], 'Diffusible,': [2145], 'nonfibrillar': [2146], 'ligands': [2147], 'Abeta1-42': [2150], 'potent': [2152, 3679], 'central': [2153, 2890], 'nervous': [2154, 2891], 'neurotoxins.': [2156], '1998;95:6448-53.': [2164], '9600986]': [2166], 'Scholar62.': [2168], 'Klyubin': [2171], 'Fadeeva': [2173, 2962], 'JV,': [2174, 2963], 'Cullen': [2175], 'WK,': [2176], 'Anwyl': [2177], 'Naturally': [2184], 'secreted': [2185], 'oligomers': [2186, 2974], 'potently': [2191], 'inhibit': [2192], 'hippocampal': [2193, 2275], 'potentiation': [2195], '2002;416:535-9.': [2199], '11932745]': [2201], 'Scholar63.': [2203], 'Akiyama': [2204], 'Barger': [2206], 'Barnum': [2208], 'Bradt': [2210], 'Bauer': [2212], 'Cole': [2214], 'GM,': [2215, 2961], 'Inflammation': [2219], '2000;21:383-421.': [2225], '10858586]': [2227], 'Scholar64.': [2229], 'Behl': [2230], 'Lesley': [2234], 'Schubert': [2236], 'D.': [2237, 3000], 'Hydrogen': [2238], 'peroxide': [2239], 'toxicity.': [2244], '1994;77:817-27.': [2246], '8004671]': [2248], 'Scholar65.': [2250], 'Harris': [2251], 'Hensley': [2253], 'Butterfield': [2255], 'DA,': [2256], 'Leedle': [2257], 'Carney': [2259], 'JM.': [2260], 'Direct': [2261], 'oxidative': [2264, 2289, 3424], 'injury': [2265, 3844], 'peptide': [2271, 2395, 2775, 2811, 2848], '(1-40)': [2272], 'neurons.': [2276, 2719], 'Exp': [2277], '1995;131:193-202.': [2279], '7895820]': [2281], 'Scholar66.': [2283], 'Markesbery': [2284], 'WR.': [2285], 'role': [2287, 2393, 3772, 3791], 'stress': [2290], 'Arch': [2294, 2578], '1999;56:1449-52.': [2296], '10593298]': [2298], 'Scholar67.': [2300], 'Sano': [2301, 2497], 'Ernesto': [2303], 'Thomas': [2305], 'RG,': [2306], 'Klauber': [2307], 'Schafer': [2309], 'Grundman': [2311], 'controlled': [2317], 'trial': [2318], 'selegiline,': [2320], 'alpha-tocopherol,': [2321], 'or': [2322], 'Cooperative': [2332], 'Study.': [2333], 'Engl': [2335, 2504, 3075], '1997;336:1216-22.': [2338], '9110909]': [2340], 'Scholar68.': [2342], 'Mattson': [2343], 'Cheng': [2345], 'Bryant': [2349], 'RE.': [2354], 'peptides': [2356, 2389, 2717], 'destabilize': [2357], 'calcium': [2358, 3263], 'homeostasis': [2359], 'render': [2361], 'cortical': [2363], 'neurons': [2364], 'vulnerable': [2365], 'excitotoxicity.': [2367], 'Neurosci.': [2369, 2399, 2721], '1992;12:376-89.': [2370], '1346802]': [2372], 'Scholar69.': [2374], 'Burdick': [2377], 'Walencewicz': [2379], 'AJ,': [2380], 'Glabe': [2381], 'Neurodegeneration': [2385], 'induced': [2386], 'vitro:': [2391], 'state.': [2397], '1993;13:1676-87.': [2400], '8463843]': [2402], 'Scholar70.': [2404], 'Lorenzo': [2405], 'Yankner': [2407], 'BA.': [2408], 'neurotoxicity': [2410], 'requires': [2411], 'formation': [2413], 'inhibited': [2416], 'congo': [2418], 'red.': [2419], '1994;91:12243-7.': [2427], '7991613]': [2429], 'Scholar71.': [2431], 'Patrick': [2432], 'GN,': [2433], 'Zukerberg': [2434], 'Nikolic': [2436], 'la': [2439], 'Monte': [2440], 'Dikkes': [2442], 'LH.': [2445], 'Conversion': [2446], 'p35': [2448], 'p25': [2450], 'deregulates': [2451], 'Cdk5': [2452], 'activity': [2453, 3873], 'promotes': [2455], 'neurodegeneration.': [2456], '1999;402:615-22.': [2458], '10604467]': [2460], 'Scholar72.': [2462], 'Lewis': [2463], 'Dickson': [2465], 'Lin': [2467, 2664], 'WL,': [2468], 'Chisholm': [2469], 'Corral': [2471], 'Jones': [2473, 3123], 'Enhanced': [2478], 'neurofibrillary': [2479], 'expressing': [2484], 'APP.': [2488], '2001;293:1487-91.': [2490], '11520987]': [2492], 'Scholar73.': [2494], 'Mayeux': [2495], 'M.': [2498], 'Treatment': [2499, 3130], '1999;341:1670-9.': [2507], '10572156]': [2509], 'Scholar74.': [2511], 'Zajaczkowski': [2512], 'Hetman': [2514], 'Nikolaev': [2516], 'Quack': [2518], 'Danysz': [2520], 'Kaczmarek': [2522], 'L.': [2523], 'Behavioural': [2524], 'evaluation': [2525, 3806], 'neurotoxic': [2528], 'effects': [2529], 'NMDA': [2531], 'receptor': [2532], 'antagonists.': [2533], 'Neurotox': [2534], 'Res.': [2535], '2000;1:299-310.': [2536], '12835097]': [2538], 'Scholar75.': [2540], 'Jain': [2541], 'KK.': [2542], 'Evaluation': [2543], 'memantine': [2545], 'neuroprotection': [2547], 'Expert': [2550], 'Opin': [2551], 'Investig': [2552], 'Drugs.': [2553], '2000;9:1397-406.': [2554], '11060751]': [2556], 'Scholar76.': [2558], 'Petersen': [2559], 'GE,': [2562], 'Waring': [2563], 'SC,': [2564], 'Ivnik': [2565], 'RJ,': [2566], 'Tangalos': [2567], 'EG,': [2568], 'Kokmen': [2569], 'E.': [2570], 'Mild': [2571], 'impairment:': [2573], 'clinical': [2574], 'outcome.': [2577], '1999;56:303-8.': [2580], '10190820]': [2582], 'Scholar77.': [2584], 'Morris': [2585], 'JC,': [2586, 2917], 'Storandt': [2587], 'McKeel': [2589], 'Rubin': [2591], 'Grant': [2595], 'diffuse': [2604], '"normal"': [2607], 'aging:': [2608], 'Evidence': [2609, 3381], 'presymptomatic': [2611], 'very': [2613], 'mild': [2614], '1996;46:707-19.': [2618], '8618671]': [2620], 'Scholar78.': [2622], 'LaVoie': [2625], 'Ye': [2629], 'Gamma-secretase': [2635], 'membrane': [2638], 'comprised': [2641], 'presenilin,': [2643], 'nicastrin,': [2644], 'Aph-1,': [2645], 'Pen-2.': [2647], '2003;100:6382-7.': [2655], '12740439]': [2657], 'Scholar79.': [2659], 'Koelsch': [2662], 'Wu': [2666], 'Terzyan': [2668], 'Ghosh': [2670], 'Structure': [2675, 3460, 3744], 'memapsin': [2681], '(beta-secretase)': [2683], 'complexed': [2684], 'inhibitor.': [2686], '2000;290:150-3.': [2688], '11021803]': [2690], 'Scholar80.': [2692], 'Cai': [2693], 'Wang': [2695, 3091], 'McCarthy': [2697], 'Wen': [2699], 'BACE1': [2708, 3872], 'generation': [2714], 'Abeta': [2716], '2001;4:233-4.': [2722], '11224536]': [2724], 'Scholar81.': [2726], 'Schenk': [2727, 2999], 'Dunn': [2731], 'Grajeda': [2735, 2877], 'Guido': [2737], 'Immunization': [2742], 'amyloid-beta': [2744, 2847], 'attenuates': [2745], 'Alzheimer-disease-like': [2746], 'PDAPP': [2750], 'mouse.': [2751], '1999;400:173-7.': [2753], '10408445]': [2755], 'Scholar82.': [2757], 'Janus': [2758], 'Pearson': [2760], 'McLaurin': [2762], 'Mathews': [2764], 'PM,': [2765], 'Schmidt': [2768], 'SD,': [2769], 'immunization': [2776], 'reduces': [2777, 3423, 3822], 'behavioural': [2778], '2000;408:979-82.': [2789], '11140685]': [2791], 'Scholar83.': [2793], 'Morgan': [2794], 'Diamond': [2796], 'Gottschall': [2798], 'PE,': [2799], 'Ugen': [2800], 'KE,': [2801], 'Dickey': [2802], 'Hardy': [2804], 'vaccination': [2812], 'prevents': [2813], 'loss': [2815, 3735], 'animal': [2818], '2000;408:982-5.': [2824], '11140686]': [2826], 'Scholar84.': [2828], 'Weiner': [2829], 'HL,': [2830], 'Maron': [2833], 'Spooner': [2835], 'ET,': [2836], 'Grenfell': [2837], 'TJ,': [2838], 'Nasal': [2844], 'administration': [2845], 'decreases': [2849, 2934], 'burden': [2852, 2938], '2000;48:567-79.': [2862], '11026440]': [2864], 'Scholar85.': [2866], 'Bard': [2867], 'Cannon': [2869], 'Burke': [2873], 'RL,': [2874], 'Games': [2875], 'Peripherally': [2882], 'administered': [2883], 'antibodies': [2884], 'against': [2885, 3033, 3288, 3817], 'enter': [2888], 'reduce': [2894], '2000;6:916-9.': [2905], '10932230]': [2907], 'Scholar86.': [2909], 'DeMattos': [2910], 'RB,': [2911], 'Dodart': [2916], 'Paul': [2918], 'DM.': [2921, 2965], 'Peripheral': [2922], 'anti-A': [2923], 'antibody': [2925, 3816], 'alters': [2926], 'plasma': [2929], 'clearance': [2932], '2001;98:8850-5.': [2953], '11438712]': [2955], 'Scholar87.': [2957], 'Shankar': [2960], 'Modulation': [2966], 'further': [2968], 'natural,': [2971], 'cell-derived': [2972], 'Aβ': [2973, 3463, 3504], '[Abstract].': [2975], 'Annual': [2976], 'Meeting': [2977], 'Society': [2980], 'Neuroscience,': [2982], 'New': [2983], 'Orleans,': [2984], 'LA,': [2985], '8-12': [2986], 'November': [2987], '2003.': [2988], 'Abstract': [2989], 'no.': [2990], '667.7.': [2991], 'Available': [2992], 'www.sfn.org.': [2994], 'Scholar88.': [2996], 'understanding': [3004], 'predicts': [3005], 'amyloid-based': [3006], 'therapeutics.': [3007], 'Annu': [3008], 'Rev': [3009], 'Pharmacol': [3010], 'Toxicol.': [3011], '2003;43:545-84.': [3012], '12415125]': [3014], 'Scholar89.': [3016], 'Hock': [3017], 'Konietzko': [3019], 'U,': [3020], 'Streffer': [3021], 'Tracy': [3023], 'Signorell': [3025], 'Muller-Tillmanns': [3027], 'Antibodies': [3032], 'slow': [3035], 'decline': [3037], '2003;38:547-54.': [3042], '12765607]': [3044], 'Scholar90.': [3046], "t'.": [3048], 'Veld': [3049], 'Ruitenberg': [3051], 'Hofman': [3053], 'Launer': [3055], 'Duijn': [3058], 'Stijnen': [3060], 'T.': [3061], ',': [3064], 'Nonsteroidal': [3065], 'antiinflammatory': [3066], 'drugs': [3067], 'risk': [3070], '2001;345:1515-21.': [3078], '11794217]': [3080], 'Scholar91.': [3082], 'Weggen': [3083], 'Eriksen': [3085], 'Sagi': [3089], 'SA,': [3090], 'Pietrzik': [3093], 'CU,': [3094], 'subset': [3099], 'NSAIDs': [3101], 'lower': [3102], 'amyloidogenic': [3103], 'Abeta42': [3104], 'independently': [3105], 'cyclooxygenase': [3107], '2001;414:212-6.': [3110], '11700559]': [3112], 'Scholar92.': [3114], 'Cherny': [3115], 'Atwood': [3117], 'CS,': [3118], 'Xilinas': [3119], 'Gray': [3121], 'DN,': [3122], 'WD,': [3124], 'McLean': [3125], 'copper-zinc': [3133], 'chelator': [3134], 'markedly': [3135], 'rapidly': [3137], '2001;30:665-76.': [3147], '11430801]': [3149], 'Scholar': [3151], 'Author,': [3152], 'InformationAffiliations:': [3156], 'From': [3157, 3338], 'Massachusetts.For': [3170], 'definition': [3171], 'terms': [3173], 'used,': [3174], 'see': [3175], 'Glossary.Acknowledgments:': [3176], 'author': [3178], 'thanks': [3179], 'his': [3180], 'colleagues': [3181], 'collaborators': [3183], 'helpful': [3186], 'discussions.Grant': [3187], 'Support:': [3188], 'By': [3189], 'National': [3191], 'Institutes': [3192], 'Health,': [3194], 'Association,': [3196], 'Foundation': [3199], 'Diseases.': [3202], 'Dr.': [3203], 'founding': [3207], 'scientist': [3208], 'Athena': [3210], 'Neurosciences,': [3211], 'now': [3212], 'Elan': [3213, 3218], 'Corporation.Disclosures:Honoraria': [3214], 'Patents': [3216], 'received:': [3217], 'Corp.Corresponding': [3219], 'Author:': [3220], 'Dennis': [3221], '77': [3233], 'Avenue': [3234], 'Louis': [3235], 'Pasteur,': [3236], 'HIM': [3237], '730,': [3238], 'MA': [3240], '02115.': [3241], 'PreviousarticleNextarticle': [3242], 'Advertisement': [3243], 'FiguresReferencesRelatedDetails': [3244], 'Metrics': [3245], 'Cited': [3246], 'byStructural': [3247], 'fingerprinting': [3248], 'pleiotropic': [3250], 'flavonoids': [3251], 'multifaceted': [3253], 'diseaseEditorial:': [3255], 'Protein': [3256, 3587, 3711], 'misfolding,': [3257], 'altered': [3258, 3868], 'mechanisms': [3259], 'neurodegenerationInvolvement': [3261], 'ions': [3264], 'amyloid-β-induced': [3266, 3483, 3793], 'lamin': [3267, 3486], 'fragmentationHippocampal': [3268], 'neural': [3269], 'circuit': [3270], 'connectivity': [3271], 'alterations': [3272], 'revealed': [3279], 'monosynaptic': [3281], 'rabies': [3282], 'virus': [3283], 'tracingProtective': [3284], 'Effects': [3285], 'Flavonoids': [3287], 'Pathological': [3291], 'Hypothesis,': [3292], 'Potential': [3293], 'Targets,': [3294], 'Structure–Activity': [3296], 'RelationshipAmyloid': [3297], 'Hydrogel': [3299], 'Formation': [3300], 'Peptide': [3303, 3443, 3841], 'Coronavirus': [3307], 'Spike': [3308], 'ProteinPotential': [3309], 'Roles': [3310], 'Glucagon-Like': [3312], 'Peptide-1': [3313], 'Its': [3315], 'Analogues': [3316], 'Dementia': [3318], 'Targeting': [3319], 'Impaired': [3320], 'Insulin': [3321], 'Secretion': [3322], 'NeurodegenerationCurrent': [3324], 'research': [3325], 'blood': [3328], 'biomarkers': [3329], 'Diagnosis': [3333], 'prognosisGluA3-containing': [3335], 'AMPA': [3336], 'receptors:': [3337], 'physiology': [3339], 'synaptic': [3341], 'dysfunction': [3342], 'disordersContribution': [3345], 'Human': [3347], 'Pluripotent': [3348], 'Stem': [3349], 'Cell-Based': [3350], 'Models': [3351], 'Drug': [3353], 'Discovery': [3354], 'Neurological': [3356, 3392], 'DisordersTargeting': [3357], 'cellular': [3358], 'batteries': [3359], 'therapy': [3362, 3646], 'neurological': [3364], 'diseasesLipocalin': [3365], 'regulates': [3367], 'iron': [3368], 'homeostasis,': [3369], 'neuroinflammation,': [3370], 'insulin': [3372], 'resistance': [3373], 'dementia:': [3380], 'current': [3384, 3402], "literatureAlzheimer's-Like": [3385], 'Pathology': [3386], 'Crossroads': [3389], 'HIV-Associated': [3391], 'DisordersDetecting': [3393], 'targeting': [3395], 'disorders': [3397], 'using': [3398], 'electrospun': [3399], 'nanofibrous': [3400], 'matrices:': [3401], 'applicationsBridging': [3405], 'Scales': [3406], 'Biological': [3410], 'Framework': [3411], 'Brain': [3413, 3519, 3535], 'Simulation': [3414], 'With': [3415], 'Virtual': [3417], 'BrainProtriptyline': [3418], 'improves': [3419, 3825], 'spatial': [3420], 'damage': 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[3505], 'Up-Regulation': [3506], 'P-gp': [3508], 'Mouse': [3510], 'Model': [3511, 3579], 'ADThe': [3513], 'P2X7': [3514], 'Receptor:': [3515], 'Central': [3516], 'Hub': [3517], 'DiseasesCopper': [3520], 'stabilizes': [3521], 'antiparallel': [3522], 'β-sheet': [3523], 'fibrils': [3524], 'β40': [3528], '(Aβ40)-Iowa': [3529], 'variantProteomic': [3530], 'Profiling': [3531], 'Plasma': [3533, 3545], 'Tissue': [3536], 'Patients': [3540], 'Reveals': [3541], 'Network': [3543], 'BiomarkersExpedition': [3546], 'Taurine': [3548, 3556], 'Biology:': [3549], 'Structural': [3550, 3725], 'Insights': [3551], 'Therapeutic': [3553], 'Perspective': [3554], 'Neurodegenerative': [3558], 'DiseasesCholesterol': [3559], 'Dementia:': [3561], 'Long': [3563], 'Complicated': [3565], 'RelationshipSuper‐Resolution': [3566], 'Infrared': [3567], 'Imaging': [3568], 'Polymorphic': [3570], 'Aggregates': [3572], 'Directly': [3573], 'NeuronsA': [3575], 'Preclinical': [3577], 'Rat': [3578], 'DiseaseGenomics': [3582], 'diseaseEnhanced': [3585], 'Translation': [3588], 'Hyper-ExcitationPersistent': [3590], 'Infection': [3591], 'Herpes': [3593], 'Simplex': [3594], 'Virus': [3595, 3607], 'Disease—A': [3599], 'Call': [3600], 'Study': [3602], 'How': [3603], 'Variability': [3604], 'Both': [3606], 'Host': [3609], 'may': [3610], 'Impact': [3611], 'DiseaseSafety,': [3612], 'Tolerability,': [3613], 'Pharmacokinetics': [3615], 'β‐Site': [3618], 'Precursor': [3620], 'Protein‐Cleaving': [3621], 'Enzyme': [3622], 'Inhibitor': [3624], 'Verubecestat': [3625], '(': [3626], 'MK': [3627], '‐8931)': [3628], 'Healthy': [3630], 'Elderly': [3631], 'Male': [3632], 'Female': [3634], 'SubjectsThe': [3635], 'Y682ENPTY687': [3636], 'motif': [3637], 'APP:': [3639], 'Progress': [3640], 'insights': [3642], 'toward': [3643], 'targeted': [3645], 'patientsγ-Secretase': [3650], 'its': [3652], 'modulators:': [3653], 'Twenty': [3654], 'years': [3655], 'beyondTranslating': [3657], 'disease–associated': [3659], 'polymorphisms': [3660], 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'GAPT': [3731], 'extraction': [3732], 'synapse': [3734], 'APPswe/PS1dE9': [3737], 'adjusting': [3741], 'Bcl‐2/Bax': [3742], 'balanceβ-Sheet': [3743], 'within': [3745], 'Extracellular': [3747], 'Domain': [3748], 'C99': [3750], 'Regulates': [3751], 'Amyloidogenic': [3752], 'ProcessingiPSC-Based': [3753], 'Compound': [3754], 'Screening': [3755], 'In': [3757], 'Vitro': [3758], 'Trials': [3759], 'Identify': [3760], 'Synergistic': [3762], 'Anti-amyloid': [3763], 'β': [3764, 3848], 'Combination': [3765], 'DiseaseFilling': [3768], 'void:': [3770], 'exercise-induced': [3774], 'BDNF': [3775], 'processingLimited': [3781], 'activation': [3782, 3798], 'intrinsic': [3785], 'apoptotic': [3786, 3802], 'pathway': [3787], 'plays': [3788], 'main': [3790], 'apoptosis': [3794], 'without': [3795], 'eliciting': [3796], 'extrinsic': [3801], 'pathwaySynthesis': [3803], 'curcumin': [3808], 'analogs': [3809], 'β-amyloid': [3811], 'imaging': [3812], 'agentsA': [3813], 'monoclonal': [3815], 'N-terminus': [3819], 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