Title: Synthesis, Characterization, Antibacterial, Antifungal Screening and Cytotoxic Activity Of Schiff Base Nickel(II) Complexes with Substituted Benzylidine Aminobenzoic Acid
Abstract: The synthesis, characterisation and antimicrobial study of Ni(II) complexes from Schiff base ligands L1 and L2 are
recorded in this study. The ligand L1, 2-((2-hydroxy-3-methoxybenzylidene)amino) benzoic acid obtained by the
condensation of o-vanillin and 2-aminobenzoic acid and the ligand L2, 2-((2-hydroxybenzylidene) amino)benzoic
acid is obtained by the condensation of salicylaldehyde and 2-aminobenzoic acid. The ligands and the complexes
were characterised by molar conductance, vibrational, electronic, 1H-NMR spectrum and redox sudies. The molar
conductance of these complexes convey the non-ionic character of the complexes. The spectral data show the
composition of the metal complexes to be ML (L is the Schiff bases L1 and L2).Antibacterial as well as antifungal
activities of these complexes of Ni(II) with the Schiff bases have been performed by disc diffusion method.The evaluated
highly biologically active [Ni(L2-2H)(H2O)3].H2O complex shows excellent cytotoxicity towards (MG-63) cancer cell
line.The results of the characterisation and biological activities are elaborately discussed in this paper.
Publication Year: 2018
Publication Date: 2018-01-01
Language: en
Type: article
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Cited By Count: 2
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