Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2910686626', 'doi': 'https://doi.org/10.1016/j.ymthe.2018.12.013', 'title': 'Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice', 'display_name': 'Self-Amplifying RNA Vaccines for Venezuelan Equine Encephalitis Virus Induce Robust Protective Immunogenicity in Mice', 'publication_year': 2019, 'publication_date': '2019-01-09', 'ids': {'openalex': 'https://openalex.org/W2910686626', 'doi': 'https://doi.org/10.1016/j.ymthe.2018.12.013', 'mag': '2910686626', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30770173', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6453513'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2018.12.013', 'pdf_url': 'https://www.cell.com/article/S1525001619300012/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://www.cell.com/article/S1525001619300012/pdf', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5077599231', 'display_name': 'Marcelo M. Samsa', 'orcid': 'https://orcid.org/0009-0001-2639-8518'}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Marcelo M. Samsa', 'raw_affiliation_strings': ['GSK, Rockville, MD 20850, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, Rockville, MD 20850, USA', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066047183', 'display_name': 'Lesley C. Dupuy', 'orcid': 'https://orcid.org/0000-0002-3796-6760'}, 'institutions': [{'id': 'https://openalex.org/I2801122164', 'display_name': 'United States Army Medical Research Institute of Infectious Diseases', 'ror': 'https://ror.org/01pveve47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I106965489', 'https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I2801122164', 'https://openalex.org/I2802581893', 'https://openalex.org/I4210088792']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lesley C. Dupuy', 'raw_affiliation_strings': ['United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA'], 'affiliations': [{'raw_affiliation_string': 'United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA', 'institution_ids': ['https://openalex.org/I2801122164']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5058956286', 'display_name': 'Clayton W. Beard', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Clayton W. Beard', 'raw_affiliation_strings': ['GSK, Rockville, MD 20850, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, Rockville, MD 20850, USA', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5023659051', 'display_name': 'Carolyn M. Six', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I2801122164', 'display_name': 'United States Army Medical Research Institute of Infectious Diseases', 'ror': 'https://ror.org/01pveve47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I106965489', 'https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I2801122164', 'https://openalex.org/I2802581893', 'https://openalex.org/I4210088792']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Carolyn M. Six', 'raw_affiliation_strings': ['United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA'], 'affiliations': [{'raw_affiliation_string': 'United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA', 'institution_ids': ['https://openalex.org/I2801122164']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102849443', 'display_name': 'Connie S. Schmaljohn', 'orcid': 'https://orcid.org/0000-0002-8834-0784'}, 'institutions': [{'id': 'https://openalex.org/I2801122164', 'display_name': 'United States Army Medical Research Institute of Infectious Diseases', 'ror': 'https://ror.org/01pveve47', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I106965489', 'https://openalex.org/I1304082316', 'https://openalex.org/I1330347796', 'https://openalex.org/I2801122164', 'https://openalex.org/I2802581893', 'https://openalex.org/I4210088792']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Connie S. Schmaljohn', 'raw_affiliation_strings': ['United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA'], 'affiliations': [{'raw_affiliation_string': 'United States Army Medical Research Institute of Infectious Diseases, Fort Detrick, MD 21702, USA', 'institution_ids': ['https://openalex.org/I2801122164']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5103432812', 'display_name': 'Peter W. Mason', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210117619', 'display_name': 'Novartis (United States)', 'ror': 'https://ror.org/028fhxy95', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I1283582996', 'https://openalex.org/I4210117619']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Peter W. Mason', 'raw_affiliation_strings': ['Novartis Vaccines & Diagnostics, Cambridge, MA 02139, USA'], 'affiliations': [{'raw_affiliation_string': 'Novartis Vaccines & Diagnostics, Cambridge, MA 02139, USA', 'institution_ids': ['https://openalex.org/I4210117619']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5102725942', 'display_name': 'Andrew J. Geall', 'orcid': 'https://orcid.org/0000-0003-3138-9218'}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Andrew J. Geall', 'raw_affiliation_strings': ['GSK, Rockville, MD 20850, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, Rockville, MD 20850, USA', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5029286510', 'display_name': 'Jeffrey B. Ulmer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey B. Ulmer', 'raw_affiliation_strings': ['GSK, Rockville, MD 20850, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, Rockville, MD 20850, USA', 'institution_ids': ['https://openalex.org/I4210114143']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5033056611', 'display_name': 'Dong Yü', 'orcid': 'https://orcid.org/0000-0002-3412-6440'}, 'institutions': [{'id': 'https://openalex.org/I4210114143', 'display_name': 'GlaxoSmithKline (United States)', 'ror': 'https://ror.org/025vn3989', 'country_code': 'US', 'type': 'company', 'lineage': ['https://openalex.org/I188950975', 'https://openalex.org/I4210114143']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Dong Yu', 'raw_affiliation_strings': ['GSK, Rockville, MD 20850, USA'], 'affiliations': [{'raw_affiliation_string': 'GSK, Rockville, MD 20850, USA', 'institution_ids': ['https://openalex.org/I4210114143']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5077599231', 'https://openalex.org/A5033056611'], 'corresponding_institution_ids': ['https://openalex.org/I4210114143', 'https://openalex.org/I4210114143'], 'apc_list': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'apc_paid': {'value': 3900, 'currency': 'USD', 'value_usd': 3900, 'provenance': 'doaj'}, 'fwci': 7.51, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 52, 'citation_normalized_percentile': {'value': 0.999977, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '27', 'issue': '4', 'first_page': '850', 'last_page': '865'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10166', 'display_name': 'Mosquito-borne diseases and control', 'score': 0.9993, 'subfield': {'id': 'https://openalex.org/subfields/2739', 'display_name': 'Public Health, Environmental and Occupational Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10976', 'display_name': 'Viral gastroenteritis research and epidemiology', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2725', 'display_name': 'Infectious Diseases'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12025', 'display_name': 'Hepatitis Viruses Studies and Epidemiology', 'score': 0.9974, 'subfield': {'id': 'https://openalex.org/subfields/2721', 'display_name': 'Hepatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/encephalitis-viruses', 'display_name': 'Encephalitis Viruses', 'score': 0.42924082}], 'concepts': [{'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.92097574}, {'id': 'https://openalex.org/C2777062976', 'wikidata': 'https://www.wikidata.org/wiki/Q473462', 'display_name': 'Venezuelan equine encephalitis virus', 'level': 4, 'score': 0.88560545}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.88133955}, {'id': 'https://openalex.org/C2777474056', 'wikidata': 'https://www.wikidata.org/wiki/Q1111605', 'display_name': 'Alphavirus', 'level': 3, 'score': 0.55936456}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5469421}, {'id': 'https://openalex.org/C83455156', 'wikidata': 'https://www.wikidata.org/wiki/Q199615', 'display_name': 'Encephalitis', 'level': 3, 'score': 0.5451223}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.46262905}, {'id': 'https://openalex.org/C67705224', 'wikidata': 'https://www.wikidata.org/wiki/Q11053', 'display_name': 'RNA', 'level': 3, 'score': 0.44466603}, {'id': 'https://openalex.org/C2908928554', 'wikidata': 'https://www.wikidata.org/wiki/Q199615', 'display_name': 'Encephalitis Viruses', 'level': 4, 'score': 0.42924082}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.2685349}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.2578476}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.13021487}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.08583251}], 'mesh': [{'descriptor_ui': 'D004666', 'descriptor_name': 'Encephalitis Virus, Venezuelan Equine', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D004685', 'descriptor_name': 'Encephalomyelitis, Venezuelan Equine', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D005784', 'descriptor_name': 'Gene Amplification', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D000071497', 'descriptor_name': 'Immunogenicity, Vaccine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': True}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000072283', 'descriptor_name': 'A549 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057134', 'descriptor_name': 'Antibodies, Neutralizing', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057134', 'descriptor_name': 'Antibodies, Neutralizing', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000914', 'descriptor_name': 'Antibodies, Viral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004655', 'descriptor_name': 'Emulsions', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004655', 'descriptor_name': 'Emulsions', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004666', 'descriptor_name': 'Encephalitis Virus, Venezuelan Equine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004685', 'descriptor_name': 'Encephalomyelitis, Venezuelan Equine', 'qualifier_ui': 'Q000821', 'qualifier_name': 'virology', 'is_major_topic': False}, {'descriptor_ui': 'D004685', 'descriptor_name': 'Encephalomyelitis, Venezuelan Equine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D012333', 'descriptor_name': 'RNA, Messenger', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014162', 'descriptor_name': 'Transfection', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014613', 'descriptor_name': 'Vaccines, Attenuated', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D014765', 'descriptor_name': 'Viral Vaccines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': False}, {'descriptor_ui': 'D014779', 'descriptor_name': 'Virus Replication', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2018.12.013', 'pdf_url': 'https://www.cell.com/article/S1525001619300012/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6453513', 'pdf_url': 'https://europepmc.org/articles/pmc6453513?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6453513', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30770173', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.ymthe.2018.12.013', 'pdf_url': 'https://www.cell.com/article/S1525001619300012/pdf', 'source': {'id': 'https://openalex.org/S51596929', 'display_name': 'Molecular Therapy', 'issn_l': '1525-0016', 'issn': ['1525-0016', '1525-0024'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [{'id': 'https://metadata.un.org/sdg/3', 'score': 0.69, 'display_name': 'Good health and well-being'}], 'grants': [{'funder': 'https://openalex.org/F4320338323', 'funder_display_name': 'U.S. Army Medical Research Institute of Infectious Diseases', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 60, 'referenced_works': ['https://openalex.org/W1511032803', 'https://openalex.org/W1585566200', 'https://openalex.org/W1915922462', 'https://openalex.org/W1943489257', 'https://openalex.org/W1967037480', 'https://openalex.org/W1967457776', 'https://openalex.org/W1970202670', 'https://openalex.org/W1980041511', 'https://openalex.org/W1981642403', 'https://openalex.org/W1982091532', 'https://openalex.org/W1988778346', 'https://openalex.org/W1988998228', 'https://openalex.org/W1990093169', 'https://openalex.org/W1990473807', 'https://openalex.org/W1991353963', 'https://openalex.org/W1994674548', 'https://openalex.org/W1999383442', 'https://openalex.org/W2004053206', 'https://openalex.org/W2006143353', 'https://openalex.org/W2008972769', 'https://openalex.org/W2009042469', 'https://openalex.org/W2013455484', 'https://openalex.org/W2022158929', 'https://openalex.org/W2027522108', 'https://openalex.org/W2033873890', 'https://openalex.org/W2038014675', 'https://openalex.org/W2038571210', 'https://openalex.org/W2051665875', 'https://openalex.org/W2051827882', 'https://openalex.org/W2052546898', 'https://openalex.org/W2053761308', 'https://openalex.org/W2055766303', 'https://openalex.org/W2066001915', 'https://openalex.org/W2066524113', 'https://openalex.org/W2070426326', 'https://openalex.org/W2082228643', 'https://openalex.org/W2095028793', 'https://openalex.org/W2096039130', 'https://openalex.org/W2099566075', 'https://openalex.org/W2105962056', 'https://openalex.org/W2108218913', 'https://openalex.org/W2109352986', 'https://openalex.org/W2129971483', 'https://openalex.org/W2137159042', 'https://openalex.org/W2156580403', 'https://openalex.org/W2162541845', 'https://openalex.org/W2162697017', 'https://openalex.org/W2168403455', 'https://openalex.org/W2170432280', 'https://openalex.org/W2186068577', 'https://openalex.org/W2396210930', 'https://openalex.org/W2560416222', 'https://openalex.org/W2610471486', 'https://openalex.org/W2736048901', 'https://openalex.org/W2761745911', 'https://openalex.org/W2774359469', 'https://openalex.org/W2775712816', 'https://openalex.org/W2782708334', 'https://openalex.org/W2820610048', 'https://openalex.org/W4241169271'], 'related_works': ['https://openalex.org/W4321438708', 'https://openalex.org/W4235641875', 'https://openalex.org/W4205894010', 'https://openalex.org/W337761396', 'https://openalex.org/W3137270593', 'https://openalex.org/W2603572037', 'https://openalex.org/W2462027926', 'https://openalex.org/W1970605491', 'https://openalex.org/W151775294', 'https://openalex.org/W1452174070'], 'abstract_inverted_index': {'Venezuelan': [0, 201], 'equine': [1, 196, 202, 397], 'encephalitis': [2, 197, 203, 398], 'virus': [3, 204], '(VEEV)': [4, 205], 'is': [5, 16, 43, 63, 206, 217, 244, 264], 'a': [6, 21, 44, 73, 82, 106, 123, 207, 222, 245, 274, 283, 307, 324], 'known': [7, 208], 'biological': [8, 209], 'defense': [9, 210], 'threat.': [10, 211], 'A': [11, 212], 'live-attenuated': [12, 45, 94, 128, 213, 246, 295, 329], 'investigational': [13, 214], 'vaccine,': [14, 215], 'TC-83,': [15, 145, 216, 346], 'available,': [17, 218], 'but': [18, 89, 219, 290], 'it': [19, 220], 'has': [20, 221], 'high': [22, 223], 'non-response': [23, 224], 'rate': [24, 225], 'and': [25, 55, 97, 102, 112, 186, 194, 198, 226, 256, 298, 303, 313, 387, 395, 399], 'can': [26, 227], 'also': [27, 155, 228, 356], 'cause': [28, 229], 'severe': [29, 230], 'reactogenicity.': [30, 231], 'We': [31, 232], 'generated': [32, 233], 'two': [33, 234], 'novel': [34, 235], 'VEE': [35, 46, 66, 236, 247, 267], 'vaccine': [36, 48, 68, 95, 237, 249, 269, 296], 'candidates': [37, 238], 'using': [38, 172, 239, 373], 'self-amplifying': [39, 240], 'mRNA': [40, 241], '(SAM).': [41, 242], 'LAV-CNE': [42, 80, 137, 243, 281, 338], 'SAM': [47, 67, 174, 248, 268, 375], 'formulated': [49, 69, 250, 270], 'with': [50, 70, 136, 251, 271, 337], 'synthetic': [51, 252], 'cationic': [52, 253], 'nanoemulsion': [53, 254], '(CNE)': [54, 255], 'carrying': [56, 257], 'the': [57, 77, 91, 167, 173, 178, 258, 278, 292, 368, 374, 379], 'RNA': [58, 110, 259, 311], 'genome': [59, 75, 260, 276], 'of': [60, 109, 144, 169, 180, 261, 310, 345, 370, 381], 'TC-83.': [61, 262], 'IAV-CNE': [62, 104, 153, 263, 305, 354], 'an': [64, 265], 'irreversibly-attenuated': [65, 266], 'CNE,': [71, 272], 'delivering': [72, 273], 'TC-83': [74, 83, 275, 284], 'lacking': [76, 277], 'capsid': [78, 279], 'gene.': [79, 280], 'launches': [81, 282], 'infection': [84, 285], 'cycle': [85, 108, 286, 309], 'in': [86, 119, 158, 287, 320, 359], 'vaccinated': [87, 135, 288, 336], 'subjects': [88, 289], 'eliminates': [90, 291], 'need': [92, 293], 'for': [93, 171, 294, 372], 'production': [96, 297], 'potentially': [98, 124, 299, 325], 'reduces': [99, 300], 'manufacturing': [100, 301], 'time': [101, 302], 'complexity.': [103, 304], 'produces': [105, 306], 'single': [107, 308], 'amplification': [111, 312], 'antigen': [113, 314], 'expression': [114, 315], 'without': [115, 316], 'generating': [116, 317], 'infectious': [117, 318], 'viruses': [118, 319], 'subjects,': [120, 321], 'thereby': [121, 322], 'creating': [122, 323], 'safer': [125, 326], 'alternative': [126, 327], 'to': [127, 142, 176, 328, 343, 377], 'vaccine.': [129, 330], 'Here,': [130, 331], 'we': [131, 332], 'demonstrated': [132, 333], 'that': [133, 334], 'mice': [134, 335], 'elicited': [138, 339], 'immune': [139, 340], 'responses': [140, 341], 'similar': [141, 342], 'those': [143, 344], 'providing': [146, 347], '100%': [147, 348], 'protection': [148, 160, 349, 361], 'against': [149, 161, 184, 350, 362, 385], 'aerosol': [150, 351], 'VEEV': [151, 162, 185, 352, 363, 386], 'challenge.': [152, 163, 353, 364], 'was': [154, 355], 'immunogenic,': [156, 357], 'resulting': [157, 358], 'significant': [159, 360], 'These': [164, 365], 'studies': [165, 366], 'demonstrate': [166, 367], 'proof': [168, 369], 'concept': [170, 371], 'platform': [175, 376], 'streamline': [177, 378], 'development': [179, 380], 'effective': [181, 382], 'attenuated': [182, 383], 'vaccines': [183, 384], 'closely': [187, 388], 'related': [188, 389], 'alphavirus': [189, 390], 'pathogens': [190, 391], 'such': [191, 392], 'as': [192, 393], 'western': [193, 394], 'eastern': [195, 396], 'Chikungunya': [199, 400], 'viruses.': [200, 401]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2910686626', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 12}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 14}, {'year': 2020, 'cited_by_count': 9}, {'year': 2019, 'cited_by_count': 1}], 'updated_date': '2024-12-18T16:36:23.775314', 'created_date': '2019-01-25'}