Publication Information

{'id': 'https://openalex.org/W2908747386', 'doi': 'https://doi.org/10.1021/acs.jmedchem.8b01572', 'title': 'Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)', 'display_name': 'Discovery of ERD-308 as a Highly Potent Proteolysis Targeting Chimera (PROTAC) Degrader of Estrogen Receptor (ER)', 'publication_year': 2019, 'publication_date': '2019-01-18', 'ids': {'openalex': 'https://openalex.org/W2908747386', 'doi': 'https://doi.org/10.1021/acs.jmedchem.8b01572', 'mag': '2908747386', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30990042'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.jmedchem.8b01572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': False, 'oa_status': 'closed', 'oa_url': None, 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5112663797', 'display_name': 'Jiantao Hu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jiantao Hu', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5036250007', 'display_name': 'Biao Hu', 'orcid': 'https://orcid.org/0000-0002-4691-6490'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Biao Hu', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100667400', 'display_name': 'Mingliang Wang', 'orcid': 'https://orcid.org/0000-0002-3934-6100'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mingliang Wang', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5061795905', 'display_name': 'Fuming Xu', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Fuming Xu', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111000407', 'display_name': 'Bukeyan Miao', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Bukeyan Miao', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5012092064', 'display_name': 'Chao‐Yie Yang', 'orcid': 'https://orcid.org/0000-0002-5445-0109'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Chao-Yie Yang', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5100742707', 'display_name': 'Mi Wang', 'orcid': 'https://orcid.org/0000-0002-5908-4072'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Mi Wang', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021508642', 'display_name': 'Zhaomin Liu', 'orcid': 'https://orcid.org/0000-0002-3158-7807'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Zhaomin Liu', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069748055', 'display_name': 'Daniel F. Hayes', 'orcid': 'https://orcid.org/0000-0003-3620-7575'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Daniel F. Hayes', 'raw_affiliation_strings': ['The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center \xa0and\xa0 Departments of Internal Medicine, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5042146609', 'display_name': 'Krishnapriya Chinnaswamy', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Krishnapriya Chinnaswamy', 'raw_affiliation_strings': ['Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5037676246', 'display_name': 'James Delproposto', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'James Delproposto', 'raw_affiliation_strings': ['Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5024364780', 'display_name': 'Jeanne A. Stuckey', 'orcid': 'https://orcid.org/0000-0002-4192-8900'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeanne Stuckey', 'raw_affiliation_strings': ['Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'Life Sciences Institute, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5073754378', 'display_name': 'Shaomeng Wang', 'orcid': 'https://orcid.org/0000-0002-8782-6950'}, 'institutions': [{'id': 'https://openalex.org/I27837315', 'display_name': 'University of Michigan–Ann Arbor', 'ror': 'https://ror.org/00jmfr291', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I27837315']}], 'countries': ['US'], 'is_corresponding': True, 'raw_author_name': 'Shaomeng Wang', 'raw_affiliation_strings': ['The Rogel Cancer Center,\xa0 Departments of Internal Medicine,\xa0 Pharmacology, University of Michigan Medical School \xa0and\xa0 Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States'], 'affiliations': [{'raw_affiliation_string': 'The Rogel Cancer Center,\xa0 Departments of Internal Medicine,\xa0 Pharmacology, University of Michigan Medical School \xa0and\xa0 Department of Medicinal Chemistry, College of Pharmacy, University of Michigan, Ann Arbor, Michigan 48109, United States', 'institution_ids': ['https://openalex.org/I27837315']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 1, 'corresponding_author_ids': ['https://openalex.org/A5073754378'], 'corresponding_institution_ids': ['https://openalex.org/I27837315'], 'apc_list': None, 'apc_paid': None, 'fwci': 12.157, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 221, 'citation_normalized_percentile': {'value': 0.999983, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '62', 'issue': '3', 'first_page': '1420', 'last_page': '1442'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12534', 'display_name': 'Protein Degradation and Inhibitors', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11041', 'display_name': 'Ubiquitin and proteasome pathways', 'score': 0.9986, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10649', 'display_name': 'Multiple Myeloma Research and Treatments', 'score': 0.9978, 'subfield': {'id': 'https://openalex.org/subfields/2720', 'display_name': 'Hematology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/fulvestrant', 'display_name': 'Fulvestrant', 'score': 0.9456506}, {'id': 'https://openalex.org/keywords/proteolysis', 'display_name': 'Proteolysis', 'score': 0.6664251}, {'id': 'https://openalex.org/keywords/chimera', 'display_name': 'Chimera (genetics)', 'score': 0.48360267}, {'id': 'https://openalex.org/keywords/estrogen-receptor-alpha', 'display_name': 'Estrogen receptor alpha', 'score': 0.46232015}], 'concepts': [{'id': 'https://openalex.org/C2780482068', 'wikidata': 'https://www.wikidata.org/wiki/Q5508491', 'display_name': 'Fulvestrant', 'level': 5, 'score': 0.9456506}, {'id': 'https://openalex.org/C84606932', 'wikidata': 'https://www.wikidata.org/wiki/Q416496', 'display_name': 'Estrogen receptor', 'level': 4, 'score': 0.7958052}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.725802}, {'id': 'https://openalex.org/C2781307694', 'wikidata': 'https://www.wikidata.org/wiki/Q33123', 'display_name': 'Proteolysis', 'level': 3, 'score': 0.6664251}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.5605823}, {'id': 'https://openalex.org/C62112901', 'wikidata': 'https://www.wikidata.org/wiki/Q189159', 'display_name': 'Cell growth', 'level': 2, 'score': 0.52873063}, {'id': 'https://openalex.org/C30278631', 'wikidata': 'https://www.wikidata.org/wiki/Q281721', 'display_name': 'Chimera (genetics)', 'level': 3, 'score': 0.48360267}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.4740714}, {'id': 'https://openalex.org/C172313692', 'wikidata': 'https://www.wikidata.org/wiki/Q14902310', 'display_name': 'Estrogen receptor alpha', 'level': 5, 'score': 0.46232015}, {'id': 'https://openalex.org/C81885089', 'wikidata': 'https://www.wikidata.org/wiki/Q189082', 'display_name': 'Cell culture', 'level': 2, 'score': 0.43881807}, {'id': 'https://openalex.org/C2777164284', 'wikidata': 'https://www.wikidata.org/wiki/Q277954', 'display_name': 'Estrogen', 'level': 2, 'score': 0.42434442}, {'id': 'https://openalex.org/C161624437', 'wikidata': 'https://www.wikidata.org/wiki/Q1988322', 'display_name': 'Small molecule', 'level': 2, 'score': 0.42097917}, {'id': 'https://openalex.org/C98274493', 'wikidata': 'https://www.wikidata.org/wiki/Q128406', 'display_name': 'Pharmacology', 'level': 1, 'score': 0.34937274}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.34614557}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.3373344}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.32491678}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.26977795}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.20739463}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.1796327}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.1591408}, {'id': 'https://openalex.org/C181199279', 'wikidata': 'https://www.wikidata.org/wiki/Q8047', 'display_name': 'Enzyme', 'level': 2, 'score': 0.10049513}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.07691583}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.06352422}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': 'Q000494', 'qualifier_name': 'pharmacology', 'is_major_topic': True}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D000970', 'descriptor_name': 'Antineoplastic Agents', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': False}, {'descriptor_ui': 'D049109', 'descriptor_name': 'Cell Proliferation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D004151', 'descriptor_name': 'Dipeptides', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015195', 'descriptor_name': 'Drug Design', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D004354', 'descriptor_name': 'Drug Screening Assays, Antitumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008024', 'descriptor_name': 'Ligands', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015394', 'descriptor_name': 'Molecular Structure', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D059748', 'descriptor_name': 'Proteolysis', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D011759', 'descriptor_name': 'Pyrrolidines', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011960', 'descriptor_name': 'Receptors, Estrogen', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013329', 'descriptor_name': 'Structure-Activity Relationship', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}, {'descriptor_ui': 'D013876', 'descriptor_name': 'Thiophenes', 'qualifier_ui': 'Q000138', 'qualifier_name': 'chemical synthesis', 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D044767', 'descriptor_name': 'Ubiquitin-Protein Ligases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1021/acs.jmedchem.8b01572', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S162030435', 'display_name': 'Journal of Medicinal Chemistry', 'issn_l': '0022-2623', 'issn': ['0022-2623', '1520-4804'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320006', 'host_organization_name': 'American Chemical Society', 'host_organization_lineage': ['https://openalex.org/P4310320006'], 'host_organization_lineage_names': ['American Chemical Society'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30990042', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': None, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'id': 'https://metadata.un.org/sdg/3', 'score': 0.86}], 'grants': [{'funder': 'https://openalex.org/F4320333123', 'funder_display_name': 'Comprehensive Cancer Center, University of Michigan', 'award_id': None}, {'funder': 'https://openalex.org/F4320337351', 'funder_display_name': 'National Cancer Institute', 'award_id': 'P30CA046592'}], 'datasets': [], 'versions': [], 'referenced_works_count': 59, 'referenced_works': ['https://openalex.org/W1488181101', 'https://openalex.org/W1512690422', 'https://openalex.org/W1565539350', 'https://openalex.org/W1792508556', 'https://openalex.org/W1967021280', 'https://openalex.org/W1978825215', 'https://openalex.org/W1989573061', 'https://openalex.org/W1994344724', 'https://openalex.org/W2003632864', 'https://openalex.org/W2025002326', 'https://openalex.org/W2025327786', 'https://openalex.org/W2030676208', 'https://openalex.org/W2043526119', 'https://openalex.org/W2090958270', 'https://openalex.org/W2101738855', 'https://openalex.org/W2109541969', 'https://openalex.org/W2110938744', 'https://openalex.org/W2127811150', 'https://openalex.org/W2128898940', 'https://openalex.org/W2141349182', 'https://openalex.org/W2151683271', 'https://openalex.org/W2156009048', 'https://openalex.org/W2176682109', 'https://openalex.org/W2237051895', 'https://openalex.org/W2288124948', 'https://openalex.org/W2332737325', 'https://openalex.org/W2336140487', 'https://openalex.org/W2400091886', 'https://openalex.org/W2409568753', 'https://openalex.org/W2411335118', 'https://openalex.org/W2468302041', 'https://openalex.org/W2553908226', 'https://openalex.org/W2585495993', 'https://openalex.org/W2589078946', 'https://openalex.org/W2593430295', 'https://openalex.org/W2597078857', 'https://openalex.org/W2604040637', 'https://openalex.org/W2604930678', 'https://openalex.org/W2611953519', 'https://openalex.org/W2622721717', 'https://openalex.org/W2625751604', 'https://openalex.org/W2704517448', 'https://openalex.org/W2735419424', 'https://openalex.org/W2740493003', 'https://openalex.org/W2743800043', 'https://openalex.org/W2751709490', 'https://openalex.org/W2765643657', 'https://openalex.org/W2766246082', 'https://openalex.org/W2767251210', 'https://openalex.org/W2778368398', 'https://openalex.org/W2791182171', 'https://openalex.org/W2791894234', 'https://openalex.org/W2792069216', 'https://openalex.org/W2794623623', 'https://openalex.org/W2805067921', 'https://openalex.org/W2806694687', 'https://openalex.org/W2807500538', 'https://openalex.org/W2808476554', 'https://openalex.org/W2883182240'], 'related_works': ['https://openalex.org/W4388837170', 'https://openalex.org/W4231312015', 'https://openalex.org/W3026181173', 'https://openalex.org/W2971197283', 'https://openalex.org/W2592929918', 'https://openalex.org/W2312249494', 'https://openalex.org/W2163860217', 'https://openalex.org/W2056214045', 'https://openalex.org/W1991229228', 'https://openalex.org/W1982853714'], 'abstract_inverted_index': {'The': [0], 'estrogen': [1, 12], 'receptor': [2], '(ER)': [3], 'is': [4, 120], 'a': [5, 140], 'validated': [6], 'target': [7], 'for': [8, 143], 'the': [9, 20, 35, 46, 112], 'treatment': [10], 'of': [11, 29, 48, 67, 71, 89, 125, 135], 'receptor-positive': [13], '(ER+)': [14], 'breast': [15, 81, 146], 'cancer.': [16, 147], 'Here,': [17], 'we': [18], 'describe': [19], 'design,': [21], 'synthesis,': [22], 'and': [23, 51, 73, 78, 86, 119], 'extensive': [24], 'structure–activity': [25], 'relationship': [26], '(SAR)': [27], 'studies': [28], 'small-molecule': [30], 'ERα': [31], 'degraders': [32], 'based': [33], 'on': [34], 'proteolysis': [36], 'targeting': [37], 'chimeras': [38], '(PROTAC)': [39], 'concept.': [40], 'Our': [41], 'efforts': [42], 'have': [43], 'resulted': [44], 'in': [45, 76, 99, 123, 130], 'discovery': [47], 'highly': [49], 'potent': [50], 'effective': [52, 122], 'PROTAC': [53], 'ER': [54, 90, 108, 116], 'degraders,': [55], 'as': [56, 94, 96], 'exemplified': [57], 'by': [58], 'ERD-308': [59, 61, 104, 136], '(32).': [60], 'achieves': [62], 'DC50': [63], '(concentration': [64], 'causing': [65], '50%': [66], 'protein': [68], 'degradation)': [69], 'values': [70], '0.17': [72], '0.43': [74], 'nM': [75, 98], 'MCF-7': [77, 131], 'T47D': [79], 'ER+': [80, 145], 'cancer': [82], 'cell': [83, 101, 126], 'lines,': [84], 'respectively,': [85], 'induces': [87, 105], '>95%': [88], 'degradation': [91, 109], 'at': [92], 'concentrations': [93], 'low': [95], '5': [97], 'both': [100], 'lines.': [102], 'Significantly,': [103], 'more': [106, 121], 'complete': [107], 'than': [110, 128], 'fulvestrant,': [111], 'only': [113], 'approved': [114], 'selective': [115], 'degrader': [117], '(SERD),': [118], 'inhibition': [124], 'proliferation': [127], 'fulvestrant': [129], 'cells.': [132], 'Further': [133], 'optimization': [134], 'may': [137], 'lead': [138], 'to': [139], 'new': [141], 'therapy': [142], 'advanced': [144]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2908747386', 'counts_by_year': [{'year': 2024, 'cited_by_count': 26}, {'year': 2023, 'cited_by_count': 39}, {'year': 2022, 'cited_by_count': 40}, {'year': 2021, 'cited_by_count': 45}, {'year': 2020, 'cited_by_count': 51}, {'year': 2019, 'cited_by_count': 11}], 'updated_date': '2024-12-19T11:49:45.830492', 'created_date': '2019-01-25'}