Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2912080176', 'doi': 'https://doi.org/10.1007/s00216-019-01608-5', 'title': 'Label-free detection of exosomes using a surface plasmon resonance biosensor', 'display_name': 'Label-free detection of exosomes using a surface plasmon resonance biosensor', 'publication_year': 2019, 'publication_date': '2019-02-05', 'ids': {'openalex': 'https://openalex.org/W2912080176', 'doi': 'https://doi.org/10.1007/s00216-019-01608-5', 'mag': '2912080176', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30719562'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00216-019-01608-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00216-019-01608-5.pdf', 'source': {'id': 'https://openalex.org/S18188872', 'display_name': 'Analytical and Bioanalytical Chemistry', 'issn_l': '1618-2642', 'issn': ['1618-2642', '1618-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://link.springer.com/content/pdf/10.1007/s00216-019-01608-5.pdf', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5051954845', 'display_name': 'Abu Ali Ibn Sina', 'orcid': 'https://orcid.org/0000-0001-8099-3863'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Abu Ali Ibn Sina', 'raw_affiliation_strings': ['Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5041146312', 'display_name': 'Ramanathan Vaidyanathan', 'orcid': 'https://orcid.org/0000-0002-9169-8605'}, 'institutions': [{'id': 'https://openalex.org/I165932596', 'display_name': 'National University of Singapore', 'ror': 'https://ror.org/01tgyzw49', 'country_code': 'SG', 'type': 'education', 'lineage': ['https://openalex.org/I165932596']}], 'countries': ['SG'], 'is_corresponding': False, 'raw_author_name': 'Ramanathan Vaidyanathan', 'raw_affiliation_strings': ['Biomedical Institute for Global Health Research & Technology, National University of Singapore, Singapore, 119228, Singapore'], 'affiliations': [{'raw_affiliation_string': 'Biomedical Institute for Global Health Research & Technology, National University of Singapore, Singapore, 119228, Singapore', 'institution_ids': ['https://openalex.org/I165932596']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016316330', 'display_name': 'Alain Wuethrich', 'orcid': 'https://orcid.org/0000-0001-9569-0478'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Alain Wuethrich', 'raw_affiliation_strings': ['Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5009273155', 'display_name': 'Laura G. Carrascosa', 'orcid': 'https://orcid.org/0000-0001-9147-5658'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Laura G. Carrascosa', 'raw_affiliation_strings': ['Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'Centre for Personalised Nanomedicine, Australian Institute for Bioengineering and Nanotechnology, The University of Queensland, Brisbane, QLD, 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046333945', 'display_name': 'Matt Trau', 'orcid': 'https://orcid.org/0000-0001-5516-1280'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Matt Trau', 'raw_affiliation_strings': ['School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia'], 'affiliations': [{'raw_affiliation_string': 'School of Chemistry and Molecular Biosciences, The University of Queensland, Brisbane, QLD, 4072, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046333945'], 'corresponding_institution_ids': ['https://openalex.org/I165143802'], 'apc_list': {'value': 2790, 'currency': 'EUR', 'value_usd': 3590, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 4.432, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 80, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '411', 'issue': '7', 'first_page': '1311', 'last_page': '1318'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Exosome Biology and Function in Intercellular Communication', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Exosome Biology and Function in Intercellular Communication', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10725', 'display_name': 'Mechanisms and Applications of RNA Interference', 'score': 0.9973, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10207', 'display_name': 'DNA Nanotechnology and Bioanalytical Applications', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/exosomes', 'display_name': 'Exosomes', 'score': 0.599963}, {'id': 'https://openalex.org/keywords/biosensors', 'display_name': 'Biosensors', 'score': 0.563195}, {'id': 'https://openalex.org/keywords/cancer-diagnostics', 'display_name': 'cancer diagnostics', 'score': 0.520746}], 'concepts': [{'id': 'https://openalex.org/C106847996', 'wikidata': 'https://www.wikidata.org/wiki/Q898756', 'display_name': 'Surface plasmon resonance', 'level': 3, 'score': 0.86489844}, {'id': 'https://openalex.org/C160756335', 'wikidata': 'https://www.wikidata.org/wiki/Q669391', 'display_name': 'Biosensor', 'level': 2, 'score': 0.8342744}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.5514152}, {'id': 'https://openalex.org/C136676167', 'wikidata': 'https://www.wikidata.org/wiki/Q1151829', 'display_name': 'Surface plasmon', 'level': 3, 'score': 0.51696724}, {'id': 'https://openalex.org/C171250308', 'wikidata': 'https://www.wikidata.org/wiki/Q11468', 'display_name': 'Nanotechnology', 'level': 1, 'score': 0.50696397}, {'id': 'https://openalex.org/C113196181', 'wikidata': 'https://www.wikidata.org/wiki/Q485223', 'display_name': 'Analytical Chemistry (journal)', 'level': 2, 'score': 0.40783796}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.40331486}, {'id': 'https://openalex.org/C110879396', 'wikidata': 'https://www.wikidata.org/wiki/Q58392', 'display_name': 'Plasmon', 'level': 2, 'score': 0.39893502}, {'id': 'https://openalex.org/C155672457', 'wikidata': 'https://www.wikidata.org/wiki/Q61231', 'display_name': 'Nanoparticle', 'level': 2, 'score': 0.37161553}, {'id': 'https://openalex.org/C192562407', 'wikidata': 'https://www.wikidata.org/wiki/Q228736', 'display_name': 'Materials science', 'level': 0, 'score': 0.36903659}, {'id': 'https://openalex.org/C49040817', 'wikidata': 'https://www.wikidata.org/wiki/Q193091', 'display_name': 'Optoelectronics', 'level': 1, 'score': 0.2838266}, {'id': 'https://openalex.org/C43617362', 'wikidata': 'https://www.wikidata.org/wiki/Q170050', 'display_name': 'Chromatography', 'level': 1, 'score': 0.2291241}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.059708863}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': True}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': True}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001943', 'descriptor_name': 'Breast Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004867', 'descriptor_name': 'Equipment Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D055354', 'descriptor_name': 'Exosomes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D009369', 'descriptor_name': 'Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000175', 'qualifier_name': 'diagnosis', 'is_major_topic': False}, {'descriptor_ui': 'D011471', 'descriptor_name': 'Prostatic Neoplasms', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D020349', 'descriptor_name': 'Surface Plasmon Resonance', 'qualifier_ui': 'Q000295', 'qualifier_name': 'instrumentation', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00216-019-01608-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00216-019-01608-5.pdf', 'source': {'id': 'https://openalex.org/S18188872', 'display_name': 'Analytical and Bioanalytical Chemistry', 'issn_l': '1618-2642', 'issn': ['1618-2642', '1618-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30719562', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1007/s00216-019-01608-5', 'pdf_url': 'https://link.springer.com/content/pdf/10.1007/s00216-019-01608-5.pdf', 'source': {'id': 'https://openalex.org/S18188872', 'display_name': 'Analytical and Bioanalytical Chemistry', 'issn_l': '1618-2642', 'issn': ['1618-2642', '1618-2650'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319900', 'host_organization_name': 'Springer Science+Business Media', 'host_organization_lineage': ['https://openalex.org/P4310319965', 'https://openalex.org/P4310319900'], 'host_organization_lineage_names': ['Springer Nature', 'Springer Science+Business Media'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'score': 0.84, 'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320320984', 'funder_display_name': 'University of Queensland', 'award_id': 'UQFEL1831057'}, {'funder': 'https://openalex.org/F4320334704', 'funder_display_name': 'Australian Research Council', 'award_id': 'DP180102868'}], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1840566035', 'https://openalex.org/W1855008975', 'https://openalex.org/W1877686344', 'https://openalex.org/W1965774359', 'https://openalex.org/W1969891160', 'https://openalex.org/W1974954833', 'https://openalex.org/W1978542539', 'https://openalex.org/W1986321004', 'https://openalex.org/W1987604193', 'https://openalex.org/W1992009819', 'https://openalex.org/W1999204959', 'https://openalex.org/W2000455734', 'https://openalex.org/W2019750756', 'https://openalex.org/W2030701238', 'https://openalex.org/W2033598310', 'https://openalex.org/W2055313665', 'https://openalex.org/W2074764544', 'https://openalex.org/W2082232379', 'https://openalex.org/W2083053655', 'https://openalex.org/W2089154872', 'https://openalex.org/W2100886586', 'https://openalex.org/W2105726520', 'https://openalex.org/W2108375854', 'https://openalex.org/W2113671336', 'https://openalex.org/W2161416851', 'https://openalex.org/W2168990146', 'https://openalex.org/W2301624354', 'https://openalex.org/W2320055906', 'https://openalex.org/W2334607640', 'https://openalex.org/W2477146923', 'https://openalex.org/W2504544746', 'https://openalex.org/W2519884037', 'https://openalex.org/W2521630585', 'https://openalex.org/W2562996961', 'https://openalex.org/W2580767461', 'https://openalex.org/W2598860043', 'https://openalex.org/W2624885502', 'https://openalex.org/W2757721278', 'https://openalex.org/W2766296746', 'https://openalex.org/W2780438240', 'https://openalex.org/W2789530224', 'https://openalex.org/W2790474542', 'https://openalex.org/W2801732228', 'https://openalex.org/W2807567618', 'https://openalex.org/W2811383566', 'https://openalex.org/W2815908227', 'https://openalex.org/W2884198871'], 'related_works': ['https://openalex.org/W4206528674', 'https://openalex.org/W2959108535', 'https://openalex.org/W2374698315', 'https://openalex.org/W2108716065', 'https://openalex.org/W2044499942', 'https://openalex.org/W2043486114', 'https://openalex.org/W2011982636', 'https://openalex.org/W2011265321', 'https://openalex.org/W1988903031', 'https://openalex.org/W1967701792'], 'abstract_inverted_index': {'The': [0], 'development': [1], 'of': [2, 45], 'a': [3, 36, 50], 'sensitive': [4], 'and': [5, 25, 42, 103, 111], 'specific': [6], 'detection': [7, 44], 'platform': [8], 'for': [9, 30, 39, 95, 117], 'exosomes': [10, 48, 67], 'is': [11], 'highly': [12], 'desirable': [13], 'as': [14, 85, 87], 'they': [15], 'are': [16], 'believed': [17], 'to': [18, 27], 'transmit': [19], 'vital': [20], 'tumour-specific': [21], 'information': [22], '(mRNAs,': [23], 'microRNAs,': [24], 'proteins)': [26], 'remote': [28], 'cells': [29], 'secondary': [31], 'metastasis.': [32], 'Herein,': [33], 'we': [34], 'report': [35], 'simple': [37], 'method': [38, 57, 105], 'the': [40, 108], 'real-time': [41, 104], 'label-free': [43, 102], 'clinically': [46], 'relevant': [47], 'using': [49], 'surface': [51], 'plasmon': [52], 'resonance': [53], '(SPR)': [54], 'biosensor.': [55], 'Our': [56], 'shows': [58], 'high': [59, 81, 109], 'specificity': [60, 110], 'in': [61, 76], 'detecting': [62, 84], 'BT474': [63], 'breast': [64], 'cancer': [65], 'cell–derived': [66], 'particularly': [68], 'from': [69], 'complex': [70], 'biological': [71], 'samples': [72], '(e.g.': [73], 'exosome': [74], 'spiked': [75], 'serum).': [77], 'This': [78], 'approach': [79], 'exhibits': [80], 'sensitivity': [82, 112], 'by': [83], 'low': [86], '8280': [88], 'exosomes/μL': [89], 'which': [90], 'may': [91, 113], 'potentially': [92, 114], 'be': [93, 115], 'suitable': [94], 'clinical': [96, 118], 'analysis.': [97], 'We': [98], 'believe': [99], 'that': [100], 'this': [101], 'along': [106], 'with': [107], 'useful': [116], 'settings.': [119]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2912080176', 'counts_by_year': [{'year': 2024, 'cited_by_count': 12}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 19}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 20}, {'year': 2019, 'cited_by_count': 3}], 'updated_date': '2024-09-18T16:02:09.219972', 'created_date': '2019-02-21'}