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'(L38↑N↑L)': [37], 'hinge': [40], 'region': [41, 207], 'at': [44, 210], 'position': [45], '38.': [46], 'This': [47], 'was': [48, 66, 94, 105, 170], 'isolated': [49], 'from': [50, 98], 'inhibitor': [53], 'naïve': [54], 'infant.': [55], 'Isothermal': [56], 'titration': [57], 'calorimetry': [58], 'showed': [59, 120, 150], '10%': [61], 'less': [62], 'L38↑N↑L': [64, 77, 92, 122, 149], 'active': [69], 'conformation': [70], 'as': [71], 'compared': [72], 'with': [73, 174], 'reference': [75], 'strain.': [76], 'displayed': [79], '±50%': [81], 'reduction': [82, 108, 164], 'KM': [84], 'kcat': [86], 'The': [87, 178, 197], 'catalytic': [88], 'efficiency': [89], '(kcat/KM)': [90], 'not': [95], 'significantly': [96], 'different': [97], 'wild': [101], 'type': [102], 'although': [103], 'there': [104], '42%': [107], 'specific': [110], 'activity': [111], 'variant.': [114], 'An': [115], 'vitro': [117], 'phenotypic': [118], 'assay': [119], 'be': [125, 188], 'susceptible': [126, 157], 'lopinavir': [128], '(LPV),': [129], 'atazanavir': [130], '(ATV)': [131], 'darunavir': [133, 154, 182], 'context': [136], 'unrelated': [139], 'Gag.': [140, 177, 196], 'However,': [141], 'presence': [144], 'related': [147, 176, 195], 'Gag,': [148], 'reduced': [151, 179], 'susceptibility': [152, 180, 212], 'while': [155], 'remaining': [156], 'LPV': [159], 'ATV.': [161], 'Furthermore,': [162], 'viral': [166], 'replication': [167], 'capacity': [168], '(RC)': [169], 'observed': [171], 'combination': [173], 'decrease': [184], 'RC': [186], 'may': [187], 'due': [189], 'PTAPP': [191], 'duplication': [192], 'present': [198], 'study': [199], 'shows': [200], 'importance': [202], 'considering': [204], 'when': [208], 'looking': [209], 'drug': [211], 'variants.': [216]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2906622443', 'counts_by_year': [{'year': 2023, 'cited_by_count': 1}, {'year': 2021, 'cited_by_count': 3}, {'year': 2020, 'cited_by_count': 1}], 'updated_date': '2024-09-13T14:11:17.267775', 'created_date': '2019-01-01'}