Title: APOE Gene Polymorphism in Patients with Alzheimer’s Disease in Iran
Abstract:Background: Alzheimer's disease is a multi-factorial disorder. The genes involved in Alzheimer's disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in pat...Background: Alzheimer's disease is a multi-factorial disorder. The genes involved in Alzheimer's disease act as risk factors. The aim of this study was to investigate the APOE gene polymorphism in patients with Alzheimer's disease in Iran.
Materials and Methods: In this analytical-descriptive study, 50 patients with Alzheimer's were investigated. Polymorphism of the APOE gene was investigated in healthy subjects and patients with Alzheimer's using Tetra Arms PCR.
Results: The frequency of the 4e /4e genotype and e4 allele was significantly higher in patients with Alzheimer's compared to healthy subjects (38/4% and57/4% versus 3/8% and 28/8%, respectively) (P≥0.009).
Conclusion: In polymorphism of the APOE gene, the 4e /4e genotype, and the e4 allele, are risk factors for Alzheimer's disease in the Iranian population.
Keywords: Alzheimer's disease, APOE Gene, Iranian populationRead More
Publication Year: 2018
Publication Date: 2018-10-10
Language: en
Type: article
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Cited By Count: 1
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