Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2904705904', 'doi': 'https://doi.org/10.1038/s41556-018-0256-3', 'title': 'Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models', 'display_name': 'Chemotherapy elicits pro-metastatic extracellular vesicles in breast cancer models', 'publication_year': 2018, 'publication_date': '2018-12-31', 'ids': {'openalex': 'https://openalex.org/W2904705904', 'doi': 'https://doi.org/10.1038/s41556-018-0256-3', 'mag': '2904705904', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30598531', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6525097'}, 'language': 'en', 'primary_location': {'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/s41556-018-0256-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'green', 'oa_url': 'https://europepmc.org/articles/pmc6525097?pdf=render', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5008466376', 'display_name': 'Ioanna Keklikoglou', 'orcid': 'https://orcid.org/0000-0003-1219-6912'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': True, 'raw_author_name': 'Ioanna Keklikoglou', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5069797655', 'display_name': 'Chiara Cianciaruso', 'orcid': 'https://orcid.org/0000-0002-5635-5404'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Chiara Cianciaruso', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5040173992', 'display_name': 'Esra Güç', 'orcid': 'https://orcid.org/0000-0002-3172-5958'}, 'institutions': [{'id': 'https://openalex.org/I4210116174', 'display_name': 'MRC Centre for Reproductive Health', 'ror': 'https://ror.org/02f4tsf92', 'country_code': 'GB', 'type': 'facility', 'lineage': ['https://openalex.org/I4210087105', 'https://openalex.org/I4210116174', 'https://openalex.org/I90344618', 'https://openalex.org/I98677209']}, {'id': 'https://openalex.org/I4210137227', 'display_name': "Queen's Medical Centre", 'ror': 'https://ror.org/03ap6wx93', 'country_code': 'GB', 'type': 'healthcare', 'lineage': ['https://openalex.org/I1334287468', 'https://openalex.org/I4210137227']}, {'id': 'https://openalex.org/I98677209', 'display_name': 'University of Edinburgh', 'ror': 'https://ror.org/01nrxwf90', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I98677209']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Esra Güç', 'raw_affiliation_strings': ['MRC Centre for Reproductive Health, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK'], 'affiliations': [{'raw_affiliation_string': 'MRC Centre for Reproductive Health, Queen’s Medical Research Institute, The University of Edinburgh, Edinburgh, UK', 'institution_ids': ['https://openalex.org/I4210116174', 'https://openalex.org/I4210137227', 'https://openalex.org/I98677209']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5001087662', 'display_name': 'Mario Leonardo Squadrito', 'orcid': 'https://orcid.org/0000-0002-1188-0299'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Mario Leonardo Squadrito', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5018738915', 'display_name': 'Laura M. Spring', 'orcid': 'https://orcid.org/0000-0001-8904-3514'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Laura M. Spring', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5105825592', 'display_name': 'Simon Tazzyman', 'orcid': 'https://orcid.org/0000-0002-3384-9989'}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Simon Tazzyman', 'raw_affiliation_strings': ['Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5053920842', 'display_name': 'Lore Lambein', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Lore Lambein', 'raw_affiliation_strings': ['Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5011597628', 'display_name': 'Amanda Poissonnier', 'orcid': 'https://orcid.org/0000-0002-9027-1159'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Amanda Poissonnier', 'raw_affiliation_strings': ['Department of Cell, Developmental and Cancer Biology, Oregon Health and Sciences University, Portland, OR, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell, Developmental and Cancer Biology, Oregon Health and Sciences University, Portland, OR, USA', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054965207', 'display_name': 'Gino B. Ferraro', 'orcid': 'https://orcid.org/0000-0002-1587-4259'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Gino B. Ferraro', 'raw_affiliation_strings': ['Edwin L. Steele Laboratories, Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Edwin L. Steele Laboratories, Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5077976858', 'display_name': 'Caroline Baer', 'orcid': None}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Caroline Baer', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5076591587', 'display_name': 'Antonino Cassará', 'orcid': 'https://orcid.org/0000-0003-1470-6576'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Antonino Cassará', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5002407601', 'display_name': 'A Guichard', 'orcid': 'https://orcid.org/0000-0001-8623-9570'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Alan Guichard', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5064268987', 'display_name': 'M. Luisa Iruela‐Arispe', 'orcid': 'https://orcid.org/0000-0002-3050-4168'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'M. Luisa Iruela-Arispe', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050962688', 'display_name': 'Claire E. Lewis', 'orcid': 'https://orcid.org/0000-0003-1938-9530'}, 'institutions': [{'id': 'https://openalex.org/I91136226', 'display_name': 'University of Sheffield', 'ror': 'https://ror.org/05krs5044', 'country_code': 'GB', 'type': 'education', 'lineage': ['https://openalex.org/I91136226']}], 'countries': ['GB'], 'is_corresponding': False, 'raw_author_name': 'Claire E. Lewis', 'raw_affiliation_strings': ['Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK'], 'affiliations': [{'raw_affiliation_string': 'Department of Oncology and Metabolism, Medical School, University of Sheffield, Sheffield, UK', 'institution_ids': ['https://openalex.org/I91136226']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025353193', 'display_name': 'Lisa M. Coussens', 'orcid': 'https://orcid.org/0000-0003-2389-1865'}, 'institutions': [{'id': 'https://openalex.org/I165690674', 'display_name': 'Oregon Health & Science University', 'ror': 'https://ror.org/009avj582', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I165690674']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Lisa M. Coussens', 'raw_affiliation_strings': ['Department of Cell, Developmental and Cancer Biology, Oregon Health and Sciences University, Portland, OR, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Cell, Developmental and Cancer Biology, Oregon Health and Sciences University, Portland, OR, USA', 'institution_ids': ['https://openalex.org/I165690674']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5034972183', 'display_name': 'Aditya Bardia', 'orcid': 'https://orcid.org/0000-0003-4885-1157'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Aditya Bardia', 'raw_affiliation_strings': ['Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Massachusetts General Hospital Cancer Center, Harvard Medical School, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5015585176', 'display_name': 'Rakesh K. Jain', 'orcid': 'https://orcid.org/0000-0001-7571-3548'}, 'institutions': [{'id': 'https://openalex.org/I4210087915', 'display_name': 'Massachusetts General Hospital', 'ror': 'https://ror.org/002pd6e78', 'country_code': 'US', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210087915', 'https://openalex.org/I48633490']}, {'id': 'https://openalex.org/I136199984', 'display_name': 'Harvard University', 'ror': 'https://ror.org/03vek6s52', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I136199984']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Rakesh K. Jain', 'raw_affiliation_strings': ['Edwin L. Steele Laboratories, Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA'], 'affiliations': [{'raw_affiliation_string': 'Edwin L. Steele Laboratories, Department of Radiation Oncology, Harvard Medical School, Massachusetts General Hospital, Boston, MA, USA', 'institution_ids': ['https://openalex.org/I4210087915', 'https://openalex.org/I136199984']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5073221843', 'display_name': 'Jeffrey W. Pollard', 'orcid': 'https://orcid.org/0000-0003-4579-0053'}, 'institutions': [{'id': 'https://openalex.org/I129975664', 'display_name': 'Albert Einstein College of Medicine', 'ror': 'https://ror.org/05cf8a891', 'country_code': 'US', 'type': 'education', 'lineage': ['https://openalex.org/I129975664', 'https://openalex.org/I4210112371']}], 'countries': ['US'], 'is_corresponding': False, 'raw_author_name': 'Jeffrey W. Pollard', 'raw_affiliation_strings': ['Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA'], 'affiliations': [{'raw_affiliation_string': 'Department of Developmental and Molecular Biology, Albert Einstein College of Medicine, New York, NY, USA', 'institution_ids': ['https://openalex.org/I129975664']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5043563746', 'display_name': 'Michele De Palma', 'orcid': 'https://orcid.org/0000-0001-9128-5459'}, 'institutions': [{'id': 'https://openalex.org/I5124864', 'display_name': 'École Polytechnique Fédérale de Lausanne', 'ror': 'https://ror.org/02s376052', 'country_code': 'CH', 'type': 'education', 'lineage': ['https://openalex.org/I2799323385', 'https://openalex.org/I5124864']}], 'countries': ['CH'], 'is_corresponding': False, 'raw_author_name': 'Michele De Palma', 'raw_affiliation_strings': ['Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland'], 'affiliations': [{'raw_affiliation_string': 'Swiss Institute for Experimental Cancer Research (ISREC), School of Life Sciences, École Polytechnique Fédérale de Lausanne (EPFL), Lausanne, Switzerland', 'institution_ids': ['https://openalex.org/I5124864']}]}], 'countries_distinct_count': 3, 'institutions_distinct_count': 9, 'corresponding_author_ids': ['https://openalex.org/A5008466376'], 'corresponding_institution_ids': ['https://openalex.org/I5124864'], 'apc_list': {'value': 9750, 'currency': 'EUR', 'value_usd': 11690, 'provenance': 'doaj'}, 'apc_paid': None, 'fwci': 21.403, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 414, 'citation_normalized_percentile': {'value': 0.787198, 'is_in_top_1_percent': False, 'is_in_top_10_percent': False}, 'cited_by_percentile_year': {'min': 99, 'max': 100}, 'biblio': {'volume': '21', 'issue': '2', 'first_page': '190', 'last_page': '202'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10773', 'display_name': 'Exosome Biology and Function in Intercellular Communication', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10773', 'display_name': 'Exosome Biology and Function in Intercellular Communication', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/1312', 'display_name': 'Molecular Biology'}, 'field': {'id': 'https://openalex.org/fields/13', 'display_name': 'Biochemistry, Genetics and Molecular Biology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10782', 'display_name': 'Nanotechnology and Imaging for Cancer Therapy and Diagnosis', 'score': 0.9977, 'subfield': {'id': 'https://openalex.org/subfields/2204', 'display_name': 'Biomedical Engineering'}, 'field': {'id': 'https://openalex.org/fields/22', 'display_name': 'Engineering'}, 'domain': {'id': 'https://openalex.org/domains/3', 'display_name': 'Physical Sciences'}}, {'id': 'https://openalex.org/T10831', 'display_name': 'Integrin Signaling in Inflammation and Cancer', 'score': 0.997, 'subfield': {'id': 'https://openalex.org/subfields/2723', 'display_name': 'Immunology and Allergy'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/extracellular-vesicles', 'display_name': 'Extracellular Vesicles', 'score': 0.540279}, {'id': 'https://openalex.org/keywords/tumor-targeting', 'display_name': 'Tumor Targeting', 'score': 0.525112}], 'concepts': [{'id': 'https://openalex.org/C2776694085', 'wikidata': 'https://www.wikidata.org/wiki/Q974135', 'display_name': 'Chemotherapy', 'level': 2, 'score': 0.68506634}, {'id': 'https://openalex.org/C502942594', 'wikidata': 'https://www.wikidata.org/wiki/Q3421914', 'display_name': 'Cancer research', 'level': 1, 'score': 0.66105354}, {'id': 'https://openalex.org/C2775930923', 'wikidata': 'https://www.wikidata.org/wiki/Q12859063', 'display_name': 'Metastatic breast cancer', 'level': 4, 'score': 0.6435542}, {'id': 'https://openalex.org/C530470458', 'wikidata': 'https://www.wikidata.org/wiki/Q128581', 'display_name': 'Breast cancer', 'level': 3, 'score': 0.5751432}, {'id': 'https://openalex.org/C20518536', 'wikidata': 'https://www.wikidata.org/wiki/Q6840469', 'display_name': 'Microvesicles', 'level': 4, 'score': 0.5390486}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.5201117}, {'id': 'https://openalex.org/C154317977', 'wikidata': 'https://www.wikidata.org/wiki/Q376266', 'display_name': 'Cytotoxic T cell', 'level': 3, 'score': 0.51933444}, {'id': 'https://openalex.org/C2779013556', 'wikidata': 'https://www.wikidata.org/wiki/Q181876', 'display_name': 'Metastasis', 'level': 3, 'score': 0.4916883}, {'id': 'https://openalex.org/C121608353', 'wikidata': 'https://www.wikidata.org/wiki/Q12078', 'display_name': 'Cancer', 'level': 2, 'score': 0.42136022}, {'id': 'https://openalex.org/C96232424', 'wikidata': 'https://www.wikidata.org/wiki/Q4118072', 'display_name': 'Cancer cell', 'level': 3, 'score': 0.41319293}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.3489805}, {'id': 'https://openalex.org/C126322002', 'wikidata': 'https://www.wikidata.org/wiki/Q11180', 'display_name': 'Internal medicine', 'level': 1, 'score': 0.270647}, {'id': 'https://openalex.org/C145059251', 'wikidata': 'https://www.wikidata.org/wiki/Q310899', 'display_name': 'microRNA', 'level': 3, 'score': 0.1621455}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.0}, {'id': 'https://openalex.org/C202751555', 'wikidata': 'https://www.wikidata.org/wiki/Q221681', 'display_name': 'In vitro', 'level': 2, 'score': 0.0}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000067128', 'descriptor_name': 'Extracellular Vesicles', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': 'Q000188', 'qualifier_name': 'drug therapy', 'is_major_topic': True}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': 'Q000627', 'qualifier_name': 'therapeutic use', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017317', 'descriptor_name': 'Annexin A6', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017317', 'descriptor_name': 'Annexin A6', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D045744', 'descriptor_name': 'Cell Line, Tumor', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018932', 'descriptor_name': 'Chemokine CCL2', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D004317', 'descriptor_name': 'Doxorubicin', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067128', 'descriptor_name': 'Extracellular Vesicles', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000067128', 'descriptor_name': 'Extracellular Vesicles', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000556', 'qualifier_name': 'secondary', 'is_major_topic': False}, {'descriptor_ui': 'D008175', 'descriptor_name': 'Lung Neoplasms', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D008325', 'descriptor_name': 'Mammary Neoplasms, Experimental', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D018345', 'descriptor_name': 'Mice, Knockout', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008819', 'descriptor_name': 'Mice, Nude', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008822', 'descriptor_name': 'Mice, Transgenic', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D017239', 'descriptor_name': 'Paclitaxel', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 8, 'locations': [{'is_oa': False, 'landing_page_url': 'https://doi.org/10.1038/s41556-018-0256-3', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S151741590', 'display_name': 'Nature Cell Biology', 'issn_l': '1465-7392', 'issn': ['1465-7392', '1476-4679'], 'is_oa': False, 'is_in_doaj': False, 'is_core': True, 'host_organization': 'https://openalex.org/P4310319908', 'host_organization_name': 'Nature Portfolio', 'host_organization_lineage': ['https://openalex.org/P4310319908', 'https://openalex.org/P4310319965'], 'host_organization_lineage_names': ['Nature Portfolio', 'Springer Nature'], 'type': 'journal'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6525097', 'pdf_url': 'https://europepmc.org/articles/pmc6525097?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://eprints.whiterose.ac.uk/140457/30/Keklikoglou_Nature_Cell_Biology_pre-accepted.pdf', 'pdf_url': 'https://eprints.whiterose.ac.uk/140457/30/Keklikoglou_Nature_Cell_Biology_pre-accepted.pdf', 'source': {'id': 'https://openalex.org/S4377196101', 'display_name': 'White Rose Research Online (University of Leeds)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I130828816', 'host_organization_name': 'University of Leeds', 'host_organization_lineage': ['https://openalex.org/I130828816'], 'host_organization_lineage_names': ['University of Leeds'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6525097', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/20.500.11820/4b02717f-15b2-4089-8f66-b385ebb8d392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.pure.ed.ac.uk/ws/files/76663625/Keklikoglou_Main_text_NCB_R1_copy.docx', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400320', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://www.research.ed.ac.uk/en/publications/4b02717f-15b2-4089-8f66-b385ebb8d392', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306400321', 'display_name': 'Edinburgh Research Explorer (University of Edinburgh)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I98677209', 'host_organization_name': 'University of Edinburgh', 'host_organization_lineage': ['https://openalex.org/I98677209'], 'host_organization_lineage_names': ['University of Edinburgh'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30598531', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6525097', 'pdf_url': 'https://europepmc.org/articles/pmc6525097?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'acceptedVersion', 'is_accepted': True, 'is_published': False}, 'sustainable_development_goals': [{'display_name': 'Good health and well-being', 'score': 0.85, 'id': 'https://metadata.un.org/sdg/3'}], 'grants': [], 'datasets': [], 'versions': [], 'referenced_works_count': 70, 'referenced_works': ['https://openalex.org/W1504464770', 'https://openalex.org/W1537032233', 'https://openalex.org/W1551407310', 'https://openalex.org/W1601681275', 'https://openalex.org/W1691160266', 'https://openalex.org/W1769783081', 'https://openalex.org/W1877686344', 'https://openalex.org/W1883024731', 'https://openalex.org/W1901372019', 'https://openalex.org/W1908116487', 'https://openalex.org/W1932669647', 'https://openalex.org/W1940048983', 'https://openalex.org/W1950118853', 'https://openalex.org/W1963904011', 'https://openalex.org/W1979751563', 'https://openalex.org/W1982276721', 'https://openalex.org/W1982441587', 'https://openalex.org/W1994344811', 'https://openalex.org/W1998261391', 'https://openalex.org/W2001740805', 'https://openalex.org/W2005134188', 'https://openalex.org/W2006550410', 'https://openalex.org/W2006951895', 'https://openalex.org/W2010291889', 'https://openalex.org/W2017056838', 'https://openalex.org/W2019315324', 'https://openalex.org/W2027654614', 'https://openalex.org/W2058085109', 'https://openalex.org/W2061687333', 'https://openalex.org/W2075419121', 'https://openalex.org/W2084304742', 'https://openalex.org/W2087179076', 'https://openalex.org/W2089258206', 'https://openalex.org/W2111449140', 'https://openalex.org/W2115394351', 'https://openalex.org/W2120621109', 'https://openalex.org/W2135581618', 'https://openalex.org/W2143839116', 'https://openalex.org/W2145261833', 'https://openalex.org/W2154971346', 'https://openalex.org/W2158062858', 'https://openalex.org/W2163035374', 'https://openalex.org/W2170852633', 'https://openalex.org/W2171549753', 'https://openalex.org/W2259481044', 'https://openalex.org/W2261862398', 'https://openalex.org/W2296538017', 'https://openalex.org/W2318433546', 'https://openalex.org/W2344732859', 'https://openalex.org/W2508312148', 'https://openalex.org/W2529551101', 'https://openalex.org/W2555906390', 'https://openalex.org/W2567639438', 'https://openalex.org/W2594569109', 'https://openalex.org/W2594599876', 'https://openalex.org/W2596133050', 'https://openalex.org/W2649656222', 'https://openalex.org/W2728674371', 'https://openalex.org/W2744433299', 'https://openalex.org/W2763910757', 'https://openalex.org/W2772615438', 'https://openalex.org/W2775714010', 'https://openalex.org/W2786004990', 'https://openalex.org/W2786514708', 'https://openalex.org/W2791748877', 'https://openalex.org/W2792356144', 'https://openalex.org/W2792558334', 'https://openalex.org/W2801901889', 'https://openalex.org/W2818713708', 'https://openalex.org/W4234586755'], 'related_works': ['https://openalex.org/W4253711409', 'https://openalex.org/W4238390078', 'https://openalex.org/W4213439341', 'https://openalex.org/W2980356694', 'https://openalex.org/W2946914098', 'https://openalex.org/W2943261504', 'https://openalex.org/W27718370', 'https://openalex.org/W2470671226', 'https://openalex.org/W2150281802', 'https://openalex.org/W1985945858'], 'abstract_inverted_index': {'Cytotoxic': [0], 'chemotherapy': [1, 18, 48], 'is': [2, 136], 'an': [3], 'effective': [4], 'treatment': [5], 'for': [6], 'invasive': [7], 'breast': [8, 68, 146], 'cancer.': [9], 'However,': [10], 'experimental': [11], 'studies': [12], 'in': [13, 41, 65, 85, 104, 120, 125, 141], 'mice': [14], 'also': [15], 'suggest': [16], 'that': [17, 30, 57, 92], 'has': [19], 'pro-metastatic': [20, 79, 130], 'effects.': [21], 'Primary': [22], 'tumours': [23], 'release': [24], 'extracellular': [25], 'vesicles': [26], '(EVs),': [27], 'including': [28], 'exosomes,': [29], 'can': [31], 'facilitate': [32, 110], 'the': [33, 45, 105, 111, 129, 142], 'seeding': [34], 'and': [35, 72, 100, 138], 'growth': [36], 'of': [37, 47, 60, 113, 118, 132, 145], 'metastatic': [38], 'cancer': [39, 69, 121, 147], 'cells': [40, 122, 127], 'distant': [42], 'organs,': [43], 'but': [44], 'effects': [46, 131], 'on': [49], 'tumour-derived': [50, 75], 'EVs': [51, 76, 82, 144], 'remain': [52], 'unclear.': [53], 'Here': [54], 'we': [55], 'show': [56], 'two': [58], 'classes': [59], 'cytotoxic': [61], 'drugs': [62], 'broadly': [63], 'employed': [64], 'pre-operative': [66], '(neoadjuvant)': [67], 'therapy,': [70], 'taxanes': [71], 'anthracyclines,': [73], 'elicit': [74], 'with': [77], 'enhanced': [78], 'capacity.': [80], 'Chemotherapy-elicited': [81], 'are': [83], 'enriched': [84], 'annexin': [86], 'A6': [87], '(ANXA6),': [88], 'a': [89], 'Ca2+-dependent': [90], 'protein': [91], 'promotes': [93], 'NF-κB-dependent': [94], 'endothelial': [95], 'cell': [96], 'activation,': [97], 'Ccl2': [98], 'induction': [99], 'Ly6C+CCR2+': [101], 'monocyte': [102], 'expansion': [103], 'pulmonary': [106], 'pre-metastatic': [107], 'niche': [108], 'to': [109], 'establishment': [112], 'lung': [114], 'metastasis.': [115], 'Genetic': [116], 'inactivation': [117], 'Anxa6': [119], 'or': [123], 'Ccr2': [124], 'host': [126], 'blunts': [128], 'chemotherapy-elicited': [133], 'EVs.': [134], 'ANXA6': [135], 'detected,': [137], 'potentially': [139], 'enriched,': [140], 'circulating': [143], 'patients': [148], 'undergoing': [149], 'neoadjuvant': [150], 'chemotherapy.': [151]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2904705904', 'counts_by_year': [{'year': 2024, 'cited_by_count': 35}, {'year': 2023, 'cited_by_count': 67}, {'year': 2022, 'cited_by_count': 76}, {'year': 2021, 'cited_by_count': 97}, {'year': 2020, 'cited_by_count': 84}, {'year': 2019, 'cited_by_count': 55}], 'updated_date': '2024-09-01T07:32:53.501839', 'created_date': '2018-12-22'}