Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2907941252', 'doi': 'https://doi.org/10.1096/fj.201802151rr', 'title': 'High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR', 'display_name': 'High levels of HtrA4 detected in preeclamptic circulation may disrupt endothelial cell function by cleaving the main VEGFA receptor KDR', 'publication_year': 2019, 'publication_date': '2019-01-02', 'ids': {'openalex': 'https://openalex.org/W2907941252', 'doi': 'https://doi.org/10.1096/fj.201802151rr', 'mag': '2907941252', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30601675'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.201802151rr', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1096/fj.201802151rr', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1096/fj.201802151rr', 'any_repository_has_fulltext': False}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5100319017', 'display_name': 'Yao Wang', 'orcid': 'https://orcid.org/0000-0002-9631-8309'}, 'institutions': [{'id': 'https://openalex.org/I2802600346', 'display_name': 'Hudson Institute of Medical Research', 'ror': 'https://ror.org/0083mf965', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802600346']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Yao Wang', 'raw_affiliation_strings': ['Department of Molecular and Translational Sciences Monash University Clayton Victoria Australia', 'Implantation and Placental Development Laboratory Centre for Reproductive Health Hudson Institute of Medical Research Clayton Victoria Australia'], 'affiliations': [{'raw_affiliation_string': 'Implantation and Placental Development Laboratory Centre for Reproductive Health Hudson Institute of Medical Research Clayton Victoria Australia', 'institution_ids': ['https://openalex.org/I2802600346']}, {'raw_affiliation_string': 'Department of Molecular and Translational Sciences Monash University Clayton Victoria Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5111832326', 'display_name': 'Mylinh La', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154771', 'display_name': 'CSIRO Manufacturing', 'ror': 'https://ror.org/04sx9wp33', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I1292875679', 'https://openalex.org/I2801453606', 'https://openalex.org/I4210154771', 'https://openalex.org/I4387156119']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Mylinh La', 'raw_affiliation_strings': ['Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia'], 'affiliations': [{'raw_affiliation_string': 'Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia', 'institution_ids': ['https://openalex.org/I4210154771']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5072082482', 'display_name': 'Tam Pham', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I4210154771', 'display_name': 'CSIRO Manufacturing', 'ror': 'https://ror.org/04sx9wp33', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I1292875679', 'https://openalex.org/I2801453606', 'https://openalex.org/I4210154771', 'https://openalex.org/I4387156119']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Tam Pham', 'raw_affiliation_strings': ['Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia'], 'affiliations': [{'raw_affiliation_string': 'Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia', 'institution_ids': ['https://openalex.org/I4210154771']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000347490', 'display_name': 'George O. Lovrecz', 'orcid': 'https://orcid.org/0000-0001-9977-5065'}, 'institutions': [{'id': 'https://openalex.org/I4210154771', 'display_name': 'CSIRO Manufacturing', 'ror': 'https://ror.org/04sx9wp33', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I1292875679', 'https://openalex.org/I2801453606', 'https://openalex.org/I4210154771', 'https://openalex.org/I4387156119']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'George O. Lovrecz', 'raw_affiliation_strings': ['Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia'], 'affiliations': [{'raw_affiliation_string': 'Commonwealth Scientific and Industrial Research Organisation (CSIRO) Manufacturing Clayton South Victoria Australia', 'institution_ids': ['https://openalex.org/I4210154771']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5006391071', 'display_name': 'Guiying Nie', 'orcid': 'https://orcid.org/0000-0001-9641-087X'}, 'institutions': [{'id': 'https://openalex.org/I2802600346', 'display_name': 'Hudson Institute of Medical Research', 'ror': 'https://ror.org/0083mf965', 'country_code': 'AU', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I2802600346']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Guiying Nie', 'raw_affiliation_strings': ['Department of Biochemistry and Molecular Biology Monash University Clayton Victoria Australia', 'Department of Molecular and Translational Sciences Monash University Clayton Victoria Australia', 'Implantation and Placental Development Laboratory Centre for Reproductive Health Hudson Institute of Medical Research Clayton Victoria Australia'], 'affiliations': [{'raw_affiliation_string': 'Implantation and Placental Development Laboratory Centre for Reproductive Health Hudson Institute of Medical Research Clayton Victoria Australia', 'institution_ids': ['https://openalex.org/I2802600346']}, {'raw_affiliation_string': 'Department of Molecular and Translational Sciences Monash University Clayton Victoria Australia', 'institution_ids': ['https://openalex.org/I56590836']}, {'raw_affiliation_string': 'Department of Biochemistry and Molecular Biology Monash University Clayton Victoria Australia', 'institution_ids': ['https://openalex.org/I56590836']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 3, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': None, 'apc_paid': None, 'fwci': 1.764, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 13, 'citation_normalized_percentile': {'value': 0.868362, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 88, 'max': 89}, 'biblio': {'volume': '33', 'issue': '4', 'first_page': '5058', 'last_page': '5066'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10290', 'display_name': 'Pregnancy and preeclampsia studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2729', 'display_name': 'Obstetrics and Gynecology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10290', 'display_name': 'Pregnancy and preeclampsia studies', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2729', 'display_name': 'Obstetrics and Gynecology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11629', 'display_name': 'Birth, Development, and Health', 'score': 0.9975, 'subfield': {'id': 'https://openalex.org/subfields/2735', 'display_name': 'Pediatrics, Perinatology and Child Health'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T12067', 'display_name': 'Renal and Vascular Pathologies', 'score': 0.9789, 'subfield': {'id': 'https://openalex.org/subfields/2740', 'display_name': 'Pulmonary and Respiratory Medicine'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [], 'concepts': [{'id': 'https://openalex.org/C2780394083', 'wikidata': 'https://www.wikidata.org/wiki/Q539568', 'display_name': 'Angiogenesis', 'level': 2, 'score': 0.8067368}, {'id': 'https://openalex.org/C146285616', 'wikidata': 'https://www.wikidata.org/wiki/Q7916455', 'display_name': 'Vascular endothelial growth factor A', 'level': 4, 'score': 0.708707}, {'id': 'https://openalex.org/C14858245', 'wikidata': 'https://www.wikidata.org/wiki/Q18028241', 'display_name': 'Kinase insert domain receptor', 'level': 5, 'score': 0.6543794}, {'id': 'https://openalex.org/C170493617', 'wikidata': 'https://www.wikidata.org/wiki/Q208467', 'display_name': 'Receptor', 'level': 2, 'score': 0.5386763}, {'id': 'https://openalex.org/C123012128', 'wikidata': 'https://www.wikidata.org/wiki/Q5376430', 'display_name': 'Endothelial stem cell', 'level': 3, 'score': 0.53228056}, {'id': 'https://openalex.org/C2777218350', 'wikidata': 'https://www.wikidata.org/wiki/Q61335', 'display_name': 'Preeclampsia', 'level': 3, 'score': 0.52985734}, {'id': 'https://openalex.org/C75217442', 'wikidata': 'https://www.wikidata.org/wiki/Q423650', 'display_name': 'Protein kinase B', 'level': 3, 'score': 0.44012192}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.4288703}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.4000584}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.3574175}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.3519427}, {'id': 'https://openalex.org/C2777025900', 'wikidata': 'https://www.wikidata.org/wiki/Q29725', 'display_name': 'Vascular endothelial growth factor', 'level': 3, 'score': 0.3121361}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.31075954}, {'id': 'https://openalex.org/C62478195', 'wikidata': 'https://www.wikidata.org/wiki/Q828130', 'display_name': 'Signal transduction', 'level': 2, 'score': 0.29577512}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.19772479}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.14746174}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.12194088}, {'id': 'https://openalex.org/C167734588', 'wikidata': 'https://www.wikidata.org/wiki/Q4356503', 'display_name': 'VEGF receptors', 'level': 2, 'score': 0.0799163}, {'id': 'https://openalex.org/C54355233', 'wikidata': 'https://www.wikidata.org/wiki/Q7162', 'display_name': 'Genetics', 'level': 1, 'score': 0.052245438}, {'id': 'https://openalex.org/C2779234561', 'wikidata': 'https://www.wikidata.org/wiki/Q11995', 'display_name': 'Pregnancy', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D061307', 'descriptor_name': 'Human Umbilical Vein Endothelial Cells', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D011225', 'descriptor_name': 'Pre-Eclampsia', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D057057', 'descriptor_name': 'Serine Proteases', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015153', 'descriptor_name': 'Blotting, Western', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057809', 'descriptor_name': 'HEK293 Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D061307', 'descriptor_name': 'Human Umbilical Vein Endothelial Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007150', 'descriptor_name': 'Immunohistochemistry', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D010766', 'descriptor_name': 'Phosphorylation', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011225', 'descriptor_name': 'Pre-Eclampsia', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D011247', 'descriptor_name': 'Pregnancy', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057057', 'descriptor_name': 'Serine Proteases', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D057057', 'descriptor_name': 'Serine Proteases', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000502', 'qualifier_name': 'physiology', 'is_major_topic': False}, {'descriptor_ui': 'D015398', 'descriptor_name': 'Signal Transduction', 'qualifier_ui': 'Q000235', 'qualifier_name': 'genetics', 'is_major_topic': False}, {'descriptor_ui': 'D042461', 'descriptor_name': 'Vascular Endothelial Growth Factor A', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D040301', 'descriptor_name': 'Vascular Endothelial Growth Factor Receptor-2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}], 'locations_count': 2, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.201802151rr', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1096/fj.201802151rr', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30601675', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1096/fj.201802151rr', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1096/fj.201802151rr', 'source': {'id': 'https://openalex.org/S25293849', 'display_name': 'The FASEB Journal', 'issn_l': '0892-6638', 'issn': ['0892-6638', '1530-6860'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.86, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [{'funder': 'https://openalex.org/F4320322127', 'funder_display_name': 'Department of Health, State Government of Victoria', 'award_id': None}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1108365'}, {'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': '1041835'}, {'funder': 'https://openalex.org/F4320338124', 'funder_display_name': 'Strategic International Collaborative Research Program', 'award_id': None}], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W133349113', 'https://openalex.org/W1740666950', 'https://openalex.org/W1974242642', 'https://openalex.org/W1976868429', 'https://openalex.org/W1980421688', 'https://openalex.org/W1983186128', 'https://openalex.org/W1983372555', 'https://openalex.org/W1984621921', 'https://openalex.org/W1985359220', 'https://openalex.org/W1989884721', 'https://openalex.org/W2000292756', 'https://openalex.org/W2001341023', 'https://openalex.org/W2004918005', 'https://openalex.org/W2006522274', 'https://openalex.org/W2009968499', 'https://openalex.org/W2015186671', 'https://openalex.org/W2025509012', 'https://openalex.org/W2033000623', 'https://openalex.org/W2035254690', 'https://openalex.org/W2035484369', 'https://openalex.org/W2040772454', 'https://openalex.org/W2045247659', 'https://openalex.org/W2046516822', 'https://openalex.org/W2051213492', 'https://openalex.org/W2056968785', 'https://openalex.org/W2060264217', 'https://openalex.org/W2061506872', 'https://openalex.org/W2064540213', 'https://openalex.org/W2073371406', 'https://openalex.org/W2076875725', 'https://openalex.org/W2081255404', 'https://openalex.org/W2091580324', 'https://openalex.org/W2093829937', 'https://openalex.org/W2097373408', 'https://openalex.org/W2100780938', 'https://openalex.org/W2108609457', 'https://openalex.org/W2143180984', 'https://openalex.org/W2154156678', 'https://openalex.org/W2156016652', 'https://openalex.org/W2164045626', 'https://openalex.org/W2407392464', 'https://openalex.org/W2509160333', 'https://openalex.org/W2519968788', 'https://openalex.org/W2559768603', 'https://openalex.org/W2883219408', 'https://openalex.org/W4211051919', 'https://openalex.org/W4251118184'], 'related_works': ['https://openalex.org/W2955618051', 'https://openalex.org/W2360943677', 'https://openalex.org/W2161808292', 'https://openalex.org/W2151772280', 'https://openalex.org/W2150108534', 'https://openalex.org/W2139412046', 'https://openalex.org/W2034393061', 'https://openalex.org/W2029619231', 'https://openalex.org/W2011095792', 'https://openalex.org/W1997324775'], 'abstract_inverted_index': {'Systemic': [0], 'endothelial': [1, 63, 173, 217], 'dysfunction': [2, 64], 'is': [3, 11, 27, 32, 122, 188], 'a': [4, 12, 28, 177, 189], 'key': [5], 'characteristic': [6], 'of': [7, 15, 53, 80, 109, 118, 148, 159, 170, 180, 193, 209], 'preeclampsia': [8], '(PE),': [9], 'which': [10, 121], 'serious': [13], 'disorder': [14], 'human': [16], 'pregnancy.': [17], 'We': [18, 46, 91, 101], 'have': [19, 47], 'previously': [20], 'reported': [21], 'that': [22, 31, 50, 94, 104, 131, 156, 186], 'high-temperature': [23], 'requirement': [24], 'factor': [25, 192], '(Htr)A4': [26], 'placenta-specific': [29], 'protease': [30], 'secreted': [33], 'into': [34], 'the': [35, 57, 68, 77, 82, 107, 115, 134, 143, 162, 167, 222], 'maternal': [36, 163], 'circulation': [37, 61, 164, 214], 'and': [38, 113, 140], 'significantly': [39], 'up-regulated': [40], 'in': [41, 56, 65, 99, 111, 138, 146, 161, 172, 212], 'PE,': [42], 'especially': [43], 'early-onset': [44], 'PE.': [45], 'also': [48], 'demonstrated': [49, 93, 130], 'high': [51, 157], 'levels': [52, 158, 208], 'HtrA4': [54, 74, 95, 105, 132, 160, 187, 210], 'detected': [55, 211], 'early': [58, 194], 'onset': [59, 195], 'PE': [60], 'induce': [62, 176], 'HUVECs.': [66], 'In': [67], 'current': [69], 'study,': [70], 'we': [71], 'investigated': [72], 'whether': [73], 'could': [75, 165], 'cleave': [76, 166], 'main': [78, 168, 223], 'receptor': [79, 85, 169, 225], 'VEGFA,': [81], 'kinase': [83], 'domain': [84], '(KDR),': [86], 'thereby': [87], 'inhibiting': [88], 'VEGFA': [89, 171, 224], 'signaling.': [90, 126], 'first': [92], 'cleaved': [96], 'recombinant': [97], 'KDR': [98, 110], 'vitro.': [100], 'then': [102], 'confirmed': [103], 'reduced': [106], 'level': [108], 'HUVECs': [112, 139], 'inhibited': [114, 142], 'VEGFA-induced': [116, 135, 144], 'phosphorylation': [117], 'Akt': [119], 'kinase,': [120], 'essential': [123], 'for': [124], 'downstream': [125], 'Further': [127], 'functional': [128], 'studies': [129, 183], 'prevented': [133], 'tube': [136], 'formation': [137], 'dose-dependently': [141], 'angiogenesis': [145], 'explants': [147], 'mouse': [149], 'aortic': [150], 'rings.': [151], 'These': [152], 'data': [153], 'strongly': [154], 'suggest': [155, 185], 'cells': [174], 'to': [175], 'wide-spread': [178], 'impairment': [179], 'angiogenesis.': [181], 'Our': [182], 'therefore': [184], 'potential': [190], 'causal': [191], 'PE.-Wang,': [196], 'Y.,': [197], 'La,': [198], 'M.,': [199], 'Pham,': [200], 'T.,': [201], 'Lovrecz,': [202], 'G.': [203, 206], 'O.,': [204], 'Nie,': [205], 'High': [207], 'preeclamptic': [213], 'may': [215], 'disrupt': [216], 'cell': [218], 'function': [219], 'by': [220], 'cleaving': [221], 'KDR.': [226]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2907941252', 'counts_by_year': [{'year': 2024, 'cited_by_count': 3}, {'year': 2023, 'cited_by_count': 2}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}, {'year': 2019, 'cited_by_count': 4}], 'updated_date': '2024-12-17T17:04:48.353404', 'created_date': '2019-01-11'}