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[66], 'oxonate': [67], '(250': [68], 'mg/kg)': [69, 74], 'rats.': [71, 158], '(100': [73], 'administered': [76], 'orally': [77], 'investigate': [79, 100], 'pharmacokinetics': [81], 'control': [83, 157, 178], 'rats,': [86, 179], 'respectively.': [87, 121, 180], 'vitro': [91, 183, 240], 'HEK293': [93, 198], 'HepaRG': [95, 203], 'cells': [96, 199, 204], 'were': [97, 169], 'effect': [102], '(15': [106], 'mg/dl)': [107], 'expression': [110, 192, 254], 'OCT1,': [112], 'OCT2': [113, 194], 'MATE1': [115, 196, 201], 'metformin,': [120], 'The': [122, 159, 181], 'showed': [126, 185], 'that': [127, 155, 186, 219, 247], 'AUC0': [129], '→': [130], '600': [131], 'metformin': [133, 145, 209, 227, 233, 257], 'significantly': [135], 'decreased': [136, 230], '33.3%,': [138], 'whereas': [139], 'cumulative': [141], 'urinary': [142, 226], 'excretion': [143, 228], 'increased': [147, 170], '25.4%': [149], 'rats': [152, 173], 'compared': [153, 174], 'renal': [160, 256], 'rOCT1,': [161], 'rOCT2': [162], 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