Publication Information

{'id': 'https://openalex.org/W2911232606', 'doi': 'https://doi.org/10.1097/xce.0000000000000150', 'title': 'Cardioprotective glucose-lowering medications: evidence and uncertainties in a new therapeutic era', 'display_name': 'Cardioprotective glucose-lowering medications: evidence and uncertainties in a new therapeutic era', 'publication_year': 2018, 'publication_date': '2018-03-01', 'ids': {'openalex': 'https://openalex.org/W2911232606', 'doi': 'https://doi.org/10.1097/xce.0000000000000150', 'mag': '2911232606', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/31646270', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6739884'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/xce.0000000000000150', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226760', 'display_name': 'Cardiovascular Endocrinology & Metabolism', 'issn_l': '2574-0954', 'issn': ['2574-0954'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310318547', 'host_organization_name': 'Wolters Kluwer', 'host_organization_lineage': ['https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'editorial', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'diamond', 'oa_url': 'https://doi.org/10.1097/xce.0000000000000150', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5046257235', 'display_name': 'Andrew J. Krentz', 'orcid': 'https://orcid.org/0000-0003-4169-0469'}, 'institutions': [{'id': 'https://openalex.org/I4210134361', 'display_name': 'Precision Research Institute', 'ror': 'https://ror.org/045d8mm77', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I4210134361']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Andrew J. Krentz', 'raw_affiliation_strings': ['ProSciento Inc., Chula Vista, California'], 'affiliations': [{'raw_affiliation_string': 'ProSciento Inc., Chula Vista, California', 'institution_ids': ['https://openalex.org/I4210134361']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5083786375', 'display_name': 'Robert Ćhilton', 'orcid': 'https://orcid.org/0000-0003-0195-5063'}, 'institutions': [{'id': 'https://openalex.org/I165951966', 'display_name': 'The University of Texas Health Science Center at San Antonio', 'ror': 'https://ror.org/02f6dcw23', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165951966']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Robert Chilton', 'raw_affiliation_strings': ['Department of Medicine, Division of Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Medicine, Division of Cardiology, University of Texas Health Science Center at San Antonio, San Antonio, Texas, USA', 'institution_ids': ['https://openalex.org/I165951966']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 2, 'corresponding_author_ids': ['https://openalex.org/A5046257235'], 'corresponding_institution_ids': ['https://openalex.org/I4210134361'], 'apc_list': {'value': 0, 'currency': 'USD', 'value_usd': 0, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': None, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 6, 'citation_normalized_percentile': {'value': 0.808889, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 80, 'max': 82}, 'biblio': {'volume': '7', 'issue': '1', 'first_page': '2', 'last_page': '3'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10401', 'display_name': 'Diabetes Treatment and Management', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2712', 'display_name': 'Endocrinology, Diabetes and Metabolism'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10839', 'display_name': 'Pancreatic function and diabetes', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2746', 'display_name': 'Surgery'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11339', 'display_name': 'Metabolism, Diabetes, and Cancer', 'score': 0.9961, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/empagliflozin', 'display_name': 'Empagliflozin', 'score': 0.97279954}, {'id': 'https://openalex.org/keywords/semaglutide', 'display_name': 'Semaglutide', 'score': 0.7815212}, {'id': 'https://openalex.org/keywords/mace', 'display_name': 'Mace', 'score': 0.70591545}, {'id': 'https://openalex.org/keywords/canagliflozin', 'display_name': 'Canagliflozin', 'score': 0.65815127}, {'id': 'https://openalex.org/keywords/clinical-endpoint', 'display_name': 'Clinical endpoint', 'score': 0.44260967}, {'id': 'https://openalex.org/keywords/dulaglutide', 'display_name': 'Dulaglutide', 'score': 0.43804651}], 'concepts': [{'id': 'https://openalex.org/C2775887513', 'wikidata': 'https://www.wikidata.org/wiki/Q5373824', 'display_name': 'Empagliflozin', 'level': 4, 'score': 0.97279954}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.9159143}, {'id': 'https://openalex.org/C2909862629', 'wikidata': 'https://www.wikidata.org/wiki/Q27261089', 'display_name': 'Semaglutide', 'level': 5, 'score': 0.7815212}, {'id': 'https://openalex.org/C2781308992', 'wikidata': 'https://www.wikidata.org/wiki/Q2526479', 'display_name': 'Liraglutide', 'level': 4, 'score': 0.7358567}, {'id': 'https://openalex.org/C2780739214', 'wikidata': 'https://www.wikidata.org/wiki/Q6723023', 'display_name': 'Mace', 'level': 4, 'score': 0.70591545}, {'id': 'https://openalex.org/C2777180221', 'wikidata': 'https://www.wikidata.org/wiki/Q3025883', 'display_name': 'Type 2 diabetes', 'level': 3, 'score': 0.6703664}, {'id': 'https://openalex.org/C2777451236', 'wikidata': 'https://www.wikidata.org/wiki/Q5030940', 'display_name': 'Canagliflozin', 'level': 4, 'score': 0.65815127}, {'id': 'https://openalex.org/C500558357', 'wikidata': 'https://www.wikidata.org/wiki/Q12152', 'display_name': 'Myocardial infarction', 'level': 2, 'score': 0.6058006}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.5876804}, {'id': 'https://openalex.org/C555293320', 'wikidata': 'https://www.wikidata.org/wiki/Q12206', 'display_name': 'Diabetes mellitus', 'level': 2, 'score': 0.56229925}, {'id': 'https://openalex.org/C2778198053', 'wikidata': 'https://www.wikidata.org/wiki/Q181754', 'display_name': 'Heart failure', 'level': 2, 'score': 0.50550175}, {'id': 'https://openalex.org/C164705383', 'wikidata': 'https://www.wikidata.org/wiki/Q10379', 'display_name': 'Cardiology', 'level': 1, 'score': 0.45532584}, {'id': 'https://openalex.org/C203092338', 'wikidata': 'https://www.wikidata.org/wiki/Q1340863', 'display_name': 'Clinical endpoint', 'level': 3, 'score': 0.44260967}, {'id': 'https://openalex.org/C2779829264', 'wikidata': 'https://www.wikidata.org/wiki/Q21011228', 'display_name': 'Dulaglutide', 'level': 5, 'score': 0.43804651}, {'id': 'https://openalex.org/C535046627', 'wikidata': 'https://www.wikidata.org/wiki/Q30612', 'display_name': 'Clinical trial', 'level': 2, 'score': 0.28412676}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.18641925}, {'id': 'https://openalex.org/C2780400711', 'wikidata': 'https://www.wikidata.org/wiki/Q2008344', 'display_name': 'Percutaneous coronary intervention', 'level': 3, 'score': 0.1233294}], 'mesh': [], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/xce.0000000000000150', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226760', 'display_name': 'Cardiovascular Endocrinology & Metabolism', 'issn_l': '2574-0954', 'issn': ['2574-0954'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310318547', 'host_organization_name': 'Wolters Kluwer', 'host_organization_lineage': ['https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6739884', 'pdf_url': 'https://europepmc.org/articles/pmc6739884?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6739884', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/31646270', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1097/xce.0000000000000150', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4210226760', 'display_name': 'Cardiovascular Endocrinology & Metabolism', 'issn_l': '2574-0954', 'issn': ['2574-0954'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310318547', 'host_organization_name': 'Wolters Kluwer', 'host_organization_lineage': ['https://openalex.org/P4310318547'], 'host_organization_lineage_names': ['Wolters Kluwer'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'display_name': 'Zero hunger', 'score': 0.5, 'id': 'https://metadata.un.org/sdg/2'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 10, 'referenced_works': ['https://openalex.org/W2146264128', 'https://openalex.org/W2343975335', 'https://openalex.org/W2425644022', 'https://openalex.org/W2519510391', 'https://openalex.org/W2607254478', 'https://openalex.org/W2619881304', 'https://openalex.org/W2626446274', 'https://openalex.org/W2646836708', 'https://openalex.org/W2766617433', 'https://openalex.org/W4256525495'], 'related_works': ['https://openalex.org/W4379108572', 'https://openalex.org/W4249360822', 'https://openalex.org/W3008828026', 'https://openalex.org/W3005278786', 'https://openalex.org/W2977069026', 'https://openalex.org/W2975677680', 'https://openalex.org/W2895591288', 'https://openalex.org/W2738292469', 'https://openalex.org/W2626110901', 'https://openalex.org/W2586985531'], 'abstract_inverted_index': {'Cardiovascular': [0, 47, 141, 190, 198], 'disease': [1, 39, 157, 342, 394, 614, 701], 'is': [2, 17, 250, 343, 555, 617, 638], 'the': [3, 18, 65, 76, 85, 180, 226, 236, 253, 278, 289, 294, 304, 311, 319, 368, 372, 384, 429, 485, 523, 529, 545, 560, 596, 600, 650, 664, 676, 696, 721], 'principal': [4], 'cause': [5], 'of': [6, 67, 75, 152, 189, 223, 242, 280, 291, 321, 335, 337, 346, 371, 377, 405, 432, 439, 462, 525, 532, 548, 595, 606, 612, 629, 652, 655, 666, 669, 678, 698], 'death': [7], 'in': [8, 25, 51, 62, 111, 118, 163, 176, 186, 205, 214, 257, 269, 283, 299, 324, 434, 475, 484, 497, 506, 514, 522, 577, 585, 615, 636, 695, 717, 748], 'patients': [9, 215, 390], 'with': [10, 64, 114, 216, 359, 391, 397, 402, 488, 509, 720, 731], 'type': [11, 26, 217, 360], '2': [12, 27, 53, 209, 218, 361], 'diabetes.': [13], 'However,': [14, 445, 528], 'while': [15, 303], 'hyperglycemia': [16], 'major': [19, 87, 271], 'risk': [20, 40, 222, 272], 'factor': [21], 'for': [22, 59, 127, 135, 148, 274, 354, 357, 453], 'microvascular': [23], 'complications': [24], 'diabetes,': [28], 'lowering': [29], 'hemoglobin': [30], 'A1c': [31], 'has': [32, 564, 702], 'only': [33], 'modest': [34], 'effects': [35], 'on': [36, 155, 340], 'reducing': [37, 300], 'cardiovascular': [38, 68, 112, 156, 224, 254, 275, 281, 327, 341, 393, 413, 454, 470, 495, 526, 546, 613, 656, 667, 700], 'and': [41, 49, 166, 184, 193, 199, 233, 400, 418, 424, 518, 542, 603, 623, 647, 661, 715, 737, 740], 'mortality.': [42], 'The': [43, 332, 472, 494, 609, 627], 'EMPA-REG': [44], 'OUTCOME': [45], '(Empagliflozin,': [46], 'Outcomes,': [48], 'Mortality': [50], 'Type': [52, 208], 'Diabetes)': [54, 210], 'trial': [55], 'was': [56, 105, 457, 491], 'a': [57, 73, 108, 149, 161, 503, 510, 535, 592, 633, 691], 'breakthrough': [58], 'clinical': [60, 333, 570, 604, 683, 750], 'trials': [61, 211, 244, 259, 285, 329], 'diabetes': [63, 219, 362, 616, 637], 'demonstration': [66], 'protection': [69, 282], 'from': [70], 'empagliflozin': [71, 417], '–': [72, 158, 415, 420, 477, 490, 729, 739], 'member': [74], 'sodium–glucose': [77], 'cotransporter': [78], '(SGLT)-2': [79], 'inhibitor': [80], 'class': [81, 150, 290], '1.': [82], 'Empagliflozin': [83, 124], 'reduced': [84, 125, 235], 'primary': [86, 237], 'adverse': [88], 'cardiac': [89], 'event': [90], '(MACE)': [91], 'endpoint': [92, 239], '(cardiovascular': [93], 'death,': [94], 'nonfatal': [95, 98, 119, 507, 515], 'myocardial': [96, 120, 516], 'infarction,': [97], 'stroke)': [99], 'by': [100, 107, 130, 173, 502, 619, 640], '14%.': [101], 'This': [102], 'beneficial': [103], 'effect': [104, 151], 'driven': [106, 500], '38%': [109], 'reduction': [110, 162, 483], 'mortality': [113, 414], 'no': [115, 519], 'significant': [116, 520], 'decrease': [117, 505, 513], 'infarction': [121, 517], 'or': [122, 267], 'stroke.': [123], 'hospitalization': [126, 134, 169], 'heart': [128, 167, 301, 630], 'failure': [129, 168, 631], '35%': [131], 'without': [132], 'affecting': [133], 'unstable': [136], 'angina.': [137], 'In': [138], 'CANVAS': [139], '(Canagliflozin': [140], 'Assessment': [142], 'Study),': [143], 'canagliflozin': [144], 'provided': [145], 'additional': [146], 'support': [147], 'SGLT-2': [153, 295], 'inhibitors': [154, 296], 'that': [159, 252, 389, 598, 690, 707, 744], 'is,': [160], 'three-point': [164], 'MACE': [165, 238, 411, 486], 'risk,': [170], 'although': [171], 'tempered': [172], 'an': [174, 406, 451, 480], 'increase': [175], 'amputations': [177], '2.': [178], 'Furthermore,': [179], 'LEADER': [181], '(Liraglutide': [182], 'Effect': [183], 'Action': [185], 'Diabetes:': [187], 'Evaluation': [188], 'Outcome': [191], 'Results)': [192], 'SUSTAIN-6': [194, 456, 476, 498], '(Trial': [195], 'to': [196, 264, 288, 309, 352, 367, 409, 459, 464, 469, 539, 556, 568, 579, 590, 688, 712, 725], 'Evaluate': [197], 'Other': [200], 'Long-term': [201], 'Outcomes': [202], 'With': [203, 207, 582], 'Semaglutide': [204], 'Subjects': [206], 'demonstrated': [212], 'that,': [213], 'at': [220], 'high': [221], 'disease,': [225], 'glucagon-like': [227], 'peptide': [228], '(GLP)-1': [229], 'receptor': [230, 306], 'agonists': [231, 307], 'liraglutide': [232, 419], 'semaglutide': [234, 433, 446, 463, 553], '3,4.': [240], 'All': [241], 'these': [243, 258, 284, 325, 583, 607, 708], 'also': [245], 'showed': [246], 'renoprotective': [247], 'effects.': [248], 'It': [249, 685], 'apparent': [251], 'benefits': [255, 322, 496, 547], 'observed': [256, 323, 474], 'are': [260, 588], 'not': [261, 448, 492], 'primarily': [262], 'attributable': [263], 'glucose': [265], 'control': [266], 'improvements': [268], 'other': [270], 'factors': [273, 426], 'events.': [276], 'Moreover,': [277], 'pattern': [279], 'differed': [286], 'according': [287], 'glucose-lowering': [292, 338, 653, 680], 'medication:': [293], 'were': [297, 499], 'effective': [298], 'failure,': [302], 'GLP-1': [305, 670], 'appeared': [308], 'attenuate': [310], 'atherosclerotic': [312, 392], 'process': [313], '5,6.': [314], 'Major': [315], 'questions': [316], 'remain': [317], 'concerning': [318], 'mechanism': [320, 665], 'practice-changing': [326], 'outcome': [328], '(CVOTs)': [330], '7,8.': [331], 'impact': [334, 651], 'combinations': [336], 'drugs': [339], 'another': [344], 'area': [345], 'research': [347], 'activity': [348], '9.': [349], 'Timely': [350], 'revisions': [351, 438], 'recommendations': [353, 572], 'antihyperglycemic': [355], 'therapy': [356], 'adults': [358], 'have': [363, 450], 'recently': [364], 'been': [365, 703], 'added': [366], 'latest': [369], 'version': [370], 'American': [373, 561], 'Diabetes': [374, 562], 'Association’s': [375], 'Standards': [376], 'Medical': [378], 'Care.': [379], 'These': [380], 'revisions,': [381], 'which': [382, 478], 'reflect': [383], 'recent': [385, 430], 'CVOT': [386, 554], 'data,': [387], 'recommends': [388], 'should': [395], 'begin': [396], 'lifestyle': [398], 'management': [399], 'metformin': [401], 'subsequent': [403], 'incorporation': [404], 'agent': [407], 'proven': [408], 'reduce': [410], 'and/or': [412], 'currently': [416, 449], 'after': [421], 'considering': [422], 'drug-specific': [423], 'patient': [425, 735], '10.': [427], 'Following': [428], 'approval': [431], 'December': [435], '2017': [436], 'further': [437, 551], 'this': [440], 'guidance': [441], 'may': [442], 'be': [443, 557, 746], 'anticipated.': [444], 'does': [447], 'indication': [452], 'protection.': [455], 'powered': [458], 'demonstrate': [460], 'noninferiority': [461], 'placebo': [465, 489], 'when': [466], 'it': [467], 'came': [468], 'safety.': [471], 'cardioprotection': [473], 'showing': [479], 'overall': [481], '26%': [482], 'compared': [487], 'sufficient.': [493], 'largely': [501], '39%': [504], 'stroke': [508], 'nonsignificant': [511], '(26%)': [512], 'difference': [521], 'rate': [524], 'death.': [527], 'small': [530], 'number': [531], 'events': [533], 'necessitates': [534], 'larger': [536], 'sample': [537], 'size': [538], 'inform': [540], 'regulators': [541], 'prescribers': [543], 'about': [544, 734], 'semaglutide.': [549], 'A': [550], 'definitive': [552], 'performed.': [558], 'Incidentally,': [559], 'Association': [563], 'signaled': [565], 'its': [566], 'intention': [567], 'update': [569], 'practice': [571, 728], 'more': [573], 'frequently': [574], 'than': [575], 'annually': [576], 'response': [578], 'new': [580, 692, 742], 'data.': [581], 'considerations': [584], 'mind,': [586], 'we': [587], 'pleased': [589], 'present': [591], 'special': [593], 'issue': [594], 'journal': [597], 'examines': [599], 'mechanisms,': [601], 'benefits,': [602], 'implications': [605], 'trials.': [608, 751], 'complex': [610], 'pathophysiology': [611], 'reviewed': [618], 'Dr': [620, 624, 641, 644, 658, 672], 'Gerardo': [621], 'Rodriguez': [622], 'Hironori': [625], 'Nakagami.': [626], 'concept': [628], 'as': [632], 'therapeutic': [634, 693], 'target': [635], 'delineated': [639], 'Nicolaus': [642], 'Marx.': [643], 'Angelo': [645], 'Avogaro': [646], 'colleagues': [648, 662], 'review': [649], 'medications': [654, 681], 'disease.': [657], 'Joshua': [659], 'Reed': [660], 'explore': [663], 'benefit': [668], 'agonists.': [671], 'Sunder': [673], 'Mudaliar': [674], 'considers': [675], 'integration': [677], 'cardioprotective': [679], 'into': [682], 'practice.': [684], 'seems': [686], 'appropriate': [687], 'believe': [689], 'era': [694], 'treatment': [697], 'diabetes-associated': [699], 'entered.': [704], 'We': [705], 'hope': [706], 'articles': [709], 'will': [710], 'help': [711], 'equip': [713], 'clinicians': [714], 'researchers': [716], 'both': [718], 'specialties': [719], 'information': [722], 'they': [723], 'require': [724], 'apply': [726], 'best': [727], 'albeit': [730], 'residual': [732], 'uncertainties': [733], 'selection': [736], 'stratification': [738], 'formulate': [741], 'hypotheses': [743], 'can': [745], 'tested': [747], 'future': [749]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2911232606', 'counts_by_year': [{'year': 2024, 'cited_by_count': 1}, {'year': 2023, 'cited_by_count': 2}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 1}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2025-01-11T03:33:41.827653', 'created_date': '2019-02-21'}