Prominin‐1 controls stem cell activation by orchestrating ciliary dynamics

Name: Work Video:
Duration: 3 min 30 s
Donald A. Singer; Kristina Thamm; Heng Zhuang; Jana Karbanová; Yan Gao; Jemma Victoria Walker; Heng Jin; Xiangnan Wu; Clarissa Coveney; Pauline Marangoni; Dongmei Lu; Portia Rebecca Clare Grayson; Tülay Gülşen; Karen Liu; Stefano Ardu; A.K. Wann; Shouqing Luo; Alexander C. Zambon; Anton M. Jetten; Christopher Tredwin; Ophir D. Klein; Massimo Attanasio; Peter Carmeliet; Wieland Β. Huttner; Denis Corbeil; Bing Hu
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1509], 'Laboratories,': [40, 103, 678, 749, 812, 1387, 1510], 'Biotechnology': [41, 104, 679, 750, 813, 1388, 1511], 'Center': [42, 44, 105, 107, 629, 680, 682, 751, 753, 814, 816, 1338, 1389, 1391, 1512, 1514, 1716], 'and': [43, 47, 78, 84, 106, 110, 217, 256, 279, 373, 431, 553, 568, 620, 656, 681, 685, 752, 756, 787, 793, 815, 819, 926, 965, 988, 1082, 1140, 1262, 1277, 1329, 1365, 1390, 1394, 1496, 1513, 1517, 1529, 1535, 1578, 1604, 1628, 1689, 1707, 1729, 1778, 1796, 1814, 1847, 1893, 1900, 1923, 1943, 1968, 2012, 2027, 2037, 2066, 2071, 2090, 2094, 2103, 2117, 2194, 2219, 2230, 2268, 2298, 2306, 2317, 2392, 2432, 2451, 2475, 2477, 2541, 2587, 2607, 2644, 2676, 2694, 2715, 2726, 2790, 2795, 2803, 2825, 2830, 2833, 2843, 2867, 2882, 2892, 2929, 2949, 2964, 2968, 2985, 2989, 3003, 3014, 3023, 3028, 3072, 3121, 3136, 3165, 3180, 3188, 3195, 3218, 3231, 3237, 3262, 3300, 3324, 3396, 3424, 3591, 3713, 3735, 3740, 3772, 3781, 3826, 3892, 3936, 3942, 3968, 4012, 4018, 4029, 4044, 4065, 4112, 4218], 'Molecular': [46, 109, 653, 684, 755, 818, 1362, 1393, 1516, 1726], 'Cellular': [48, 111, 686, 757, 820, 1395, 1518], 'Bioengineering,': [49, 112, 687, 758, 821, 1396, 1519], 'Technische': [50, 113, 688, 759, 822, 1397, 1520], 'Universität': [51, 114, 689, 760, 823, 1398, 1521], 'Dresden,': [52, 53, 115, 116, 658, 690, 691, 761, 762, 824, 825, 1367, 1399, 1400, 1522, 1523, 1731], 'Germany': [54, 117, 659, 692, 763, 826, 1368, 1401, 1524, 1732], 'Heng': [62, 64, 176, 178, 771, 773, 885, 887, 1439, 1448], 'Zhuang': [63, 65, 772, 774], 'Department': [74, 137, 180, 191, 218, 252, 280, 302, 427, 554, 565, 591, 614, 783, 846, 889, 900, 927, 961, 989, 1011, 1136, 1263, 1274, 1300, 1323, 1579, 1600], 'Cariology,': [76, 785, 1527], 'Endodontology': [77, 786, 1528], 'Operative': [79, 788, 1530], 'Dentistry,': [80, 789, 1531], 'Peking': [81, 790, 1532], 'School': [83, 140, 792, 849, 1534, 1544], 'Hospital': [85, 794, 1536], 'Stomatology,': [87, 142, 796, 851, 1538, 1546], 'Beijing,': [88, 146, 797, 855, 1539, 1550], 'China': [89, 147, 201, 798, 856, 910, 1540, 1551, 1573], 'Jana': [97, 99, 806, 808, 1441], 'Karbanová': [98, 100, 807, 809, 2554], 'Yan': [125, 127, 834, 836, 1443], 'Gao': [126, 128, 835, 837], 'Orthodontics,': [139, 848, 1543], 'Capital': [143, 852, 1547], 'Medical': [144, 196, 310, 452, 853, 905, 1019, 1161, 1548, 1568, 1620, 1649], 'University,': [145, 854, 1549], 'Jemma': [155, 158, 864, 867, 1445], 'Victoria': [156, 159, 865, 868, 1446], 'Walker': [157, 160, 866, 869], 'Jin': [177, 179, 886, 888], 'Internal': [182, 304, 593, 891, 1013, 1302, 1554, 1614], 'Medicine,': [183, 194, 305, 594, 892, 903, 1014, 1303, 1555, 1566, 1615], 'Iowa,': [186, 597, 895, 1306, 1558], 'Iowa': [187, 598, 896, 1307, 1559], 'City,': [188, 599, 897, 1308, 1560], 'IA,': [189, 600, 898, 1309, 1561], 'USA': [190, 228, 290, 314, 479, 515, 564, 579, 601, 899, 937, 999, 1023, 1188, 1224, 1273, 1288, 1310, 1562, 1589, 1624, 1663, 1685, 1700], 'Emergency': [193, 902, 1565], 'Tianjin': [195, 904, 1567], 'General': [198, 907, 1570], 'Hospital,': [199, 908, 1571], 'Tianjin,': [200, 909, 1572], 'Xiangnan': [209, 211, 918, 920, 1450], 'Wu': [210, 212, 919, 921], 'Program': [213, 275, 549, 922, 984, 1258], 'in': [214, 276, 550, 923, 985, 1259, 1575, 1869, 1906, 1935, 2056, 2068, 2080, 2097, 2264, 2287, 2331, 2379, 2443, 2447, 2519, 2546, 2580, 2601, 2656, 2687, 2708, 2716, 2885, 2900, 2938, 2999, 3091, 3192, 3448, 3469, 3521, 3535, 3583, 3631, 3695, 3706, 3765, 3851, 3888, 3958, 4038, 4109, 4209], 'Craniofacial': [215, 277, 372, 551, 924, 986, 1081, 1260, 1576, 1627], 'Biology': [216, 278, 495, 552, 655, 925, 987, 1204, 1261, 1364, 1577, 1665, 1728], 'Orofacial': [220, 282, 556, 929, 991, 1265, 1581], 'Sciences,': [221, 258, 283, 433, 473, 506, 557, 930, 967, 992, 1142, 1182, 1215, 1266, 1582, 1606, 1657, 1676], 'California,': [224, 286, 560, 575, 933, 995, 1269, 1284, 1585, 1696], 'San': [225, 287, 561, 576, 934, 996, 1270, 1285, 1586, 1697], 'Francisco,': [226, 288, 562, 577, 935, 997, 1271, 1286, 1587, 1698], 'CA,': [227, 289, 478, 563, 578, 936, 998, 1187, 1272, 1287, 1588, 1662, 1699], 'Clarissa': [236, 239, 945, 948, 1452], 'R': [237, 240, 946, 949, 1453], 'Coveney': [238, 241, 947, 950], 'Arthritis': [242, 417, 951, 1126], 'Research': [243, 418, 511, 952, 1127, 1220, 1591, 1681], 'Centre': [245, 370, 420, 954, 1079, 1129, 1593], 'Osteoarthritis': [247, 422, 956, 1131, 1595], 'Pathogenesis,': [248, 423, 957, 1132, 1596], 'Kennedy': [249, 424, 958, 1133, 1597], 'Institute,': [250, 425, 476, 959, 1134, 1185, 1598, 1660, 1739], 'Nuffield': [251, 426, 960, 1135, 1599], 'Orthopaedics,': [254, 429, 963, 1138, 1602], 'Rheumatology,': [255, 430, 964, 1139, 1603], 'Musculoskeletal': [257, 432, 966, 1141, 1605], 'Oxford,': [261, 262, 436, 437, 970, 971, 1145, 1146, 1609, 1610], 'Pauline': [271, 273, 980, 982, 1455], 'Marangoni': [272, 274, 981, 983], 'Dongmei': [298, 300, 1007, 1009, 1457], 'Lu': [299, 301, 1008, 1010], 'Texas': [308, 1017, 1618], 'Southwestern': [309, 1018, 1619], 'Center,': [311, 1020, 1621], 'Dallas,': [312, 1021, 1622], 'TX,': [313, 1022, 1623], 'Portia': [322, 326, 1031, 1035, 1459], 'Rebecca': [323, 327, 1032, 1036, 1460], 'Clare': [324, 328, 1033, 1037, 1461], 'Grayson': [325, 329, 1034, 1038], 'Tulay': [345, 347, 1054, 1056, 1463], 'Gulsen': [346, 348, 1055, 1057], 'Karen': [364, 367, 1073, 1076, 1465], 'J': [365, 368, 1074, 1077, 1466], 'Liu': [366, 369, 1075, 1078], 'Regenerative': [374, 1083, 1629], 'Biology,': [375, 632, 1084, 1341, 1630, 1719], "King's": [376, 1085, 1631], 'College': [377, 1086, 1632, 1736], 'London,': [378, 379, 1087, 1088, 1633, 1634, 1740], 'Stefano': [388, 390, 1097, 1099, 1468], 'Ardu': [389, 391, 1098, 1100], 'Division': [392, 497, 1101, 1206, 1667], 'Cariology': [394, 1103, 1638], '&': [395, 1104, 1639, 1809, 2131, 2135, 2205, 2227, 2255, 2367, 3406], 'Endodontology,': [396, 1105, 1640], 'Geneva,': [401, 402, 1110, 1111, 1645, 1646], 'Switzerland': [403, 1112, 1647], 'Angus': [411, 414, 1120, 1123, 1470], 'KT': [412, 415, 1121, 1124, 1471], 'Wann': [413, 416, 1122, 1125], 'Shouqing': [446, 448, 1155, 1157, 1473], 'Luo': [447, 449, 1156, 1158], 'orcid.org/0000-0002-7998-3059': [450, 1159], 'Alexander': [466, 469, 1175, 1178, 1475], 'C': [467, 470, 1176, 1179, 1476], 'Zambon': [468, 471, 1177, 1180], 'Biopharmaceutical': [472, 1181], 'Keck': [474, 1183, 1658], 'Graduate': [475, 1184, 1659], 'Claremont,': [477, 1186, 1661], 'Anton': [487, 490, 1196, 1199, 1478], 'M': [488, 491, 1197, 1200, 1479], 'Jetten': [489, 492, 1198, 1201], 'orcid.org/0000-0003-0954-4445': [493, 1202], 'Cell': [494, 654, 1203, 1363, 1727], 'Section,': [496, 1205, 1666], 'Intramural': [499, 1208, 1669], 'Research,': [500, 1209, 1670], 'National': [501, 507, 1210, 1216, 1671, 1677], 'Institute': [502, 569, 651, 1211, 1278, 1360, 1672, 1690, 1724], 'Environmental': [504, 1213, 1674], 'Health': [505, 1214, 1675], 'Institutes': [508, 1217, 1678], 'Health,': [510, 1219, 1680], 'Triangle': [512, 1221, 1682], 'Park,': [513, 1222, 1683], 'NC,': [514, 1223, 1684], 'Christopher': [523, 525, 1232, 1234, 1481], 'Tredwin': [524, 526, 1233, 1235], 'Ophir': [542, 545, 1251, 1254, 1483], 'D': [543, 546, 1252, 1255, 1484], 'Klein': [544, 547, 1253, 1256], 'orcid.org/0000-0002-6254-7082': [548, 1257], 'Pediatrics': [567, 1276, 1688], 'Human': [571, 1280, 1692], 'Genetics,': [572, 657, 1281, 1366, 1693, 1730], 'Massimo': [587, 589, 1296, 1298, 1486], 'Attanasio': [588, 590, 1297, 1299], 'Peter': [609, 611, 1318, 1320, 1488], 'Carmeliet': [610, 612, 1319, 1321], 'orcid.org/0000-0001-7961-1821': [613, 1322], 'Oncology,': [616, 1325, 1703], 'Laboratory': [617, 1326, 1704], 'Angiogenesis': [619, 1328, 1706], 'Vascular': [621, 1330, 1708], 'Metabolism,': [622, 1331, 1709], 'KU': [623, 1332, 1710], 'Leuven,': [624, 625, 633, 1333, 1334, 1342, 1711, 1712, 1720], 'Belgium': [626, 634, 1335, 1343, 1713, 1721], 'VIB-KU': [627, 1336], 'Leuven': [628, 1337, 1715], 'Cancer': [631, 1340, 1718, 1738], 'Wieland': [642, 645, 1351, 1354, 1490], 'B': [643, 646, 1352, 1355, 1491], 'Huttner': [644, 647, 1353, 1356], 'orcid.org/0000-0003-4143-7201': [648, 1357], 'Max': [649, 1358], 'Planck': [650, 1359, 1723], 'Denis': [667, 671, 1376, 1380, 1493], 'Corbeil': [668, 672, 1377, 1381, 1494], 'Corresponding': [669, 702, 1378, 1411], 'Author': [670, 703, 1379, 1412, 1433], '[email': [673, 706, 1382, 1415, 1757, 1767], 'protected]': [674, 707, 1383, 1416, 1758, 1768], 'orcid.org/0000-0003-1181-3659': [675, 1384], 'Bing': [700, 704, 1409, 1413, 1497], 'Hu': [701, 705, 1410, 1414, 1498], 'orcid.org/0000-0001-5085-3114': [708, 1417], 'Information': [1434], 'Singer1,‡,': [1436], 'Thamm2,‡,': [1438], 'Zhuang1,3,‡,': [1440], 'Karbanová2,': [1442], 'Gao1,4,': [1444], 'Walker1,': [1447], 'Jin5,6,': [1449], 'Wu7,': [1451], 'Coveney8,': [1454], 'Marangoni7,': [1456], 'Lu9,': [1458], 'Grayson1,': [1462], 'Gulsen1,19,': [1464], 'Liu10,': [1467], 'Ardu11,': [1469], 'Wann8,': [1472], 'Luo12,': [1474], 'Zambon13,': [1477], 'Jetten14,': [1480], 'Tredwin1,': [1482], 'Klein7,15,': [1485], 'Attanasio5,': [1487], 'Carmeliet16,17,': [1489], 'Huttner18,': [1492], '*,2': [1495], '*,1': [1499], '1Peninsula': [1500], '2Tissue': [1508], '3Department': [1525], '4Department': [1541], '5Department': [1552], '6Department': [1563], '7Program': [1574], '8Arthritis': [1590], '9Department': [1612], '10Centre': [1625], '11Division': [1636], '12Peninsula': [1648], '13Biopharmaceutical': [1656], '14Cell': [1664], '15Department': [1686], '16Department': [1701], '17VIB-KU': [1714], '18Max': [1722], '19Present': [1733], 'address:': [1734], 'London': [1737], '‡These': [1742], 'authors': [1743], 'contributed': [1744], 'equally': [1745], 'to': [1746, 1799, 1802, 1959, 1989, 2099, 2119, 2237, 2239, 2281, 2384, 2473, 2846, 2879, 2924, 2933, 2978, 3362, 3383, 3432, 3604, 3617, 3619, 3645, 3651, 3732, 3948, 4126, 4131, 4148, 4160], 'work': [1748], '*Corresponding': [1749, 1759], 'author.': [1750, 1760], 'Tel:': [1751, 1761], '+49': [1752], '351': [1753], '463': [1754], '40118;': [1755], 'E-mail:': [1756, 1766], '+44': [1762], '1752': [1763], '437': [1764], '804;': [1765], 'The': [1769, 1826, 1916, 1996, 2740, 2767, 3061, 3568, 3622, 3776, 3924, 3972, 4215], 'EMBO': [1770], 'Journal': [1771], '(2019)38:e99845https://doi.org/10.15252/embj.201899845': [1772], 'PDFDownload': [1773], 'PDF': [1774], 'article': [1776], 'text': [1777], 'main': [1779], 'figures.': [1780], 'Peer': [1781], 'ReviewDownload': [1782], 'a': [1783, 1841, 1862, 1877, 1950, 1979, 2342, 2349, 2376, 2516, 2577, 2683, 2735, 2748, 2854, 2970, 3034, 3146, 3352, 3549, 3648, 3785, 4035], 'summary': [1784], 'the': [1786, 1830, 1873, 1910, 1925, 1936, 1972, 1992, 2048, 2162, 2198, 2303, 2309, 2355, 2359, 2386, 2399, 2507, 2581, 2590, 2611, 2624, 2636, 2710, 2761, 2847, 2874, 2896, 2901, 2907, 2912, 2934, 2945, 2957, 2979, 3000, 3018, 3140, 3162, 3245, 3256, 3273, 3295, 3355, 3370, 3416, 3437, 3470, 3495, 3514, 3522, 3524, 3531, 3536, 3538, 3553, 3584, 3632, 3658, 3663, 3686, 3707, 3718, 3728, 3766, 3791, 3815, 3819, 3846, 3866, 3882, 3913, 3980, 3985, 4000, 4039, 4062, 4099, 4119, 4145, 4191, 4204], 'editorial': [1787, 1791], 'decision': [1788, 1792], 'including': [1790], 'letters,': [1793], 'reviewer': [1794], 'comments': [1795], 'responses': [1798], 'feedback.': [1800], 'ToolsAdd': [1801], 'favoritesDownload': [1803], 'CitationsTrack': [1804], 'CitationsPermissions': [1805], 'ShareFacebookTwitterLinked': [1806], 'InMendeleyWechatReddit': [1807], 'Figures': [1808], 'Info': [1810], 'Abstract': [1811], 'Proper': [1812], 'temporal': [1813, 2881], 'spatial': [1815, 2883], 'cells': [1819, 1871, 1958, 2036, 2039, 2070, 2184, 2199, 2297, 2301, 2347, 2353, 2446, 2455, 2470, 2690, 2733, 2763, 2800, 2840, 2863, 2870, 2960, 2974, 2982, 3002, 3006, 3070, 3075, 3164, 3168, 3451, 3454, 3573, 3586, 3602, 3701, 3710, 3722, 3769, 3916, 3921, 3961], 'relies': [1820], 'on': [1821, 2022, 2112, 2273, 2320, 2410, 2610, 2906, 3017, 3033, 3065, 3077, 3101, 3145, 3170, 3184, 3241, 3272, 3291, 3530, 3563, 3912, 4061, 4185, 4222], 'highly': [1822, 3528], 'coordinated': [1823, 3402], 'signaling.': [1825], 'primary': [1827, 1985, 2043, 2083, 2187, 2215, 2235, 2261, 2314, 2390, 2404, 2433, 2711, 2737, 2897, 2908, 2966, 3143, 3356, 3466, 3615, 3659, 3696, 3729, 3760, 3787, 3805, 3929, 3949, 4005, 4042, 4107, 4127, 4142], 'cilium': [1828, 1844, 2216, 2236, 2262, 2315, 2405, 2712, 2738, 2898, 2909, 2927, 2947, 3357, 3393, 3397, 3419, 3430, 3467, 3581, 3596, 3788, 3806, 3858, 4128, 4143], 'is': [1829, 1834, 1903, 1949, 2004, 2059, 2211, 2424, 2440, 2755, 3150, 3413, 3540, 3625, 3670, 3818, 3938, 4077, 4123], 'sensory': [1831], 'organelle': [1832], 'that': [1833, 1866, 1947, 2121, 2189, 2243, 2374, 2703, 2719, 2754, 2864, 2956, 3690, 3753, 3848, 3931, 4118], 'responsible': [1835, 2191, 2245], 'transmitting': [1837, 2195], 'extracellular': [1838, 1960, 2597, 3867, 4058, 4173], 'signals': [1839, 2196], 'into': [1840, 2197, 2398, 3657, 3724, 3759], 'cell.': [1842], 'Primary': [1843, 3392], 'size,': [1845, 2217], 'architecture,': [1846, 2218], 'assembly–disassembly': [1848, 2220, 3395], 'are': [1850, 1987, 2029, 2190, 2244, 2382, 2471, 2620, 2654, 2697, 2720, 3090, 3117, 3214, 3320, 3400, 3932, 4198], 'under': [1851], 'rigid': [1852], 'cycle-dependent': [1854], 'control.': [1855], 'Using': [1856, 1971, 3860], 'mouse': [1857, 1975, 2339, 2741, 3247, 3297, 3305], 'incisor': [1858, 1976, 2032, 2340, 2730, 2742, 2782, 3633, 4040, 4072], 'tooth': [1859, 1977, 2033, 2360], 'epithelia': [1860], 'as': [1861, 1978, 2146, 2341, 2421, 2646, 2682, 2820, 3119, 3216, 3307, 3322, 3351, 3436, 3599, 3954], 'model,': [1863], 'we': [1864, 2335, 2381, 2408, 2851, 2903, 2954, 3472, 3511, 3547, 3688, 3875, 3955, 3996], 'show': [1865, 2702], 'require': [1872], 'proper': [1874, 2113], 'functions': [1875, 3468], 'cholesterol-binding': [1878], 'membrane': [1879, 1889, 2565, 2585, 2598, 2625, 2643, 3398], 'glycoprotein,': [1880, 2566], '(Prom1/CD133),': [1882], 'which': [1883, 2380, 2423], 'sequential': [1885, 2007], 'recruitment': [1886, 2008, 3778], 'components,': [1890], 'histone': [1891, 3342, 3754], 'deacetylase,': [1892], 'transcription': [1894], 'factors.': [1895], 'Nuclear': [1896], 'translocation': [1897, 2718], 'Prom1': [1899, 1919, 1948, 2058, 2075, 2439, 2478, 2520, 2529, 2614, 2678, 2704, 3799, 3835, 3849, 3879, 3905, 3927, 3951, 3975, 3981, 4001, 4015, 4033, 4051, 4102, 4122, 4138, 4167, 4194, 4207, 4210, 4224], 'these': [1901], 'molecules': [1902, 3434, 3597], 'particularly': [1904, 3763], 'evident': [1905, 3764, 3939], 'transit': [1907, 2299, 2750, 2798, 2838, 2848, 2980, 3004, 3024, 3052, 3073, 3166, 3196, 3363, 3384, 3708, 3725, 3767, 3901, 3914, 4066, 4090, 4113, 4149, 4186], 'amplifying': [1908, 2300, 2751, 2799, 2839, 2849, 2981, 3005, 3025, 3053, 3074, 3167, 3197, 3364, 3385, 3709, 3726, 3768, 3794, 3885, 3902, 3915, 4067, 4091, 4114, 4150, 4187], 'cells,': [1909, 2073, 2794, 2829, 2850, 3533, 3727], 'immediate': [1911], 'derivatives': [1912], 'cells.': [1915, 2275, 2394], 'absence': [1917], 'impairs': [1920, 2082], 'abolishes': [1924], 'growth': [1926], 'stimulation': [1927], 'effects': [1928], 'sonic': [1930, 2015], 'hedgehog': [1931, 2016], '(SHH)': [1932, 2017, 2836], 'treatment,': [1933], 'resulting': [1934], 'disruption': [1937], 'quiescence': [1941], 'maintenance': [1942, 2116, 3827], 'activation.': [1944, 3592], 'We': [1945, 2700, 3751], 'propose': [1946], 'key': [1951, 2412, 3417, 3627], 'regulator': [1952], 'ensuring': [1953], 'appropriate': [1954], 'response': [1955, 3644], 'signals,': [1961], 'with': [1962, 2014, 2062, 2427, 2531, 2594, 2641, 2661, 2944, 3030, 3152, 3348, 3376, 3422, 3485, 3614, 3699, 3802, 3919, 3928, 3934, 4079, 4104, 4140, 4200], 'important': [1963], 'implications': [1964], 'development,': [1966], 'regeneration,': [1967], 'diseases.': [1969], 'Synopsis': [1970], 'continuously': [1973, 2337], 'growing': [1974, 2338], 'model': [1980, 2292, 2343], 'activation,': [1984], 'cilia': [1986, 2044, 2084, 2188, 2391, 2967, 3177, 3203, 3616, 3697, 3730, 3761, 3930, 4043, 4108], 'shown': [1988], 'function': [1990], 'at': [1991, 2302, 2354, 2776, 3804, 4074, 4144], 'onset': [1993], 'differentiation.': [1995, 2092], 'surface': [1999, 3910], 'marker': [2000, 2415, 3353], 'prominin-1': [2001], '(Prom1,': [2002, 2418], 'CD133)': [2003], 'required': [2005, 3676], 'components': [2011, 2064, 3420], 'coordination': [2013], 'signalling,': [2018], 'shedding': [2019], 'new': [2020], 'light': [2021], 'how': [2023, 2677, 3465], 'state': [2026], 'differentiation': [2028, 2249], 'balanced.': [2030], 'Mouse': [2031, 2729], 'epithelial': [2034, 2345, 2731, 3960], 'transit-amplifying': [2038, 2072], 'display': [2040], 'distinct,': [2041], 'dynamic': [2042, 2214, 2377, 2736, 2948, 3786, 4036], 'biogenesis.': [2045], 'Deletion': [2046, 3445], 'component': [2050], 'IFT88': [2051, 3226, 3447, 3476, 3816], 'disrupts': [2052], 'vivo.': [2057], 'differentially': [2060, 3800], 'co-expressed': [2061], 'Arl13b': [2065, 3373, 3691, 3780, 3803, 3937], 'Hdac6': [2067, 3375, 3782], 'respectively.': [2074], 'knockout': [2076], 'or': [2077, 2157, 2170, 2481, 2567, 2634, 2663, 2807, 3341, 3374, 3452, 3653, 3869, 4178], 'Lys138': [2078], 'mutation': [2079, 3817], 'mice': [2081, 2522, 3480, 3489, 3983], 'biogenesis,': [2085], 'quiescent': [2086], 'proliferation,': [2089], 'lineage': [2091, 2248], 'GLIS2': [2093], 'PROM1': [2095, 2498], 'cooperate': [2096], 'nuclei': [2098, 4045], 'regulate': [2100], 'SHH': [2101, 3438, 3623, 3646, 3679], 'signaling': [2102, 2591, 3611, 3630, 3680], 'its': [2104, 2318, 3292, 3703, 4172], 'downstream': [2105, 2241], 'target': [2106], 'STAT3.': [2107], 'Introduction': [2108], 'homeostasis': [2110], 'depends': [2111], 'guarantee': [2120], 'balanced': [2122], 'lineages': [2124], 'can': [2125, 2141, 2159, 2679], 'be': [2126, 2680, 2772, 3733], 'produced': [2127], 'upon': [2128, 2635, 2808, 3265], 'necessity': [2129], '(Li': [2130], 'Clevers,': [2132], '2010;': [2133, 3638], 'Cheung': [2134], 'Rando,': [2136], '2013).': [2137, 2459], 'Stem': [2138, 2208], 'hypoactivation': [2140], 'have': [2142, 2325, 2484, 2734], 'severe': [2143, 3456], 'consequence': [2144], 'such': [2145, 2819, 3435, 3598], 'regeneration': [2147], 'failure': [2148, 3820], '(Chen': [2149], 'et': [2150, 2167, 2174, 2178, 2201, 2223, 2251, 2371, 2436, 2457, 2491, 2495, 2513, 2524, 2535, 2551, 2555, 2559, 2574, 2616, 2631, 2649, 2668, 2672, 3442, 3460, 3482, 3491, 3636, 3640, 3682, 3744, 3748, 3829, 3842, 3963], 'al,': [2151, 2168, 2175, 2179, 2202, 2224, 2252, 2372, 2437, 2458, 2492, 2496, 2514, 2525, 2536, 2552, 2556, 2560, 2575, 2617, 2632, 2650, 2669, 2673, 3443, 3461, 3483, 3492, 3637, 3641, 3683, 3745, 3749, 3830, 3843, 3964], '2012),': [2152], 'while': [2153, 2538, 3534, 3702], 'hyperactivation': [2156], 'aging': [2158], 'either': [2160, 2622, 3865, 4171], 'exhaust': [2161], 'pool': [2165, 2753], '(Flach': [2166], '2014)': [2169], 'initiate': [2171], 'oncogenesis': [2172], '(Reya': [2173], '2001;': [2176], 'Plaks': [2177], '2015).': [2180], 'At': [2181], 'quiescence,': [2182], 'produce': [2185], 'long': [2186], 'sensing': [2193], '(Izawa': [2200, 2222], '2015;': [2203, 2225], 'Sanchez': [2204, 2226], 'Dynlacht,': [2206, 2228, 3407], '2016).': [2207, 3408, 3684], 'accompanied': [2212], 'modifications': [2221], '2016)': [2229], 'release': [2231], 'factors': [2233], 'from': [2234, 2627, 2760, 3504], 'cytoplasm': [2238], 'trigger': [2240], 'cascades': [2242], '(Berbari': [2250], '2009;': [2253], 'Goetz': [2254], 'Anderson,': [2256], '2010).': [2257], 'Most': [2258], 'evidence': [2259], 'participation': [2263], 'renewal': [2269, 3590], 'has': [2270, 2278, 2705, 2747, 2995, 4034], 'been': [2271, 2279, 2327], 'based': [2272, 2609, 3169, 3183, 3290, 3562], 'cultured': [2274], 'Historically': [2276], 'it': [2277], 'difficult': [2280], 'investigate': [2282, 3464], 'vivo': [2288, 2939], 'since': [2289], 'very': [2290], 'few': [2291], 'systems': [2293, 2549], 'possess': [2294], 'enriched': [2295], 'same': [2304, 3274], 'time': [2305], 'location.': [2307], 'Therefore,': [2308], 'molecular': [2310, 2401, 2684, 2713, 3608], 'mechanisms': [2311], 'assembly': [2316, 3825], 'impact': [2319], 'fate': [2323, 3854], 'determination': [2324, 3855], 'not': [2326, 4124], 'fully': [2328], 'understood': [2329], 'yet': [2330], 'tissue/organ': [2332], 'level.': [2333], 'Here,': [2334], 'use': [2336], 'where': [2344, 3516, 3984, 4014], 'represent': [2348], 'large': [2350], 'proportion': [2351], 'distal': [2356], 'end': [2357, 3872, 4181], 'epithelium': [2361, 2745], 'named': [2362], 'cervical': [2363, 2743], 'loop': [2364, 2744, 4059, 4174], '(CL)': [2365], '(Jussila': [2366], 'Thesleff,': [2368], '2012;': [2369], 'Biehs': [2370], '2013)': [2373], 'provides': [2375], 'system': [2378, 2876], 'able': [2383], 'profile': [2385], 'functional': [2387], 'associations': [2388], 'between': [2389, 3190, 3304], 'To': [2395, 2894, 3463], 'gain': [2396], 'insight': [2397], 'precise': [2400], 'cues': [2402], 'elements': [2406, 3656], 'recruitment,': [2407], 'focus': [2409], 'one': [2411, 3414, 3626, 4141], 'called': [2416], 'also': [2419, 2853, 4130], 'known': [2420], 'CD133),': [2422], 'specifically': [2425, 3675], 'associated': [2426, 2593, 3613, 3698], 'plasmalemmal': [2428, 2628], 'protrusions': [2429, 2629], '(e.g.,': [2430], 'microvilli': [2431, 3953], 'cilium)': [2434], '(Corbeil': [2435], '2001).': [2438], 'widely': [2441], 'used': [2442, 2681], 'identifying': [2444], 'various': [2448, 2501, 2547, 2602], 'somatic': [2449], 'tissues': [2450], 'initiating': [2452], 'cancer': [2453, 2468], '(Grosse-Gehling': [2456], 'In': [2460, 2527, 3643, 3685, 3946], 'cancer,': [2461], 'numerous': [2462], 'lines': [2463], 'evidences': [2465], 'suggest': [2466], 'Prom1high': [2467], 'resistant': [2472], 'radio-': [2474], 'chemo-therapies': [2476], 'neutralizing': [2479], 'antibodies': [2480, 2918, 3863, 3976, 4002, 4169], 'targeted': [2482], 'toxin': [2483], 'anti-tumor': [2485], 'activity': [2486], 'through': [2487, 3737, 3856], 'unclear': [2488], 'mechanism': [2489], '(Damek-Poprawa': [2490], '2011;': [2493], 'Waldron': [2494], '2011).': [2497, 2651, 3750], 'mutations': [2499], 'cause': [2500, 3837], 'human': [2502], 'retinal': [2503], 'disorders': [2504], 'disrupting': [2506, 3580], 'cilium-derived': [2508], 'photoreceptor': [2509, 3822, 3839], 'outer': [2510, 3823], 'segment': [2511, 3824], '(Fargeas': [2512, 2573], '2015),': [2515], 'phenomenon': [2517], 'phenocopied': [2518], 'null': [2521], '(Zacchigna': [2523, 3841], '2009).': [2526], 'photoreceptors,': [2528], 'interacts': [2530], 'protocadherin': [2532], '21': [2533, 3507], '(Yang': [2534], '2008),': [2537], 'other': [2539, 2568, 3959], 'lipid': [2540], 'protein': [2542, 3336, 4219], 'interactors': [2543], 'were': [2544, 2605, 2931, 3204, 4229], 'identified': [2545, 2606, 2852], 'biological': [2548, 2685], '(Röper': [2550], '2000;': [2553], '2008;': [2557, 2670], 'Mak': [2558], '2012)': [2561], 'making': [2562], 'pentaspan': [2564], 'members': [2569, 3440], 'prominin': [2571], 'family': [2572], '2003),': [2576], 'potential': [2578], 'mechanoprotein': [2579], 'organization': [2582], 'plasma': [2584, 2642], 'protrusion,': [2586], 'hence': [2588], 'influencing': [2589], 'pathways': [2592], 'them.': [2595], 'Furthermore,': [2596], 'vesicles': [2599, 2653], 'found': [2600, 3689], 'body': [2603], 'fluids': [2604], 'immunoisolated': [2608], 'presence': [2612], '(Marzesco': [2615], '2005).': [2618], 'They': [2619], 'released': [2621], 'budding': [2626], '(Dubreuil': [2630], '2007)': [2633, 3484], 'fusion': [2637], 'multivesicular': [2639], 'bodies': [2640], 'discharged': [2645], 'exosomes': [2647], '(Bauer': [2648], 'Prom1+': [2652], 'upregulated': [2655], 'cerebrospinal': [2657], 'fluid': [2658], 'patients': [2660], 'gliomas': [2662], 'degenerative': [2664], 'neurological': [2665], 'disease': [2666], '(Huttner': [2667], 'Bobinger': [2671], '2017).': [2674, 3462], 'If': [2675], 'tool': [2686], 'regulating': [2688, 3610], 'regenerative': [2692], 'medicine': [2693], 'anti-cancer': [2695], 'therapies': [2696], 'still': [2698], 'uncertain.': [2699], 'now': [2701], 'essential': [2706], 'roles': [2707], 'recruiting': [2709], 'compartments': [2714], 'nuclear': [2717], 'critical': [2721], 'homeostasis.': [2727], 'Results': [2728], 'biogenesis': [2739, 3431, 3789], '(CLE)': [2746], 'significant': [2749, 3257, 3550], 'adjacent,': [2756], 'but': [2757, 4129], 'molecularly': [2758], 'distinct': [2759, 2996, 3862], '(Appendix': [2764, 2940, 3543, 4007], 'Fig': [2765, 2805, 2941, 3281, 3544, 3715, 3774, 3894, 3944, 3966, 3970, 4008, 4027], 'S1A).': [2766], 'two': [2768, 3861], 'populations': [2770], 'could': [2771, 3997], 'distinguished': [2773], 'instance,': [2775], 'postnatal': [2777, 3505], 'day': [2778, 3506], '7': [2779], '(P7)': [2780], 'lower': [2781, 4071], 'CLE': [2783, 2875, 2994, 3020, 3080, 3242, 3889, 4041, 4073], 'immunofluorescence': [2785], '(IF)': [2786], 'using': [2787, 2817, 2914, 3084, 3103, 3210, 3313, 3559, 3979, 4003, 4052, 4168], 'markers': [2788, 2818, 3067], 'Sox2': [2789, 3012, 3235, 3261], 'Bmi1': [2791], 'Ki67': [2796, 3015, 3238, 3263], '(Fig': [2801, 2841, 2871, 2983, 3509, 3566, 3577, 3711, 3770, 3797, 3890, 3922, 3940, 3991], '1A': [2802], 'Appendix': [2804, 2986, 3280, 3714, 3773, 3893, 3943, 3969], 'S1B)': [2806], 'laser': [2809], 'capture': [2810], 'microdissection': [2811], 'followed': [2812, 2919, 3081, 3106], 'real-time': [2814, 3085], 'RT–PCR': [2815, 3086], 'profiling': [2816, 3064, 4221], 'Sox2,': [2821], 'Bmi1,': [2822], 'CDKn1c,': [2823], 'CDKn2b,': [2824], 'p16': [2826], 'CDK5r1,': [2831], 'c-Myc,': [2832], 'Sonic': [2834], 'Hedgehog': [2835], '1B': [2842], 'C).': [2844], 'Neighboring': [2845], 'zone': [2857, 3557], 'harboring': [2858], 'scattered': [2859], 'clusters': [2860], 'Ki67-positive': [2862], 'represented': [2865, 3784], 'activated': [2866, 3499], 'self-renewing': [2868], '1A).': [2872], 'Hence,': [2873, 3579], 'enabled': [2877], 'us': [2878], 'monitor': [2880], 'changes': [2884], 'during': [2888, 3429, 3807], 'self-renewal.': [2893], 'validate': [2895, 3999], 'profiles': [2899], 'CLE,': [2902, 3523, 3687], 'performed': [2904, 3100, 3209, 3312], 'immunostaining': [2905, 3240], 'axoneme': [2910, 3394], '(or': [2911], 'core)': [2913], 'anti-acetylated': [2915], 'α-tubulin': [2916], '(AcTub)': [2917], 'three-dimensional': [2921], '(3D)': [2922], 'measurements': [2923], 'determine': [2925], 'whether': [2926], 'size': [2928], 'integrity': [2930], 'linked': [2932], 'status': [2937], 'S1C).': [2942], 'Consistent': [2943], 'conventional': [2946], 'cycle': [2951], 'linkage': [2952], 'concept,': [2953], 'confirmed': [2955], 'CLE-associated': [2958], '(CLESCs)': [2961], 'had': [2962, 3906], 'longer': [2963], 'larger': [2965], 'possessed': [2969], 'higher': [2971], 'number': [2972], 'retaining': [2975], 'them': [2976], 'comparing': [2977], '1D–G': [2984], 'Figs': [2987], 'S1D': [2988], 'E).': [2990], 'Figure': [2991, 4031], '1.': [2992], 'Incisor': [2993], 'A.': [3007, 4046], 'Representative': [3008, 3125, 3329, 4047, 4163], 'IF': [3009, 3126, 3330, 4048, 4164], 'staining': [3010, 3128, 3271, 3332, 4049, 4165], '(green)': [3013, 3236, 3350, 4060, 4103], '(red)': [3016, 3239, 4106], 'P7': [3019, 3078], 'regions': [3027, 3243, 3289, 3515, 4069, 4189], 'counterstained': [3029, 3151, 4078, 4199], 'DAPI': [3031, 3153, 4080, 4201], '(blue)': [3032], 'sagittal': [3035, 3147], 'section.': [3036, 3148], 'Dotted': [3037, 3251, 4082], 'lines,': [3038, 3252, 4083], 'basement': [3039, 3253, 4084], 'membrane;': [3040], 'yellow': [3041], 'arrowheads': [3042], 'mark': [3043], 'approximate': [3044], 'boundaries.': [3047], 'SCs,': [3048, 4086], 'cells;': [3050, 3054, 4088, 4092], 'TACs,': [3051, 4089], 'Ant,': [3055], 'anterior;': [3056], 'Post,': [3057], 'posterior.': [3058], 'B,': [3059], 'C.': [3060, 4133], 'mRNA': [3062, 4216], 'expression': [3063, 3526, 3539, 3704, 3880, 3911, 4016, 4037, 4120], 'specific': [3066, 3607, 4053], '(B)': [3071], 'captured': [3076], 'incisors': [3079], 'analysis': [3083], '(C).': [3087], 'qRT–PCR': [3088], 'results': [3089], 'arbitrary': [3092], 'values': [3093], 'after': [3094], 'normalization': [3095], 'GapDH.': [3097], 'Statistics': [3098, 3207, 3310], 'was': [3099, 3208, 3311, 3498, 3518, 3527, 3574, 3692, 3762, 3977, 3988, 4020, 4157], 'triplicates': [3102], 'one-way': [3104, 3211], 'ANOVA': [3105], "Bonferroni's": [3108], 'test.': [3109], '*P': [3110], '<': [3111, 3114, 3222, 3317], '0.05;': [3112], '**P': [3113, 3221, 3316], '0.01.': [3115, 3223, 3318], 'Data': [3116, 3213, 3319], 'presented': [3118, 3215, 3321], 'mean': [3120, 3217, 3323], 'standard': [3122, 3219, 3325], 'deviation.': [3123, 3220, 3326], 'D.': [3124, 4162], 'double': [3127, 3331], 'E-cadherin': [3130], '(ECad,': [3131], 'green,': [3132], 'border)': [3135], 'AcTub': [3137, 3171, 3349, 3377, 3935], '(red,': [3138], 'cores': [3141, 3160], 'cilia)': [3144], 'Sample': [3149, 4076], '(blue).': [3154, 4081, 4202], 'E.': [3155], '3D': [3156, 3185, 3285, 3560, 4096], 'reconstructions': [3157], 'immunostaining.': [3172], 'F,': [3173], 'G.': [3174], 'Quantification': [3175], 'length': [3178], '(F)': [3179, 4220], 'volume': [3181, 3302, 3558], '(G)': [3182], 'reconstruction': [3186, 3286, 3561, 4097], '(E)': [3187, 4217], 'comparison': [3189, 3303, 3918], 'those': [3191], 'regions.': [3199, 4116], 'Numbers': [3200], 'quantified': [3202], 'indicated': [3205, 3246, 3296, 3308], '(n).': [3206], 'ANOVA.': [3212], 'H.': [3224], 'Tamoxifen-induced': [3225], 'deletion': [3227, 3266], 'strategy': [3228], '(top': [3229], 'panel)': [3230], 'representative': [3232, 4135], 'images': [3233], 'strains': [3248, 3298, 3306], '(bottom': [3249], 'panels).': [3250], 'membrane.': [3254, 4085], 'Note': [3255, 4117, 4203], 'reduction': [3258, 3551], 'both': [3260], 'immunolabeling': [3264, 3293, 3371, 3565], 'IFT88.': [3268], 'For': [3269], 'Cre': [3270, 3496, 3517, 3525], 'set': [3275, 4158], 'samples,': [3277], 'please': [3278], 'see': [3279, 3993, 4010], 'S1F.': [3282], 'I,': [3283], 'J.': [3284], 'Sox2-positive': [3288, 3564], '(I)': [3299], 'their': [3301], '(J).': [3309], "Student's": [3314], 't-test:': [3315], 'K,': [3327], 'L.': [3328], 'ADP-ribosylation': [3334, 3664], 'factor-like': [3335, 3665], '13B': [3337, 3666], '(Arl13b,': [3338], 'red,': [3339, 3346], 'K)': [3340], 'deacetylase': [3343, 3755], '6': [3344, 3756], '(Hdac6,': [3345], 'L)': [3347, 3379], 'core': [3358], 'following': [3359], 'transition.': [3366, 3387], 'M.': [3367], 'Summary': [3368], '(K,': [3378], 'along': [3380, 3426, 3790, 3881], 'Download': [3388, 3390], 'figure': [3389], 'PowerPoint': [3391], 'formation': [3399], 'closely': [3401], 'cellular': [3403], 'events': [3404], '(Sanchez': [3405], 'Intraflagellar': [3409], 'Transport': [3410], '88': [3411], '(IFT88)': [3412], 'intrinsic': [3418, 3595], 'associating': [3421], 'centrosomes': [3423], 'moving': [3425], 'microtubules': [3428], 'transport': [3433], 'pathway': [3439, 3624], '(Pazour': [3441, 3828], '2002).': [3444, 3831], 'neural': [3449], 'crest-derived': [3450], 'mesenchymal': [3453], 'causes': [3455], 'craniofacial': [3457], 'deformities': [3458], '(Tian': [3459], 'CLESCs,': [3471], 'therefore': [3473, 3783], 'temporally': [3474], 'deleted': [3475], 'crossing': [3478], 'IFT88flox/flox': [3479], '(Haycraft': [3481], 'tamoxifen-inducible': [3486], 'Rosa26CreER': [3487], 'transgenic': [3488], '(Badea': [3490], '2003).': [3493], 'After': [3494], 'recombinase': [3497], '10': [3501], 'days': [3502], 'starting': [3503], '(P21)': [3508], '1H),': [3510], 'first': [3512], 'analyzed': [3513], 'expressed.': [3519], 'Interestingly': [3520], 'focused': [3529], 'mesenchyme,': [3537], 'homogenous': [3542], 'S1F).': [3545], 'Next,': [3546], 'observed': [3548, 3752], 'total': [3554], '1H–J).': [3567], 'amount': [3569], 'proliferating': [3571], 'Ki67+': [3572], 'considerably': [3575], 'reduced': [3576], '1H).': [3578], 'impeded': [3587], 'Besides': [3593], 'general': [3594], 'IFT88,': [3600], 'need': [3603], 'recruit': [3605, 3652], 'temporary': [3606], 'players': [3609], 'pathway(s)': [3612], 'respond': [3618], 'external': [3620], 'stimulation.': [3621], 'cell-related': [3629], 'CLESCs': [3634, 4006], '(Seidel': [3635], 'Zhao': [3639], '2014).': [3642], 'signal,': [3647], 'needs': [3650], 'express': [3654], 'different': [3655, 4227], 'cilium.': [3660], 'Among': [3661], 'them,': [3662], 'ATPase': [3667], '(hereafter': [3668], 'Arl13b)': [3669], 'an': [3671, 3877, 3907], 'unique': [3672], 'cilium-associated': [3673], 'molecule': [3674], 'mediating': [3678], '(Mariani': [3681], 'preferentially': [3693], 'expressed': [3694], 'disappeared': [3705], '1K': [3712], 'S1G).': [3716, 3775], 'On': [3717], 'contrary,': [3719], 'when': [3720], 'transitioned': [3723], 'begin': [3731], 'disassembled': [3734], 'absorbed': [3736], 'deacetylase-mediated': [3738], 'tubulin': [3739], 'cortactin': [3741], 'deacetylation': [3742], '(Pugacheva': [3743], '2007;': [3746], 'Perdiz': [3747], '(Hdac6)': [3757], 'recruited': [3758], '1L': [3771], 'successive': [3777], 'cell–transit': [3793, 3884], 'axis': [3796, 3887], '1M).': [3798], 'co-expresses': [3801], 'One': [3811], 'major': [3812], 'defect': [3813], 'Interestingly,': [3832], 'alterations': [3833], 'gene': [3836], 'similar': [3838], 'defects': [3840], '2009),': [3844], 'raising': [3845], 'possibility': [3847], 'participates': [3850], 'affecting': [3857], 'dynamics.': [3859], 'targeting': [3864, 4057], 'domain': [3868], 'cytoplasmic': [3870, 4179], 'C-terminal': [3871, 4180], 'Prom1,': [3874], 'detected': [3876], 'increased': [3878, 3908], '2A': [3891], 'S2A,': [3895], 'respectively).': [3896], 'From': [3897], 'toward': [3900], 'transition,': [3904], '2B).': [3923], 'association': [3925, 4100, 4139], 'highlighted': [3933], '2C': [3941], 'S2B).': [3945], 'addition': [3947], 'cilia,': [3950], 'labels': [3952], 'previously': [3956], 'demonstrated': [3957], '(Weigmann': [3962], '1997;': [3965], '2B': [3967], 'S2C).': [3971], 'specificity': [3973], 'validated': [3978], 'KO': [3982, 4195, 4211], 'respective': [3986], 'immunoreactivity': [3987], 'almost': [3989], 'abolished': [3990], '2D,': [3992], 'below).': [3994], 'Likewise,': [3995], 'again': [3998], 'established': [4004], 'S2E,': [4009], 'Materials': [4011], 'Methods)': [4013], '(transcript': [4017], 'protein)': [4019], 'silenced': [4021], 'short': [4023], 'hairpin': [4024], 'RNA': [4025], '(shRNA;': [4026], '2E': [4028], 'F).': [4030], '2.': [4032], 'antibody': [4054], 'clone': [4055], '13A4': [4056], 'P7.': [4075], 'Ams,': [4093], 'ameloblasts.': [4094], 'B.': [4095], 'showing': [4098], 'AcTub-labeled': [4105], 'limited': [4125], 'microvilli.': [4132], 'A': [4134], 'example': [4136], 'transition': [4152], 'region.': [4153], 'Green': [4154], 'channel': [4155], 'transparency': [4156], 'up': [4159], '70%.': [4161], 'directed': [4170], '(clone': [4175], '13A4,': [4176], 'green)': [4177], '(Biorbyt,': [4182], 'Orb129549,': [4183], 'red)': [4184], 'WT': [4192], 'vs.': [4193], 'mice.': [4196, 4212], 'Samples': [4197], 'lack': [4205], 'labeling': [4208], 'E,': [4213], 'F.': [4214], 'shRNA-mediated': [4223], 'knockdown': [4225], '(3': [4226], 'shRNAs': [4228], 'used,': [4230], 'mar': [4231]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2904392013', 'counts_by_year': [{'year': 2024, 'cited_by_count': 10}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 10}, {'year': 2020, 'cited_by_count': 12}, {'year': 2019, 'cited_by_count': 7}], 'updated_date': '2024-12-14T15:08:17.273756', 'created_date': '2018-12-22'}
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