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1534, 1718], 'Kenji': [84, 86, 885, 887, 1624], 'Schorpp': [85, 87, 886, 888], 'Assay': [88, 746, 889, 1547], 'Development': [89, 747, 890, 1548, 1721], 'Screening': [91, 749, 892, 1550, 1723, 1989], 'Platform,': [92, 750, 893, 1551, 1724], 'molecular': [95, 753, 896, 1554, 1727], 'Toxicology': [96, 754, 897, 1555, 1728], 'Pharmacology,': [98, 756, 899, 1557, 1730], 'München—German': [101, 759, 902, 1560, 1733], 'Research': [102, 308, 760, 803, 903, 1109, 1561, 1604, 1734, 1831], 'Environmental': [105, 311, 763, 806, 906, 1112, 1564, 1607, 1737, 1834], 'Health,': [106, 764, 907, 1565, 1738], 'Fan': [116, 118, 917, 919, 1626], 'Zhao': [117, 119, 918, 920], 'Basic': [122, 187, 664, 923, 988, 1465, 1743], 'Medical': [123, 188, 245, 257, 390, 592, 665, 924, 989, 1046, 1058, 1191, 1393, 1466, 1744, 1798, 1810, 1848], 'Sciences,': [124, 139, 143, 150, 189, 204, 208, 215, 666, 681, 685, 692, 925, 940, 944, 951, 990, 1005, 1009, 1016, 1467, 1482, 1486, 1493, 1745, 1760, 1764, 1771], 'School': 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1630], 'Zheng': [182, 184, 983, 985, 3217], 'Sunit': [227, 229, 1028, 1030, 1632], 'Mandad': [228, 230, 1029, 1031], 'Bioanalytical': [231, 578, 1032, 1379], 'Mass': [232, 579, 1033, 1380, 1785], 'Spectrometry': [233, 580, 1034, 1381, 1786], 'Group,': [234, 581, 1035, 1382, 1787], 'Max': [235, 514, 582, 1036, 1315, 1383, 1788], 'Planck': [236, 515, 583, 1037, 1316, 1384, 1789, 1864], 'Biophysical': [239, 586, 1040, 1387, 1792], 'Göttingen,': [241, 259, 260, 588, 1042, 1060, 1061, 1389, 1794, 1812, 1813], 'Bioanalytics,': [243, 590, 1044, 1391], 'Goettingen,': [247, 248, 594, 595, 1048, 1049, 1395, 1396, 1800, 1801], 'Neuro-': [252, 1053, 1805], 'Sensory': [254, 1055, 1807], 'Physiology,': [255, 1056, 1808], 'Iris': [269, 271, 1070, 1072, 1634], 'Macheleidt': [270, 272, 1071, 1073], 'Pathology': [275, 611, 637, 1076, 1412, 1438, 1817], 'Anand': [295, 297, 1096, 1098, 1636], 'Ramani': [296, 298, 1097, 1099], 'IUF-Leibniz': [307, 802, 1108, 1603], 'Tomáš': [322, 324, 1123, 1125, 1638], 'Kubelka': [323, 325, 1124, 1126], 'Maciej': [350, 352, 1151, 1153, 1640], 'Dawidowski': [351, 353, 1152, 1154], 'Drug': [382, 1183, 1840], 'Technology': [383, 1184, 1841], 'Pharmaceutical': [385, 1186, 1843], 'Biotechnology,': [386, 1187, 1844], 'Faculty': [387, 1188, 1845], 'Pharmacy,': [389, 1190, 1847], 'Warsaw,': [393, 394, 1194, 1195, 1851, 1852], 'Poland': [395, 1196, 1853], 'Kristina': [403, 405, 1204, 1206, 1642], 'Golfmann': [404, 406, 1205, 1207], 'Arpit': [425, 427, 1226, 1228, 1644], 'Wason': [426, 428, 1227, 1229], 'Chunhua': [447, 449, 1248, 1250, 1646], 'Yang': [448, 450, 1249, 1251], 'Georgia': [454, 539, 1255, 1340, 1857], 'State': [455, 540, 1256, 1341, 1858], 'Atlanta,': [457, 542, 1258, 1343, 1860], 'GA,': [458, 543, 1259, 1344, 1861], 'USA': [459, 544, 1260, 1345, 1862], 'Judith': [467, 469, 1268, 1270, 1648], 'Simons': [468, 470, 1269, 1271], 'Hans-Günther': [489, 491, 1290, 1292, 1650], 'Schmalz': [490, 492, 1291, 1293], 'Anthony': [508, 511, 1309, 1312, 1652], 'A': [509, 512, 1310, 1313, 1653, 4000], 'Hyman': [510, 513, 1311, 1314], 'Cell': [519, 1320, 1868], 'Biology': [520, 1321, 1869], 'Genetics,': [522, 1323, 1871], 'Dresden,': [523, 1324, 1872], 'Ritu': [532, 534, 1333, 1335, 1655], 'Aneja': [533, 535, 1334, 1336], 'Roland': [552, 554, 1353, 1355, 1657], 'Ullrich': [553, 555, 1354, 1356], 'Henning': [574, 576, 1375, 1377, 1659], 'Urlaub': [575, 577, 1376, 1378], 'Margarete': [604, 606, 1405, 1407, 1661], 'Odenthal': [605, 607, 1406, 1408], 'orcid.org/0000-0002-2424-0960': [608, 1409], 'Reinhardt': [631, 633, 1432, 1434, 1663], 'Büttner': [632, 634, 1433, 1435], 'Haitao': [657, 659, 1458, 1460, 1665], 'Li': [658, 660, 1459, 1461], 'orcid.org/0000-0001-6741-293X': [661, 1462], 'Michael': [704, 706, 1505, 1507, 1667], 'Sattler': [705, 707, 1506, 1508], 'orcid.org/0000-0002-1594-0527': [708, 1509], 'Kamyar': [742, 744, 1543, 1545, 1669], 'Hadian': [743, 745, 1544, 1546], 'Jay': [774, 778, 1575, 1579, 1672], 'Gopalakrishnan': [775, 779, 1576, 1580, 1673, 2790], 'Corresponding': [776, 1577], 'Author': [777, 1578, 1618], '[email': [780, 1581, 1881], 'protected]': [781, 1582, 1882], 'orcid.org/0000-0002-0639-8705': [782, 1583], 'Information': [1619], 'Mariappan1,2,': [1621], 'Soni3,4,': [1623], 'Schorpp5,': [1625], 'Zhao6,7,8,': [1627], 'Minakar9,': [1629], 'Zheng6,7,8,': [1631], 'Mandad10,11,12,': [1633], 'Macheleidt13,': [1635], 'Ramani1,14,': [1637], 'Kubelka4,': [1639], 'Dawidowski3,4,15,': [1641], 'Golfmann2,': [1643], 'Wason2,': [1645], 'Yang16,': [1647], 'Simons2,': [1649], 'Schmalz9,': [1651], 'Hyman17,': [1654], 'Aneja16,': [1656], 'Ullrich2,': [1658], 'Urlaub10,11,': [1660], 'Odenthal13,': [1662], 'Büttner13,': [1664], 'Li6,7,8,': [1666], 'Sattler3,4,': [1668], 'Hadian5': [1670], '*,1,2,14': [1674], '1Institute': [1675], '2Center': [1683], '3Institute': [1694], '4Biomolecular': [1703], '5Assay': [1720], '6Department': [1741], '7MOE': [1755], '8Tsinghua-Peking': [1767], '9Department': [1776], '10Bioanalytical': [1784], '11Bioanalytics,': [1796], '12Department': [1803], '13Institute': [1815], '14IUF-Leibniz': [1830], '15Department': [1838], '16Department': [1854], '17Max': [1863], '*Corresponding': [1874], 'author.': [1875], 'Tel:': [1876], '+49': [1877], '211': [1878], '8111561;': [1879], 'E-mail:': [1880], 'The': [1883, 2156, 2164, 3390, 3426], 'EMBO': [1884], 'Journal': [1885], '(2019)38:e99876https://doi.org/10.15252/embj.201899876': [1886], 'See': [1887], 'also:': [1888], 'Y': [1889], 'Liu': [1890], '&': [1891, 1932, 2232, 2256, 2665, 3052], 'L': [1892], 'Pelletier': [1893], '(January': [1894], '2019)': [1895], 'PDFDownload': [1896], 'PDF': [1897], 'article': [1899], 'text': [1900], 'main': [1902], 'figures.': [1903], 'Peer': [1904], 'ReviewDownload': [1905], 'a': [1906, 1938, 2071, 2085, 2124, 2160, 2239, 2311, 2396, 2444, 2450, 2538, 2558, 2836, 2856, 2864, 2883, 2895, 2949, 2975, 2988, 3096, 3114, 3207, 3250, 3282, 3362, 3744, 3823, 3925, 3956, 3966, 3976, 3986], 'summary': [1907], 'editorial': [1910, 1914], 'decision': [1911, 1915], 'including': [1913, 2058, 2092], 'letters,': [1916], 'reviewer': [1917], 'comments': [1918], 'responses': [1921], 'to': [1922, 1925, 1965, 1997, 2022, 2029, 2034, 2076, 2088, 2114, 2143, 2185, 2283, 2350, 2398, 2414, 2431, 2461, 2489, 2499, 2530, 2540, 2594, 2632, 2648, 2670, 2680, 2705, 2720, 2804, 2820, 2824, 2832, 2917, 2925, 2951, 2983, 3094, 3103, 3108, 3131, 3166, 3263, 3300, 3312, 3396, 3472, 3750, 3756, 3767, 3773, 3787, 3816, 3828, 3839, 3844, 3903, 3958, 3974, 4010], 'feedback.': [1923], 'ToolsAdd': [1924], 'favoritesDownload': [1926], 'CitationsTrack': [1927], 'CitationsPermissions': [1928], 'ShareFacebookTwitterLinked': [1929], 'InMendeleyWechatReddit': [1930], 'Figures': [1931], 'Info': [1933], 'Abstract': [1934], 'Centrosome': [1935, 2102], 'amplification': [1936, 2103, 2305, 2548, 3343], 'is': [1937, 2104, 2141, 2159, 2183, 2310, 2395, 2645, 3228, 3361, 3435, 3955], 'hallmark': [1939, 2312], 'human': [1941, 2108, 2314], 'cancers': [1942, 2094, 2315], 'that': [1943, 1992, 2048, 2371, 2701, 2771, 2861, 2886, 2899, 2939, 2964, 3070, 3098, 3112, 3121, 3146, 3190, 3781, 3951, 3979], 'can': [1944, 2360, 2407, 2629, 2965, 3980], 'trigger': [1945], 'cell': [1947, 2042, 2116, 2325, 2352, 2417, 2436, 2979, 2995, 3017, 3309, 3422, 3543, 3866, 3961], 'invasion.': [1948, 2392], 'To': [1949, 2959, 3290], 'survive,': [1950], 'cluster': [1953, 2457, 2490, 2714, 3046], 'amplified': [1954, 2204], 'extra': [1955, 1969, 2020, 2079, 2192, 2295, 2375, 2385, 2420, 2441, 2459, 2491, 2576, 2627, 2703, 2822, 2842, 2915, 2957, 2999, 3101, 3126, 3298, 3463, 3468, 3557, 3561, 3572, 3592, 3722, 3730, 3785, 3891], 'centrosomes': [1956, 2021, 2145, 2296, 2376, 2386, 2421, 2442, 2460, 2492, 2577, 2628, 2674, 2704, 2780, 2803, 2823, 2843, 2916, 2958, 2973, 3000, 3045, 3073, 3102, 3127, 3165, 3265, 3299, 3474, 3477, 3497, 3573, 3593, 3740, 3764, 3786, 3830], 'achieve': [1958, 2443], 'pseudobipolar': [1959, 2445], 'division.': [1960], 'Here,': [1961, 2127], 'we': [1962, 2068, 2699, 2834, 2853, 2937, 2971, 3068, 3092, 3247, 3277, 3306, 3887, 3917, 3984], 'set': [1963], 'out': [1964], 'prevent': [1966, 2633, 2952, 3795, 3910, 3959], 'clustering': [1967, 2120, 2198, 2529, 2565, 2608, 2622, 2636, 3124, 3318, 3599], 'centrosomes.': [1970, 2193], 'Tubulin,': [1971], 'interacting': [1973, 3151], 'with': [1974, 2374, 2440, 2543, 2785, 2799, 2841, 2956, 3080, 3152, 3252, 3285, 3288, 3576, 3608, 3698, 3743], 'centrosomal': [1976, 2401, 2643, 2962, 3154, 3492], 'protein': [1977, 2133, 2561, 2588, 3155], 'CPAP,': [1978], 'negatively': [1979, 2774], 'regulates': [1980, 2775], 'CPAP-dependent': [1981], 'peri-centriolar': [1982, 2245], 'material': [1983, 2188, 2246], 'recruitment,': [1984], 'concurrently': [1986], 'microtubule': [1987, 2218, 2684, 3082, 3196, 3482, 3499, 3580, 3589, 3746], 'nucleation.': [1988, 3581], 'compounds': [1991, 4004], 'perturb': [1993, 3123, 3981], 'led': [1996], 'identification': [1999], 'CCB02,': [2001, 2863, 3965], 'which': [2002, 2081, 2249, 2279, 2406, 2454, 2796, 3260, 3748], 'selectively': [2003, 2152], 'binds': [2004, 3192], 'CPAP': [2007, 2174, 2890, 3191, 3223, 3283, 3609], 'binding': [2008, 2171, 2175, 2891, 3224], 'site': [2009, 2176, 2892, 2898, 3225], 'tubulin.': [2011, 3289], 'Genetic': [2012], 'chemical': [2014], 'perturbation': [2015], 'activates': [2019, 2801, 3297], 'nucleate': [2023, 2706, 2805, 2825, 2918, 3104, 3167, 3301, 3478, 3788], 'enhanced': [2024, 2708, 2827, 2920, 3105, 3302, 3479, 3790, 3804], 'numbers': [2025, 3009], 'microtubules': [2027, 2253, 2711, 2807, 2830, 2923, 3106, 3172, 3611, 3793, 3807], 'prior': [2028, 2831, 2924, 3107], 'mitosis.': [2030, 2288, 3109, 3604], 'This': [2031, 2367], 'causes': [2032], 'undergo': [2035, 2432, 2500], 'centrosome': [2036, 2099, 2119, 2197, 2203, 2236, 2269, 2304, 2344, 2448, 2528, 2547, 2564, 2598, 2607, 2621, 2721, 2763, 3008, 3317, 3342], 'de-clustering,': [2037], 'prolonged': [2038, 3520], 'multipolar': [2039, 2426, 2501, 2532, 2571, 3132, 3502, 3629, 3840, 3884], 'mitosis,': [2040, 2427, 2494, 2567, 2833], 'death.': [2043, 2437], '3D-organotypic': [2044], 'invasion': [2045, 2326], 'assays': [2046, 2878], 'reveal': [2047, 2616], 'CCB02': [2049, 2167, 2881, 2908, 2940], 'has': [2050, 2317, 2534, 2900, 2941, 3379], 'broad': [2051], 'anti-invasive': [2052], 'activity': [2053, 2761, 2778], 'in': [2054, 2107, 2137, 2207, 2211, 2287, 2346, 2356, 2423, 2493, 2566, 2568, 2573, 2606, 2623, 2715, 2767, 2788, 2839, 2974, 3012, 3025, 3074, 3128, 3321, 3328, 3346, 3432, 3522, 3556, 3568, 3591, 3666, 3836, 3854, 3911, 3929], 'various': [2055, 2090], 'models,': [2057], 'tyrosine': [2059], 'kinase': [2060], 'inhibitor': [2061, 2555, 2866, 3968], '(TKI)-resistant': [2062], 'EGFR-mutant': [2063], 'non-small-cell': [2064, 3014], 'lung': [2065, 3015], 'cancers.': [2066], 'Thus,': [2067, 2303, 2526, 2698, 2819, 3091], 'have': [2069, 2496, 2769, 2879], 'identified': [2070, 2862, 2880], 'vulnerability': [2072], 'activation': [2077, 2195], 'centrosomes,': [2080, 2278, 2672, 2991], 'may': [2082, 2726, 2751, 3122], 'serve': [2083], 'as': [2084, 2537, 2655, 2753, 2882, 2948, 3116, 3280, 3415, 3661], 'global': [2086], 'approach': [2087], 'target': [2089, 2950, 3364, 3957], 'tumors,': [2091], 'drug-resistant': [2093], 'exhibiting': [2095, 3519, 3628], 'high': [2096, 2544], 'incidence': [2097], 'amplification.': [2100], 'Synopsis': [2101], 'frequently': [2105], 'observed': [2106, 3011, 3880, 3924], 'tumors': [2109, 2542], 'yet': [2110], 'manage': [2113], 'circumvent': [2115, 2462], 'death': [2117, 3867], 'generation': [2122], 'pseudo-bipolar': [2125], 'spindle.': [2126], 'genetically': [2128, 2845], 'perturbing': [2129, 2846, 3147, 3906], 'between': [2131, 2585], 'centrosomal-P4.1-associated': [2132], '(CPAP)': [2134], 'tubulin': [2136, 2773, 2884, 2906, 2912, 3149, 3227, 3233, 3255], 'extra-centrosome-containing': [2138], 'found': [2142, 2938], 'activate': [2144, 2191, 3100, 3163], 'before': [2146, 2712], 'onset': [2148, 3420], 'mitosis': [2150, 2658, 2716, 2926, 3050, 3347, 3521, 3837, 3855, 3885], 'thereby': [2151, 3205], 'inducing': [2153], 'mitotic': [2154, 2433, 2463, 3136, 3403, 3413, 3513, 3626], 'catastrophe.': [2155], 'CPAP-tubulin': [2157, 2169, 2181, 3186], 'cell-specific': [2162], 'target.': [2163], 'small-molecule': [2165], 'compound': [2166, 3988], 'inhibits': [2168], 'interaction,': [2170, 3983], 'β-tubulin.': [2178], 'sufficient': [2184], 'enhance': [2186], 'pericentriolar': [2187], 'recruitment': [2189], 'Extra-centrosome': [2194], 'reduces': [2200], 'vitro': [2208], 'tumorigenesis': [2210], 'vivo.': [2212], 'Introduction': [2213], 'Centrosomes': [2214], 'are': [2215, 2377], 'major': [2217], 'organizing': [2219], 'centers': [2220], '(MTOC)': [2221], 'mammalian': [2223], '(Zheng': [2225], 'et': [2226, 2260, 2328, 2332, 2336, 2340, 2364, 2466, 2470, 2474, 2478, 2482, 2507, 2511, 2515, 2519, 2523, 2550, 2579, 2610, 2660, 2687, 2691, 2695, 2735, 2739, 2743, 2747, 2791, 2816, 3031, 3035, 3039, 3056, 3060, 3064, 3085, 3181, 3214, 3218, 3236, 3240, 3272, 3997], 'al,': [2227, 2261, 2329, 2333, 2337, 2341, 2365, 2467, 2471, 2475, 2479, 2483, 2508, 2512, 2516, 2520, 2524, 2551, 2580, 2611, 2661, 2688, 2692, 2696, 2736, 2740, 2744, 2748, 2792, 2817, 3032, 3036, 3040, 3057, 3061, 3065, 3086, 3182, 3215, 3219, 3237, 3241, 3273, 3998], '1995;': [2228], 'Nigg,': [2229], '2004;': [2230, 2689], 'Nigg': [2231], 'Raff,': [2233], '2009).': [2234], 'Each': [2235, 3683], 'consists': [2237], 'pair': [2240, 2989], 'centrioles': [2242], 'surrounded': [2243], '(PCM),': [2247], 'from': [2248, 2380, 2635, 2728, 2930, 3150, 3394, 3418, 3598, 3797], 'spindle': [2250, 2446], 'astral': [2252], 'emanate': [2254], '(Bettencourt-Dias': [2255], 'Glover,': [2257], '2007;': [2258, 3033], 'Conduit': [2259], '2010).': [2262], 'In': [2263, 2289, 2981, 3736, 3972], 'healthy': [2264], 'cells,': [2265, 2358, 2405, 2625, 3259, 3570, 3738, 3916], 'strict': [2266], 'regulation': [2267], 'duplication': [2270], 'ensures': [2271], 'formation': [2273], 'only': [2275, 2987], 'two': [2276, 3329, 3337, 3383, 3388], 'functional': [2277], 'assemble': [2280], 'bipolar': [2281, 3769], 'spindles': [2282, 2572, 3133, 3630], 'avoid': [2284], 'chromosomal': [2285, 2299, 2321], 'aberrations': [2286, 2309], 'contrast,': [2290], 'many': [2291], 'harbor': [2294], 'accompanied': [2297], 'instability': [2300, 2322], '(Nigg,': [2301], '2002).': [2302], 'its': [2307, 2782, 3200], 'structural': [2308], 'direct': [2318, 2583, 2783], 'consequences': [2319], 'on': [2320, 2850, 3244, 3382, 3991], '(Ganem': [2327, 2506], '2009;': [2330, 2509], 'Godinho': [2331], '2014;': [2334, 2663, 2693, 3087], 'Ganier': [2335], '2018;': [2338], 'Marteil': [2339], '2018).': [2342], 'Intriguingly,': [2343], 'loss': [2345], 'normal': [2347, 2381, 2984], 'leads': [2349], 'irreversible': [2351], 'cycle': [2353], 'arrest,': [2354], 'whereas': [2355], 'still': [2361], 'continue': [2362], '(Wong': [2363], '2015).': [2366, 2697], 'raises': [2368], 'possibility': [2370], 'fundamentally': [2378], 'different': [2379], 'use': [2384], 'benefit': [2389], 'cellular': [2391, 2876], 'Consequently,': [2393], 'there': [2394], 'need': [2397], 'identify': [2399, 2960, 3095, 3313, 3975], 'unique': [2400, 2961], 'properties': [2402, 2963], 'be': [2408, 2595, 2630, 2649, 2966, 3751], 'exploited': [2409], 'conceptually': [2411], 'new': [2412], 'strategies': [2413], 'counteract': [2415, 2541], 'proliferation.': [2418, 3962], 'Amplified': [2419], 'should': [2422], 'theory': [2424], 'cause': [2425, 3341], 'leading': [2428, 3130, 3838], 'catastrophe': [2434, 2464, 3137], 'However,': [2438], 'via': [2447, 2933, 3199, 3266], 'clustering,': [2449, 2599], 'key': [2451], 'mechanism': [2452, 3097], 'their': [2458, 4008], '(Basto': [2465], '2008;': [2468, 2472, 2737, 3037, 3054, 3058], 'Kwon': [2469, 3055], 'Leber': [2473, 2510, 3059], '2010;': [2476, 2513, 3062], 'Pannu': [2477, 2690, 3063], '2015;': [2480, 3041], 'Chavali': [2481], '2016).': [2484, 2612, 3043, 3220], 'Indeed,': [2485], 'when': [2486, 3886], 'failed': [2488, 3827], 'they': [2495, 2713], 'been': [2497, 2535, 2902], 'shown': [2498, 2593, 2770], 'divisions': [2502, 2533], 'enter': [2504, 2657], 'apoptosis': [2505], 'Kawamura': [2514], '2013;': [2517, 2521], 'Marthiens': [2518], 'Mason': [2522], '2014).': [2525, 3066, 3274], 'inhibiting': [2527], 'induce': [2531, 2821], 'proposed': [2536], 'strategy': [2539], 'incidences': [2545], '(Ogden': [2549], '2012).': [2552, 2793, 2818, 3183], 'An': [2553], 'allosteric': [2554], 'HSET,': [2557], 'kinesin': [2559], 'motor': [2560], 'required': [2562, 2596], 'fact': [2569], 'induced': [2570], 'containing': [2575, 2986, 3689], '(Watts': [2578], '2013).': [2581, 2667, 3242, 3999], 'Accordingly,': [2582, 2668], 'PCM': [2587, 2605, 2644, 2813, 3178], 'CEP215': [2589], 'HSET': [2591], 'was': [2592, 4005], 'highlighting': [2600], 'an': [2601, 2707, 2826, 2919, 2942, 3168, 3789, 3803], 'essential': [2602], 'role': [2603], '(Chavali': [2609], 'While': [2613], 'these': [2614, 3075, 3245, 3783, 3825, 3947], 'studies': [2615, 2766], 'advantages': [2618], 'targeting': [2620], 'how': [2626], 'manipulated': [2631], 'them': [2634, 2929, 3597, 3796], 'remains': [2637], 'largely': [2638], 'unknown.': [2639], 'Microtubule': [2640], 'nucleation': [2641, 2685, 3083, 3590], 'spatiotemporally': [2646], 'regulated': [2647], 'minimal': [2650, 3745], 'during': [2651, 3047, 3316], 'interphase': [2652, 2673, 2802, 3048, 3072, 3164, 3395, 3602], 'increases': [2654], '(Conduit': [2659], '2010,': [2662], 'Avidor-Reiss': [2664], 'Gopalakrishnan,': [2666], 'compared': [2669, 3471], 'metaphase': [2671, 3129, 3770, 3841], 'remain': [2675, 3574], 'relatively': [2676], 'inactive': [2677, 3079, 3575], 'displaying': [2678], 'reduced': [2679, 3081, 3254, 3579], 'moderate': [2681], 'level': [2682, 2709, 2828, 2921, 3170, 3791, 3805], '(Piehl': [2686], 'Sabino': [2694], 'wondered': [2700], 'activating': [2702, 3023, 3782], 'could': [2717, 3099, 3162, 3794, 3909], 'potentially': [2718], 'lead': [2719], 'declustering.': [2722, 2764], 'Although': [2723], 'rationale': [2725], 'differ': [2727], 'current': [2729], 'view': [2730], 'centrosome-declustering': [2732], 'mechanisms': [2733, 2758, 3120], '(Kwon': [2734], 'Fielding': [2738], '2011;': [2741, 2745], 'Kramer': [2742], 'Watts': [2746], '2013),': [2749], 'it': [2750], 'represent': [2752], 'one': [2754, 3117], 'alternative': [2757], 'linking': [2759], 'microtubule-nucleating': [2760, 2777], 'Our': [2765, 3184], 'Drosophila': [2768, 3158], 'cytoplasmic-free': [2772], 'through': [2781], 'Sas-4': [2786, 3156], '(CPAP': [2787], 'humans;': [2789], 'Mutated': [2794], 'Sas-4,': [2795], 'cannot': [2797], 'interact': [2798], 'tubulin,': [2800], 'robust': [2806], 'recruiting': [2809, 3174], 'increasing': [2810, 3175], 'amounts': [2811, 3176], 'proteins': [2814, 3179], '(Gopalakrishnan': [2815, 3180], 'developed': [2835], 'proof-of-principle': [2837, 3948], 'experiment': [2838], 'interaction.': [2848, 2869], 'Based': [2849], 'experiment,': [2852], 'established': [2854], 'AlphaScreen,': [2855], 'proximity-based': [2857], 'protein–protein': [2858], 'assay': [2860, 3994], 'selective': [2865], 'Nuclear': [2870], 'magnetic': [2871], 'resonance': [2872], '(NMR)': [2873], 'experiments': [2874, 3311, 3446, 3949], 'pull-down': [2877], 'binder': [2885], 'competes': [2887], 'β-tubulin,': [2894], 'previously': [2896, 3144], 'uncharacterized': [2897], 'not': [2901, 2910, 3229, 3340], 'occupied': [2903, 3230], 'known': [2905], 'binders.': [2907], 'but': [2909], 'conventional': [2911], 'binders': [2913, 3234], 'activated': [2914], 'prevented': [2928], 'clustering.': [2931], 'Finally,': [2932, 3902], 'mouse': [2934], 'xenograft': [2935, 3651, 3691], 'experiments,': [2936], 'anti-tumor': [2943], 'activity.': [2944], 'Results': [2945], 'targeted': [2967], 'cancer-selective': [2969], 'chemotherapy,': [2970], 'analyzed': [2972, 3431], 'spectrum': [2976], 'lines.': [2980], 'contrast': [2982], 'tested': [2993, 4006], 'lines': [2996, 3018], 'invariably': [2997], 'displayed': [2998], '(Appendix': [3001, 3138], 'Fig': [3002, 3089, 3139, 3873, 3942], 'S1Ai': [3003], 'ii).': [3005, 3945], 'Highly': [3006], 'increased': [3007], 'were': [3010, 3261, 3392, 3606], 'TKI-resistant': [3013], '(NSCLC)': [3019], 'carrying': [3020], 'somatic': [3021], 'mutations': [3024], 'EGFR': [3026], '(H1975T790M': [3027], 'HCC827-GR;': [3029], 'Engelman': [3030], 'Guo': [3034], 'Pagliarini': [3038], 'Ahsan,': [3042], 'Extra': [3044], '(Gergely': [3051], 'Basto,': [3053], 'Interestingly,': [3067], 'noticed': [3069], 'clustered': [3071, 3571, 3739], 'remained': [3078], '(Pannu': [3084], 'Appendix': [3088, 3872, 3941], 'S1Aiii).': [3090], 'sought': [3093], 'We': [3110, 3143, 3411, 3719, 3779, 3879], 'hypothesized': [3111], 'such': [3113], 'manipulation': [3115], 'eventual': [3135], 'S1B': [3140], 'C).': [3142], 'showed': [3145], 'cytoplasmic': [3148], '(the': [3157], 'homologue': [3159], 'CPAP)': [3161], 'elevated': [3169], 'recent': [3185], 'crystal': [3187], 'structure': [3188], 'revealed': [3189], 'β-tubulin': [3193], 'outer': [3197], 'surface': [3198], 'conserved': [3201], 'PN2-3': [3202], 'C-terminal': [3203], 'loop–helix,': [3204], 'forming': [3206], 'high-affinity': [3208], 'complex': [3209], 'requiring': [3210], "CPAP's": [3211], 'Phe375': [3212], '(Sharma': [3213], '2016;': [3216], 'Importantly,': [3221], 'so-far-studied': [3232], '(Pryor': [3235], '2002;': [3238], 'Prota': [3239], 'Building': [3243], 'studies,': [3246], 'introduced': [3248, 3888], 'CPAPF375A,': [3249], 'mutant': [3251], 'significantly': [3253], 'into': [3257, 3890], 'MCF10A': [3258, 3331, 3385, 3465, 3559, 3724], 'engineered': [3262], 'amplify': [3264], 'doxycycline-induced': [3267], 'overexpression': [3268, 3371], 'Plk4': [3270], '(Godinho': [3271], 'For': [3275], 'clarity,': [3276], 'term': [3278], 'CPAPF375A': [3279], 'CPAPΔT,': [3281], 'variant': [3284], 'diminished': [3286], 'test': [3291, 3904], 'whether': [3292, 3905], 'introducing': [3293], 'CPAP-WT': [3294, 3325, 3374, 3408, 3525, 3549, 3632, 3659, 3703, 3733], 'or': [3295, 3319, 3326, 3344, 3376, 3460, 3578, 3633, 3663, 3734], 'CPAPΔT': [3296, 3327, 3377, 3553, 3586, 3634, 3664, 3799, 3889], 'levels': [3303, 3480], 'microtubules,': [3305], 'performed': [3307], 'live': [3308], 'imaging': [3310], 'events': [3314], 'occurring': [3315], 'declustering': [3320], 'real': [3322], 'time.': [3323], 'Expressing': [3324], 'centrosomes-containing': [3330, 3723], '(without': [3333], 'doxycycline': [3334, 3727], 'induction;': [3335, 3728], '−Dox,': [3336], 'centrosomes)': [3338, 3731], 'did': [3339], 'delay': [3345], '(Fig': [3348, 3868, 3900, 3936], '1Ai': [3349], 'ii,': [3351, 3939], 'Movie': [3353, 3760, 3777, 3820, 3848, 3875], 'EV1A': [3354], 'B).': [3356], 'Figure': [3357], '1.': [3358], 'A.': [3365], 'Proof-of-principle': [3366], 'experiment.': [3367], 'Time-lapse': [3368], 'images': [3369, 3544], 'show': [3370], 'Myc-tagged': [3373], '(i)': [3375, 3669], '(ii)': [3378, 3682], 'no': [3380, 3577], 'effect': [3381], 'centrosome-containing': [3384, 3464, 3558, 3892], '(−Dox,': [3387], 'centrosomes).': [3389, 3469], 'imaged': [3393], 'cytokinesis.': [3397, 3425], 'Bar': [3398, 3508, 3621, 3670], 'graph': [3399, 3509, 3622, 3671], 'right': [3401, 3511, 3673], 'quantifies': [3402, 3512, 3623], 'duration': [3404, 3414, 3514], 'overexpressing': [3407], 'CPAPΔT.': [3410, 3527, 3709, 3735], 'define': [3412], 'time': [3416, 3835], 'consumed': [3417, 3832], 'rounding': [3423], 'until': [3424], 'number': [3427], '(n)': [3430], 'each': [3433, 3441, 3688], 'condition': [3434, 3684], 'indicated': [3436], 'top': [3439], 'bar.': [3442], 'Number': [3443], 'independent': [3445], '(N),': [3447], '(N)': [3448, 3528, 3636], '=': [3449, 3529, 3637, 3700, 3706], '3.': [3450, 3530, 3638], 'Error': [3451, 3531, 3639, 3693], 'bars,': [3452, 3532, 3640, 3694], 'mean': [3453, 3533, 3641, 3695], '±': [3454, 3534, 3642, 3696], 'SEM.': [3455, 3535, 3643], 'Unpaired': [3456, 3536, 3644, 3710], 't-test.': [3457], 'CPAP-WT-': [3458], '(iii)': [3459, 3475], 'CPAPΔT-expressing': [3461, 3476, 3851], '(iv)': [3462], '(+Dox,': [3467, 3560], 'Note': [3470], 'CPAP-WT-expressing': [3473, 3569, 3737], 'asters': [3483, 3500], 'already': [3484], 'prophase-like': [3486], 'stage': [3487], '(iv).': [3488], 'White': [3489], 'arrows': [3490, 3495], 'indicate': [3491, 3496], 'dots.': [3493], 'Red': [3494], 'nucleating': [3498], 'causing': [3501], 'spindles.': [3503], 'Scale': [3504, 3616], 'bar,': [3505, 3617], '2': [3506, 3618], 'μm.': [3507, 3619], 'percentage': [3516], 'expressing': [3524, 3658, 3732], 't-test': [3537, 3645, 3711], '***P': [3538, 3712], '<': [3539, 3647, 3713], '0.0001.': [3540, 3714], 'B–D.': [3541], 'Fixed': [3542], 'showing': [3545], 'expression': [3547, 3587, 3800], '(top': [3550], 'panel)': [3551, 3555], '(bottom': [3554], 'centrosomes),': [3562], 'MDA-MB-231,': [3563], 'H1975T790M': [3565], 'cells.': [3566], 'Note,': [3567], 'On': [3582], 'other': [3584], 'hand,': [3585], 'enhances': [3588], '(arrows)': [3594], 'preventing': [3596], 'G2-like': [3601], 'Cells': [3605], 'stained': [3607], '(GFP),': [3610], '(α-tubulin,': [3612], 'red),': [3613], 'Cep152': [3614], '(magenta).': [3615], 'E.': [3620], 'percentages': [3624], 'upon': [3631], 'expression.': [3635], '**P': [3646], '0.001.': [3648], 'F.': [3649], 'Subcutaneous': [3650], 'tumor': [3652, 3676], 'volume': [3653, 3677], 'measurements': [3654], 'MDA-MB-231': [3656, 3921], '(red)': [3660], 'control': [3662, 3861], '(blue)': [3665], 'nude': [3667], 'mice.': [3668], 'shows': [3674], 'total': [3675], 'reduction': [3678], 'day': [3680], '22.': [3681], 'used': [3685], 'four': [3686], 'mice': [3687], '4': [3690, 3857], 'tumors.': [3692], 'SEM': [3697], 'n': [3699, 3705], '16': [3701, 3707], 'Download': [3715, 3717], 'figure': [3716], 'PowerPoint': [3718], 'then': [3720], 'monitored': [3721], '(with': [3726], '+Dox,': [3729], 'initially': [3741], 'dispersed': [3742, 3763, 3784, 3810], 'nucleation,': [3747], 'appears': [3749], 'G2': [3752, 3813], 'phase': [3753], '(from': [3754, 3771, 3814, 3842], '1:55': [3755], '2:10th': [3757], 'minutes': [3758, 3775, 3818, 3846], 'EV1C).': [3761, 3778, 3821, 3849], 'These': [3762], 'eventually': [3765], 're-clustered': [3766], 'form': [3768], '2:10': [3772], '2:35th': [3774], 'speculated': [3780], 're-clustering.': [3798], 'indeed': [3801], 'caused': [3802], 'state': [3811], '1:35': [3815], '2:20th': [3817], 'As': [3822], 'result,': [3824], 're-cluster': [3829], 'much': [3833], 'longer': [3834, 3859], '2:20': [3843], '3:35th': [3845], 'Overall,': [3850], 'resided': [3853], '~': [3856], 'times': [3858], 'than': [3860], 'apparently': [3864], 'underwent': [3865], '1Aiii': [3869], 'iv,': [3871], 'S2A,': [3874], 'EV1C': [3876], 'D).': [3878], 'similar': [3881], 'effects': [3882], 'breast': [3893, 3933], '(MDA-MB-231)': [3895], 'NSCLC': [3897], '(H1975T790M)': [3898], '1B–E).': [3901], 'vivo': [3912, 3930], 'growth': [3913, 3931], 'subcutaneously': [3918], 'implanted': [3919], 'CPAPΔT-carrying': [3920], 'significant': [3926], 'decrease': [3927], 'xenografts': [3935], '1Fi': [3937], 'S2Bi': [3943], 'Together,': [3946], 'suggest': [3950], 'Identification': [3963], 'specific': [3967], 'order': [3973], 'small': [3977], 'molecule': [3978], 'initiated': [3985], 'high-throughput': [3987], 'screen': [3989], 'based': [3990], 'AlphaScreen': [3993], 'technology': [3995], '(Schorpp': [3996], 'library': [4001], '25,000': [4003], 'ability': [4009]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2904633247', 'counts_by_year': [{'year': 2024, 'cited_by_count': 5}, {'year': 2023, 'cited_by_count': 2}, {'year': 2022, 'cited_by_count': 8}, {'year': 2021, 'cited_by_count': 5}, {'year': 2020, 'cited_by_count': 5}, {'year': 2019, 'cited_by_count': 4}, {'year': 2018, 'cited_by_count': 1}], 'updated_date': '2024-12-24T08:28:58.345895', 'created_date': '2018-12-22'}