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'of': [14, 81, 133, 140, 152, 162, 168, 191, 202, 207, 232, 269, 275, 307], 'the': [15, 116, 129, 159, 166, 186, 189, 199, 229, 304, 308, 332], 'insulin': [16, 19, 25, 47, 82, 145, 195, 208, 233, 240, 279, 309, 333], 'receptor': [17, 20, 209, 310], 'and': [18, 22, 31, 49, 84, 126, 212, 248, 261, 281, 311, 326, 346], 'substrate-1': [21], 'subsequently': [23], 'induces': [24, 241], 'resistance,': [26], 'resulting': [27], 'in': [28, 115, 124, 128, 165, 179, 259, 284, 296], 'metabolic': [29, 66, 85, 107, 134, 282], 'syndrome': [30, 108, 283], 'type': [32], '2': [33], 'diabetes': [34, 264], 'mellitus': [35], '(T2DM).': [36], 'However,': [37], 'it': [38], 'is': [39, 223, 253], 'unknown': [40], 'how': [41], 'MG53': [42, 71, 112, 122, 142, 154, 164, 175, 193, 203, 222, 242, 258, 271, 276, 289, 301, 319, 338], 'from': [43, 244], 'muscle': [44, 56], 'regulates': [45], 'systemic': [46, 65, 150, 267, 278], 'response': [48, 146], 'energy': [50], 'metabolism.': [51], 'Increasing': [52], 'evidence': [53], 'demonstrates': [54], 'that': [55, 63, 70, 221, 227], 'secretes': [57], 'proteins': [58], 'as': [59, 74, 313, 323], 'myokines': [60], 'cardiokines': [62], 'regulate': [64], 'processes.': [67], 'We': [68, 118], 'hypothesize': [69], 'may': [72], 'act': [73], 'myokine/cardiokine,': [76], 'contributing': [77], 'to': [78, 156, 184, 303], 'interorgan': [79, 230], 'regulation': [80, 231], 'sensitivity': [83], 'homeostasis.': [86], 'Methods:': [87], 'Using': [88], 'perfused': [89], 'rodent': [90, 246], 'hearts': [91, 247], 'skeletal': [93, 249], 'muscle,': [94], 'we': [95, 197, 219], 'investigated': [96], 'whether': [97], 'high': [98, 100, 236, 239], 'glucose,': [99], 'insulin,': [101], 'their': [103], 'combination': [104], '(conditions': [105], 'mimicking': [106], 'T2DM)': [110], 'alters': [111], 'protein': [113, 155], 'concentration': [114], 'perfusate.': [117], 'also': [119], 'measured': [120], 'serum': [121], 'levels': [123], 'rodents': [125, 262], 'humans': [127, 260], 'presence': [130], 'absence': [132], 'diseases,': [135], 'particularly': [136], 'T2DM.': [137], 'The': [138], 'effects': [139, 295], 'circulating': [141, 163, 257, 288, 337], 'on': [143, 194], 'multiorgan': [144], 'were': [147], 'evaluated': [148], 'by': [149, 172, 255], 'delivery': [151, 268], 'recombinant': [153, 270], 'mice.': [157, 182, 299], 'Furthermore,': [158], 'potential': [160, 200], 'involvement': [161], 'pathogenesis': [167], 'T2DM': [169, 297, 345], 'was': [170], 'assessed': [171], 'neutralizing': [173, 287], 'blood': [174], 'with': [176, 204, 263, 290], 'monoclonal': [177, 291], 'antibodies': [178, 292], 'diabetic': [180], 'db/db': [181, 298], 'Finally,': [183], 'delineate': [185], 'mechanism': [187], 'underlying': [188], 'action': [190], 'extracellular': [192, 205, 305], 'signaling,': [196], 'analyzed': [198], 'interaction': [201], 'domain': [206, 306], 'using': [210], 'coimmunoprecipitation': [211], 'surface': [213], 'plasmon': [214], 'resonance': [215], 'assays.': [216], 'Results:': [217], 'Here,': [218], 'demonstrate': [220], 'glucose-sensitive': [225], 'myokine/cardiokine': [226, 325], 'governs': [228], 'sensitivity.': [234], 'First,': [235], 'glucose': [237], 'secretion': [243], 'isolated': [245], 'muscle.': [250], 'Second,': [251], 'hyperglycemia': [252], 'accompanied': [254], 'increased': [256], 'mellitus.': [265], 'Third,': [266], 'cardiac-specific': [273], 'overexpression': [274], 'causes': [277], 'resistance': [280], 'mice,': [285], 'whereas': [286], 'has': [293, 320], 'therapeutic': [294, 342], 'Mechanistically,': [300], 'binds': [302], 'acts': [312], 'an': [314, 327], 'allosteric': [315], 'blocker.': [316], 'Conclusions:': [317], 'Thus,': [318], 'dual': [321], 'actions': [322], 'synergistically': [330], 'inhibiting': [331], 'signaling': [334], 'pathway.': [335], 'Targeting': [336], 'opens': [339], 'new': [341], 'avenue': [343], 'for': [344], 'its': [347], 'complications.': [348]}, 'cited_by_api_url': 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