Synthetic biology for bioengineering virus‐like particle vaccines

Name: Work Video:
Duration: 3 min 30 s
Hayley K. Charlton; João Vidigal; Manuel J.T. Carrondo; Anton P. J. Middelberg; António Roldão; Linda H.L. Lua
{'id': 'https://openalex.org/W2906695249', 'doi': 'https://doi.org/10.1002/bit.26890', 'title': 'Synthetic biology for bioengineering virus‐like particle vaccines', 'display_name': 'Synthetic biology for bioengineering virus‐like particle vaccines', 'publication_year': 2018, 'publication_date': '2018-12-31', 'ids': {'openalex': 'https://openalex.org/W2906695249', 'doi': 'https://doi.org/10.1002/bit.26890', 'mag': '2906695249', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30597533', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/7161758'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/bit.26890', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/bit.26890', 'source': {'id': 'https://openalex.org/S151564723', 'display_name': 'Biotechnology and Bioengineering', 'issn_l': '0006-3592', 'issn': ['0006-3592', '1097-0290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'type': 'review', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'bronze', 'oa_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/bit.26890', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5022558777', 'display_name': 'Hayley K. Charlton', 'orcid': 'https://orcid.org/0000-0002-3015-003X'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Hayley K. Charlton Hume', 'raw_affiliation_strings': ['The University of Queensland, Australian Institute of Bioengineering and Nanotechnology, St Lucia, Queensland, Australia'], 'affiliations': [{'raw_affiliation_string': 'The University of Queensland, Australian Institute of Bioengineering and Nanotechnology, St Lucia, Queensland, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5017399502', 'display_name': 'João Vidigal', 'orcid': 'https://orcid.org/0000-0001-6486-4762'}, 'institutions': [{'id': 'https://openalex.org/I4210159117', 'display_name': 'Instituto de Biologia Experimental e Tecnológica', 'ror': 'https://ror.org/0599z7n30', 'country_code': 'PT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210159117']}, {'id': 'https://openalex.org/I83558840', 'display_name': 'Universidade Nova de Lisboa', 'ror': 'https://ror.org/02xankh89', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I83558840']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'João Vidigal', 'raw_affiliation_strings': ['Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal', 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República Oeiras Portugal'], 'affiliations': [{'raw_affiliation_string': 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal', 'institution_ids': ['https://openalex.org/I4210159117']}, {'raw_affiliation_string': 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República Oeiras Portugal', 'institution_ids': ['https://openalex.org/I83558840']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5021060711', 'display_name': 'Manuel J.T. Carrondo', 'orcid': 'https://orcid.org/0000-0002-4550-4574'}, 'institutions': [{'id': 'https://openalex.org/I4210159117', 'display_name': 'Instituto de Biologia Experimental e Tecnológica', 'ror': 'https://ror.org/0599z7n30', 'country_code': 'PT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210159117']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'Manuel J. T. Carrondo', 'raw_affiliation_strings': ['Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal'], 'affiliations': [{'raw_affiliation_string': 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal', 'institution_ids': ['https://openalex.org/I4210159117']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5048165624', 'display_name': 'Anton P. J. Middelberg', 'orcid': 'https://orcid.org/0000-0001-5922-5704'}, 'institutions': [{'id': 'https://openalex.org/I5681781', 'display_name': 'University of Adelaide', 'ror': 'https://ror.org/00892tw58', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I5681781']}], 'countries': ['AU'], 'is_corresponding': False, 'raw_author_name': 'Anton P. J. Middelberg', 'raw_affiliation_strings': ['Faculty of Engineering, Computer and Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia'], 'affiliations': [{'raw_affiliation_string': 'Faculty of Engineering, Computer and Mathematical Sciences, The University of Adelaide, Adelaide, South Australia, Australia', 'institution_ids': ['https://openalex.org/I5681781']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5066601894', 'display_name': 'António Roldão', 'orcid': 'https://orcid.org/0000-0003-0414-4899'}, 'institutions': [{'id': 'https://openalex.org/I4210159117', 'display_name': 'Instituto de Biologia Experimental e Tecnológica', 'ror': 'https://ror.org/0599z7n30', 'country_code': 'PT', 'type': 'nonprofit', 'lineage': ['https://openalex.org/I4210159117']}, {'id': 'https://openalex.org/I83558840', 'display_name': 'Universidade Nova de Lisboa', 'ror': 'https://ror.org/02xankh89', 'country_code': 'PT', 'type': 'education', 'lineage': ['https://openalex.org/I83558840']}], 'countries': ['PT'], 'is_corresponding': False, 'raw_author_name': 'António Roldão', 'raw_affiliation_strings': ['Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal', 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República Oeiras Portugal'], 'affiliations': [{'raw_affiliation_string': 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Biologia Experimental e Tecnológica (iBET) Oeiras Portugal', 'institution_ids': ['https://openalex.org/I4210159117']}, {'raw_affiliation_string': 'Health &amp; Pharma Division, Animal Cell Technology Unit, Instituto de Tecnologia Química e Biológica António Xavier, Universidade Nova de Lisboa, Av. da República Oeiras Portugal', 'institution_ids': ['https://openalex.org/I83558840']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5012782295', 'display_name': 'Linda H.L. Lua', 'orcid': 'https://orcid.org/0000-0002-9756-7083'}, 'institutions': [{'id': 'https://openalex.org/I165143802', 'display_name': 'University of Queensland', 'ror': 'https://ror.org/00rqy9422', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165143802']}], 'countries': ['AU'], 'is_corresponding': True, 'raw_author_name': 'Linda H. L. Lua', 'raw_affiliation_strings': ['The University of Queensland, St Lucia, Queensland, Australia'], 'affiliations': [{'raw_affiliation_string': 'The University of Queensland, St Lucia, Queensland, Australia', 'institution_ids': ['https://openalex.org/I165143802']}]}], 'institution_assertions': [], 'countries_distinct_count': 2, 'institutions_distinct_count': 4, 'corresponding_author_ids': ['https://openalex.org/A5012782295'], 'corresponding_institution_ids': ['https://openalex.org/I165143802'], 'apc_list': {'value': 4840, 'currency': 'USD', 'value_usd': 4840, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 1.221, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 76, 'citation_normalized_percentile': {'value': 0.999733, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 97, 'max': 98}, 'biblio': {'volume': '116', 'issue': '4', 'first_page': '919', 'last_page': '935'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T12576', 'display_name': 'vaccines and immunoinformatics approaches', 'score': 0.9998, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T12856', 'display_name': 'Transgenic Plants and Applications', 'score': 0.993, 'subfield': {'id': 'https://openalex.org/subfields/1305', 'display_name': 'Biotechnology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T11016', 'display_name': 'Monoclonal and Polyclonal Antibodies Research', 'score': 0.9923, 'subfield': {'id': 'https://openalex.org/subfields/2741', 'display_name': 'Radiology, Nuclear Medicine and Imaging'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/synthetic-biology', 'display_name': 'Synthetic Biology', 'score': 0.54595834}], 'concepts': [{'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.54895663}, {'id': 'https://openalex.org/C191908910', 'wikidata': 'https://www.wikidata.org/wiki/Q862838', 'display_name': 'Synthetic biology', 'level': 2, 'score': 0.54595834}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.5364237}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.48352122}, {'id': 'https://openalex.org/C2522874641', 'wikidata': 'https://www.wikidata.org/wiki/Q808', 'display_name': 'Virus', 'level': 2, 'score': 0.4293754}], 'mesh': [{'descriptor_ui': 'D057005', 'descriptor_name': 'Bioengineering', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019295', 'descriptor_name': 'Computational Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008958', 'descriptor_name': 'Models, Molecular', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D058615', 'descriptor_name': 'Synthetic Biology', 'qualifier_ui': 'Q000379', 'qualifier_name': 'methods', 'is_major_topic': False}, {'descriptor_ui': 'D058425', 'descriptor_name': 'Vaccines, Virus-Like Particle', 'qualifier_ui': 'Q000737', 'qualifier_name': 'chemistry', 'is_major_topic': False}], 'locations_count': 4, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/bit.26890', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/bit.26890', 'source': {'id': 'https://openalex.org/S151564723', 'display_name': 'Biotechnology and Bioengineering', 'issn_l': '0006-3592', 'issn': ['0006-3592', '1097-0290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc7161758', 'pdf_url': 'https://europepmc.org/articles/pmc7161758?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'other-oa', 'license_id': 'https://openalex.org/licenses/other-oa', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7161758', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30597533', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1002/bit.26890', 'pdf_url': 'https://rss.onlinelibrary.wiley.com/doi/am-pdf/10.1002/bit.26890', 'source': {'id': 'https://openalex.org/S151564723', 'display_name': 'Biotechnology and Bioengineering', 'issn_l': '0006-3592', 'issn': ['0006-3592', '1097-0290'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320595', 'host_organization_name': 'Wiley', 'host_organization_lineage': ['https://openalex.org/P4310320595'], 'host_organization_lineage_names': ['Wiley'], 'type': 'journal'}, 'license': 'publisher-specific-oa', 'license_id': 'https://openalex.org/licenses/publisher-specific-oa', 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320300', 'funder_display_name': 'European Commission', 'award_id': '602640'}, {'funder': 'https://openalex.org/F4320334704', 'funder_display_name': 'Australian Research Council', 'award_id': 'DP160102915'}], 'datasets': [], 'versions': [], 'referenced_works_count': 194, 'referenced_works': ['https://openalex.org/W1522276317', 'https://openalex.org/W1524190110', 'https://openalex.org/W1577655218', 'https://openalex.org/W1605628016', 'https://openalex.org/W1627986553', 'https://openalex.org/W1659622831', 'https://openalex.org/W1822718834', 'https://openalex.org/W1824426708', 'https://openalex.org/W1828689731', 'https://openalex.org/W1902557223', 'https://openalex.org/W1913839522', 'https://openalex.org/W1928945856', 'https://openalex.org/W1933315991', 'https://openalex.org/W1943974440', 'https://openalex.org/W1944238595', 'https://openalex.org/W1963406113', 'https://openalex.org/W1964708816', 'https://openalex.org/W1965438714', 'https://openalex.org/W1965817460', 'https://openalex.org/W1967006002', 'https://openalex.org/W1967231211', 'https://openalex.org/W1967781933', 'https://openalex.org/W1968455781', 'https://openalex.org/W1969484410', 'https://openalex.org/W1975983467', 'https://openalex.org/W1977472956', 'https://openalex.org/W1977574119', 'https://openalex.org/W1978826596', 'https://openalex.org/W1978978157', 'https://openalex.org/W1980752041', 'https://openalex.org/W1982045798', 'https://openalex.org/W1984942971', 'https://openalex.org/W1986029358', 'https://openalex.org/W1987130080', 'https://openalex.org/W1987218429', 'https://openalex.org/W1989544708', 'https://openalex.org/W1989820287', 'https://openalex.org/W1992837689', 'https://openalex.org/W1993791910', 'https://openalex.org/W1994712533', 'https://openalex.org/W1996472983', 'https://openalex.org/W1997259921', 'https://openalex.org/W1997341424', 'https://openalex.org/W1998683102', 'https://openalex.org/W2003382316', 'https://openalex.org/W2004541209', 'https://openalex.org/W2007622060', 'https://openalex.org/W2007739356', 'https://openalex.org/W2008226030', 'https://openalex.org/W2008241299', 'https://openalex.org/W2008446799', 'https://openalex.org/W2010595807', 'https://openalex.org/W2014391882', 'https://openalex.org/W2017003739', 'https://openalex.org/W2017321063', 'https://openalex.org/W2018382627', 'https://openalex.org/W2018557719', 'https://openalex.org/W2022263688', 'https://openalex.org/W2025658157', 'https://openalex.org/W2026130776', 'https://openalex.org/W2029926070', 'https://openalex.org/W2030543393', 'https://openalex.org/W2032128657', 'https://openalex.org/W2035014358', 'https://openalex.org/W2039025915', 'https://openalex.org/W2039702671', 'https://openalex.org/W2041647202', 'https://openalex.org/W2042588700', 'https://openalex.org/W2042940716', 'https://openalex.org/W2046182783', 'https://openalex.org/W2049816729', 'https://openalex.org/W2050676026', 'https://openalex.org/W2053363572', 'https://openalex.org/W2053707749', 'https://openalex.org/W2054243692', 'https://openalex.org/W2056913645', 'https://openalex.org/W2057218172', 'https://openalex.org/W2057257531', 'https://openalex.org/W2059316367', 'https://openalex.org/W2060807469', 'https://openalex.org/W2063996876', 'https://openalex.org/W2064129235', 'https://openalex.org/W2064572737', 'https://openalex.org/W2065076563', 'https://openalex.org/W2065306943', 'https://openalex.org/W2066344573', 'https://openalex.org/W2066950276', 'https://openalex.org/W2067258361', 'https://openalex.org/W2068945309', 'https://openalex.org/W2070765070', 'https://openalex.org/W2073262651', 'https://openalex.org/W2074673579', 'https://openalex.org/W2075515367', 'https://openalex.org/W2076909664', 'https://openalex.org/W2078905626', 'https://openalex.org/W2078964476', 'https://openalex.org/W2079170562', 'https://openalex.org/W2083994938', 'https://openalex.org/W2085687119', 'https://openalex.org/W2086984669', 'https://openalex.org/W2089190345', 'https://openalex.org/W2089331061', 'https://openalex.org/W2089676160', 'https://openalex.org/W2091610604', 'https://openalex.org/W2092706417', 'https://openalex.org/W2095042599', 'https://openalex.org/W2096569427', 'https://openalex.org/W2099241512', 'https://openalex.org/W2099438254', 'https://openalex.org/W2101406373', 'https://openalex.org/W2105176211', 'https://openalex.org/W2107720194', 'https://openalex.org/W2108648420', 'https://openalex.org/W2114838733', 'https://openalex.org/W2115405950', 'https://openalex.org/W2115467628', 'https://openalex.org/W2116063606', 'https://openalex.org/W2117443644', 'https://openalex.org/W2119947460', 'https://openalex.org/W2120098575', 'https://openalex.org/W2120321866', 'https://openalex.org/W2120350078', 'https://openalex.org/W2124808556', 'https://openalex.org/W2126451036', 'https://openalex.org/W2129761180', 'https://openalex.org/W2130635082', 'https://openalex.org/W2135332827', 'https://openalex.org/W2135474317', 'https://openalex.org/W2137092277', 'https://openalex.org/W2138149764', 'https://openalex.org/W2140700622', 'https://openalex.org/W2141211628', 'https://openalex.org/W2146700406', 'https://openalex.org/W2148514348', 'https://openalex.org/W2149458203', 'https://openalex.org/W2149913957', 'https://openalex.org/W2151583667', 'https://openalex.org/W2154516306', 'https://openalex.org/W2160237938', 'https://openalex.org/W2163102374', 'https://openalex.org/W2163413324', 'https://openalex.org/W2165081595', 'https://openalex.org/W2168513578', 'https://openalex.org/W2168779710', 'https://openalex.org/W2171226614', 'https://openalex.org/W2171732889', 'https://openalex.org/W2171740232', 'https://openalex.org/W2175888490', 'https://openalex.org/W2180512905', 'https://openalex.org/W2265567604', 'https://openalex.org/W2270666604', 'https://openalex.org/W2323929490', 'https://openalex.org/W2337081411', 'https://openalex.org/W2339357145', 'https://openalex.org/W2340524139', 'https://openalex.org/W2361469323', 'https://openalex.org/W2400052146', 'https://openalex.org/W2401318063', 'https://openalex.org/W2404761593', 'https://openalex.org/W2414983771', 'https://openalex.org/W2440721038', 'https://openalex.org/W2460435976', 'https://openalex.org/W2473763698', 'https://openalex.org/W2481265022', 'https://openalex.org/W2496393183', 'https://openalex.org/W2504026434', 'https://openalex.org/W2521490702', 'https://openalex.org/W2549793658', 'https://openalex.org/W2555070631', 'https://openalex.org/W2560177593', 'https://openalex.org/W2577943323', 'https://openalex.org/W2586227482', 'https://openalex.org/W2588086300', 'https://openalex.org/W2593922109', 'https://openalex.org/W2594286126', 'https://openalex.org/W2594354292', 'https://openalex.org/W2597802884', 'https://openalex.org/W2603780899', 'https://openalex.org/W2604574031', 'https://openalex.org/W2605491919', 'https://openalex.org/W2606397497', 'https://openalex.org/W2607397084', 'https://openalex.org/W2615188291', 'https://openalex.org/W2638715417', 'https://openalex.org/W2652705574', 'https://openalex.org/W2724618708', 'https://openalex.org/W2747141897', 'https://openalex.org/W2763475437', 'https://openalex.org/W2776707578', 'https://openalex.org/W2906695249', 'https://openalex.org/W29871937', 'https://openalex.org/W344638284', 'https://openalex.org/W4301709901', 'https://openalex.org/W940409508'], 'related_works': ['https://openalex.org/W4391375266', 'https://openalex.org/W4386371748', 'https://openalex.org/W2188759708', 'https://openalex.org/W2147145791', 'https://openalex.org/W2130076355', 'https://openalex.org/W2119695867', 'https://openalex.org/W2097433578', 'https://openalex.org/W2082860237', 'https://openalex.org/W1993764875', 'https://openalex.org/W1990804418'], 'abstract_inverted_index': {'Abstract': [0], 'Vaccination': [1], 'is': [2, 177], 'the': [3, 64, 129, 158, 163, 192, 248, 255], 'most': [4], 'effective': [5], 'method': [6], 'of': [7, 83, 108, 125, 160, 167, 194, 204, 209, 250], 'disease': [8, 147], 'prevention': [9], 'and': [10, 14, 25, 48, 61, 101, 146, 165, 184, 188, 198, 216, 244], 'control.': [11], 'Many': [12], 'viruses': [13, 85], 'bacteria': [15], 'that': [16, 79, 91, 112], 'once': [17], 'caused': [18], 'catastrophic': [19], 'pandemics': [20], '(e.g.,': [21, 207], 'smallpox,': [22], 'poliomyelitis,': [23], 'measles,': [24], 'diphtheria)': [26], 'are': [27, 74, 87, 154, 220], 'either': [28], 'eradicated': [29], 'or': [30], 'effectively': [31], 'controlled': [32], 'through': [33, 149], 'routine': [34], 'vaccination': [35], 'programs.': [36], 'Nonetheless,': [37], 'vaccine': [38, 58, 144, 218, 237, 252], 'manufacturing': [39, 65, 185, 225], 'remains': [40], 'incredibly': [41], 'challenging.': [42], 'Viruses': [43], 'exhibiting': [44], 'high': [45, 49], 'antigenic': [46], 'diversity': [47], 'mutation': [50], 'rates': [51], 'cannot': [52], 'be': [53, 115], 'fairly': [54], 'contested': [55], 'using': [56], 'traditional': [57], 'production': [59], 'methods': [60], 'complexities': [62], 'surrounding': [63], 'processes,': [66, 226], 'which': [67], 'impose': [68], 'significant': [69], 'limitations.': [70], 'Virus‐like': [71], 'particles': [72], '(VLPs)': [73], 'recombinantly': [75], 'produced': [76], 'viral': [77], 'structures': [78], 'exhibit': [80], 'immunoprotective': [81], 'traits': [82], 'native': [84], 'but': [86], 'noninfectious.': [88], 'Several': [89], 'VLPs': [90, 113, 138], 'compositionally': [92], 'match': [93], 'a': [94, 106, 123], 'given': [95], 'natural': [96], 'virus': [97], 'have': [98], 'been': [99], 'developed': [100], 'licensed': [102], 'as': [103], 'vaccines.': [104], 'Expansively,': [105], 'plethora': [107], 'studies': [109], 'now': [110], 'confirms': [111], 'can': [114, 230], 'designed': [116], 'to': [117, 128, 134, 142, 180, 224], 'safely': [118], 'present': [119], 'heterologous': [120], 'antigens': [121, 197], 'from': [122], 'variety': [124], 'pathogens': [126], 'unrelated': [127], 'chosen': [130], 'carrier': [131], 'VLPs.': [132], 'Owing': [133], 'this': [135], 'design': [136], 'versatility,': [137], 'offer': [139], 'technological': [140], 'opportunities': [141, 153], 'modernize': [143], 'supply': [145], 'response': [148], 'rational': [150, 202], 'bioengineering.': [151], 'These': [152], 'greatly': [155], 'enhanced': [156, 213], 'with': [157, 247], 'application': [159], 'synthetic': [161, 175, 227], 'biology,': [162], 'redesign': [164], 'construction': [166], 'novel': [168, 195], 'biological': [169], 'entities.': [170], 'This': [171], 'review': [172], 'outlines': [173], 'how': [174], 'biology': [176, 228], 'currently': [178], 'applied': [179, 223], 'engineer': [181], 'VLP': [182, 205, 236, 251], 'functions': [183, 206], 'process.': [186], 'Current': [187], 'developing': [189], 'technologies': [190], 'for': [191, 201], 'identification': [193], 'target‐specific': [196], 'their': [199], 'usefulness': [200], 'engineering': [203], 'presentation': [208], 'structurally': [210], 'diverse': [211], 'antigens,': [212], 'antigen': [214], 'immunogenicity,': [215], 'improved': [217], 'stability)': [219], 'described.': [221], 'When': [222], 'approaches': [229], 'also': [231], 'overcome': [232], 'specific': [233], 'challenges': [234, 243], 'in': [235], 'production.': [238], 'Finally,': [239], 'we': [240], 'address': [241], 'several': [242], 'benefits': [245], 'associated': [246], 'translation': [249], 'development': [253], 'into': [254], 'industry.': [256]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2906695249', 'counts_by_year': [{'year': 2024, 'cited_by_count': 9}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 14}, {'year': 2021, 'cited_by_count': 20}, {'year': 2020, 'cited_by_count': 18}, {'year': 2019, 'cited_by_count': 3}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2025-01-08T10:23:21.875071', 'created_date': '2019-01-11'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
