Get quick answers to your questions about the article from our AI researcher chatbot
{'id': 'https://openalex.org/W2902472115', 'doi': 'https://doi.org/10.1172/jci123366', 'title': 'Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem', 'display_name': 'Subdominance and poor intrinsic immunogenicity limit humoral immunity targeting influenza HA stem', 'publication_year': 2019, 'publication_date': '2019-01-22', 'ids': {'openalex': 'https://openalex.org/W2902472115', 'doi': 'https://doi.org/10.1172/jci123366', 'mag': '2902472115', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30521496', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6355240'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci123366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'hybrid', 'oa_url': 'https://doi.org/10.1172/jci123366', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5063478843', 'display_name': 'Hyon‐Xhi Tan', 'orcid': 'https://orcid.org/0000-0003-1064-3934'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hyon-Xhi Tan', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5074973143', 'display_name': 'Sinthujan Jegaskanda', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Sinthujan Jegaskanda', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050741919', 'display_name': 'Jennifer A. Juno', 'orcid': 'https://orcid.org/0000-0002-9072-1017'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jennifer A. Juno', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5003875832', 'display_name': 'Robyn Esterbauer', 'orcid': 'https://orcid.org/0000-0002-7091-0048'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Robyn Esterbauer', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5080273334', 'display_name': 'Julius Wong', 'orcid': 'https://orcid.org/0000-0003-0253-6151'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Julius Wong', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5014732630', 'display_name': 'Hannah G. Kelly', 'orcid': 'https://orcid.org/0000-0002-4652-5609'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Hannah G. Kelly', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5101555935', 'display_name': 'Yi Liu', 'orcid': 'https://orcid.org/0000-0002-2157-8368'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Yi Liu', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030634473', 'display_name': 'Danielle Tilmanis', 'orcid': None}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Danielle Tilmanis', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5025769696', 'display_name': 'Aeron C. Hurt', 'orcid': 'https://orcid.org/0000-0003-1826-4314'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Aeron C. Hurt', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5030635221', 'display_name': 'Jonathan W. Yewdell', 'orcid': 'https://orcid.org/0000-0002-3826-1906'}, 'institutions': [], 'countries': [], 'is_corresponding': False, 'raw_author_name': 'Jonathan W. Yewdell', 'raw_affiliation_strings': [], 'affiliations': []}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5054025307', 'display_name': 'Stephen J. Kent', 'orcid': 'https://orcid.org/0000-0002-8539-4891'}, 'institutions': [{'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I4210105123', 'display_name': 'Peter Doherty Institute', 'ror': 'https://ror.org/016899r71', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I1320473756', 'https://openalex.org/I165779595', 'https://openalex.org/I4210105123', 'https://openalex.org/I4210158168']}, {'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I1337719021', 'display_name': 'Australian Research Council', 'ror': 'https://ror.org/05mmh0f86', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I1337719021', 'https://openalex.org/I2801453606', 'https://openalex.org/I4210132349']}, {'id': 'https://openalex.org/I4210099671', 'display_name': 'Melbourne Sexual Health Centre', 'ror': 'https://ror.org/013fdz725', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099671', 'https://openalex.org/I4210163178']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Stephen J. Kent', 'raw_affiliation_strings': [' Australian Research Council (ARC) Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia.', ' Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', ' Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID),', ' Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.', ' NIH, Bethesda, Maryland, USA.', ' WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.'], 'affiliations': [{'raw_affiliation_string': ' Australian Research Council (ARC) Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I1337719021']}, {'raw_affiliation_string': ' Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I4210105123']}, {'raw_affiliation_string': ' WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I4210105123']}, {'raw_affiliation_string': ' Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID),', 'institution_ids': ['https://openalex.org/I4210134534']}, {'raw_affiliation_string': ' Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I4210099671', 'https://openalex.org/I56590836']}, {'raw_affiliation_string': ' NIH, Bethesda, Maryland, USA.', 'institution_ids': ['https://openalex.org/I1299303238']}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5002477860', 'display_name': 'Adam K. Wheatley', 'orcid': 'https://orcid.org/0000-0002-5593-9387'}, 'institutions': [{'id': 'https://openalex.org/I4210105123', 'display_name': 'Peter Doherty Institute', 'ror': 'https://ror.org/016899r71', 'country_code': 'AU', 'type': 'facility', 'lineage': ['https://openalex.org/I1320473756', 'https://openalex.org/I165779595', 'https://openalex.org/I4210105123', 'https://openalex.org/I4210158168']}, {'id': 'https://openalex.org/I4210134534', 'display_name': 'National Institute of Allergy and Infectious Diseases', 'ror': 'https://ror.org/043z4tv69', 'country_code': 'US', 'type': 'facility', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238', 'https://openalex.org/I4210134534']}, {'id': 'https://openalex.org/I4210099671', 'display_name': 'Melbourne Sexual Health Centre', 'ror': 'https://ror.org/013fdz725', 'country_code': 'AU', 'type': 'healthcare', 'lineage': ['https://openalex.org/I4210099671', 'https://openalex.org/I4210163178']}, {'id': 'https://openalex.org/I165779595', 'display_name': 'University of Melbourne', 'ror': 'https://ror.org/01ej9dk98', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I165779595']}, {'id': 'https://openalex.org/I1299303238', 'display_name': 'National Institutes of Health', 'ror': 'https://ror.org/01cwqze88', 'country_code': 'US', 'type': 'government', 'lineage': ['https://openalex.org/I1299022934', 'https://openalex.org/I1299303238']}, {'id': 'https://openalex.org/I56590836', 'display_name': 'Monash University', 'ror': 'https://ror.org/02bfwt286', 'country_code': 'AU', 'type': 'education', 'lineage': ['https://openalex.org/I56590836']}, {'id': 'https://openalex.org/I1337719021', 'display_name': 'Australian Research Council', 'ror': 'https://ror.org/05mmh0f86', 'country_code': 'AU', 'type': 'government', 'lineage': ['https://openalex.org/I1337719021', 'https://openalex.org/I2801453606', 'https://openalex.org/I4210132349']}], 'countries': ['AU', 'US'], 'is_corresponding': False, 'raw_author_name': 'Adam K. Wheatley', 'raw_affiliation_strings': [' Australian Research Council (ARC) Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia.', ' Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', ' Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID),', ' Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.', ' NIH, Bethesda, Maryland, USA.', ' WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.'], 'affiliations': [{'raw_affiliation_string': ' WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I4210105123']}, {'raw_affiliation_string': ' Laboratory of Viral Diseases, National Institute of Allergy and Infectious Diseases (NIAID),', 'institution_ids': ['https://openalex.org/I4210134534']}, {'raw_affiliation_string': ' Melbourne Sexual Health Centre and Department of Infectious Diseases, Alfred Hospital and Central Clinical School, Monash University, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I4210099671', 'https://openalex.org/I56590836']}, {'raw_affiliation_string': ' Australian Research Council (ARC) Centre for Excellence in Convergent Bio-Nano Science and Technology, University of Melbourne, Parkville, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I165779595', 'https://openalex.org/I1337719021']}, {'raw_affiliation_string': ' NIH, Bethesda, Maryland, USA.', 'institution_ids': ['https://openalex.org/I1299303238']}, {'raw_affiliation_string': ' Department of Microbiology and Immunology, University of Melbourne at The Peter Doherty Institute for Infection and Immunity, Melbourne, Victoria, Australia.', 'institution_ids': ['https://openalex.org/I4210105123', 'https://openalex.org/I165779595']}]}], 'countries_distinct_count': 2, 'institutions_distinct_count': 7, 'corresponding_author_ids': [], 'corresponding_institution_ids': [], 'apc_list': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'apc_paid': {'value': 5200, 'currency': 'USD', 'value_usd': 5200, 'provenance': 'doaj'}, 'fwci': 11.201, 'has_fulltext': True, 'fulltext_origin': 'pdf', 'cited_by_count': 75, 'citation_normalized_percentile': {'value': 0.999974, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 98, 'max': 99}, 'biblio': {'volume': '129', 'issue': '2', 'first_page': '850', 'last_page': '862'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T10167', 'display_name': 'Influenza Virus Research and Epidemiology', 'score': 1.0, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T11020', 'display_name': 'Natural Killer Cells in Immunity', 'score': 0.9987, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}, {'id': 'https://openalex.org/T10580', 'display_name': 'Immunobiology of Dendritic Cells', 'score': 0.9981, 'subfield': {'id': 'https://openalex.org/subfields/2403', 'display_name': 'Immunology'}, 'field': {'id': 'https://openalex.org/fields/24', 'display_name': 'Immunology and Microbiology'}, 'domain': {'id': 'https://openalex.org/domains/1', 'display_name': 'Life Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/t-cell-immunity', 'display_name': 'T Cell Immunity', 'score': 0.514795}], 'concepts': [{'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.6364127}, {'id': 'https://openalex.org/C2780868878', 'wikidata': 'https://www.wikidata.org/wiki/Q1660197', 'display_name': 'Immunogenicity', 'level': 3, 'score': 0.6267881}, {'id': 'https://openalex.org/C2778692840', 'wikidata': 'https://www.wikidata.org/wiki/Q9136673', 'display_name': 'Hemagglutinin (influenza)', 'level': 3, 'score': 0.61459416}, {'id': 'https://openalex.org/C28328180', 'wikidata': 'https://www.wikidata.org/wiki/Q48196', 'display_name': 'Stem cell', 'level': 2, 'score': 0.5954443}, {'id': 'https://openalex.org/C203014093', 'wikidata': 'https://www.wikidata.org/wiki/Q101929', 'display_name': 'Immunology', 'level': 1, 'score': 0.5933431}, {'id': 'https://openalex.org/C159047783', 'wikidata': 'https://www.wikidata.org/wiki/Q7215', 'display_name': 'Virology', 'level': 1, 'score': 0.58034086}, {'id': 'https://openalex.org/C22070199', 'wikidata': 'https://www.wikidata.org/wiki/Q192995', 'display_name': 'Vaccination', 'level': 2, 'score': 0.55837446}, {'id': 'https://openalex.org/C2779341262', 'wikidata': 'https://www.wikidata.org/wiki/Q182581', 'display_name': 'Immunity', 'level': 3, 'score': 0.5371891}, {'id': 'https://openalex.org/C195616568', 'wikidata': 'https://www.wikidata.org/wiki/Q128711', 'display_name': 'Epitope', 'level': 3, 'score': 0.5040383}, {'id': 'https://openalex.org/C8891405', 'wikidata': 'https://www.wikidata.org/wiki/Q1059', 'display_name': 'Immune system', 'level': 2, 'score': 0.4492192}, {'id': 'https://openalex.org/C159654299', 'wikidata': 'https://www.wikidata.org/wiki/Q79460', 'display_name': 'Antibody', 'level': 2, 'score': 0.4381707}, {'id': 'https://openalex.org/C147483822', 'wikidata': 'https://www.wikidata.org/wiki/Q103537', 'display_name': 'Antigen', 'level': 2, 'score': 0.4196979}, {'id': 'https://openalex.org/C2780689484', 'wikidata': 'https://www.wikidata.org/wiki/Q383260', 'display_name': 'Influenza vaccine', 'level': 3, 'score': 0.41312194}, {'id': 'https://openalex.org/C95444343', 'wikidata': 'https://www.wikidata.org/wiki/Q7141', 'display_name': 'Cell biology', 'level': 1, 'score': 0.105127394}], 'mesh': [{'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D056724', 'descriptor_name': 'Immunity, Humoral', 'qualifier_ui': 'Q000187', 'qualifier_name': 'drug effects', 'is_major_topic': True}, {'descriptor_ui': 'D000071497', 'descriptor_name': 'Immunogenicity, Vaccine', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': 'Q000008', 'qualifier_name': 'administration & dosage', 'is_major_topic': True}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': True}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D001402', 'descriptor_name': 'B-Lymphocytes', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000882', 'descriptor_name': 'Haplorhini', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D019267', 'descriptor_name': 'Hemagglutinin Glycoproteins, Influenza Virus', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006801', 'descriptor_name': 'Humans', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D056724', 'descriptor_name': 'Immunity, Humoral', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': 'Q000276', 'qualifier_name': 'immunology', 'is_major_topic': False}, {'descriptor_ui': 'D007252', 'descriptor_name': 'Influenza Vaccines', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008297', 'descriptor_name': 'Male', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008807', 'descriptor_name': 'Mice, Inbred BALB C', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D013234', 'descriptor_name': 'Stem Cells', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': 'Q000473', 'qualifier_name': 'pathology', 'is_major_topic': False}, {'descriptor_ui': 'D006377', 'descriptor_name': 'T-Lymphocytes, Helper-Inducer', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci123366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6355240', 'pdf_url': 'https://europepmc.org/articles/pmc6355240?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6355240', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'http://hdl.handle.net/11343/253311', 'pdf_url': 'http://minerva-access.unimelb.edu.au/bitstreams/44d60411-a082-5e73-91ac-de832a78097b/download', 'source': {'id': 'https://openalex.org/S4377196259', 'display_name': 'Minerva Access (University of Melbourne)', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I165779595', 'host_organization_name': 'University of Melbourne', 'host_organization_lineage': ['https://openalex.org/I165779595'], 'host_organization_lineage_names': ['University of Melbourne'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://research.monash.edu/en/publications/515234cb-559f-41d0-be47-b824b0071ee0', 'pdf_url': 'https://research.monash.edu/files/281533986/262176448_oa.pdf', 'source': {'id': 'https://openalex.org/S4306402625', 'display_name': 'Monash University Research Portal (Monash University)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I56590836', 'host_organization_name': 'Monash University', 'host_organization_lineage': ['https://openalex.org/I56590836'], 'host_organization_lineage_names': ['Monash University'], 'type': 'repository'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30521496', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1172/jci123366', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S114430552', 'display_name': 'Journal of Clinical Investigation', 'issn_l': '0021-9738', 'issn': ['0021-9738', '1558-8238'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320279', 'host_organization_name': 'American Society for Clinical Investigation', 'host_organization_lineage': ['https://openalex.org/P4310320279'], 'host_organization_lineage_names': ['American Society for Clinical Investigation'], 'type': 'journal'}, 'license': 'cc-by', 'license_id': 'https://openalex.org/licenses/cc-by', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320334705', 'funder_display_name': 'National Health and Medical Research Council', 'award_id': 'ID1129099'}], 'datasets': [], 'versions': [], 'referenced_works_count': 47, 'referenced_works': ['https://openalex.org/W1193861902', 'https://openalex.org/W1816587284', 'https://openalex.org/W1839670155', 'https://openalex.org/W1841805549', 'https://openalex.org/W1935400227', 'https://openalex.org/W1976609017', 'https://openalex.org/W1989368177', 'https://openalex.org/W1993102001', 'https://openalex.org/W1993577147', 'https://openalex.org/W2002632348', 'https://openalex.org/W2006840424', 'https://openalex.org/W2014180504', 'https://openalex.org/W2022615852', 'https://openalex.org/W2032809145', 'https://openalex.org/W2040440325', 'https://openalex.org/W2060045669', 'https://openalex.org/W2070601214', 'https://openalex.org/W2076213364', 'https://openalex.org/W2085229531', 'https://openalex.org/W2086021932', 'https://openalex.org/W2086966158', 'https://openalex.org/W2095082043', 'https://openalex.org/W2104391453', 'https://openalex.org/W2117278984', 'https://openalex.org/W2120255678', 'https://openalex.org/W2129973151', 'https://openalex.org/W2130737480', 'https://openalex.org/W2135151522', 'https://openalex.org/W2135858175', 'https://openalex.org/W2139413077', 'https://openalex.org/W2139427540', 'https://openalex.org/W2139924928', 'https://openalex.org/W2163135112', 'https://openalex.org/W2188526495', 'https://openalex.org/W2212428564', 'https://openalex.org/W2274976235', 'https://openalex.org/W2289890884', 'https://openalex.org/W2319605428', 'https://openalex.org/W2408990701', 'https://openalex.org/W2464400647', 'https://openalex.org/W2474050077', 'https://openalex.org/W2491683774', 'https://openalex.org/W2555334376', 'https://openalex.org/W2588930849', 'https://openalex.org/W2765584638', 'https://openalex.org/W2786999835', 'https://openalex.org/W385144914'], 'related_works': ['https://openalex.org/W3137796232', 'https://openalex.org/W2911873019', 'https://openalex.org/W2767495920', 'https://openalex.org/W2412388604', 'https://openalex.org/W2399635918', 'https://openalex.org/W2316263092', 'https://openalex.org/W2131252851', 'https://openalex.org/W2117847535', 'https://openalex.org/W2111831969', 'https://openalex.org/W2019183242'], 'abstract_inverted_index': {'Both': [0], 'natural': [1], 'influenza': [2, 7, 68, 150, 182], 'infection': [3, 69], 'and': [4, 57, 70, 74, 97, 100, 186], 'current': [5], 'seasonal': [6, 149], 'vaccines': [8, 151, 183], 'primarily': [9], 'induce': [10], 'neutralizing': [11], 'antibody': [12, 48, 95], 'responses': [13, 63, 156], 'against': [14, 157], 'highly': [15], 'diverse': [16], 'epitopes': [17], 'within': [18], 'the': [19, 22, 35, 65, 82, 89, 116, 134, 158, 167, 171, 178], '“head”': [20], 'of': [21, 45, 67, 93, 138, 166, 180], 'viral': [23], 'hemagglutinin': [24], '(HA)': [25], 'protein.': [26], 'There': [27], 'is': [28, 174], 'increasing': [29], 'interest': [30], 'in': [31, 64, 72, 91, 161], 'redirecting': [32], 'immunity': [33, 140], 'toward': [34], 'more': [36], 'conserved': [37], 'HA': [38, 53, 108, 118, 159, 172], 'stem': [39, 83, 109, 160, 173], 'or': [40, 136], 'stalk': [41], 'as': [42], 'a': [43, 130], 'means': [44], 'broadening': [46], 'protective': [47], 'responses.': [49, 103], 'Here': [50], 'we': [51, 105, 144], 'examined': [52], 'stem–specific': [54], 'B': [55, 99], 'cell': [56, 62, 102, 128], 'T': [58], 'follicular': [59], 'helper': [60], '(Tfh)': [61], 'context': [66], 'immunization': [71], 'mouse': [73], 'monkey': [75], 'models.': [76], 'We': [77], 'found': [78, 106], 'that': [79, 107, 146], 'during': [80], 'infection,': [81], 'domain': [84], 'was': [85], 'immunologically': [86], 'subdominant': [87], 'to': [88, 133, 176], 'head': [90], 'terms': [92], 'serum': [94], 'production': [96], 'antigen-specific': [98], 'Tfh': [101, 127], 'Similarly,': [104], 'immunogens': [110], 'were': [111], 'poorly': [112], 'immunogenic': [113], 'compared': [114], 'with': [115, 119, 125], 'full-length': [117], 'abolished': [120], 'sialic': [121], 'acid': [122], 'binding': [123], 'activity,': [124], 'limiting': [126], 'elicitation': [129], 'potential': [131], 'constraint': [132], 'induction': [135], 'boosting': [137], 'anti-stem': [139], 'by': [141], 'vaccination.': [142], 'Finally,': [143], 'confirm': [145], 'currently': [147], 'licensed': [148], 'can': [152], 'boost': [153], 'preexisting': [154], 'memory': [155], 'humans.': [162], 'An': [163], 'increased': [164], 'understanding': [165], 'immune': [168], 'dynamics': [169], 'surrounding': [170], 'essential': [175], 'inform': [177], 'design': [179], 'next-generation': [181], 'for': [184], 'broad': [185], 'durable': [187], 'protection.': [188]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2902472115', 'counts_by_year': [{'year': 2024, 'cited_by_count': 4}, {'year': 2023, 'cited_by_count': 10}, {'year': 2022, 'cited_by_count': 13}, {'year': 2021, 'cited_by_count': 16}, {'year': 2020, 'cited_by_count': 22}, {'year': 2019, 'cited_by_count': 10}], 'updated_date': '2024-09-12T05:28:06.733870', 'created_date': '2018-12-11'}