Publication Information

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[38, 190, 316, 354, 400, 453, 498, 534, 602, 673, 830, 950, 1054, 1173, 1213, 1278, 1322, 1525, 1732, 1844, 1908, 1976, 2075, 2151, 2190, 2308, 2401, 2655, 2767, 2864, 3109, 3191, 3247, 3379, 3439, 3559, 3624, 3787, 3901, 4022, 4049, 4098, 4181, 4243, 4424], 'By': [39], '1960s,': [41], 'sphingolipids': [42, 138, 198, 619, 1072, 2872, 4465, 4548], 'were': [43, 2783, 2795, 2806, 3113, 3121, 3252], 'recognized': [44], 'as': [45, 463, 839, 1084, 1089, 1401, 1717, 1987, 2338, 2661, 3817, 4200, 4251, 4267, 4475], 'normal': [46, 3172], 'constituents': [47], 'plasma': [50, 55], 'membrane,': [51], 'myelin': [52], 'sheath,': [53], 'known': [57, 2103], 'to': [58, 202, 281, 440, 461, 542, 680, 686, 714, 732, 737, 747, 778, 965, 979, 997, 1095, 1223, 1232, 1863, 2009, 2104, 2170, 2203, 2228, 2658, 2799, 2827, 3135, 3144, 3196, 3263, 3386, 3569, 3575, 3640, 3643, 3831, 3838, 3856, 3882, 4058, 4296, 4300, 4307, 4316, 4354, 4506, 4535], 'accumulate': [59, 1480, 2016], 'patients': [61, 3307, 3924], 'with': [62, 407, 433, 834, 1130, 2088, 2098, 2323, 2409, 2484, 2570, 2679, 2797, 2938, 3024, 3425, 3451, 3592, 3878, 3990, 4194, 4270], 'sphingolipidoses,': [63], 'storage': [64], 'disorders': [65], 'caused': [66, 2600, 2725, 3054, 3585, 3975], 'inborn': [68, 2833], 'errors': [69, 2834], 'sphingolipid': [71, 120, 484, 614, 990, 1003, 1019, 1045, 1058, 1198, 1286, 1307, 2194, 3119, 4083, 4259, 4303, 4437, 4445, 4497], 'metabolism.': [72, 615, 3276, 3327, 4438], 'Sphingolipid': [73, 1007, 3875], 'structure': [74], 'is': [75, 90, 222, 322, 426, 655, 772, 1009, 1201, 1288, 1310, 1457, 1561, 1734, 1761, 1831, 1853, 1859, 1861, 1978, 2102, 2127, 2154, 2243, 2329, 2568, 3022, 3198, 3208, 3441, 3572, 3670, 3988, 4061, 4086], 'centered': [76], 'long-chain': [79, 274, 4555, 4557], 'base': [80, 4556, 4558], '(LCB)': [81], 'backbone.': [82], 'In': [83, 122, 259, 317, 730, 1097, 2402, 3836, 4314], 'mammalian': [84, 1348, 1438], 'cells,': [85, 3450, 3802], 'most': [87, 2667, 3303], 'prevalent': [88], 'LCB': [89, 93, 229, 4111], 'sphingosine.': [91], 'The': [92, 454, 649, 696, 769, 974, 1079, 1174, 2666, 3192, 3296, 4004, 4050], 'anchor': [94], 'can': [95, 1332, 2212, 3961, 4198, 4335], 'be': [96, 715, 966, 977, 995, 1333, 2201, 2213, 3133, 3261, 3567, 3584, 3644, 3920, 3951, 4126, 4192, 4336], 'modified': [97], 'addition': [100, 731, 3837, 4315], 'polar': [102], 'headgroups': [103], 'at': [104, 1940], 'C1': [106], 'position': [107], 'acylation': [109], 'free': [112], 'amino': [113], 'group,': [114], 'generating': [115, 1946], 'vast': [117], 'array': [118], 'species.': [121], '1969–1970,': [123], 'Stoffel': [124, 355, 499, 563, 4428], 'colleagues': [126], 'published': [127], 'series': [129], 'reports': [131], 'mapping': [132], 'final': [134, 261, 365], 'metabolic': [135, 262, 1927, 3912, 4271], 'fate': [136], 'yeast': [141, 809, 902, 1094], 'Hansenula': [142], 'ciferrii': [143], '(2.Stoffel': [144, 291, 329, 375, 509, 577], 'W.': [145, 171, 292, 330, 376, 510, 578, 762, 1493, 1584, 1660, 2474, 2928, 3415, 3769, 3997], 'LeKim': [146, 293, 331, 377, 511, 579], 'D.': [147, 294, 332, 378, 512, 580, 760, 1242, 1251, 2050, 2165, 2284, 2363, 2420, 2429, 2617, 2874, 2883, 3071, 3211, 3220, 3343, 3352, 3661, 3698], 'Sticht': [148, 295, 333, 379, 513, 581], 'G.': [149, 296, 334, 380, 471, 514, 582, 1151, 1658, 1810, 2122, 2289, 3663, 4151], 'Distribution': [150, 297, 335, 381, 515, 583], 'properties': [152, 299, 337, 383, 517, 585], 'dihydrosphingosine-1-phosphate': [154, 301, 339, 385, 519, 587, 860], 'aldolase': [155, 302, 340, 386, 506, 520, 588], '(sphinganine-1-phosphate': [156, 303, 341, 387, 507, 521, 589], 'alkanal-lyase).Hoppe': [157, 304, 342, 388, 522, 590], 'Seylers': [158, 305, 343, 389, 523, 591], 'Z.': [159, 306, 344, 390, 524, 592, 2163], 'Physiol.': [160, 307, 345, 391, 525, 593, 3616], 'Chem.': [161, 308, 346, 392, 526, 594, 660, 817, 863, 910, 1512, 1603, 1677, 2138, 4041], '1969;': [162, 309, 347, 393, 527, 595], '350:': [163, 310, 348, 394, 528, 596], '1233-1241Crossref': [164, 311, 349, 395, 529, 597], 'PubMed': [165, 186, 312, 350, 396, 449, 494, 530, 598, 669, 791, 826, 872, 919, 948, 1050, 1169, 1209, 1274, 1318, 1391, 1468, 1521, 1572, 1612, 1642, 1686, 1728, 1772, 1840, 1904, 1972, 2071, 2147, 2186, 2272, 2304, 2397, 2452, 2494, 2536, 2582, 2611, 2651, 2860, 2906, 2948, 2990, 3036, 3065, 3105, 3187, 3243, 3375, 3435, 3555, 3620, 3682, 3717, 3755, 3783, 3897, 4018, 4045, 4094, 4177, 4239, 4379, 4420], 'Scopus': [166, 187, 313, 351, 397, 450, 495, 531, 599, 670, 792, 827, 873, 920, 1051, 1170, 1210, 1275, 1319, 1392, 1469, 1522, 1573, 1613, 1643, 1687, 1729, 1773, 1841, 1905, 1973, 2072, 2148, 2187, 2305, 2398, 2453, 2495, 2537, 2583, 2612, 2652, 2861, 2907, 2949, 2991, 3037, 3066, 3106, 3188, 3244, 3376, 3436, 3556, 3621, 3683, 3718, 3756, 3784, 3898, 4019, 4046, 4095, 4178, 4240, 4380, 4421], '(48)': [167, 314, 352, 398, 532, 600], 'Google': [168, 189, 315, 353, 399, 452, 497, 533, 601, 672, 794, 829, 875, 922, 949, 1053, 1172, 1212, 1277, 1321, 1394, 1471, 1524, 1575, 1615, 1645, 1689, 1731, 1775, 1843, 1907, 1975, 2074, 2150, 2189, 2273, 2307, 2400, 2455, 2497, 2539, 2585, 2614, 2654, 2863, 2909, 2951, 2993, 3039, 3068, 3108, 3190, 3246, 3378, 3438, 3558, 3623, 3685, 3720, 3758, 3786, 3900, 4021, 4048, 4097, 4180, 4242, 4382, 4423], 'Scholar,': [169, 795, 923, 1576, 1616, 1646, 1690, 2274, 2456, 2498, 2540, 2586, 2615, 2910, 2952, 2994, 3040, 3069, 3686, 3721, 3759, 4383], '3.Stoffel': [170], 'Studies': [172], 'biosynthesis': [175, 1008, 1069, 1287, 3207], 'degradation': [177, 1059, 2852], 'sphingosine': [179, 225, 604, 637, 813, 906, 1635, 2168, 3112, 3195, 3612, 4566, 4569], 'bases.Chem.': [180], 'Phys.': [181], 'Lipids.': [182], '1970;': [183], '5:': [184], '139-158Crossref': [185], '(46)': [188, 4020], 'Using': [191], 'radioactive': [192], 'precursors,': [193], 'showed': [195, 567], 'that': [196, 219, 250, 359, 543, 557, 568, 704, 1065, 1142, 1154, 1221, 1325, 1331, 2242, 2815, 3204, 3489, 3918, 4010, 4064, 4331, 4432], 'all': [197, 3806], 'are': [199, 265, 278, 1116, 1229, 1283, 2078, 2769, 3163], 'ultimately': [200], 'degraded': [201], 'LCBs.': [203], 'Degradation': [204], 'LCBs': [206, 738], 'involved': [207, 773], 'an': [208, 213, 427, 574, 998, 1718, 1896, 2062, 2353, 3561], 'initial': [209], 'phosphorylation': [210], '(suggested': [211], 'ATP': [214], 'requirement).': [215], 'We': [216, 2656, 2768], 'now': [217], 'know': [218], 'this': [220, 2659, 4539], 'step': [221, 576], 'catalyzed': [223, 544], 'kinases': [226], 'yields': [228], 'phosphates': [230], '(LCBPs),': [231], 'including': [232], 'prolific': [234], 'bioactive': [235], 'lipid,': [236], 'sphingosine-1-phosphate': [237, 478, 657, 1715, 1962, 2126, 2382, 2480, 2565, 2636, 2934, 3019, 3090, 3421, 3710, 4405, 4563, 4564], '(S1P),': [238], 'which': [239, 712, 725, 971, 1015, 1743, 2211, 2225, 3259, 3808, 4547], 'ligates': [240], 'family': [242, 1042], 'G': [244], 'protein-coupled': [245], 'receptors': [246, 248], '[S1P': [247], '(S1PRs)]': [249], 'play': [251, 4550], 'key': [252, 481, 2221, 3635], 'roles': [253, 1434, 4481], 'development,': [255, 1109, 4485], 'physiology,': [256], 'immunology.': [258], 'step,': [263], 'LCBPs': [264, 572, 743, 758, 883, 987], 'cleaved,': [266], 'yielding': [267], 'ethanolamine': [268, 4553], 'phosphate': [269, 605, 2292, 4554, 4559, 4567, 4570], '(EP)': [270], 'corresponding': [273], 'aldehyde.': [275], 'Both': [276], 'products': [277], 'further': [279, 4348], 'metabolized': [280], 'carbon': [282], 'dioxide': [283], 'or': [284, 988, 2690, 3266, 3811, 4122, 4272], 'reutilized': [285, 323], 'synthesis': [288], 'phospholipids': [290], 'particular,': [318], 'aldehyde': [320], 'product': [321, 3827, 4503], 'formation': [326, 3170], 'plasmalogens': [328], 'et': [356, 500, 564, 1263, 1371, 1713, 2051, 2378, 2441, 2477, 2519, 2561, 2895, 2931, 2973, 3015, 3232, 3364, 3418, 3538, 3666, 3742], 'al.': [357, 501, 565], 'demonstrated': [358], 'enzyme': [361, 455, 482, 504, 1021, 4123, 4431], 'responsible': [362], 'cleavage': [366, 570], 'reaction': [367, 541, 560], 'was': [368, 414, 456, 573, 745, 877, 2339, 2413, 2729], 'enriched': [369], 'endoplasmic': [372, 428], 'reticulum': [373], '(ER)': [374], 'Its': [401], 'topology': [402], 'ER': [405], 'membrane': [406, 431, 1075], 'its': [408, 2130, 4451], 'catalytic': [409], 'site': [410, 1942], 'facing': [411], 'cytosol': [413], 'later': [415], 'described': [416], '(4.Ikeda': [417], 'M.': [418, 847, 1359, 1363, 1487, 1578, 1650, 1694, 1712, 1806, 1883, 1957, 2036, 2042, 2048, 2280, 2510, 2619, 2743, 2964, 3073, 3150, 3529, 3651, 3659, 3727, 3763, 4399], 'Kihara': [419], 'A.': [420, 644, 1036, 1255, 1355, 1620, 1622, 1696, 1953, 2361, 2365, 2367, 2369, 2433, 2504, 2514, 2550, 2627, 2741, 2887, 2958, 2968, 3004, 3081, 3224, 3356, 3523, 3533, 3657, 3692, 3864, 4143, 4393], 'Igarashi': [421], 'Y.': [422, 1357, 1814, 1885, 1887, 2560, 3014, 3152, 3655], 'Sphingosine-1-phosphate': [423, 1665], 'lyase': [424, 559, 606, 1266, 1373, 1504, 1595, 1666, 1716, 1894, 1963, 2054, 2134, 2293, 2383, 2444, 2481, 2521, 2566, 2637, 2898, 2935, 2975, 3020, 3091, 3235, 3367, 3422, 3540, 4159, 4568, 4571], '(SPL)': [425, 607], 'reticulum-resident,': [429], 'integral': [430], 'protein': [432, 1535, 2095, 2230, 2320, 2821], 'pyridoxal': [435, 546, 4561], '5′-phosphate': [436, 547, 4562], 'binding': [437], 'domain': [438], 'exposed': [439], 'cytosol.Biochem.': [442], 'Biophys.': [443], 'Res.': [444, 786, 1382, 4014], 'Commun.': [445, 787], '2004;': [446, 1837], '325:': [447, 3753], '338-343Crossref': [448], '(124)': [451], 'recently': [457, 2730], 'crystallized': [458], 'shown': [460, 2340, 4330], 'function': [462, 476, 2030, 2060, 3148], 'homodimer': [465], '(5.Bourquin': [466], 'F.': [467, 642, 2377, 2508, 2623, 2962, 3077, 3527, 4145], 'Riezman': [468], 'H.': [469, 927, 1184, 1293, 2116, 2251, 2466, 2920, 3407, 3647, 4069], 'Capitani': [470, 4150], 'Grutter': [472, 4152], 'M.G.': [473, 4153], 'Structure': [474], 'lyase,': [479], 'metabolism.Structure.': [485], '2010;': [486, 1047, 1513, 1604, 3679, 4376], '18:': [487], '1054-1065Abstract': [488], 'Full': [489, 491, 664, 666, 821, 823, 867, 869, 914, 916, 1386, 1388, 1516, 1518, 1607, 1609, 1681, 1683, 2142, 2144, 2646, 2648, 3100, 3102, 3182, 3184, 3892, 3894], 'Text': [490, 492, 665, 667, 822, 824, 868, 870, 915, 917, 1387, 1389, 1517, 1519, 1608, 1610, 1682, 1684, 2143, 2145, 2647, 2649, 3101, 3103, 3183, 3185, 3893, 3895], 'PDF': [493, 668, 825, 871, 918, 1390, 1520, 1611, 1685, 2146, 2650, 3104, 3186, 3896], '(60)': [496], '"dihydrosphingosine-1-phosphate': [505], 'alkanal-lyase)"': [508], 'Based': [535], 'similarity': [538], '(PLP)-dependent': [548], 'threonine': [549], 'allothreonine': [551], 'aldolases,': [552], 'he': [553], 'hypothesized': [554], 'proved': [556], 'requires': [561], 'PLP.': [562], 'also': [566, 2155, 2330, 2770, 3253], 'irreversible': [575], 'Thus,': [603, 951, 2309], 'guards': [608, 4433], 'sole': [610], 'exit': [611, 4435], 'point': [612, 4534], 'Evolutionary': [616], 'conservation': [617], 'allowed': [620, 1786], 'cloning': [622], 'first': [625], 'SPL': [626, 689, 954, 1082, 1102, 1115, 1180, 1349, 1436, 1778, 1875, 1911, 1926, 1977, 2001, 2013, 2208, 2233, 2311, 2328, 2355, 2662, 2801, 3271, 3283, 3292, 3323, 3440, 3475, 3494, 3513, 3826, 3906, 3948, 4115, 4131, 4140, 4189, 4320, 4342, 4346, 4353, 4495], 'gene,': [627], 'DPL1,': [628], 'from': [629, 1093, 1802, 1825, 2671], 'Saccharomyces': [630, 653, 782, 858, 943, 2267], 'cerevisiae': [631, 654, 859], 'using': [632], 'genetic': [634, 699, 2854], 'screen': [635, 685, 1139], 'resistance': [638], '(6.Saba': [639], 'J.D.': [640, 799, 892, 1194, 1303, 1499, 1590, 1662, 1959, 2282, 4079], 'Nara': [641], 'Bielawska': [643], 'Garrett': [645], 'S.': [646, 925, 1692, 2249, 2373, 2458, 2460, 2470, 2472, 2548, 2631, 2912, 2914, 2924, 2926, 3002, 3085, 3399, 3401, 3411, 3413, 3665, 3741, 4362], 'Hannun': [647, 850], 'Y.A.': [648, 851], 'BST1': [650], 'gene': [651, 720, 771, 1103, 1176, 4120, 4443], 'lyase.J.': [658], 'Biol.': [659, 785, 816, 862, 909, 1511, 1602, 1676, 2137], '1997;': [661, 864], '272:': [662, 865], '26087-26090Abstract': [663], '(213)': [671], 'Disruption': [674], 'DPL1': [676, 770], 'conferred': [677], 'profound': [678, 735], 'sensitivity': [679, 736], 'LCBs,': [681], 'creating': [682], 'facile': [684], 'identify': [687], 'other': [688, 2716, 3118, 4290], 'genes': [690, 703, 1141], 'isolate': [692], 'suppressors': [693], '(Fig.': [694, 1396, 1473, 2700], '1).': [695], 'identification': [697, 1132, 3943], 'manipulation': [700, 4456], 'SPL-encoding': [702], 'followed': [705], 'revealed': [706, 3499, 4324, 4461], 'many': [707, 2816], 'biological': [708], 'functions': [709, 4463], 'SPL,': [711], 'appears': [713], 'encoded': [716], 'single': [719], 'every': [722, 4442], 'genome': [723, 2417], 'it': [726, 1858], 'has': [727, 4025, 4447, 4460], 'been': [728, 4448], 'identified.': [729, 4454], 'exhibiting': [733, 885], 'calcium,': [740], 'dpl1Δ': [741, 842], 'accumulated': [742, 2871], 'resistant': [746], 'heat': [748], 'shock': [749], 'nutrient': [751, 779], 'deprivation,': [752], 'suggesting': [753, 3203], 'protective': [755], 'role': [756, 2222, 3322, 3511, 3594, 3840, 3929, 3936, 4027, 4257, 4318, 4470], '(7.Gottlieb': [759], 'Heideman': [761], 'Zhou': [763], 'J.': [764, 768, 929, 1245, 1449, 1553, 1656, 1710, 1753, 1951, 2044, 2046, 2253, 2359, 2423, 2476, 2512, 2607, 2625, 2877, 2930, 2966, 3061, 3079, 3214, 3346, 3417, 3531, 3649, 3713, 3725, 4234, 4391], 'Oskouian': [765, 2463, 2917, 3404], 'B.': [766, 1030, 1247, 1249, 1365, 2425, 2427, 2464, 2879, 2881, 2918, 3216, 3218, 3348, 3350, 3405, 4364], 'Saba': [767, 798, 891, 928, 1193, 1302, 1498, 1589, 1661, 1958, 2045, 2252, 2281, 4078], 'mediating': [775], 'response': [777, 1671, 2008, 3855, 4057, 4223], 'deprivation': [780], 'cerevisiae.Mol.': [783], 'Cell': [784], '1999;': [788, 2857], '1:': [789], '66-71Crossref': [790], '(63)': [793, 2306], '8.Birchwood': [796], 'C.J.': [797, 890, 3868, 4387], 'Dickson': [800, 893], 'R.C.': [801, 894], 'Cunningham': [802, 895], 'K.W.': [803, 896], 'Calcium': [804, 897], 'influx': [805, 898], 'signaling': [807, 900, 1163, 1199, 1308, 1455, 1559, 1759, 2177, 3469, 3796, 4084], 'stimulated': [810, 903], 'intracellular': [812, 905, 4411], '1-phosphate': [814, 907, 1265, 1503, 1594, 2053, 2443, 2897, 3234, 3366, 3613], 'accumulation.J.': [815, 908], '2001;': [818, 911], '276:': [819, 912], '11712-11718Abstract': [820, 913], '(83)': [828, 921, 2149], 'However,': [831, 962, 2152], 'when': [832, 1285], 'combined': [833], 'mutations': [835, 2412, 2522, 2728, 2782, 2819, 2976, 3541], 'S1P': [837, 1834, 1846, 1852, 1893, 1899, 1948, 2101, 2153, 3110, 4012, 4158, 4162, 4500], 'phosphatase—identified': [838], 'high-copy': [841], 'suppressor': [843], '(9.Mao': [844], 'C.': [845, 1137, 1160, 1618, 1624, 2375, 3653, 3735, 3761, 4032, 4360], 'Wadleigh': [846], 'Jenkins': [848], 'G.M.': [849, 3729], 'Obeid': [852, 3871], 'L.M.': [853, 3872], 'Identification': [854], 'characterization': [856], 'phosphatase.J.': [861], '28690-28694Abstract': [866], '(141)': [874], 'Scholar)—dpl1Δ': [876], 'lethal,': [878], 'accumulating': [879], 'massive': [880], 'amounts': [881], 'disrupted': [886, 3500], 'calcium': [887, 3629], 'homeostasis': [888, 1508, 1599], '(8.Birchwood': [889], '10.Kim': [924], 'Fyrst': [926, 1183, 1292, 2250, 4068], 'Accumulation': [930, 2254], 'phosphorylated': [932, 2256], 'sphingoid': [933, 2257], 'long': [934, 2258], 'chain': [935, 2259], 'bases': [936, 2260], 'results': [937, 1105, 2261], 'cell': [939, 1961, 2263, 3931, 4517], 'growth': [940, 1740, 2264], 'inhibition': [941, 952, 1056, 1083, 1895, 2265, 4060], 'cerevisiae.Genetics.': [944, 2268], '2000;': [945, 2269, 3179], '156:': [946, 2270], '1519-1529Crossref': [947, 2271], 'LCBP': [956], 'accumulation': [957], 'may': [958, 2200, 2312, 3132, 3829, 3950, 4249, 4305, 4533, 4549], 'have': [959, 4329], 'positive': [960, 4133], 'consequences.': [961], 'there': [963, 3571], 'seems': [964], 'sweet': [968], 'spot': [969], 'beyond': [970], 'toxicity': [972], 'occurs.': [973], 'latter': [975], 'could': [976, 994, 1060, 2003, 3260, 3583, 3799, 3971, 4102, 4125, 4184], 'due': [978, 996, 1231, 2826], 'toxic': [980, 2131], 'effects': [981, 3627, 4134], 'very': [983], 'high': [984, 1860], 'levels': [985, 3120, 3251], 'upstream': [989], 'intermediates.': [991], 'Alternatively,': [992], 'lethality': [993], 'indirect': [999], 'effect': [1000, 2132], 'global': [1002, 1918, 3274], 'homeostatic': [1004], 'regulatory': [1005], 'networks.': [1006], 'tightly': [1010], 'controlled': [1011], 'ORM': [1013], 'proteins,': [1014], 'inhibit': [1016], 'rate-limiting': [1018], 'biosynthetic': [1020], 'serine': [1022], 'palmitoyltransferase': [1023], '(SPT)': [1024], '(11.Breslow': [1025], 'D.K.': [1026], 'Collins': [1027], 'S.R.': [1028, 1879], 'Bodenmiller': [1029], 'Aebersold': [1031], 'R.': [1032, 1190, 1253, 1299, 2431, 2500, 2544, 2735, 2885, 2954, 2998, 3222, 3354, 3519, 3737, 4075, 4385], 'Simons': [1033], 'K.': [1034, 1188, 1257, 1297, 1700, 2040, 2435, 2621, 2889, 3075, 3226, 3358, 3603, 3688, 4073], 'Shevchenko': [1035], 'Ejsing': [1037], 'C.S.': [1038, 1451, 1555, 1755], 'Weissman': [1039], 'J.S.': [1040], 'Orm': [1041], 'proteins': [1043, 2318, 4190], 'mediate': [1044, 1155], 'homeostasis.Nature.': [1046], '463:': [1048], '1048-1053Crossref': [1049], '(433)': [1052], 'Complete': [1055], 'result': [1061], 'feedback': [1063], 'signals': [1064, 3858], 'prevent': [1066, 1143], 'de': [1067, 1368, 3155, 3205], 'novo': [1068, 3206], 'essential': [1071, 1202, 1311, 2128, 2331, 3321, 4087, 4469], 'needed': [1073, 1862, 2156], 'stability': [1076], 'organization.': [1078], 'recognition': [1080], 'double-edged': [1086], 'sword': [1087], 'reappears': [1088], 'consistent': [1091, 1129, 3591], 'theme': [1092], 'man.': [1096, 3295], 'Caenorhabditis': [1098], 'elegans,': [1099], 'silencing': [1100, 3474], 'spl-1': [1104], 'semilethality,': [1107], 'delayed': [1108], 'reproductive': [1111, 1226], 'defects.': [1112, 2718, 4292], 'Worms': [1113], 'lacking': [1114], 'sluggish,': [1117], 'starved,': [1118], 'pump': [1120], 'food': [1121], 'poorly,': [1122], 'characteristics': [1123], 'aging': [1125, 1145, 2324, 3945], 'nematodes': [1127], 'Spl-1': [1134], 'elegans': [1138, 1161], 'accelerated': [1144], '(12.Samuelson': [1146], 'A.V.': [1147], 'Carr': [1148], 'C.E.': [1149], 'Ruvkun': [1150], 'Gene': [1152, 4182], 'activities': [1153], 'increased': [1156, 1540, 2349, 3199], 'life': [1157], 'span': [1158], 'insulin-like': [1162], 'mutants.Genes': [1164], 'Dev.': [1165, 2182, 2642, 3096], '2007;': [1166, 1465, 1569, 1769], '21:': [1167], '2976-2994Crossref': [1168], '(152)': [1171], 'Sply': [1175, 1195, 1280, 1304, 1326, 3329, 3381, 4053, 4080], 'encodes': [1177], 'fruit': [1178, 3331], 'fly': [1179, 3332], '(13.Herr': [1181, 1290, 4066], 'D.R.': [1182, 1291, 3874, 3999, 4067], 'Phan': [1185, 1294, 4070], 'V.': [1186, 1295, 1816, 4071], 'Heinecke': [1187, 1296, 4072], 'Georges': [1189, 1298, 4074], 'Harris': [1191, 1300, 4076], 'G.L.': [1192, 1301, 4077], 'regulation': [1196, 1305, 2192, 4081], 'molecules': [1200, 1309, 4085], 'Drosophila': [1204, 1313, 3380, 4089], 'development.Development.': [1205, 1314, 4090], '2003;': [1206, 1315, 4091], '130:': [1207, 1316, 4092], '2443-2453Crossref': [1208, 1317, 4093], '(103)': [1211, 1320, 4096], 'Sply-null': [1214], 'larvae': [1215, 1220], 'exhibit': [1216, 1225, 1527, 2022, 2105, 2236, 3389], 'semilethality;': [1217], 'rare': [1219, 1545, 2751, 4246], 'survive': [1222], 'adulthood': [1224], 'defects': [1227, 1240, 2077, 3341], 'flightless': [1230], 'abnormal': [1233], 'flight': [1234], 'muscle': [1235], 'patterning': [1236], 'neuromuscular': [1238, 3338], 'junction': [1239, 3339], '(14.Atkinson': [1241, 2419, 2873, 3210, 3342], 'Nikodinovic': [1243, 2421, 2875, 3212, 3344], 'Glumac': [1244, 2422, 2876, 3213, 3345], 'Asselbergh': [1246, 2424, 2878, 3215, 3347], 'Ermanoska': [1248, 2426, 2880, 3217, 3349], 'Blocquel': [1250, 2428, 2882, 3219, 3351], 'Steiner': [1252, 2430, 2884, 3221, 3353], 'Estrada-Cuzcano': [1254, 2432, 2886, 3223, 3355], 'Peeters': [1256, 2434, 2888, 3225, 3357], 'Ooms': [1258, 2436, 2890, 3227, 3359], 'T.': [1259, 2437, 2552, 2891, 3006, 3154, 3228, 3360, 3605, 3739, 3866], 'De': [1260, 2438, 2892, 3229, 3361], 'Vriendt': [1261, 2439, 2893, 3230, 3362], 'E.': [1262, 1654, 2371, 2440, 2506, 2516, 2546, 2894, 2960, 2970, 3000, 3231, 3363, 3525, 3535], 'al.Sphingosine': [1264, 2052, 2442, 2896, 3233, 3365], 'deficiency': [1267, 1505, 1596, 1667, 2445, 2899, 3236, 3272, 3368, 3828, 4141], 'causes': [1268, 1443, 2446, 2900, 3237, 3369, 3487], 'Charcot-Marie-Tooth': [1269, 2447, 2901, 3238, 3370], 'neuropathy.Neurology.': [1270, 2448, 2902, 3239, 3371], '2017;': [1271, 2301, 2449, 2491, 2533, 2579, 2903, 2945, 2987, 3033, 3240, 3372, 3432, 3552, 3617, 4042], '88:': [1272, 2450, 2904, 3241, 3373], '533-542Crossref': [1273, 2451, 2905, 3242, 3374], '(42)': [1276, 2454, 2908, 3245, 3377], 'Interestingly,': [1279], 'mutant': [1281, 3382, 4054, 4186], 'phenotypes': [1282, 1547, 3946, 4055], 'attenuated': [1284], 'suppressed': [1289], 'This': [1323, 1921], 'suggests': [1324], 'mutants': [1327, 3949], 'sphingolipidosis': [1330, 4029, 4541], 'ameliorated': [1334], 'substrate': [1336], 'depletion': [1337], 'strategies.': [1338], 'Sgpl1': [1339, 1441, 1475], 'LacZ': [1340], 'reporter': [1341], 'mice': [1342, 1479, 1780, 1877, 1913, 2015], 'reveal': [1343], 'expression': [1346, 1374, 1403, 3453, 3505, 3669], '(15.Borowsky': [1350], 'A.D.': [1351], 'Bandhuvula': [1352], 'P.': [1353, 1370, 1453, 1557, 1702, 1757, 2838, 3767], 'Kumar': [1354, 1952], 'Yoshinaga': [1356], 'Nefedov': [1358], 'Fong': [1360], 'L.G.': [1361], 'Zhang': [1362, 1956], 'Baridon': [1364], 'Dillard': [1366], 'L.': [1367, 2846, 3765], 'Jong': [1369], 'al.Sphingosine-1-phosphate': [1372, 2520, 2974, 3539], 'embryonic': [1376], 'adult': [1378], 'murine': [1379, 3280, 3445], 'tissues.J.': [1380], 'Lipid': [1381], '2012;': [1383, 2183, 3714, 3889], '53:': [1384], '1920-1931Abstract': [1385], '(35)': [1393], 'Scholar)': [1395, 1472], '2).': [1397], 'Specific': [1398], 'patterns,': [1399], 'such': [1400, 3816, 4266], 'rich': [1402, 4005], 'thymic': [1406, 1529, 1937, 1965], 'reticular': [1407], 'network,': [1408], 'gut': [1409], 'epithelium,': [1410], 'sebaceous': [1411], 'glands,': [1412], 'corticomedullary': [1413], 'region': [1414], 'pelvis': [1416], 'kidney,': [1419, 2333], 'discrete': [1420], 'olfactory': [1421], 'bulb': [1422], 'ganglia,': [1423], 'spinal': [1424], 'cord': [1425], 'gray': [1426], 'matter,': [1427], 'cranial': [1429, 2693, 2707], 'nerves,': [1430], 'intimate': [1431], 'myriad': [1432, 4462], 'undiscovered': [1433], 'physiology.': [1439], 'Global': [1440], 'disruption': [1442, 1871, 1897, 3486], 'runting': [1444], 'early': [1446, 1462, 1566, 1766], 'death': [1447], '(16.Schmahl': [1448, 1552, 1752], 'Raymond': [1450, 1554, 1754], 'Soriano': [1452, 1556, 1756], 'PDGF': [1454, 1558, 1758], 'specificity': [1456, 1560, 1760], 'mediated': [1458, 1562, 1762, 2065], 'through': [1459, 1563, 1763, 1892, 3797], 'multiple': [1460, 1564, 1764], 'immediate': [1461, 1565, 1765, 3955], 'genes.Nat.': [1463, 1567, 1767], 'Genet.': [1464, 1568, 1768], '39:': [1466, 1570, 1770], '52-60Crossref': [1467, 1571, 1771], '(153)': [1470, 1574, 1774], '3).': [1474], 'KO': [1476, 1779, 1876, 1912, 1919, 2014, 2234, 2356, 3284, 3495], '(SPL': [1477], 'KO)': [1478], 'sphingolipids,': [1481], 'triglycerides,': [1482], 'cholesteryl': [1484], 'esters': [1485], '(17.Bektas': [1486], 'Allende': [1488, 1579, 1817], 'M.L.': [1489, 1580, 1648, 1818], 'Lee': [1490, 1581, 1651], 'B.G.': [1491, 1582, 1652], 'Chen': [1492, 1583, 1659], 'Amar': [1494, 1585], 'M.J.': [1495, 1586, 1812], 'Remaley': [1496, 1587], 'A.T.': [1497, 1588], 'Proia': [1500, 1591, 1663, 1819, 2113], 'R.L.': [1501, 1592, 1664, 1820, 2114], 'Sphingosine': [1502, 1593, 4099, 4365], 'disrupts': [1506, 1597, 2056], 'lipid': [1507, 1598, 3167, 3275], 'liver.J.': [1510, 1601], '285:': [1514, 1605], '10880-10889Abstract': [1515, 1606], '(144)': [1523, 1614], 'They': [1526], 'lymphopenia,': [1528], 'atrophy,': [1530, 4279], 'neutrophilia,': [1531], 'anemia,': [1532], 'nephrosis': [1533, 2483, 2937, 3424, 4268], '(excessive': [1534], 'loss': [1536], 'urine),': [1539], 'cortical': [1541], 'bone': [1542, 1722], 'thickness,': [1543], 'developmental': [1546, 3340], 'often': [1548], 'involving': [1549], 'vascular': [1550, 1745, 3587, 3596, 4273, 4280], 'structures': [1551], '17.Bektas': [1577], '18.Weber': [1617], 'Krueger': [1619], 'Munk': [1621], 'Bode': [1623], 'Van': [1625, 2110, 2120], 'Veldhoven': [1626, 2111], 'P.P.': [1627, 2112], 'Graler': [1628, 2279], 'M.H.': [1629], 'Discontinued': [1630], 'postnatal': [1631], 'thymocyte': [1632], 'development': [1633, 1751, 3517, 3993], '1-phosphate-lyase-deficient': [1636], 'mice.J.': [1637], 'Immunol.': [1638], '2009;': [1639, 2139, 3752], '183:': [1640], '4292-4301Crossref': [1641], '(49)': [1644], '19.Allende': [1647], 'Bektas': [1649], 'Bonifacino': [1653], 'Kang': [1655], 'Tuymetova': [1657], 'produces': [1668, 2209], 'pro-inflammatory': [1670], 'while': [1672], 'impairing': [1673], 'neutrophil': [1674], 'trafficking.J.': [1675], '2011;': [1678, 4174], '286:': [1679], '7348-7358Abstract': [1680], '(134)': [1688], '20.Weske': [1691], 'Vaidya': [1693], 'Reese': [1695], 'von': [1697], 'Wnuck': [1698], 'Lipinski': [1699], 'Keul': [1701], 'Bayer': [1703], 'J.K.': [1704], 'Fischer': [1705], 'J.W.': [1706], 'Flogel': [1707], 'U.': [1708, 4155], 'Nelsen': [1709], 'Epple': [1711], 'al.Targeting': [1714], 'anabolic': [1719], 'therapy': [1720], 'loss.Nat.': [1723], 'Med.': [1724, 1968, 3678, 4040], '2018;': [1725, 2608, 2643, 2762, 3062, 3097], '24:': [1726], '667-678Crossref': [1727], '(71)': [1730], '[SPL': [1733], 'target': [1736, 4011], 'platelet-derived': [1739], 'factor': [1741], 'pathway,': [1742], 'controls': [1744], 'integrity,': [1746], 'skeletal': [1747], 'patterning,': [1748], 'glomeruli': [1750], 'Scholar).]': [1776], 'Conditional': [1777], 'live': [1781], 'longer': [1782], 'have,': [1784], 'thus,': [1785], 'deeper': [1787], 'investigation': [1788], "SPL's": [1790, 4468, 4479], 'functions.': [1791], 'S1P-mediated': [1792, 3626], 'activation': [1793, 2351, 3675], 'S1PR1': [1795, 3668], 'mature': [1797], 'lymphocytes': [1798], 'mediates': [1799], 'their': [1800, 2000], 'egress': [1801, 1824, 2006], 'thymus': [1804, 1826], '(21.Matloubian': [1805], 'Lo': [1807], 'C.G.': [1808], 'Cinamon': [1809], 'Lesneski': [1811], 'Xu': [1813, 1884, 2543, 2997], 'Brinkmann': [1815], 'Cyster': [1821, 1888], 'J.G.': [1822, 1889], 'Lymphocyte': [1823, 1890], 'peripheral': [1828, 2698], 'lymphoid': [1829], 'organs': [1830], 'dependent': [1832], 'receptor': [1835, 4565], '1.Nature.': [1836], '427:': [1838], '355-360Crossref': [1839], '(2065)': [1842], 'An': [1845], 'chemotactic': [1847], 'gradient': [1848, 1870, 1949], 'between': [1849, 3703], 'tissues': [1850], 'where': [1851, 1857], 'low': [1854, 2798], 'blood': [1856, 2867], 'enable': [1864], 'T-cell': [1865], 'egress,': [1866], 'exemplified': [1867], 'lymphopenia': [1873, 1916], '(22.Schwab': [1878], 'Pereira': [1880], 'J.P.': [1881, 2161], 'Matloubian': [1882], 'Huang': [1886], 'sequestration': [1891], 'gradients.Science.': [1900], '2005;': [1901], '309:': [1902], '1735-1739Crossref': [1903], '(648)': [1906], 'Dendritic': [1909, 1960], 'cell-specific': [1910], 'recapitulate': [1914], 'mice.': [1920], 'reveals': [1922], 'importance': [1924], 'activity': [1928, 2002, 2107, 2380], 'within': [1929], 'dendritic': [1930, 1988], 'cells': [1931, 1938, 1989, 3460], '(a': [1932], 'tiny': [1933], 'population': [1934], 'resident': [1936], 'located': [1939], 'egress)': [1944], '(23.Zamora-Pineda': [1950], 'Suh': [1954], 'J.H.': [1955], 'regulates': [1964], 'egress.J.': [1966], 'Exp.': [1967], '2016;': [1969, 2068, 4015, 4417], '213:': [1970], '2773-2791Crossref': [1971], '(37)': [1974], 'influenced': [1979], 'stress': [1981, 3601], 'conditions,': [1982, 4265, 4274], 'raising': [1983], 'possibility': [1985], 'that,': [1986], 'patrol': [1990], 'body': [1992], 'search': [1994], 'danger-associated': [1996], 'antigens,': [1997], 'modulation': [1998], 'regulate': [2004], 'lymphocyte': [2005], 'environmental': [2010], 'conditions.': [2011], 'Neural-specific': [2012], 'LCBs/LCBPs': [2017], 'brain': [2020, 2640, 3094], 'deficits': [2023], 'spatial': [2025], 'learning,': [2026], 'memory,': [2027], 'motor': [2029], '(24.Mitroi': [2031], 'D.N.': [2032, 2276], 'Deutschmann': [2033], 'A.U.': [2034], 'Raucamp': [2035], 'Karunakaran': [2037, 2277], 'I.': [2038, 2278, 2502, 2518, 2554, 2956, 2972, 3008, 3521, 3537], 'Glebov': [2039], 'Hans': [2041], 'Walter': [2043], 'Gräler': [2047], 'Ehninger': [2049, 2283], 'ablation': [2055], 'presynaptic': [2057, 2081, 2171], 'architecture': [2058], 'via': [2061, 2298, 3463, 4117], 'ubiquitin-': [2063], 'proteasome': [2064], 'mechanism.Sci.': [2066], 'Rep.': [2067], '6:': [2069, 4175], '37064Crossref': [2070], '(31)': [2073, 3719], 'These': [2076], 'accompanied': [2079], 'pathology': [2082], 'reduced': [2084, 3390, 3504], 'synaptic': [2085, 2158], 'plasticity': [2086], 'associated': [2087, 2322, 2408, 2569, 2796, 3023, 4269], 'calcium-dependent': [2090], 'induction': [2091], 'unfolded': [2094], 'response.': [2096], 'Consistent': [2097], 'these': [2099, 4311], 'findings,': [2100], 'neurotoxic': [2106], '(25.Hagen': [2108], 'N.': [2109, 2733, 2739, 2848, 4147], 'Park': [2115], 'Merrill': [2117], 'Jr.,': [2118], 'A.H.': [2119], 'Echten-Deckert': [2121, 2288], 'Subcellular': [2123], 'origin': [2124], 'deficient': [2135], 'neurons.J.': [2136], '284:': [2140], '11346-11353Abstract': [2141], 'transmission': [2159], '(26.Chan': [2160], 'Hu': [2162], 'Sieburth': [2164], 'Recruitment': [2166], 'kinase': [2169, 4100], 'terminals': [2172], 'conserved': [2175], 'muscarinic': [2176], 'pathway': [2178, 3886, 4459], 'promotes': [2179], 'neurotransmitter': [2180], 'release.Genes': [2181], '26:': [2184], '1070-1085Crossref': [2185], '(52)': [2188, 4381], 'Tight': [2191], 'metabolism': [2195, 2836, 3876, 4260, 4304, 4446], 'precise': [2197], 'tissue': [2198], 'compartments': [2199], 'critical': [2202], 'support': [2204, 3576], 'healthy': [2205], 'neuronal': [2206, 2296, 2310], 'function.': [2207, 3825], 'EP,': [2210], 'incorporated': [2214], 'into': [2215], 'phosphatidylethanolamine': [2216, 2299, 4560], '(PtdE).': [2217], 'PtdE': [2218, 2247], 'plays': [2219, 3324], 'autophagy,': [2224, 3631], 'neurons': [2226, 2235, 3333], 'use': [2227], 'clear': [2229], 'aggregates.': [2231], 'Cultured': [2232], 'block': [2238], 'autophagic': [2240, 2314, 3842], 'flux': [2241, 3771], 'alleviated': [2244], 'exogenous': [2246], '(10.Kim': [2248], '27.Mitroi': [2275], 'Ledesma': [2285], 'M.D.': [2286], 'van': [2287], 'SGPL1': [2290, 2411, 2567, 2727, 2748, 3021, 3457, 3485], '(sphingosine': [2291], '1)': [2294], 'modulates': [2295], 'autophagy': [2297], 'production.Autophagy.': [2300], '13:': [2302], '885-899Crossref': [2303], 'facilitate': [2313], 'clearance': [2315, 2825], 'misfolded': [2317], 'aggregates': [2321], 'age-related': [2326], 'neurodegeneration.': [2327], 'skin,': [2334], 'platelet': [2336, 2350, 2391], 'functions,': [2337], 'nephrosis,': [2343], 'podocyte': [2344], 'effacement,': [2345], 'skin': [2346, 2388, 3137], 'irritation,': [2347, 2389], 'inducible': [2354], 'mouse': [2357, 3496], '(28.Schümann': [2358], 'Grevot': [2360], 'Ledieu': [2362], 'Wolf': [2364], 'Schubart': [2366], 'Piaia': [2368], 'Sutter': [2370], 'Côté': [2372], 'Beerli': [2374], 'Pognan': [2376], 'al.Reduced': [2379], 'induces': [2384], 'podocyte-related': [2385], 'glomerular': [2386, 3446, 3581], 'proteinuria,': [2387], 'activation.Toxicol.': [2392], 'Pathol.': [2393], '2015;': [2394, 3780], '43:': [2395], '694-703Crossref': [2396], '(22)': [2399], '2017–2018,': [2403], 'novel': [2405, 2633, 3087, 4036, 4540], 'human': [2406, 3326, 3387, 3479, 4322, 4355, 4452], 'syndrome': [2407, 2573, 2596, 2664, 3027, 3050, 3265, 4573], 'inactivating': [2410], 'diagnostic': [2416], 'sequencing': [2418], '29.Lovric': [2457, 2911], 'Goncalves': [2459, 2913, 3400], 'Gee': [2461, 2915, 3402], 'H.Y.': [2462, 2916, 3403], 'Srinivas': [2465, 2919, 3406], 'Choi': [2467, 2921, 3408], 'W.I.': [2468, 2922, 3409], 'Shril': [2469, 2923, 3410], 'Ashraf': [2471, 2925, 3412], 'Tan': [2473, 2927, 3414], 'Rao': [2475, 2929, 3416], 'al.Mutations': [2478, 2932, 3419], 'cause': [2482, 2523, 2752, 2936, 2977, 3423, 3542], 'ichthyosis': [2485, 2939, 3426], 'adrenal': [2487, 2525, 2576, 2598, 2683, 2723, 2755, 2941, 2979, 3030, 3052, 3428, 3497, 3515, 3544, 4287], 'insufficiency.J.': [2488, 2756, 2942, 3429], 'Clin.': [2489, 2531, 2757, 2943, 2985, 3430, 3550], 'Invest.': [2490, 2532, 2944, 2986, 3177, 3431, 3551], '127:': [2492, 2534, 2946, 2988, 3433, 3553], '912-928Crossref': [2493, 2947, 3434], '(114)': [2496, 2950, 3437], '30.Prasad': [2499, 2953], 'Hadjidemetriou': [2501, 2955, 3520], 'Maharaj': [2503, 2957, 3522], 'Meimaridou': [2505, 2959, 3524], 'Buonocore': [2507, 2961, 3526], 'Saleem': [2509, 2963, 3528], 'Hurcombe': [2511, 2965, 3530], 'Bierzynska': [2513, 2967, 3532], 'Barbagelata': [2515, 2969, 3534], 'Bergada': [2517, 2971, 3536], 'primary': [2524, 2722, 2754, 2978, 3543, 4225, 4285], 'insufficiency': [2526, 2599, 2663, 2724, 2980, 3053, 3293, 3545, 3907, 4572], 'steroid-resistant': [2528, 2982, 3547], 'nephrotic': [2529, 2572, 2681, 2983, 3026, 3264, 3548], 'syndrome.J.': [2530, 2984, 3549], '942-953Crossref': [2535, 2989, 3554], '(92)': [2538, 2992, 3557], '31.Janecke': [2541, 2995], 'A.R.': [2542, 2996, 4401], 'Steichen-Gersdorf': [2545, 2999], 'Waldegger': [2547, 3001], 'Entenmann': [2549, 3003], 'Giner': [2551, 3005], 'Krainer': [2553, 3007], 'Huber': [2555, 3009], 'L.A.': [2556, 2745, 3010], 'Hess': [2557, 3011], 'M.W.': [2558, 3012], 'Frishberg': [2559, 3013], 'al.Deficiency': [2562, 3016], 'congenital': [2571, 2575, 2639, 2680, 3025, 3029, 3093], 'calcifications.Hum.': [2577, 3031], 'Mutat.': [2578, 2856, 3032], '38:': [2580, 3034], '365-372Crossref': [2581, 3035], '(50)': [2584, 3038], '32.Linhares': [2587, 3041], 'N.D.': [2588, 3042], 'Arantes': [2589, 3043], 'R.R.': [2590, 3044], 'Araujo': [2591, 3045], 'S.A.': [2592, 3046], 'Pena': [2593, 3047], 'S.D.J.': [2594, 3048], 'Nephrotic': [2595, 3049], 'variant': [2603, 3057], 'SGPL1.Clin.': [2605, 3059], 'Kidney': [2606, 3060], '11:': [2609, 3063], '462-467Crossref': [2610, 3064], '(23)': [2613, 3067, 4179], '33.Bamborschke': [2616, 3070], 'Pergande': [2618, 3072], 'Becker': [2620, 3074], 'Koerber': [2622, 3076], 'Dotsch': [2624, 3078], 'Vierzig': [2626, 3080], 'Weber': [2628, 3082], 'L.T.': [2629, 3083], 'Cirak': [2630, 3084], 'mutation': [2634, 3088], 'causing': [2638, 3092], 'malformation.Brain': [2641, 3095], '40:': [2644, 3098], '480-483Abstract': [2645, 3099], '(29)': [2653, 3107], 'refer': [2657], 'condition': [2660], '(SPLIS).': [2665], 'severely': [2668, 3304], 'affected': [2669, 3305], 'suffered': [2670], 'hydrops': [2672], 'fetalis': [2673], 'and/or': [2674, 2685], 'perinatal': [2675, 3299], 'death.': [2676], 'Others': [2677], 'presented': [2678], 'syndrome,': [2682], 'insufficiency,': [2684, 4288], 'neurological': [2686], 'symptoms': [2687], '(developmental': [2688], 'delay': [2689], 'regression,': [2691], 'ataxia,': [2692], 'nerve': [2694, 2708], 'defects,': [2695, 2714, 2790], 'seizures,': [2696], 'neuropathy)': [2699], '4).': [2701], 'Some': [2702], 'exhibited': [2703], 'hypothyroidism,': [2704], 'ichthiosis,': [2705], 'immunodeficiency,': [2706, 4286], 'palsies,': [2709], 'bony': [2710], 'abnormalities,': [2711], 'hypocalcemia,': [2712], 'gonadal': [2713], 'birth': [2717], 'Another': [2719], 'case': [2720], 'reported': [2731], '(34.Settas': [2732], 'Persky': [2734], 'Faucz': [2736], 'F.R.': [2737], 'Sheanon': [2738], 'Voutetakis': [2740], 'Lodish': [2742], 'Metherell': [2744], 'Stratakis': [2746], 'C.A.': [2747], 'deficiency:': [2749], 'Endocrinol.': [2758], 'Metab.': [2759], 'December': [2760], '3,': [2761], '(Epub': [2763], 'ahead': [2764], 'print.)Google': [2766], 'aware': [2771], 'five': [2773], 'additional': [2774], 'unreported': [2775], 'cases': [2776], 'SPLIS': [2778, 2781, 2817, 2865, 3136, 3201, 3257, 3306, 3565, 3641, 3923, 3967, 4248, 4514], '(unpublished': [2779, 3492], 'observations).': [2780, 3493], 'varied': [2784], 'included': [2786], 'nonsense': [2787], 'mutations,': [2788], 'splicing': [2789], 'missense': [2792, 2818], 'mutations.': [2793], 'All': [2794], 'undetectable': [2800], 'abundance': [2802], 'activity.': [2804], 'Mutations': [2805], 'distributed': [2807], 'throughout': [2808], 'polypeptide': [2810], 'sequence.': [2811], 'Cellular': [2812], 'findings': [2813], 'suggested': [2814], 'induce': [2820], 'instability': [2822], 'rapid': [2824], 'misfolding,': [2828], 'common': [2830, 4263, 4544], 'defect': [2831], '(35.Bross': [2837], 'Corydon': [2839], 'T.J.': [2840], 'Andresen': [2841], 'B.S.': [2842], 'Jorgensen': [2843], 'M.M.': [2844], 'Bolund': [2845], 'Gregersen': [2847], 'Protein': [2849], 'misfolding': [2850], 'diseases.Hum.': [2855], '14:': [2858, 4237], '186-198Crossref': [2859], '(192)': [2862], 'patient': [2866, 4516], 'fibroblast': [2869], 'cultures': [2870], 'elevated,': [3114], 'whereas': [3115], 'ceramides': [3116, 3131, 3938], 'variably': [3122], 'affected.': [3123], 'Changes': [3124], 'level': [3127], 'composition': [3129], 'relevant': [3134], 'manifestations,': [3138], 'because': [3139], 'specific': [3140], 'ceramide': [3141, 4113], 'species': [3142], 'contribute': [3143, 3639, 3830, 4306], "integument's": [3146], 'barrier': [3147, 3175], '(36.Behne': [3149], 'Uchida': [3151], 'Seki': [3153], 'Montellano': [3156], 'P.O.': [3157], 'Elias': [3158], 'P.M.': [3159], 'Holleran': [3160], 'W.M.': [3161], 'Omega-hydroxyceramides': [3162], 'required': [3164, 4407], 'corneocyte': [3166], 'envelope': [3168], '(CLE)': [3169], 'epidermal': [3173], 'permeability': [3174, 3852], 'function.J.': [3176], 'Dermatol.': [3178], '114:': [3180], '185-192Abstract': [3181], '(137)': [3189], 'ratio': [3193], 'dihydrosphingosine': [3197], 'plasma,': [3202], 'inhibited': [3209], 'Cholesterol': [3248], 'triglyceride': [3250], 'elevated': [3254], 'some': [3256, 4204], 'patients,': [3258], 'related': [3262], 'direct': [3268], 'impact': [3269, 3904], 'Phenotypes': [3277], 'observed': [3278], 'invertebrate': [3282], 'models': [3285], 'had': [3286, 3481, 4132], 'signaled': [3287], 'devastating': [3289], 'consequences': [3290, 3917, 3956, 4109], 'fetal': [3297], 'deaths': [3300], 'pleiotropic': [3310], 'disease': [3311, 3913, 3973, 4531], 'features': [3312], 'provided': [3313], 'stark': [3315], 'unequivocal': [3317], 'confirmation': [3318], 'Silencing': [3328, 3456], 'triggers': [3334], 'axonal': [3335], 'degeneration': [3336], 'nephrocytes,': [3383], 'equivalents': [3385], 'podocytes,': [3388, 3803], 'foot': [3391, 3818], 'process': [3392], 'density': [3393], 'impaired': [3395], 'albumin': [3396], 'uptake': [3397], '(29.Lovric': [3398], 'highly': [3442], 'expressed': [3443], 'podocytes': [3447, 3480], 'mesangial': [3449, 3459, 3801], 'little': [3452], 'endothelium.': [3455], 'impairs': [3461], 'migration': [3462, 3810], 'inactivation': [3464], 'small': [3466], 'Rho': [3467], 'GTPase': [3468], 'downstream': [3470], 'S1PR1/3.': [3472], 'Although': [3473, 3560, 4244], 'siRNA': [3477], 'no': [3482, 3573, 4476], 'appreciable': [3483], 'effect,': [3484], 'changes': [3488, 3853], 'suggest': [3490], 'injury': [3491], 'glands': [3498], 'adrenocortical': [3501], 'zonation': [3502], 'steroidogenic': [3507], 'enzymes,': [3508], 'indicating': [3509], 'gland': [3516], '(30.Prasad': [3518], 'immune-mediated': [3562], 'mechanism': [3563], 'would': [3566], 'plausible,': [3568], 'date,': [3570], 'evidence': [3574], 'this.': [3577], 'Adrenal': [3578], 'calcifications': [3579], 'dysfunction': [3582], 'compromise': [3588, 3800], 'hemorrhage,': [3590], "S1P's": [3593, 3928], 'maturation,': [3597], 'permeability,': [3598], 'shear': [3600], '(37.Yanagida': [3602], 'Hla': [3604], 'Vascular': [3606], 'immunobiology': [3608], 'circulatory': [3611], 'gradient.Annu.': [3614], 'Rev.': [3615], '79:': [3618], '67-91Crossref': [3619], '(67)': [3622], 'Whether': [3625], 'homeostasis,': [3630], 'epigenetic': [3632], 'regulation,': [3633], 'proinflammatory': [3636], 'transcriptional': [3637], 'hubs': [3638], 'remains': [3642, 4295], 'determined': [3645], '(38.Lee': [3646], 'Deng': [3648], 'Kujawski': [3650], 'Yang': [3652], 'Liu': [3654], 'Herrmann': [3656], 'Kortylewski': [3658], 'Horne': [3660], 'Somlo': [3662], 'Forman': [3664], 'al.STAT3-induced': [3667], 'crucial': [3671], 'persistent': [3673], 'STAT3': [3674], 'tumors.Nat.': [3677], '16:': [3680], '1421-1428Crossref': [3681], '(310)': [3684], '39.Ihlefeld': [3687], 'Claas': [3689], 'R.F.': [3690], 'Koch': [3691], 'Pfeilschifter': [3693], 'J.M.': [3694], 'Meyer': [3695], 'Zu': [3696], 'Heringdorf': [3697], 'Evidence': [3699], 'link': [3702], 'histone': [3704, 3745], 'deacetylation': [3705], 'Ca2+': [3707], 'homoeostasis': [3708], 'lyase-deficient': [3711], 'fibroblasts..Biochem.': [3712], '447:': [3715], '457-464Crossref': [3716], '40.Hait': [3722], 'N.C.': [3723], 'Allegood': [3724], 'Maceyka': [3726], 'Strub': [3728], 'Harikumar': [3730], 'K.B.': [3731], 'Singh': [3732], 'S.K.': [3733], 'Luo': [3734], 'Marmorstein': [3736], 'Kordula': [3738], 'Milstien': [3740], 'al.Regulation': [3743], 'acetylation': [3746], 'nucleus': [3749], 'sphingosine-1-phosphate.Science.': [3751], '1254-1257Crossref': [3754], '(745)': [3757], '41.Tommasino': [3760], 'Marconi': [3762], 'Ciarlo': [3764], 'Matarrese': [3766], 'Malorni': [3768], 'Autophagic': [3770], 'autophagosome': [3773], 'morphogenesis': [3774], 'require': [3775, 3809], 'participation': [3777], 'sphingolipids.Apoptosis.': [3779], '20:': [3781], '645-657Crossref': [3782], '(28)': [3785], 'Dysregulation': [3788], 'actin': [3790], 'cytoskeletal': [3791], 'organization': [3792], 'aberrant': [3794, 3977, 4499], 'S1PR': [3795, 3978, 3985], 'Rho-GTPases': [3798], 'neurons,': [3805], 'maintenance': [3812], 'morphological': [3814], 'structures,': [3815], 'processes,': [3819], 'dendrites,': [3820], 'axons': [3822], 'proper': [3824], 'cellular': [3832, 4489, 4527], 'pathologies': [3833], 'SPLIS.': [3835, 4510], "EP's": [3839], 'flux,': [3843], 'hexadecenal/BAX': [3844], 'S1P/BAK': [3846], 'cooperative': [3847], 'interactions': [3848, 4334], 'trigger': [3849], 'mitochondrial': [3850, 3885], 'outer-membrane': [3851], 'apoptotic': [3857], '(42.Chipuk': [3859], 'J.E.': [3860], 'McStay': [3861], 'G.P.': [3862], 'Bharti': [3863], 'Kuwana': [3865], 'Clarke': [3867, 4394], 'Siskind': [3869], 'L.J.': [3870], 'Green': [3873], 'cooperates': [3877], 'BAK': [3879], 'BAX': [3881], 'promote': [3883], 'apoptosis.Cell.': [3888], '148:': [3890], '988-1000Abstract': [3891], '(313)': [3899], 'Finally,': [3902], 'aging,': [3909, 4486], 'carcinogenesis,': [3910], 'remain': [3914], 'unknown.': [3915], 'Long-term': [3916], 'might': [3919, 4107, 4191], 'expected': [3921], 'light': [3926], 'transformation': [3932], 'cancer,': [3934], 'diabetes,': [3940], 'obscured': [3952], 'organ': [3958], 'failure.': [3959], 'One': [3960], 'envision': [3962], 'different': [3963], 'strategies': [3964, 4537], 'treating': [3966, 4170], 'patients.': [3968], 'Targeting': [3969], 'S1PRs': [3970], 'correct': [3972], 'manifestations': [3974], 'signaling.': [3979], 'Food': [3981], 'Drug': [3983], 'Administration-approved': [3984], 'antagonist': [3986], '(fingolimod)': [3987], 'available,': [3989], 'others': [3991], '(43.Chew': [3994], 'W.S.': [3995], 'Wang': [3996], 'Herr': [3998], 'To': [4000], 'fingolimod': [4001], 'beyond:': [4003], 'pipeline': [4006], 'drug': [4008], 'candidates': [4009], 'signaling.Pharmacol.': [4013], '113:': [4016], '521-532Crossref': [4017], 'Substrate': [4023], 'reduction': [4024], 'treatment': [4030], '(44.Arenz': [4031], 'Recent': [4033], 'advances': [4034], 'treatments': [4037], 'sphingolipidoses.Future': [4039], '9:': [4043], '1687-1700Crossref': [4044], '(13)': [4047], 'attenuation': [4051], 'SPT': [4059], 'encouraging': [4062], 'regard': [4065], 'inhibitors': [4101], 'mitigate': [4103], 'S1P-dependent': [4104, 4332], 'toxicities,': [4105], 'but': [4106], 'worsen': [4108], 'accumulation.': [4114], 'replacement': [4116, 4124], 'bone-marrow': [4118], 'transplantation,': [4119], 'therapy,': [4121], 'considered.': [4127], 'Delivery': [4128], 'soluble': [4130], 'preclinical': [4137], 'model': [4138, 4483, 4520], '(45.Huwiler': [4142], 'Bourquin': [4144], 'Kotelevets': [4146], 'Pastukhov': [4148], 'O.': [4149], 'Zangemeister-Wittke': [4154], 'prokaryotic': [4157], 'degrades': [4160], 'extracellular': [4161], 'vitro': [4164], 'vivo:': [4167], 'implication': [4168], 'hyperproliferative': [4171], 'disorders.PLoS': [4172], 'One.': [4173], 'e22436Crossref': [4176], 'editing': [4183], 'repair': [4185], 'SGPL1.': [4187], 'Misfolded': [4188], 'revived': [4193], 'chaperones.': [4195], 'Importantly,': [4196], 'PLP': [4197], 'act': [4199], 'chaperone': [4202], 'PLP-dependent': [4205], 'enzymes': [4206, 4367], '(46.Lorenz': [4207], 'E.C.': [4208], 'Lieske': [4209], 'J.C.': [4210], 'Seide': [4211], 'B.M.': [4212], 'Meek': [4213], 'A.M.': [4214], 'Olson': [4215], 'J.B.': [4216], 'Bergstralh': [4217], 'E.J.': [4218], 'Milliner': [4219], 'D.S.': [4220], 'Sustained': [4221], 'pyridoxine': [4222], 'hyperoxaluria': [4226], 'type': [4227], '1': [4228], 'recipients': [4229], 'kidney': [4231], 'alone': [4232], 'transplant.Am.': [4233], 'Transplant.': [4235], '2014;': [4236], '1433-1438Crossref': [4238], '(27)': [4241], 'disease,': [4247], 'serve': [4250], 'harbinger': [4253], 'broader': [4256], 'more': [4262, 4543], 'medical': [4264], 'neurodegenerative': [4275], 'diseases': [4276], '(spinal': [4277], 'muscular': [4278], 'dementia,': [4281], "Alzheimer's": [4283], 'disease),': [4284], 'endocrine': [4291], 'Much': [4293], 'work': [4294], 'elucidate': [4297, 4523], 'how': [4298], 'what': [4301], 'extent': [4302], 'pathophysiology': [4309, 4508], 'sporadic': [4312], 'diseases.': [4313], 'biology': [4323], 'SPLIS,': [4326], 'recent': [4327], 'studies': [4328], 'host-pathogen': [4333], 'modulated': [4337], 'both': [4339], "host's": [4341], 'pathogen-derived': [4345], 'homologs,': [4347], 'expanding': [4349], 'relevance': [4351], 'health': [4356], '(47.Seo': [4357], 'Y.J.': [4358], 'Blake': [4359], 'Alexander': [4361], 'Hahm': [4363], '1-phosphate-metabolizing': [4366], 'control': [4368], 'influenza': [4369], 'virus': [4370], 'propagation': [4371], 'viral': [4373], 'cytopathogenicity.J.': [4374], 'Virol.': [4375], '84:': [4377], '8124-8131Crossref': [4378], '48.Custódio': [4384], 'McLean': [4386], 'Scott': [4388], 'A.E.': [4389], 'Lowther': [4390], 'Kennedy': [4392], 'D.J.': [4395, 4397], 'Campopiano': [4396], 'Sarkar-Tyson': [4398], 'Brown': [4400], 'Characterization': [4402], 'secreted': [4404], 'lyases': [4406], 'virulence': [4409], 'survival': [4412], 'Burkholderia': [4414], 'pseudomallei.Mol.': [4415], 'Microbiol.': [4416], '102:': [4418], '1004-1019Crossref': [4419], '(16)': [4422], 'Fifty': [4425], 'years': [4426], 'ago,': [4427], 'characterized': [4429], 'Since': [4439], 'then,': [4440], 'nearly': [4441], 'cloned': [4449], 'ortholog': [4453], 'Genetic': [4455], 'nature.': [4467], 'humans': [4472], 'should': [4473, 4522], 'come': [4474], 'surprise,': [4477], 'considering': [4478], 'fundamental': [4480], 'organism': [4484], 'reproduction,': [4487], 'homeostasis.': [4490], 'Every': [4491], 'biochemical': [4492, 4525], 'consequence': [4493], 'deficiency—cytotoxic': [4496], 'accumulation,': [4498], 'signaling,': [4501], 'depletion—likely': [4504], 'contributes': [4505], 'Further': [4511], 'analysis': [4512], 'pathologies,': [4515], 'lines,': [4518], 'systems': [4521], 'basis': [4528], 'therapeutic': [4536], 'conditions': [4545], 'role.': [4552]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2910050152', 'counts_by_year': [{'year': 2024, 'cited_by_count': 13}, {'year': 2023, 'cited_by_count': 14}, {'year': 2022, 'cited_by_count': 16}, {'year': 2021, 'cited_by_count': 12}, {'year': 2020, 'cited_by_count': 13}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2025-01-08T17:22:36.191393', 'created_date': '2019-01-25'}