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['https://openalex.org/W4362732314', 'https://openalex.org/W4220762825', 'https://openalex.org/W3002252804', 'https://openalex.org/W2970769690', 'https://openalex.org/W2951336120', 'https://openalex.org/W2761319966', 'https://openalex.org/W2118269576', 'https://openalex.org/W2089539955', 'https://openalex.org/W2013987088', 'https://openalex.org/W2009268228'], 'abstract_inverted_index': {'<b>Background:</b>': [0], 'In': [1, 71], 'RESTORE': [2], 'study': [3, 226], '(528': [4], 'pts,': [5], 'GOLD': [6, 78, 116, 133], 'II-III)': [7], 'erdosteine': [8, 37, 150, 180, 246], '300': [9], 'mg': [10], 'bid': [11], 'added': [12], 'to': [13, 43, 112, 184, 209, 215], 'usual': [14], 'COPD': [15, 49], 'therapy': [16], 'reduced': [17, 153, 201], 'exacerbation': [18, 39, 45, 104, 155, 186, 203, 239], 'rate': [19, 40, 156, 204], 'by': [20, 26, 157], '17.1%': [21], '(p=0.01)': [22], 'and': [23, 30, 41, 126, 205], 'lowered': [24], 'duration': [25], '24.6%': [27], '(p=0.02).': [28], '<b>Aim': [29], 'Objective:</b>': [31], 'To': [32], 'assess': [33], 'the': [34, 99, 106, 143, 149, 154, 182, 202, 207, 213, 224], 'effect': [35], 'of': [36, 85, 245], 'on': [38, 238], 'time': [42, 100, 183, 208, 214], 'first': [44, 103, 185, 210, 216], 'in': [46, 63, 132, 142, 148, 223, 231, 247], 'moderately': [47, 248], 'severe': [48, 114, 249], 'spirometrically': [50], 'defined': [51, 56], 'patients.': [52, 82], '<b>Methods:</b>': [53], 'Exacerbations': [54], 'were': [55, 92], 'as': [57], 'a': [58, 219, 235, 242], 'symptomatic': [59], 'worsening': [60], 'requiring': [61], 'change': [62], 'regular': [64], 'medication': [65], 'or': [66, 173], 'health': [67], 'care': [68], 'resources': [69], 'utilization.': [70], 'this': [72, 232], 'post-hoc': [73], 'analysis': [74], 'we': [75], 'consider': [76], '254': [77], 'II': [79, 117, 134], '(2011': [80], 'definition)': [81], 'The': [83], 'frequency': [84], 'exacerbations': [86, 137], 'per': [87], 'patient/year': [88], '(12': [89], 'months': [90], 'treatment)': [91], 'analyzed': [93], 'non-parametrically': [94], '(Wilcoxon': [95], 'rank': [96], 'sum': [97], 'test),': [98], 'free': [101], 'from': [102, 170], 'using': [105], 'log-rank': [107], 'test': [108], '(Kaplan–Meier).': [109], '<b>Results:</b>': [110], 'Compared': [111], 'more': [113], 'patients,': [115], 'patients': [118], 'had': [119], 'similar': [120], 'baseline': [121], 'characteristics': [122], 'but': [123], 'higher': [124], 'FEV1': [125], 'FVC': [127], 'values.': [128], 'After': [129], '1-year': [130], 'treatment': [131, 175], 'subgroup,': [135], '74': [136], '(57.8%)': [138], 'have': [139], 'been': [140], 'registered': [141], 'placebo': [144, 196], 'vs.': [145, 190], '53': [146], '(42.1%)': [147], 'group.': [151], 'Erdosteine': [152, 199], '47%': [158], '(OR:': [159], '0.530,': [160], '95%': [161], 'CI': [162], '0.322-0.872,': [163], 'p=': [164], '0.017).': [165], 'This': [166], 'result': [167], 'was': [168, 218], 'independent': [169], 'individual': [171], 'variables': [172], 'background': [174], 'including': [176], 'ICS': [177], 'use.': [178], 'Additionally': [179], 'increased': [181], '(Median': [187], 'time:': [188], '183': [189], '167': [191], 'days': [192], 'Δ%': [193], '+7.1': [194], 'vs': [195], 'P>0.001).': [197], '<b>Conclusions:</b>': [198], 'significantly': [200, 230], 'increase': [206], 'exacerbation.': [211], 'Although': [212], 'event': [217], 'less': [220], 'sensitive': [221], 'marker': [222], 'total': [225], 'population': [227], 'it': [228], 'improved': [229], 'subgroup': [233], 'with': [234], 'large': [236], 'benefit': [237], 'rate,': [240], 'suggesting': [241], 'potential': [243], 'role': [244], 'COPD.': [250]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2905910532', 'counts_by_year': [{'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-14T01:06:12.396922', 'created_date': '2019-01-01'}