Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics

Name: Work Video:
Duration: 3 min 30 s
Michał Grzybek; Alessandra Palladini; Vasileia Ismini Alexaki; Michał A. Surma; Kai Simons; Triantafyllos Chavakis; Christian Klose; Ünal Coskun
{'id': 'https://openalex.org/W2901084196', 'doi': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'title': 'Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics', 'display_name': 'Comprehensive and quantitative analysis of white and brown adipose tissue by shotgun lipidomics', 'publication_year': 2019, 'publication_date': '2019-01-30', 'ids': {'openalex': 'https://openalex.org/W2901084196', 'doi': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'mag': '2901084196', 'pmid': 'https://pubmed.ncbi.nlm.nih.gov/30777728', 'pmcid': 'https://www.ncbi.nlm.nih.gov/pmc/articles/6437637'}, 'language': 'en', 'primary_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764545133', 'display_name': 'Molecular Metabolism', 'issn_l': '2212-8778', 'issn': ['2212-8778'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'type': 'article', 'type_crossref': 'journal-article', 'indexed_in': ['crossref', 'doaj', 'pubmed'], 'open_access': {'is_oa': True, 'oa_status': 'gold', 'oa_url': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'any_repository_has_fulltext': True}, 'authorships': [{'author_position': 'first', 'author': {'id': 'https://openalex.org/A5016682467', 'display_name': 'Michał Grzybek', 'orcid': 'https://orcid.org/0000-0003-2083-0506'}, 'institutions': [{'id': 'https://openalex.org/I4210164390', 'display_name': 'Paul Langerhans Institute Dresden', 'ror': 'https://ror.org/05ke5hb07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I3018134672', 'https://openalex.org/I4210162051', 'https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210160326', 'display_name': 'German Center for Diabetes Research', 'ror': 'https://ror.org/04qq88z54', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160326']}, {'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I4210152419', 'display_name': 'Deutsches Diabetes-Zentrum e.V.', 'ror': 'https://ror.org/04ews3245', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michal Grzybek', 'raw_affiliation_strings': ['German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'raw_affiliation_string': 'German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'institution_ids': ['https://openalex.org/I4210160326', 'https://openalex.org/I44260953', 'https://openalex.org/I4210152419']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5050853748', 'display_name': 'Alessandra Palladini', 'orcid': 'https://orcid.org/0000-0001-5307-8643'}, 'institutions': [{'id': 'https://openalex.org/I4210164390', 'display_name': 'Paul Langerhans Institute Dresden', 'ror': 'https://ror.org/05ke5hb07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I3018134672', 'https://openalex.org/I4210162051', 'https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210160326', 'display_name': 'German Center for Diabetes Research', 'ror': 'https://ror.org/04qq88z54', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160326']}, {'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I4210152419', 'display_name': 'Deutsches Diabetes-Zentrum e.V.', 'ror': 'https://ror.org/04ews3245', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Alessandra Palladini', 'raw_affiliation_strings': ['German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'raw_affiliation_string': 'German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'institution_ids': ['https://openalex.org/I4210160326', 'https://openalex.org/I44260953', 'https://openalex.org/I4210152419']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5004023214', 'display_name': 'Vasileia Ismini Alexaki', 'orcid': 'https://orcid.org/0000-0003-3935-8985'}, 'institutions': [{'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Vasileia I. Alexaki', 'raw_affiliation_strings': ['Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I78650965']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5056618033', 'display_name': 'Michał A. Surma', 'orcid': 'https://orcid.org/0000-0001-7833-2214'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Michal A. Surma', 'raw_affiliation_strings': ['Lipotype GmbH, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Lipotype GmbH, Dresden, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5000708652', 'display_name': 'Kai Simons', 'orcid': 'https://orcid.org/0000-0002-9231-9996'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Kai Simons', 'raw_affiliation_strings': ['Lipotype GmbH, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Lipotype GmbH, Dresden, Germany', 'institution_ids': []}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5086672334', 'display_name': 'Triantafyllos Chavakis', 'orcid': 'https://orcid.org/0000-0002-1869-5141'}, 'institutions': [{'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I4210164390', 'display_name': 'Paul Langerhans Institute Dresden', 'ror': 'https://ror.org/05ke5hb07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I3018134672', 'https://openalex.org/I4210162051', 'https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210152419', 'display_name': 'Deutsches Diabetes-Zentrum e.V.', 'ror': 'https://ror.org/04ews3245', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I4210160326', 'display_name': 'German Center for Diabetes Research', 'ror': 'https://ror.org/04qq88z54', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160326']}], 'countries': ['DE'], 'is_corresponding': False, 'raw_author_name': 'Triantafyllos Chavakis', 'raw_affiliation_strings': ['German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Dresden, Germany', 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'institution_ids': ['https://openalex.org/I44260953', 'https://openalex.org/I4210152419', 'https://openalex.org/I4210160326']}, {'raw_affiliation_string': 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'raw_affiliation_string': 'Institute for Clinical Chemistry and Laboratory Medicine, Faculty of Medicine, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I78650965']}]}, {'author_position': 'middle', 'author': {'id': 'https://openalex.org/A5071326290', 'display_name': 'Christian Klose', 'orcid': 'https://orcid.org/0000-0003-2853-4533'}, 'institutions': [], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Christian Klose', 'raw_affiliation_strings': ['Lipotype GmbH, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'Lipotype GmbH, Dresden, Germany', 'institution_ids': []}]}, {'author_position': 'last', 'author': {'id': 'https://openalex.org/A5046329655', 'display_name': 'Ünal Coskun', 'orcid': 'https://orcid.org/0000-0003-4375-3144'}, 'institutions': [{'id': 'https://openalex.org/I4210160326', 'display_name': 'German Center for Diabetes Research', 'ror': 'https://ror.org/04qq88z54', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I4210160326']}, {'id': 'https://openalex.org/I4210152419', 'display_name': 'Deutsches Diabetes-Zentrum e.V.', 'ror': 'https://ror.org/04ews3245', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I315704651', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I44260953', 'display_name': 'Heinrich Heine University Düsseldorf', 'ror': 'https://ror.org/024z2rq82', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I44260953']}, {'id': 'https://openalex.org/I4210164390', 'display_name': 'Paul Langerhans Institute Dresden', 'ror': 'https://ror.org/05ke5hb07', 'country_code': 'DE', 'type': 'facility', 'lineage': ['https://openalex.org/I1305996414', 'https://openalex.org/I3018134672', 'https://openalex.org/I4210162051', 'https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}, {'id': 'https://openalex.org/I78650965', 'display_name': 'TU Dresden', 'ror': 'https://ror.org/042aqky30', 'country_code': 'DE', 'type': 'education', 'lineage': ['https://openalex.org/I78650965']}], 'countries': ['DE'], 'is_corresponding': True, 'raw_author_name': 'Ünal Coskun', 'raw_affiliation_strings': ['German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany'], 'affiliations': [{'raw_affiliation_string': 'German Center for Diabetes Research (DZD e.V.), Neuherberg, Germany', 'institution_ids': ['https://openalex.org/I4210160326', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953']}, {'raw_affiliation_string': 'Paul Langerhans Institute Dresden of the Helmholtz Zentrum Munich at the University Clinic Carl Gustav Carus, TU Dresden, Dresden, Germany', 'institution_ids': ['https://openalex.org/I4210164390', 'https://openalex.org/I78650965']}]}], 'institution_assertions': [], 'countries_distinct_count': 1, 'institutions_distinct_count': 5, 'corresponding_author_ids': ['https://openalex.org/A5071326290', 'https://openalex.org/A5046329655'], 'corresponding_institution_ids': ['https://openalex.org/I4210160326', 'https://openalex.org/I4210152419', 'https://openalex.org/I44260953', 'https://openalex.org/I4210164390', 'https://openalex.org/I78650965'], 'apc_list': {'value': 2700, 'currency': 'USD', 'value_usd': 2700, 'provenance': 'doaj'}, 'apc_paid': {'value': 2700, 'currency': 'USD', 'value_usd': 2700, 'provenance': 'doaj'}, 'fwci': 4.613, 'has_fulltext': True, 'fulltext_origin': 'ngrams', 'cited_by_count': 40, 'citation_normalized_percentile': {'value': 0.999956, 'is_in_top_1_percent': True, 'is_in_top_10_percent': True}, 'cited_by_percentile_year': {'min': 95, 'max': 96}, 'biblio': {'volume': '22', 'issue': None, 'first_page': '12', 'last_page': '20'}, 'is_retracted': False, 'is_paratext': False, 'primary_topic': {'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, 'topics': [{'id': 'https://openalex.org/T11457', 'display_name': 'Adipose Tissue and Metabolism', 'score': 0.9997, 'subfield': {'id': 'https://openalex.org/subfields/2737', 'display_name': 'Physiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10528', 'display_name': 'Adipokines, Inflammation, and Metabolic Diseases', 'score': 0.9969, 'subfield': {'id': 'https://openalex.org/subfields/2713', 'display_name': 'Epidemiology'}, 'field': {'id': 'https://openalex.org/fields/27', 'display_name': 'Medicine'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}, {'id': 'https://openalex.org/T10387', 'display_name': 'Fatty Acid Research and Health', 'score': 0.9908, 'subfield': {'id': 'https://openalex.org/subfields/2916', 'display_name': 'Nutrition and Dietetics'}, 'field': {'id': 'https://openalex.org/fields/29', 'display_name': 'Nursing'}, 'domain': {'id': 'https://openalex.org/domains/4', 'display_name': 'Health Sciences'}}], 'keywords': [{'id': 'https://openalex.org/keywords/shotgun', 'display_name': 'Shotgun', 'score': 0.60816824}], 'concepts': [{'id': 'https://openalex.org/C58017582', 'wikidata': 'https://www.wikidata.org/wiki/Q6556376', 'display_name': 'Lipidomics', 'level': 2, 'score': 0.79805005}, {'id': 'https://openalex.org/C2781434637', 'wikidata': 'https://www.wikidata.org/wiki/Q486396', 'display_name': 'Shotgun', 'level': 3, 'score': 0.60816824}, {'id': 'https://openalex.org/C171089720', 'wikidata': 'https://www.wikidata.org/wiki/Q193583', 'display_name': 'Adipose tissue', 'level': 2, 'score': 0.5935996}, {'id': 'https://openalex.org/C151955695', 'wikidata': 'https://www.wikidata.org/wiki/Q654528', 'display_name': 'White adipose tissue', 'level': 3, 'score': 0.4900316}, {'id': 'https://openalex.org/C71924100', 'wikidata': 'https://www.wikidata.org/wiki/Q11190', 'display_name': 'Medicine', 'level': 0, 'score': 0.3680727}, {'id': 'https://openalex.org/C70721500', 'wikidata': 'https://www.wikidata.org/wiki/Q177005', 'display_name': 'Computational biology', 'level': 1, 'score': 0.3366926}, {'id': 'https://openalex.org/C60644358', 'wikidata': 'https://www.wikidata.org/wiki/Q128570', 'display_name': 'Bioinformatics', 'level': 1, 'score': 0.3149764}, {'id': 'https://openalex.org/C185592680', 'wikidata': 'https://www.wikidata.org/wiki/Q2329', 'display_name': 'Chemistry', 'level': 0, 'score': 0.30906525}, {'id': 'https://openalex.org/C86803240', 'wikidata': 'https://www.wikidata.org/wiki/Q420', 'display_name': 'Biology', 'level': 0, 'score': 0.30573237}, {'id': 'https://openalex.org/C134018914', 'wikidata': 'https://www.wikidata.org/wiki/Q162606', 'display_name': 'Endocrinology', 'level': 1, 'score': 0.288325}, {'id': 'https://openalex.org/C55493867', 'wikidata': 'https://www.wikidata.org/wiki/Q7094', 'display_name': 'Biochemistry', 'level': 1, 'score': 0.1597935}, {'id': 'https://openalex.org/C104317684', 'wikidata': 'https://www.wikidata.org/wiki/Q7187', 'display_name': 'Gene', 'level': 2, 'score': 0.0}], 'mesh': [{'descriptor_ui': 'D002001', 'descriptor_name': 'Adipose Tissue, Brown', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D052436', 'descriptor_name': 'Adipose Tissue, White', 'qualifier_ui': 'Q000378', 'qualifier_name': 'metabolism', 'is_major_topic': True}, {'descriptor_ui': 'D000081362', 'descriptor_name': 'Lipidomics', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D008055', 'descriptor_name': 'Lipids', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': True}, {'descriptor_ui': 'D002001', 'descriptor_name': 'Adipose Tissue, Brown', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D052436', 'descriptor_name': 'Adipose Tissue, White', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D000818', 'descriptor_name': 'Animals', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D005260', 'descriptor_name': 'Female', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D051379', 'descriptor_name': 'Mice', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}, {'descriptor_ui': 'D008810', 'descriptor_name': 'Mice, Inbred C57BL', 'qualifier_ui': '', 'qualifier_name': None, 'is_major_topic': False}], 'locations_count': 6, 'locations': [{'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764545133', 'display_name': 'Molecular Metabolism', 'issn_l': '2212-8778', 'issn': ['2212-8778'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': False, 'landing_page_url': 'https://doaj.org/article/e95cc001e0cc4e5d95b45e0b3f55f6bb', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306401280', 'display_name': 'DOAJ (DOAJ: Directory of Open Access Journals)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': None, 'host_organization_name': None, 'host_organization_lineage': [], 'host_organization_lineage_names': [], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}, {'is_oa': True, 'landing_page_url': 'https://europepmc.org/articles/pmc6437637', 'pdf_url': 'https://europepmc.org/articles/pmc6437637?pdf=render', 'source': {'id': 'https://openalex.org/S4306400806', 'display_name': 'Europe PMC (PubMed Central)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1303153112', 'host_organization_name': 'European Bioinformatics Institute', 'host_organization_lineage': ['https://openalex.org/I1303153112'], 'host_organization_lineage_names': ['European Bioinformatics Institute'], 'type': 'repository'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6437637', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764455111', 'display_name': 'PubMed Central', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1101/470690', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306402567', 'display_name': 'bioRxiv (Cold Spring Harbor Laboratory)', 'issn_l': None, 'issn': None, 'is_oa': True, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I2750212522', 'host_organization_name': 'Cold Spring Harbor Laboratory', 'host_organization_lineage': ['https://openalex.org/I2750212522'], 'host_organization_lineage_names': ['Cold Spring Harbor Laboratory'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': 'submittedVersion', 'is_accepted': False, 'is_published': False}, {'is_oa': False, 'landing_page_url': 'https://pubmed.ncbi.nlm.nih.gov/30777728', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S4306525036', 'display_name': 'PubMed', 'issn_l': None, 'issn': None, 'is_oa': False, 'is_in_doaj': False, 'is_core': False, 'host_organization': 'https://openalex.org/I1299303238', 'host_organization_name': 'National Institutes of Health', 'host_organization_lineage': ['https://openalex.org/I1299303238'], 'host_organization_lineage_names': ['National Institutes of Health'], 'type': 'repository'}, 'license': None, 'license_id': None, 'version': None, 'is_accepted': False, 'is_published': False}], 'best_oa_location': {'is_oa': True, 'landing_page_url': 'https://doi.org/10.1016/j.molmet.2019.01.009', 'pdf_url': None, 'source': {'id': 'https://openalex.org/S2764545133', 'display_name': 'Molecular Metabolism', 'issn_l': '2212-8778', 'issn': ['2212-8778'], 'is_oa': True, 'is_in_doaj': True, 'is_core': True, 'host_organization': 'https://openalex.org/P4310320990', 'host_organization_name': 'Elsevier BV', 'host_organization_lineage': ['https://openalex.org/P4310320990'], 'host_organization_lineage_names': ['Elsevier BV'], 'type': 'journal'}, 'license': 'cc-by-nc-nd', 'license_id': 'https://openalex.org/licenses/cc-by-nc-nd', 'version': 'publishedVersion', 'is_accepted': True, 'is_published': True}, 'sustainable_development_goals': [], 'grants': [{'funder': 'https://openalex.org/F4320320879', 'funder_display_name': 'Deutsche Forschungsgemeinschaft', 'award_id': '288034826 - IRTG 2251'}], 'datasets': [], 'versions': [], 'referenced_works_count': 52, 'referenced_works': ['https://openalex.org/W1548116773', 'https://openalex.org/W1587026990', 'https://openalex.org/W1904658532', 'https://openalex.org/W1923854859', 'https://openalex.org/W1969623610', 'https://openalex.org/W1973017243', 'https://openalex.org/W1979249143', 'https://openalex.org/W1980516061', 'https://openalex.org/W1984954439', 'https://openalex.org/W1989378845', 'https://openalex.org/W2004341529', 'https://openalex.org/W2011078603', 'https://openalex.org/W2013234028', 'https://openalex.org/W2045432341', 'https://openalex.org/W2050408756', 'https://openalex.org/W2067191792', 'https://openalex.org/W2087250756', 'https://openalex.org/W2087925166', 'https://openalex.org/W2093824918', 'https://openalex.org/W2094352498', 'https://openalex.org/W2096477524', 'https://openalex.org/W2096717747', 'https://openalex.org/W2114912181', 'https://openalex.org/W2123923369', 'https://openalex.org/W2133614954', 'https://openalex.org/W2136070507', 'https://openalex.org/W2139556877', 'https://openalex.org/W2145029774', 'https://openalex.org/W2147621341', 'https://openalex.org/W2164909963', 'https://openalex.org/W2169972181', 'https://openalex.org/W2170015161', 'https://openalex.org/W2176909443', 'https://openalex.org/W2218580839', 'https://openalex.org/W2260135833', 'https://openalex.org/W2331049262', 'https://openalex.org/W2336833178', 'https://openalex.org/W2406149527', 'https://openalex.org/W2408169179', 'https://openalex.org/W2557626865', 'https://openalex.org/W2559274342', 'https://openalex.org/W2587617334', 'https://openalex.org/W2605432571', 'https://openalex.org/W2623068422', 'https://openalex.org/W2624437652', 'https://openalex.org/W2743155225', 'https://openalex.org/W2743237851', 'https://openalex.org/W2783037826', 'https://openalex.org/W2795187531', 'https://openalex.org/W2795702337', 'https://openalex.org/W2809625799', 'https://openalex.org/W4399576166'], 'related_works': ['https://openalex.org/W4312500048', 'https://openalex.org/W4237847293', 'https://openalex.org/W4224238427', 'https://openalex.org/W2959388557', 'https://openalex.org/W2398159460', 'https://openalex.org/W2068725718', 'https://openalex.org/W2041068624', 'https://openalex.org/W2009238464', 'https://openalex.org/W1838794090', 'https://openalex.org/W1505329110'], 'abstract_inverted_index': {'Shotgun': [0], 'lipidomics': [1, 81], 'enables': [2], 'an': [3, 170], 'extensive': [4], 'analysis': [5], 'of': [6, 27, 49, 60, 67, 82, 103, 108, 163, 173, 203, 224, 233], 'lipids': [7], 'from': [8, 131], 'tissues': [9], 'and': [10, 17, 24, 76, 94, 120, 133, 149, 187, 191, 205], 'fluids.': [11], 'Each': [12], 'specimen': [13, 93], 'requires': [14], 'appropriate': [15], 'extraction': [16, 88], 'processing': [18], 'procedures': [19], 'to': [20, 40, 57, 90, 151, 220], 'ensure': [21], 'good': [22], 'coverage': [23], 'reproducible': [25, 199], 'quantification': [26, 48], 'the': [28, 47, 50, 58, 68, 86, 91, 144, 174, 222, 225, 231], 'lipidome.': [29], 'Adipose': [30], 'tissue': [31], '(AT)': [32], 'has': [33], 'become': [34], 'a': [35, 74, 99, 139, 182], 'research': [36], 'focus': [37], 'with': [38, 98, 143, 209], 'regard': [39], 'its': [41, 156], 'involvement': [42], 'in': [43, 123, 185, 214, 218, 230], 'obesity-related': [44], 'pathologies.': [45], 'However,': [46], 'AT': [51, 125, 137, 179, 204], 'lipidome': [52], 'is': [53], 'particularly': [54], 'challenging': [55], 'due': [56], 'predominance': [59], 'triacylglycerides,': [61], 'which': [62, 84, 159], 'elicit': [63], 'high': [64, 96], 'ion': [65], 'suppression': [66], 'remaining': [69], 'lipid': [70, 87, 112, 146, 157], 'classes.': [71, 113], 'We': [72], 'present': [73], 'new': [75], 'validated': [77], 'method': [78, 197], 'for': [79, 110], 'shotgun': [80], 'AT,': [83], 'tailors': [85], 'procedure': [89], 'target': [92], 'features': [95], 'reproducibility': [97], 'linear': [100], 'dynamic': [101], 'range': [102], 'at': [104], 'least': [105], '4': [106], 'orders': [107], 'magnitude': [109], 'all': [111, 177], 'Utilizing': [114], 'this': [115], 'method,': [116], 'we': [117], 'observed': [118], 'tissue-specific': [119], 'diet-related': [121], 'differences': [122], 'three': [124, 178], 'types': [126, 180], '(brown,': [127], 'gonadal,': [128], 'inguinal': [129], 'subcutaneous)': [130], 'lean': [132], 'obese': [134], 'mice.': [135], 'Brown': [136], 'exhibited': [138], 'distinct': [140], 'lipidomic': [141, 201], 'profile': [142], 'greatest': [145], 'class': [147], 'diversity': [148], 'responded': [150], 'high-fat': [152], 'diet': [153], 'by': [154], 'altering': [155], 'composition,': [158], 'shifted': [160], 'towards': [161], 'that': [162], 'white': [164], 'AT.': [165], 'Moreover,': [166], 'diet-induced': [167], 'obesity': [168], 'promoted': [169], 'overall': [171], 'remodeling': [172], 'lipidome,': [175], 'where': [176], 'featured': [181], 'significant': [183], 'increase': [184], 'longer': [186], 'more': [188], 'unsaturated': [189], 'triacylglyceride': [190], 'phospholipid': [192], 'species.': [193], 'The': [194], 'here': [195], 'presented': [196], 'facilitates': [198], 'systematic': [200], 'profiling': [202], 'could': [206], 'be': [207], 'integrated': [208], 'further': [210], '–omics': [211], 'approaches': [212], 'used': [213], '(pre-)': [215], 'clinical': [216], 'research,': [217], 'order': [219], 'advance': [221], 'understanding': [223], 'molecular': [226], 'metabolic': [227], 'dynamics': [228], 'involved': [229], 'pathogenesis': [232], 'obesity-associated': [234], 'disorders.': [235]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2901084196', 'counts_by_year': [{'year': 2024, 'cited_by_count': 2}, {'year': 2023, 'cited_by_count': 8}, {'year': 2022, 'cited_by_count': 6}, {'year': 2021, 'cited_by_count': 15}, {'year': 2020, 'cited_by_count': 7}, {'year': 2019, 'cited_by_count': 2}], 'updated_date': '2024-12-18T11:09:15.331087', 'created_date': '2018-11-29'}
Publication Information

Basic Information

Access and Citation

AI Researcher Chatbot

Primary Location

Authors

Topics

Keywords

Related Works
