Abstract: Few studies have been published on new-onset geriatric epilepsy especially in older Chinese people. This study was to have a comprehensive understanding of new-onset geriatric epilepsy and find a more reasonable diagnosis and management of epilepsy in older people.One hundred and three patients with onset age 60 years and older were admitted between January 2008 and December 2016. Electronic medical records were reviewed to collect information.There were 103 older patients with new-onset epilepsy. The mean age of the patients was 68.5 ± 6.4 years (range: 60-89 years), and there were 67 (65%) men and 36 (35%) women. The mean onset age was 67.9 ± 6.2 years (range: 60-89 years). The most common identifiable etiology of symptomatic seizures was autoimmune epilepsy in 43 (41.7%) patients. The second most common etiology was stroke in 15 (14.6%) patients. Seven (6.8%) older patients with acute seizures present with status epilepticus and 26 (25.2%) patients experienced clustered seizures (more than three events in 24 h) at seizure onset. Focal seizures (96.1%) were more common than generalized seizures (3.9%). Fifty-three (51.5%) patients had an abnormal brain magnetic resonance imaging (MRI) scan. Among them, video-electroencephalogram findings in 31 (30.1%) patients correlated with MRI abnormalities. Levetiracetam was the most used drugs before admission, in hospital, and during follow-up.Autoimmune encephalitis is becoming an increasing risk factor of subsequent epilepsy in older people. Older patients with new epilepsy are more likely to respond to antiepileptic drugs, and drug-resistant epilepsy is uncommon.中国人群新发老年癫痫:一项单中心研究摘要背景: 中国人群新发老年癫痫的研究报道较少。本研究的目的是全面了解中国人群新发老年癫痫,以便对其更好地诊断及治疗。 方法: 2008年1月至2016年12月期间收入院的所有发病年龄大于等于60岁的老年癫痫患者,回顾分析其临床资料。 结果: 共103例患者为新发老年癫痫。平均入院年龄为68.5±6.4岁 (范围: 60-89 岁) ,其中男性67例 (65%) ,女性36例 (35%)。平均发病年龄 67.9±6.2 岁 (范围: 60-89 岁)。 症状性癫痫最常见病因为自身免疫性癫痫,共43例 (41.7%) 患者。第二大常见病因是卒中,共15例 (14.6%) 患者。新发急性老年癫痫患者中7例 (6.8%) 经历了癫痫持续状态,26例 (25.2%) 患者起病时经历了丛集发作 (24小时发作次数大于3次) 。局灶性癫痫 (96.1%) 比全面性癫痫 (3.9%) 更常见。 53例 (51.5%) 患者头颅核磁共振异常。其中,31例 (30.1%) 患者视频脑电结果与核磁共振异常一致。左乙拉西坦是老年癫痫人群中,包括入院前、住院时及出院后随访期间最常用的抗癫痫药物。 结论: 自身免疫性脑炎正成为老年人群癫痫的一大危险因素。新发的老年癫痫患者对抗癫痫药物疗效反应较好,难治性癫痫不常见。.