Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2909045342', 'doi': 'https://doi.org/10.1016/j.intimp.2019.01.013', 'title': 'IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis', 'display_name': 'IL-37 attenuates allergic process via STAT6/STAT3 pathways in murine allergic rhinitis', 'publication_year': 2019, 'publication_date': '2019-01-18', 'ids': {'openalex': 'https://openalex.org/W2909045342', 'doi': 'https://doi.org/10.1016/j.intimp.2019.01.013', 'mag': '2909045342', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30665041'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.intimp.2019.01.013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158377717', 'display_name': 'International Immunopharmacology', 'issn_l': '1567-5769', 'issn': ['1567-5769', '1878-1705'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100322864', 'display_name': 'Li Wang', 'orcid': 'https://orcid.org/0000-0001-8599-7249'}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Jue Wang', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101567723', 'display_name': 'Yang Shen', 'orcid': 'https://orcid.org/0000-0001-6607-7818'}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yang Shen', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100331659', 'display_name': 'Cong Li', 'orcid': 'https://orcid.org/0009-0007-3829-7953'}, 'institutions': [{'id': 'https://openalex.org/I4210165203', 'display_name': 'Dazhou Central Hospital', 'ror': 'https://ror.org/05qz7n275', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210165203']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Cong Li', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, Dazhou Central Hospital, Dazhou, Sichuan, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210165203']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100320825', 'display_name': 'Chuan Liu', 'orcid': 'https://orcid.org/0000-0003-0642-3154'}, 'institutions': [{'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}, {'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Chuan Liu', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I87780372', 'https://openalex.org/I4210129459']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100698055', 'display_name': 'Zhihai Wang', 'orcid': 'https://orcid.org/0000-0002-5609-1058'}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Zhi-Hai Wang', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5016375133', 'display_name': 'Yan-Shi Li', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Yan-Shi Li', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5005099065', 'display_name': 'Ke Xia', 'orcid': 'https://orcid.org/0000-0001-9699-9901'}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': False, 'raw_author_name': 'Xia Ke', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5100628940', 'display_name': 'Guo‐Hua Hu', 'orcid': 'https://orcid.org/0000-0002-1001-6386'}, 'institutions': [{'id': 'https://openalex.org/I4210129459', 'display_name': 'First Affiliated Hospital of Chongqing Medical University', 'ror': 'https://ror.org/033vnzz93', 'country_code': 'CN', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210129459']}, {'id': 'https://openalex.org/I87780372', 'display_name': 'Chongqing Medical University', 'ror': 'https://ror.org/017z00e58', 'country_code': 'CN', 'type': 'education', 'lineage': ['https://openalex.org/I87780372']}], 'countries': ['CN'], 'is_corresponding': True, 'raw_author_name': 'Guo-Hua Hu', 'raw_affiliation_strings': ["Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China"], 'affiliations': [{'raw_affiliation_string': "Department of Otorhinolaryngology, The First Affiliated Hospital of Chongqing Medical University, No. 1 Yixueyuan Road, Yuzhong District, Chongqing 400016, People's Republic of China", 'institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': ['https://openalex.org/A5100628940'], 'corresponding_institution_ids': ['https://openalex.org/I4210129459', 'https://openalex.org/I87780372'], 'apc_list': {'value': 3130, 'currency': 'USD', 'value_usd': 3130, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 3.688, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 30, 'citation_normalized_percentile': {'value': 0.999957, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 94, 'max': 95}, 'biblio': {'volume': '69', 'issue': None, 'first_page': '27', 'last_page': '33'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10051', 'display_name': 'Asthma', 'score': 0.9995, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10877', 'display_name': 'Allergic Rhinitis and its Impact on Asthma', 'score': 0.9994, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10837', 'display_name': 'Atopic Dermatitis and Skin Microbiome', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/2708', 'display_name': 'Dermatology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/gata3', 'display_name': 'GATA3', 'score': 0.83544385}, {'id': 'https://openalex.org/keywords/stat6', 'display_name': 'STAT6', 'score': 0.78869957}, {'id': 'https://openalex.org/keywords/allergic-inflammation', 'display_name': 'Allergic inflammation', 'score': 0.62017554}, {'id': 'https://openalex.org/keywords/house-dust-mite-allergens', 'display_name': 'House Dust Mite Allergens', 'score': 0.488907}, {'id': 'https://openalex.org/keywords/interleukin-13', 'display_name': 'Interleukin 13', 'score': 0.47127435}, {'id': 'https://openalex.org/keywords/allergic-response', 'display_name': 'Allergic response', 'score': 0.4342563}], 'concepts': [{'id': 'https://openalex.org/C102037460', 'wikidata': 'https://www.wikidata.org/wiki/Q18025464', 'display_name': 'GATA3', 'level': 4, 'score': 0.83544385}, {'id': 'https://openalex.org/C145430368', 'wikidata': 'https://www.wikidata.org/wiki/Q14914613', 'display_name': 'STAT6', 'level': 4, 'score': 0.78869957}, {'id': 'https://openalex.org/C2779727006', 'wikidata': 'https://www.wikidata.org/wiki/Q426188', 'display_name': 'FOXP3', 'level': 3, 'score': 0.76099527}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.67326427}, {'id': 'https://openalex.org/C2778923194', 'wikidata': 'https://www.wikidata.org/wiki/Q14912019', 'display_name': 'STAT3', 'level': 3, 'score': 0.63977164}, {'id': 'https://openalex.org/C2779675166', 'wikidata': 'https://www.wikidata.org/wiki/Q4732119', 'display_name': 'Allergic inflammation', 'level': 3, 'score': 0.62017554}, {'id': 'https://openalex.org/C2776946954', 'wikidata': 'https://www.wikidata.org/wiki/Q420291', 'display_name': 'Ovalbumin', 'level': 3, 'score': 0.6184312}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.60035014}, {'id': 'https://openalex.org/C191732599', 'wikidata': 'https://www.wikidata.org/wiki/Q14865947', 'display_name': 'Interleukin 4', 'level': 3, 'score': 0.5447094}, {'id': 'https://openalex.org/C74737994', 'wikidata': 'https://www.wikidata.org/wiki/Q18031207', 'display_name': 'RAR-related orphan receptor gamma', 'level': 4, 'score': 0.5399499}, {'id': 'https://openalex.org/C141105273', 'wikidata': 'https://www.wikidata.org/wiki/Q79455', 'display_name': 'Immunoglobulin E', 'level': 3, 'score': 0.5098435}, {'id': 'https://openalex.org/C2778690821', 'wikidata': 'https://www.wikidata.org/wiki/Q212354', 'display_name': 'Cytokine', 'level': 2, 'score': 0.48103076}, {'id': 'https://openalex.org/C32046619', 'wikidata': 'https://www.wikidata.org/wiki/Q14878303', 'display_name': 'Interleukin 13', 'level': 4, 'score': 0.47127435}, {'id': 'https://openalex.org/C74172505', 'wikidata': 'https://www.wikidata.org/wiki/Q194908', 'display_name': 'Interleukin', 'level': 3, 'score': 0.45228076}, {'id': 'https://openalex.org/C2776090121', 'wikidata': 'https://www.wikidata.org/wiki/Q193529', 'display_name': 'T cell', 'level': 3, 'score': 0.45166543}, {'id': 'https://openalex.org/C2776953665', 'wikidata': 'https://www.wikidata.org/wiki/Q4732121', 'display_name': 'Allergic response', 'level': 4, 'score': 0.4342563}, {'id': 'https://openalex.org/C2776914184', 'wikidata': 'https://www.wikidata.org/wiki/Q101991', 'display_name': 'Inflammation', 'level': 2, 'score': 0.39415154}, {'id': 'https://openalex.org/C86339819', 'wikidata': 'https://www.wikidata.org/wiki/Q407384', 'display_name': 'Transcription factor', 'level': 3, 'score': 0.37422037}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.35263708}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.34117767}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.33197066}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.2383244}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.116766244}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D065631', 'descriptor_name': 'Rhinitis, Allergic', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D000485', 'descriptor_name': 'Allergens', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D016207', 'descriptor_name': 'Cytokines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004195', 'descriptor_name': 'Disease Models, Animal', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004804', 'descriptor_name': 'Eosinophils', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007073', 'descriptor_name': 'Immunoglobulin E', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007073', 'descriptor_name': 'Immunoglobulin E', 'qualifier_ui': 'Q000097', 'qualifier_name': 'blood', 'is_major_topic': False}, {'descriptor_ui': 'D007375', 'descriptor_name': 'Interleukin-1', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010047', 'descriptor_name': 'Ovalbumin', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D010047', 'descriptor_name': 'Ovalbumin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D065631', 'descriptor_name': 'Rhinitis, Allergic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D050796', 'descriptor_name': 'STAT3 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050800', 'descriptor_name': 'STAT6 Transcription Factor', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D050800', 'descriptor_name': 'STAT6 Transcription Factor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018417', 'descriptor_name': 'Th1 Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D018418', 'descriptor_name': 'Th2 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1016/j.intimp.2019.01.013', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S158377717', 'display_name': 'International Immunopharmacology', 'issn_l': '1567-5769', 'issn': ['1567-5769', '1878-1705'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30665041', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.81, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81500774'}, {'funder': 'https://openalex.org/F4320321001', 'funder_display_name': 'National Natural Science Foundation of China', 'award_id': '81470676'}], 'datasets': [], 'versions': [], 'referenced_works_count': 37, 'referenced_works': ['https://openalex.org/W1683610473', 'https://openalex.org/W1957571574', 'https://openalex.org/W1964224890', 'https://openalex.org/W1973755752', 'https://openalex.org/W1981799488', 'https://openalex.org/W1990650777', 'https://openalex.org/W1995957006', 'https://openalex.org/W2052121459', 'https://openalex.org/W2055243308', 'https://openalex.org/W2063058007', 'https://openalex.org/W2072104606', 'https://openalex.org/W2077297620', 'https://openalex.org/W2093194698', 'https://openalex.org/W2101035994', 'https://openalex.org/W2110317317', 'https://openalex.org/W2117611528', 'https://openalex.org/W2120948675', 'https://openalex.org/W2130614990', 'https://openalex.org/W2131371764', 'https://openalex.org/W2134836702', 'https://openalex.org/W2140507240', 'https://openalex.org/W2144421609', 'https://openalex.org/W2144712546', 'https://openalex.org/W2145544715', 'https://openalex.org/W2150195134', 'https://openalex.org/W2155703113', 'https://openalex.org/W2158300165', 'https://openalex.org/W2160681513', 'https://openalex.org/W2175077154', 'https://openalex.org/W2765968104', 'https://openalex.org/W2777140416', 'https://openalex.org/W2783693314', 'https://openalex.org/W2800980962', 'https://openalex.org/W2916610774', 'https://openalex.org/W3192241548', 'https://openalex.org/W4229553561', 'https://openalex.org/W4251519441'], 'related_works': ['https://openalex.org/W4313453554', 'https://openalex.org/W342072828', 'https://openalex.org/W3104050778', 'https://openalex.org/W3031659971', 'https://openalex.org/W2969240960', 'https://openalex.org/W2909045342', 'https://openalex.org/W2765986776', 'https://openalex.org/W2471680413', 'https://openalex.org/W2160330666', 'https://openalex.org/W2108651164'], 'abstract_inverted_index': {'Allergic': [0], 'rhinitis': [1], '(AR)': [2], 'is': [3, 26, 34, 55], 'a': [4, 14], 'common': [5], 'upper': [6], 'airway': [7], 'allergic': [8, 106, 199], 'disease': [9], 'caused': [10], 'by': [11, 37], 'allergens': [12], 'triggering': [13], 'type': [15], '2': [16, 44], 'immune': [17, 59], 'response.': [18], 'The': [19, 141], 'imbalance': [20], 'of': [21, 31, 40, 61, 66, 84, 134, 145], 'CD4+': [22, 126], 'T': [23, 41, 127], 'cell': [24, 128], 'subsets': [25], 'the': [27, 38, 50, 58, 64, 81, 91, 105, 130, 188], 'essential': [28], 'immunological': [29], 'feature': [30], 'AR,': [32], 'which': [33], 'mainly': [35], 'characterized': [36], 'predominance': [39], 'helper': [42], '(Th)': [43], 'cells.': [45], 'Recent': [46], 'studies': [47], 'indicated': [48], 'that': [49], 'anti-inflammatory': [51], 'factor': [52], 'interleukin': [53], '(IL)-37': [54], 'involved': [56], 'in': [57, 86, 176, 201], 'regulation': [60], 'AR.': [62], 'However,': [63, 164], 'mechanism': [65], 'IL-37': [67, 85, 103, 165, 184, 197], 'acts': [68], 'on': [69, 170], 'AR': [70, 87, 97, 202], 'has': [71], 'not': [72], 'been': [73], 'fully': [74], 'elucidated.': [75], 'Thus,': [76], 'we': [77], 'sought': [78], 'to': [79], 'assess': [80], 'protective': [82], 'role': [83], 'and': [88, 109, 117, 132, 136, 149, 153, 157, 172, 180, 192, 207], 'further': [89], 'explore': [90], 'possible': [92], 'mechanism.': [93], 'An': [94], 'ovalbumin': [95], '(OVA)-induced': [96], 'murine': [98], 'model': [99], 'was': [100, 185], 'established.': [101], 'After': [102], 'treatment,': [104], 'symptoms': [107], '(sneezes': [108], 'nasal': [110, 112], 'rubbings),': [111], 'mucosal': [113], 'infiltration': [114], 'with': [115], 'eosinophils,': [116], 'serum': [118], 'IgE': [119], 'production': [120], 'were': [121, 139, 161], 'found': [122, 186], 'significantly': [123], 'attenuated.': [124], 'For': [125], 'subsets,': [129], 'proliferation': [131], 'differentiation': [133], 'Th2': [135], 'Th17': [137], 'cells': [138], 'restrained.': [140], 'relevant': [142], 'effector': [143], 'cytokines': [144], 'IL-4,': [146], 'IL-5,': [147], 'IL-6,': [148], 'IL-17a': [150], 'protein': [151], 'expression': [152], 'transcription': [154], 'factors': [155], 'GATA3': [156], 'RORγt': [158], 'mRNA': [159], 'levels': [160], 'obviously': [162], 'decreased.': [163], 'had': [166], 'no': [167], 'significant': [168], 'effect': [169], 'Th1': [171], 'Treg': [173], 'response': [174], 'including': [175], 'IFN-γ,': [177], 'IL-10,': [178], 'T-bet,': [179], 'Foxp3': [181], 'expression.': [182, 194], 'Furthermore,': [183], 'down-regulated': [187], 'STAT6,': [189], 'STAT3,': [190], 'phospho-STAT6,': [191], 'phospho-STAT3': [193], 'In': [195], 'conclusion,': [196], 'alleviates': [198], 'inflammation': [200], 'possibly': [203], 'through': [204], 'repressing': [205], 'STAT6': [206], 'STAT3': [208], 'signaling': [209], 'pathways.': [210]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2909045342', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 5}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 10}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-09-18T22:15:48.261228', 'created_date': '2019-01-25'}