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112, 130, 148, 181, 205, 227, 249, 279, 296, 326, 357, 390, 421, 452, 485, 518, 551, 582, 615, 631, 649, 681, 713, 745, 778, 811, 846, 865, 894, 956, 993, 1026, 1057, 1075, 1093, 1126, 1150, 1172, 1194, 1224, 1241, 1271, 1302, 1335, 1366, 1397, 1430, 1463, 1496, 1527, 1560, 1576, 1594, 1626, 1658, 1690, 1723, 1756, 1791, 1810, 1839, 1901, 2410, 3313, 3352, 3383, 3751, 3837, 4016, 4114, 4229, 4260], 'this': [49, 82, 113, 131, 149, 182, 206, 228, 250, 280, 297, 327, 358, 391, 422, 453, 486, 519, 552, 583, 616, 632, 650, 682, 714, 746, 779, 812, 847, 866, 895, 957, 994, 1027, 1058, 1076, 1094, 1127, 1151, 1173, 1195, 1225, 1242, 1272, 1303, 1336, 1367, 1398, 1431, 1464, 1497, 1528, 1561, 1577, 1595, 1627, 1659, 1691, 1724, 1757, 1792, 1811, 1840, 1902, 2330, 2727, 2993, 3611, 3879], 'author': [50, 83, 114, 132, 150, 183, 207, 229, 251, 281, 298, 328, 359, 392, 423, 454, 487, 520, 553, 584, 617, 633, 651, 683, 715, 747, 780, 813, 848, 867, 896, 958, 995, 1028, 1059, 1077, 1095, 1128, 1152, 1174, 1196, 1226, 1243, 1273, 1304, 1337, 1368, 1399, 1432, 1465, 1498, 1529, 1562, 1578, 1596, 1628, 1660, 1692, 1725, 1758, 1793, 1812, 1841, 1903, 2147], 'Amy': [51, 54, 996, 999, 1910], 'C': [52, 55, 997, 1000, 1911], 'Mandigo': [53, 56, 998, 1001], 'Nicolas': [84, 86, 1029, 1031, 1913], 'Gordon': [85, 87, 1030, 1032], 'Fangjin': [115, 117, 1060, 1062, 1915], 'Huang': [116, 118, 1061, 1063], 'Cedars-Sinai': [119, 137, 854, 1064, 1082, 1799], 'Medical': [120, 138, 799, 855, 944, 1065, 1083, 1744, 1800, 1889, 2010, 2073], 'Los': [122, 140, 857, 1067, 1085, 1802, 2012], 'Angeles,': [123, 141, 858, 1068, 1086, 1803, 2013], 'CA,': [124, 142, 859, 888, 1069, 1087, 1804, 1833, 2014, 2107], 'Sanchaika': [133, 135, 1078, 1080, 1917], 'Gaur': [134, 136, 1079, 1081], 'Renée': [151, 154, 1096, 1099, 1919], 'de': [152, 155, 1097, 1100], 'Leeuw': [153, 156, 1098, 1101], 'Shuang': [184, 187, 1129, 1132, 1921], 'G': [185, 188, 717, 720, 1130, 1133, 1662, 1665, 1922, 1969], 'Zhao': [186, 189, 1131, 1134], 'Radiation': [192, 214, 236, 766, 876, 934, 1137, 1159, 1181, 1711, 1821, 1879, 2018, 2063, 2095], 'Oncology,': [193, 215, 237, 767, 800, 877, 935, 945, 1138, 1160, 1182, 1712, 1745, 1822, 1880, 1890, 2019, 2064, 2074, 2096], 'University': [194, 216, 238, 287, 622, 881, 1139, 1161, 1183, 1232, 1567, 1826, 2020, 2037, 2100], 'Michigan,': [196, 218, 240, 1141, 1163, 1185, 2022], 'Ann': [197, 219, 241, 1142, 1164, 1186, 2023], 'Arbor,': [198, 220, 242, 1143, 1165, 1187, 2024], 'MI,': [199, 221, 243, 1144, 1166, 1188, 2025], 'Joseph': [208, 210, 1153, 1155, 1924], 'Evans': [209, 211, 1154, 1156], 'Sumin': [230, 232, 1175, 1177, 1926], 'Han': [231, 233, 1176, 1178], 'Theodore': [252, 254, 1197, 1199, 1928], 'Parsons': [253, 255, 1198, 1200], 'Pathology,': [268, 315, 1213, 1260, 2029], 'Ruth': [282, 284, 1227, 1229, 1930], 'Birbe': [283, 285, 1228, 1230], 'Cooper': [286, 1231], 'Health,': [288, 1233, 2038], 'Camden,': [289, 1234, 2039], 'NJ,': [290, 1235, 2040], 'Peter': [299, 301, 424, 426, 1244, 1246, 1369, 1371, 1932, 1941], 'McCue': [300, 302, 1245, 1247], 'Christopher': [329, 331, 1274, 1276, 1934], 'McNair': [330, 332, 1275, 1277], 'Saswati': [360, 363, 1305, 1308, 1936], 'N': [361, 364, 1306, 1309, 1937], 'Chand': [362, 365, 1307, 1310], 'Ylenia': [393, 395, 1338, 1340, 1939], 'Cendon-Florez': [394, 396, 1339, 1341], 'Gallagher': [425, 427, 1370, 1372], 'Jennifer': [455, 458, 1400, 1403, 1943], 'McCann': [457, 460, 1402, 1405], 'Neermala': [488, 491, 1433, 1436, 1946], 'Poudel': [489, 492, 1434, 1437, 1947], 'Neupane': [490, 493, 1435, 1438], 'Ayesha': [521, 524, 1466, 1469, 1949], 'A': [522, 525, 1467, 1470, 1950], 'Shafi': [523, 526, 1468, 1471], 'Emanuela': [554, 556, 1499, 1501, 1952], 'Dylgjeri': [555, 557, 1500, 1502], 'Lucas': [585, 588, 1530, 1533, 1954], 'Brand': [587, 590, 1532, 1535], 'Tapio': [618, 620, 1563, 1565, 1957], 'Visakorpi': [619, 621, 1564, 1566], 'Tampere,': [624, 625, 1569, 1570, 2044, 2045], 'Finland': [626, 1571, 2046], 'Ganesh': [634, 637, 1579, 1582, 1959], 'V': [635, 638, 1580, 1583, 1960], 'Raj': [636, 639, 1581, 1584], 'UT': [640, 1585], 'Southwestern,': [641, 1586, 2048], 'Dallas,': [642, 1587, 2049], 'TX,': [643, 1588, 2050], 'Costas': [652, 655, 1597, 1600, 1962], 'D': [653, 656, 1598, 1601, 1963], 'Lallas': [654, 657, 1599, 1602], 'Urology,': [670, 702, 734, 878, 925, 1615, 1647, 1679, 1823, 1870, 2054, 2097], 'Edouard': [684, 687, 1629, 1632, 1965], 'Trabulsi': [686, 689, 1631, 1634], 'Leonard': [716, 719, 1661, 1664, 1968], 'Gomella': [718, 721, 1663, 1666], 'Adam': [748, 751, 1693, 1696, 1971], 'P': [749, 752, 1694, 1697, 1972, 3391, 3399, 3407, 3415, 3423, 3430, 3561, 3599], 'Dicker': [750, 753, 1695, 1698], 'Wm.': [781, 784, 1726, 1729, 1974], 'Kevin': [782, 785, 1727, 1730, 1975], 'Kelly': [783, 786, 1728, 1731], 'Benjamin': [814, 817, 1759, 1762, 1977], 'E': [815, 818, 898, 901, 1760, 1763, 1843, 1846, 1978, 1987], 'Leiby': [816, 819, 1761, 1764], 'Pharmacology': [832, 1777, 2083], 'and': [833, 879, 1778, 1824, 1985, 2084, 2098, 2128, 2146, 2171, 2203, 2226, 2259, 2280, 2298, 2319, 2322, 2346, 2359, 2385, 2486, 2505, 2546, 2658, 2719, 2777, 2917, 2936, 2945, 2968, 3016, 3028, 3037, 3063, 3122, 3134, 3165, 3205, 3283, 3299, 3311, 3322, 3346, 3364, 3502, 3545, 3557, 3573, 3576, 3589, 3640, 3677, 3712, 3730, 3736, 3822, 3828, 3850, 3862, 3871, 3942, 3954, 4038, 4058, 4116, 4216, 4224, 4232], 'Experimental': [834, 1779, 2085], 'Therapeutics,': [835, 1780, 2086], 'Beatrice': [849, 851, 1794, 1796, 1980], 'Knudsen': [850, 852, 899, 902, 1795, 1797, 1844, 1847], 'orcid.org/0000-0002-1301-890X': [853, 1798], 'Felix': [868, 871, 1813, 1816, 1982], 'Y': [869, 872, 1814, 1817, 1983], 'Feng': [870, 873, 1815, 1818], 'Departments': [874, 1819], 'Medicine,': [880, 1825, 2099], 'California,': [883, 1828, 2102], 'San': [884, 886, 1829, 1831, 2103, 2105], 'Francisco,': [885, 887, 1830, 1832, 2104, 2106], 'Karen': [897, 900, 1842, 1845, 1986], 'Information': [1905], '*,1,2,': [1909], 'Mandigo1,2,': [1912], 'Gordon1,2,': [1914], 'Huang3,': [1916], 'Gaur3,': [1918], 'Leeuw1,2,': [1920], 'Zhao4,': [1923], 'Evans4,': [1925], 'Han4,': [1927], 'Parsons2,5,': [1929], 'Birbe6,': [1931], 'McCue2,5,': [1933], 'McNair1,2,': [1935], 'Chand1,2,': [1938], 'Cendon-Florez1,2,': [1940], 'Gallagher1,2,': [1942], 'McCann1,2,': [1945], 'Neupane1,2,': [1948], 'Shafi1,2,': [1951], 'Dylgjeri1,2,': [1953], 'Brand1,2,': [1956], 'Visakorpi7,': [1958], 'Raj8,': [1961], 'Lallas2,9,': [1964], 'Trabulsi2,9,': [1967], 'Gomella2,9,': [1970], 'Dicker2,10,': [1973], 'Kelly2,11,': [1976], 'Leiby2,12,': [1979], 'Knudsen3,': [1981], 'Feng13': [1984], 'Knudsen1,2,9,10,11': [1988], '1Department': [1989], '2Sidney': [1999], '3Cedars-Sinai': [2009], '4Department': [2016], '5Department': [2027], '6Cooper': [2036], '7University': [2042], '8UT': [2047], '9Department': [2052], '10Department': [2061], '11Department': [2071], '12Department': [2081], '13Departments': [2093], '*Corresponding': [2109], 'author.': [2110], 'Tel:': [2111], '+1': [2112], '215': [2113], '503': [2114], '8574;': [2115], 'E-mail:': [2116], 'EMBO': [2119], 'Mol': [2120], 'Med': [2121], '(2018)10:e8816https://doi.org/10.15252/emmm.201708816': [2122], 'PDFDownload': [2123], 'PDF': [2124], 'article': [2126], 'text': [2127], 'main': [2129], 'figures.': [2130], 'Peer': [2131], 'ReviewDownload': [2132], 'a': [2133, 2221, 2353, 2366, 2423, 2441, 2463, 2552, 2586, 2651, 2963, 2989, 3031, 3157, 3278, 3314, 3541, 3594, 3779, 3802, 3857, 3920, 3968, 4050, 4098, 4198, 4255, 4267], 'summary': [2134], 'the': [2136, 2180, 2189, 2200, 2308, 2336, 2347, 2375, 2413, 2680, 2737, 2908, 2918, 2930, 2939, 2947, 2976, 2996, 3079, 3142, 3331, 3372, 3483, 3514, 3531, 3690, 3708, 3761, 3951, 3991, 4030, 4036, 4047, 4083, 4106, 4139, 4150, 4217, 4234, 4277], 'editorial': [2137, 2141], 'decision': [2138, 2142], 'including': [2140, 2380, 2448, 2558, 2831, 3213], 'letters,': [2143], 'reviewer': [2144], 'comments': [2145], 'responses': [2148], 'to': [2149, 2152, 2253, 2283, 2415, 2443, 2688, 2752, 2871, 2882, 2898, 2905, 2928, 3096, 3125, 3188, 3362, 3368, 3580, 3670, 3702, 3842, 3903, 4028, 4068, 4128, 4191], 'feedback.': [2150], 'ToolsAdd': [2151], 'favoritesDownload': [2153], 'CitationsTrack': [2154], 'CitationsPermissions': [2155], 'ShareFacebookTwitterLinked': [2156], 'InMendeleyWechatReddit': [2157], 'Figures': [2158], '&': [2159, 2458, 2509, 2513, 2536, 2596], 'Info': [2160], 'Abstract': [2161], 'holds': [2163], 'major': [2164], 'functions': [2165, 2362, 2519, 2895, 2913, 3982], 'on': [2166, 2302, 2953, 2981, 3149, 3482, 3492, 3634], 'chromatin,': [2167], 'damage': [2169, 2850, 3744, 3753, 3774, 3938], 'transcriptional': [2172, 2186, 2191, 2360, 2376, 2506, 2758, 2951, 3001, 3988, 4084, 4141, 4226, 4257], 'regulation,': [2173], 'both': [2174, 4222], 'which': [2176, 2397, 2437, 2539, 2754, 3110, 3264, 4265], 'are': [2177, 2363, 2391, 2547, 2567, 2612, 2787, 3209, 3563, 3567, 3571, 3578, 3601, 3607, 4111, 4221, 4243], 'relevant': [2178], 'in': [2179, 2210, 2269, 2296, 2307, 2316, 2323, 2395, 2400, 2428, 2466, 2551, 2570, 2581, 2585, 2603, 2663, 2709, 2726, 2757, 2803, 2914, 2938, 3000, 3047, 3092, 3116, 3211, 3257, 3361, 3371, 3662, 3679, 3693, 3742, 3766, 3840, 3853, 3864, 3883, 3898, 3940, 3947, 3990, 4024, 4035, 4062, 4118, 4145, 4149, 4172, 4193, 4201, 4209, 4233, 4245, 4262], 'context': [2181, 2940, 3992, 4151], 'cancer.': [2183, 2429], 'Here,': [2184], 'unbiased': [2185, 4147], 'profiling': [2187], 'revealed': [2188, 2213, 2248, 3856], 'downstream': [2190], 'profile': [2192], 'enzymatic': [2195, 2358, 2958, 3071, 3083, 3088, 3114, 3147, 3203, 3251, 3273, 3658, 3747, 3764, 3799, 3896, 3914, 3963], 'activity.': [2196, 4042], 'Further': [2197], 'investigation': [2198, 2247, 2550], 'PARP-1-regulated': [2201, 3952, 4199], 'transcriptome': [2202, 3953, 4200], 'secondary': [2204], 'strategies': [2205], 'assessing': [2207], 'activity': [2209, 2216, 2241, 2377, 2937, 2959, 3072, 3089, 3115, 3148, 3153, 3204, 3235, 3274, 3659, 3748, 3765, 3800, 3834, 3852, 3915, 3964], 'patient': [2211], 'tissues': [2212, 3056, 3867, 3874, 3885], 'that': [2214, 2238, 2249, 2333, 2565, 2572, 2608, 2617, 2767, 2782, 2794, 2874, 2889, 3179, 3208, 3249, 3496, 3797, 3832, 3893, 3912, 4080, 4251], 'was': [2217, 2227, 2926, 2986, 3090, 3154, 3176, 3236, 3328, 3632, 3660, 3770, 3792, 3807, 4094, 4214], 'unexpectedly': [2218], 'enriched': [2219, 2399, 2706], 'as': [2220, 2365, 2440, 2714, 2731, 2748, 2750, 2962, 2988, 3156, 3277, 3668, 3707, 3801, 3919, 3967, 4022, 4170], 'function': [2222, 2295, 2306, 2367, 2802, 2935, 2964, 2980, 3158, 3252, 3279, 3803, 3897, 3921, 3969, 4132], 'disease': [2224, 2966, 2990, 3281, 3696, 3718, 3805, 3957], 'progression': [2225, 2967, 3282, 3697, 3806, 3958, 3972], 'associated': [2228, 2798, 2846, 2970, 3238, 3266, 3285, 3771, 3809, 3927], 'with': [2229, 2665, 2694, 2772, 2799, 2847, 2971, 3239, 3267, 3286, 3473, 3490, 3593, 3772, 3810, 3928, 4010, 4077], 'poor': [2230, 2972, 3287, 3945], 'outcome': [2231, 2973, 3288, 3946], 'independent': [2232, 3973], 'double-strand': [2235, 3785], 'breaks,': [2236], 'suggesting': [2237, 2616, 3831], 'enhanced': [2239, 3233], 'may': [2242, 3943, 4253], 'promote': [2243], 'aggressive': [2244, 2982], 'phenotypes.': [2245, 2955], 'Mechanistic': [2246], 'active': [2250], 'served': [2252], 'enhance': [2254, 2286], 'E2F1': [2255], 'transcription': [2256, 3005, 3014], 'activity,': [2258], 'specifically': [2260], 'promoted': [2261], 'E2F1-mediated': [2262], 'induction': [2263], 'factors': [2267, 2341, 2390, 3006, 3015, 3839], 'involved': [2268, 2756, 3741], 'homologous': [2270, 2574], 'recombination': [2271, 2575], '(HR).': [2272], 'Conversely,': [2273], 'inhibition': [2275, 4012], 'reduced': [2276], 'HR': [2277, 2389, 2673, 2735, 2801], 'thus': [2281, 4196], 'acted': [2282], 'induce': [2284], 'or': [2285, 2583, 2696, 3192, 3225, 3935], '"BRCA-ness".': [2287], 'These': [2288, 2867, 2885, 3101, 3246, 4248], 'observations': [2289], 'bring': [2290], 'new': [2291], 'understanding': [2292, 2892], 'cancer': [2297, 2327, 2370, 2560, 2701], 'have': [2299, 2522, 2540], 'significant': [2300, 3382], 'ramifications': [2301], 'predicting': [2303], 'inhibitor': [2305], 'clinical': [2309, 2549, 2600, 2654, 2669, 2792, 2886, 2901, 3044, 3150, 3315], 'setting.': [2310], 'Synopsis': [2311], 'By': [2312], 'integrating': [2313], 'data': [2314, 2602, 3046, 3102, 3247, 3606, 3910, 4218, 4249], 'generated': [2315, 3042, 3329], 'model': [2317], 'systems': [2318], 'human': [2320, 2915, 3055], 'tissues,': [2321], 'silico': [2324], 'analyses': [2325], 'patient-derived': [2328], 'data,': [2329, 3627], 'study': [2331], 'reveals': [2332], 'affects': [2335], 'expression': [2337, 2409, 3714, 3934, 4048, 4065], 'through': [2342, 2528, 2578, 3652], 'E2F1.': [2343], 'Co-targeting': [2344], 'cell': [2348, 2383, 2478, 3118, 3129, 3190, 4236], 'cycle': [2349, 2384], 'machinery': [2350], 'could': [2351], 'be': [2352, 3699, 4254], 'novel': [2354], 'treatment': [2355, 4188], 'strategy.': [2356], 'regulatory': [2361], 'elevated': [2364, 3091, 3112, 3145, 3256, 3661, 3762, 3894, 3966], 'prostate': [2369, 2559, 2700, 3636, 3672, 3866], '(PCa)': [2371], 'progression.': [2372, 2402, 3038], 'impacts': [2374, 2412], 'E2F1,': [2379], 'regulation': [2381, 2404, 2507, 3002, 3989], 'DDR': [2386, 2878], 'gene': [2387], 'expression.': [2388], 'frequently': [2392], 'transcriptionally': [2393], 'deregulated': [2394], 'PCa,': [2396, 2944, 3062, 3212, 3639, 3735, 3827], 'is': [2398, 2422, 2431, 2563, 2620, 2755, 2791, 2797, 2896, 2960, 2969, 3030, 3184, 3253, 3265, 3275, 3284, 3749, 3835, 3881, 3900, 3916, 3925, 3965], 'PCa': [2401, 2667, 2773, 2780, 2832, 2985, 3008, 3035, 3049, 3098, 3295, 3664, 3873, 3923, 3971, 3999, 4263], 'Transcriptional': [2403], 'response': [2414, 2610, 2625, 2851, 2904], 'PARPi.': [2416, 2906], 'Introduction': [2417], 'Poly(ADP-ribose)': [2418], 'polymerase': [2419], '1': [2420, 3617], '(PARP-1)': [2421], 'multifunctional': [2424], 'protein': [2425, 3705, 3933], 'importance': [2427], 'an': [2432, 4146], 'abundantly': [2433], 'expressed': [2434], 'nuclear': [2435, 2446], 'enzyme': [2436], 'uses': [2438], 'NAD+': [2439], 'substrate': [2442], 'poly(ADP-ribose)-ylate': [2444], '(PARylate)': [2445], 'proteins,': [2447], 'automodification': [2449], 'itself': [2452], "(D'Amours": [2453], 'et': [2454, 2475, 2481, 2490, 2496, 2502, 2592, 2627, 2631, 2635, 2639, 2643, 2647, 2676, 2684, 2761, 2808, 2812, 2816, 2820, 2824, 2828, 2834, 2838, 2856, 2860, 2864, 3021, 3025, 3051, 3137, 3755, 3789, 4090, 4134], 'al,': [2455, 2476, 2482, 2491, 2497, 2503, 2593, 2628, 2632, 2636, 2640, 2644, 2648, 2677, 2685, 2762, 2809, 2813, 2817, 2821, 2825, 2829, 2835, 2839, 2857, 2861, 2865, 3022, 3026, 3052, 3138, 3756, 3790, 4091, 4135], '1999;': [2456], 'Krishnakumar': [2457], 'Kraus,': [2459], '2010).': [2460], 'plays': [2462], 'key': [2464, 2468, 3004, 3032], 'role': [2465, 2997], 'several': [2467], 'biological': [2469], 'processes:': [2470], 'replication': [2471], 'fork': [2472], 'stability': [2473, 2488], '(Bryant': [2474], '2009),': [2477], 'death': [2479], '(Yu': [2480], '2002),': [2483], 'genomic': [2487], '(Durkacz': [2489, 3754], '1980),': [2492], 'telomere': [2493], 'maintenance': [2494], '(Beneke': [2495], '2008),': [2498, 2538], 'chromatin': [2499], 'organization': [2500], '(Poirier': [2501], '1982),': [2504], '(Kraus': [2508], 'Lis,': [2510], '2003;': [2511], 'Knudsen,': [2514], '2014).': [2515], 'The': [2516, 4203], 'been': [2523, 2541, 2845, 3011, 4126], 'targeted': [2524], 'anti-cancer': [2526], 'effects': [2527, 4085, 4142], 'use': [2529], 'pharmacological': [2531], 'PARP': [2532], 'inhibitors': [2533], '(PARPi;': [2534], 'Lord': [2535, 2595], 'Ashworth,': [2537, 2597], 'approved': [2542], 'ovarian': [2544], 'cancer,': [2545], 'under': [2548], 'number': [2553, 3228, 4052, 4269], 'other': [2555, 3838, 3980], 'tumor': [2556, 2805, 2954, 2983, 2994], 'types,': [2557], '(PCa).': [2561], 'It': [2562], 'thought': [2564], 'PARPi': [2566, 2624, 2657, 2770, 2788, 2795, 2842, 2872, 2883, 2923, 3040, 4081, 4117, 4167, 4187], 'especially': [2568], 'effective': [2569], 'tumors': [2571, 2606, 2781], 'lack': [2573], '(HR)': [2576], 'capacity': [2577], 'loss-of-function': [2579], 'mutations': [2580], 'BRCA1': [2582], 'BRCA2,': [2584], 'phenomenon': [2587], 'termed': [2588], 'synthetic': [2589], 'lethality': [2590], '(McCabe': [2591], '2006;': [2594], '2017).': [2598, 2840], 'However,': [2599, 2721, 3232, 3689], 'trial': [2601, 2655, 2682, 2728, 3045], 'BRCA1/2': [2604, 2618, 2942], 'mutant-selected': [2605], 'indicate': [2607, 2873, 2888, 3248, 4219, 4250], 'objective': [2609], 'rates': [2611], 'only': [2613, 3255], '~': [2614], '40%,': [2615], 'mutation': [2619], 'not': [2621, 2768, 2778, 3185, 3254, 3380, 3808, 3901, 3926], 'sufficient': [2622], '(Fong': [2626], '2009;': [2629], 'Audeh': [2630], '2010;': [2633], 'Gelmon': [2634], '2011;': [2637, 3023], 'Kaye': [2638], '2012;': [2641], 'Sandhu': [2642], '2013;': [2645, 2814, 2858, 2862], 'Coleman': [2646], '2015).': [2649, 3053], 'Additionally,': [2650, 2841], 'recently': [2652], 'published': [2653], 'combining': [2656], 'androgen': [2659, 3017, 3994, 4087], 'receptor': [2660, 3018], '(AR)-directed': [2661], 'therapy': [2662, 3060, 3127], 'patients': [2664, 2693], 'advanced': [2666, 3048], 'demonstrated': [2668, 3012, 3960], 'benefit,': [2670], 'irrespective': [2671], 'status': [2674, 3183, 3216], '(Clarke': [2675], '2018).': [2678, 2866], 'Furthermore,': [2679, 3039, 3196], 'TO-PARP': [2681], '(Mateo': [2683, 3050], '2015)': [2686], 'led': [2687, 2881], 'FDA': [2689], 'Breakthrough': [2690], 'Status': [2691], 'BRCA2': [2695, 2718], 'ATM': [2697], 'mutant': [2698], 'castration-resistant': [2699, 4130], '(CRPC).': [2702], 'Olaparib': [2703], 'responders': [2704, 2724, 2771], 'were': [2705, 2729, 3067, 3198, 3304, 3342, 3359, 3366, 3497, 3538, 3983, 4001, 4156, 4164, 4183], 'defects': [2708, 2879], 'genes,': [2712, 4105], 'such': [2713], 'biallelic': [2715], 'loss': [2716, 2743], 'ATM.': [2720], 'while': [2722], 'most': [2723], '(14/16)': [2725], 'categorized': [2730], 'biomarker': [2732, 2738], 'positive': [2733, 3509, 3523, 3592, 3858], 'deficiency,': [2736], 'suite': [2739], 'included': [2740, 4244], 'single': [2741], 'copy': [2742, 3227], 'factors,': [2747], 'well': [2749], 'alterations': [2751, 3207], 'HDAC2,': [2753], 'repression': [2759], '(Rountree': [2760], '2000).': [2763], 'While': [2764], 'these': [2765, 2876, 3626, 3909, 4109], 'studies': [2766], 'all': [2769, 2779], 'harbor': [2774], 'HR-defective': [2775], 'tumors,': [2776, 2877], 'exhibit': [2783], 'aberrant': [2784], 'responsive,': [2789], 'there': [2790, 3197, 4220, 4252], 'evidence': [2793], 'resistance': [2796, 2843, 2870], 'restored': [2800], 'multiple': [2804], 'types': [2806], '(Edwards': [2807], '2008;': [2810], 'Barber': [2811], 'Christie': [2815], '2017;': [2818, 2822, 2826, 2836], 'Kondrashova': [2819], 'Pishvaian': [2823], 'Weigelt': [2827], '2017),': [2830], '(Goodall': [2833], 'Quigley': [2837], 'has': [2844, 3010, 3041, 4124], 'differential': [2848, 4063], '(DDR)': [2852], 'network': [2853], 'functioning': [2854], '(Jaspers': [2855], 'Johnson': [2859], 'Gogola': [2863], 'mechanisms': [2868], 'likely': [2880], 'responses.': [2884], 'findings': [2887], 'further': [2890, 3500, 3891, 4095], 'mechanistic': [2891], 'needed': [2897], 'develop': [2899], 'useful': [2900], 'biomarkers': [2902, 2921], 'Given': [2907], 'potential': [2909], 'implications': [2910], 'PARP-1-mediated': [2912, 2950, 3987], 'malignancies,': [2916], 'need': [2919], 'response,': [2924], 'it': [2925], 'imperative': [2927], 'discern': [2929], 'molecular': [2931, 3206], 'basis': [2932], 'wild-type': [2943], 'determine': [2946, 3759], 'contribution': [2948], 'events': [2952], 'Results': [2956], 'increased': [2961, 3189, 3276, 3904], 'To': [2974, 3140, 3623, 3758, 3985, 4137], 'ascertain': [2975], 'impact': [2977, 3143, 4031], 'behavior,': [2984], 'utilized': [2987], 'system.': [2991], 'In': [2992, 4179], 'type,': [2995], 'relevance': [3009, 3955], '(ETS': [3013], '(AR);': [3019], 'Brenner': [3020], '2012),': [3027], 'AR': [3029, 3226, 4041, 4131], 'driver': [3033], 'initiation': [3036], 'promising': [3043], 'Initially,': [3054], 'from': [3057, 3107, 3293], 'primary,': [3058], 'hormone': [3059, 3126, 3996], '(HT)-sensitive': [3061, 3128], 'metastatic': [3064], 'CRPC': [3065, 3117, 3300, 3373, 4194, 4212], '(mCRPC)': [3066], 'queried': [3068], 'via': [3073, 3306, 3330], 'immunohistochemistry': [3074, 3307], '(IHC)': [3075], 'PAR': [3077, 3326, 3340, 3357, 3469, 3512, 3588, 3655, 3713, 3726, 3861], '(Poly(ADP-ribose),': [3078], 'product': [3080], 'activity;': [3084], 'Fig': [3085, 3163, 3172, 3218, 3223, 3230, 3244, 3685, 3889, 4025, 4073, 4121, 4173, 4239], '1A).': [3086], 'mCRPC': [3093, 3641, 3680, 3767, 3884, 3899], 'when': [3094, 3603, 4066, 4189], 'compared': [3095, 3124, 3343, 3367, 3669, 4067, 4190], 'primary': [3097, 3169, 3294, 3345, 3638, 3663, 3734, 3826, 3872], '(Fig': [3099, 3642, 3720, 3814], '1B).': [3100], 'give': [3103], 'confirmation': [3104], 'predictions': [3106], 'preclinical': [3108], 'models': [3109], 'showed': [3111], 'lines': [3119, 3130, 3566, 4237], '(including': [3120, 3131], 'C4-2': [3121, 4154], 'LNCaP-abl)': [3123], 'LNCaP,': [3132], 'LAPC4,': [3133], 'VCaP;': [3135], '2012).': [3139, 4092, 4136], 'query': [3141], 'outcomes,': [3151], 'assessed': [3155], 'proliferative': [3160], 'indices': [3161], '(Appendix': [3162, 3171, 3217, 3222, 3229, 4120, 4238], 'S1A)': [3164], 'cT': [3166], 'stage': [3167], 'at': [3168, 3494, 3648], 'diagnosis': [3170], 'S1B).': [3173], 'No': [3174], 'correlation': [3175, 3585, 3859], 'observed,': [3177], 'indicating': [3178, 3892], 'higher': [3180, 3646], 'activation': [3182], 'simply': [3186, 3700], 'due': [3187], 'proliferation': [3191], 'larger': [3193], 'volume': [3194], 'tumor.': [3195], 'no': [3199], 'correlations': [3200], 'between': [3201, 3344, 3587, 3860], 'frequent': [3210], 'TMPRSS2:ERG': [3214], 'fusion': [3215], 'S1C),': [3219], 'PTEN': [3220], 'score': [3221, 3327], 'S1D),': [3224], 'S1E).': [3231], 'significantly': [3237], 'decreased': [3240], 'progression-free': [3241, 3369], 'survival': [3242, 3370], '(PFS;': [3243], '1C).': [3245], 'CRPC,': [3258, 4153], 'but': [3259, 3878, 4276], 'also': [3260, 4125], 'predictive': [3261], 'PFS,': [3263], 'disease-specific': [3268], 'mortality.': [3269], 'Figure': [3270, 3616], '1.': [3271], 'A.': [3289], 'Tissue': [3290], 'microarrays': [3291], '(TMAs)': [3292], '(n': [3296, 3301, 3435, 3440, 3445, 3450, 4055, 4070, 4273], '=': [3297, 3302, 3379, 3392, 3400, 3408, 3416, 3424, 3431, 3436, 3441, 3446, 3451, 3869, 3876, 3887, 4056, 4071, 4274], '132)': [3298], '148)': [3303], 'stained': [3305], 'poly(ADP-ribose;': [3309], 'PAR),': [3310], 'scored': [3312], 'pathologist': [3316], '(T.': [3317], 'Parsons)': [3318], 'intensity': [3320, 3543, 3596], '(0–3)': [3321], 'percentage': [3323], '(0–3).': [3324], 'B.': [3325], 'equation:': [3332], '(intensity': [3333], '×': [3334, 3338], '1)': [3335], '+': [3336], '(percentage': [3337], '2).': [3339], 'scores': [3341, 3358], 'CRPC.': [3347, 4202], '****P': [3348], 'value': [3349, 3666, 3675, 3683], '<': [3350, 3376], '0.0001': [3351], 'Chi-square': [3353], 'test.': [3354], 'C.': [3355], 'Manual': [3356], 'divided': [3360], 'quartiles': [3363], 'then': [3365, 4008, 4163], 'TMAs.': [3374], '*P': [3375], '0.05,': [3377], 'ns': [3378], 'statistically': [3381], 'Log-rank': [3384], '(Mantel-Cox).': [3385], '1st': [3386, 3394, 3402, 3433], 'quartile': [3387, 3395, 3403, 3411, 3419, 3434, 3439, 3444, 3449], 'vs.': [3388, 3396, 3404, 3412, 3420, 3427, 4211], '2nd': [3389, 3410, 3418, 3438], 'quartile,': [3390, 3398, 3406, 3414, 3422, 3429], '0.1482;': [3393], '3rd': [3397, 3413, 3426, 3443], '0.5794;': [3401], '4th': [3405, 3421, 3428, 3448], '0.0160;': [3409], '0.3869;': [3417], '0.2110;': [3425], '0.0201.': [3432], '24);': [3437], '22);': [3442], '27);': [3447], '26).': [3452], 'D.': [3453], 'Top': [3454, 3476], 'left:': [3455, 3507], 'Representative': [3456], 'image': [3457, 3481, 3493], 'one': [3459], 'TMA': [3460, 3518, 3535], 'core': [3461, 4256], 'after': [3462, 3540], 'multiplex': [3463], 'fluorescent': [3464], 'IHC': [3465, 3631], 'γH2AX': [3467, 3529, 3590, 3863], '(green),': [3468], '(red),': [3470], '(purple),': [3472], '(blue).': [3475], 'right:': [3477, 3528], 'Insets': [3478], 'parent': [3480], 'left.': [3484], 'Numbers': [3485], 'above': [3486, 3769], 'inset': [3487], 'columns': [3488], 'coincide': [3489], 'numbers': [3491], 'left': [3495], 'chosen': [3498], 'magnification': [3501, 3647], 'representation': [3503], '(boxed': [3504], 'areas).': [3505], 'Bottom': [3506, 3520, 3527], 'Percent': [3508, 3522], 'staining': [3510, 3524], 'entirety': [3515, 3532], 'each': [3517, 3534, 3854, 4230], 'cohort.': [3519, 3536], 'middle:': [3521], 'PARP-1.': [3526], 'Data': [3537, 3614], 'considered': [3539], 'median': [3542, 3595, 3818], 'cutoff': [3544], 'analyzed': [3546], 'statistical': [3548], 'significance': [3549], 'using': [3550, 4097], 'two-tailed': [3551], "Student's": [3552], 't-test': [3553], 'PAR,': [3555], 'PARP-1,': [3556], 'γH2AX,': [3558, 3778], 'respectively.': [3559], 'Exact': [3560, 3598], 'values': [3562, 3600, 3727, 3819], 'indicated.': [3564], 'Horizontal': [3565], 'median.': [3568], 'Box': [3569], 'limits': [3570], '25%': [3572], '75%': [3574], 'percentiles,': [3575], 'whiskers': [3577], 'min': [3579], 'max.': [3581], 'E.': [3582], 'Two-tailed': [3583], 'Spearman': [3584], 'test': [3586], '(%': [3591], 'cutoff).': [3597], 'indicated': [3602, 3796], 'available.': [3604], 'available': [3608], 'online': [3609], 'figure.': [3612], '[emmm201708816-sup-0003-SDataFig1.pdf]': [3618], 'Download': [3619, 3621], 'figure': [3620], 'PowerPoint': [3622], 'expand': [3624], 'upon': [3625, 4186], 'multiplexed': [3628], 'quantifiable': [3629], 'immunofluorescent': [3630], 'performed': [3633], 'non-neoplastic': [3635, 3671, 3865], 'tissue,': [3637], '1D': [3643], 'top': [3644], 'left,': [3645], 'right).': [3649], 'As': [3650, 3959, 3978, 4043], 'measured': [3651], 'quantification': [3653], 'immunoreactivity,': [3656], '(median': [3665, 3674, 3682], '62.03)': [3667], 'tissue': [3673, 3681], '51.52),': [3676], 'highest': [3678], '69.10;': [3684], '1D,': [3686, 3721, 3815], 'bottom': [3687, 3722, 3816], 'left).': [3688], 'observed': [3691, 3768], 'increase': [3692], 'PARylation': [3694], 'during': [3695], 'cannot': [3698], 'attributed': [3701], 'total': [3703], 'expression,': [3706], 'ratios': [3709], 'levels': [3715, 3929], 'differed': [3716], 'across': [3717], 'states': [3719], 'middle;': [3723], 'medians': [3724], '51.67,': [3728], '54.29,': [3729], '47.81': [3731], 'non-neoplastic,': [3733, 3825], 'mCRPC,': [3737, 3829, 3941], 'respectively).': [3738], 'Being': [3739], 'intricately': [3740], 'repair,': [3745, 3775], 'induced': [3750], '1980).': [3757], 'whether': [3760], 'immunoreactivity': [3776], 'measure': [3780], 'breaks': [3786], '(DSBs;': [3787], 'Podhorecka': [3788], '2010),': [3791], 'performed.': [3793], 'This': [3794, 4093], 'analysis': [3795], 'DSBs': [3813], 'right;': [3817], '44.20,': [3820], '51.80,': [3821], '46.20': [3823], 'respectively),': [3830], 'regulated': [3836, 4113, 4185, 4207, 4259], 'addition': [3841], 'damage.': [3844], 'Dual': [3845], 'assessment': [3846], 'DSB': [3848, 3906, 3976], 'specimen': [3855], '(r': [3868, 3875, 3886], '0.2853),': [3870], '0.3573),': [3877], 'association': [3880], 'lacking': [3882], '−0.03825;': [3888], '1E),': [3890], 'attributable': [3902], 'repair.': [3907, 3977], 'Together,': [3908], 'demonstrate': [3911], 'heterogeneous,': [3917], 'increases': [3918], 'progression,': [3924], 'either': [3931, 4165], 'predict': [3944], 'PCa.': [3948], 'Identification': [3949], 'above,': [3961], 'such,': [3979], 'analyzed.': [3984], 'assess': [3986, 4029, 4138], 'signaling,': [3995], 'therapy-sensitive': [3997], '(HT-sensitive)': [3998], 'cells': [4000, 4155, 4213], 'deprived': [4002, 4157], 'steroids': [4004, 4159], '72': [4006, 4161], 'h,': [4007, 4162], 'treated': [4009, 4166], '(or': [4013, 4168], 'control)': [4014, 4169], 'followed': [4015], '16': [4017, 4177], 'h': [4018], 'dihydrotestosterone': [4019], '(DHT)': [4020], 'stimulation': [4021], 'depicted': [4023, 4171], '2A': [4026], '(left)': [4027, 4175], 'suppression': [4034, 4060], 'presence': [4037], 'absence': [4039], 'expected,': [4044], 'DHT': [4045, 4069, 4115], 'altered': [4046], 'large': [4051, 4268], 'transcripts': [4054, 4182], '1358),': [4057], 'resulted': [4061], 'transcript': [4064], '877;': [4072], '2A,': [4074], 'right),': [4075], 'consistent': [4076], 'previous': [4078], 'reports': [4079], 'alters': [4082], 'signaling': [4088], '(Schiewer': [4089, 4133], 'confirmed': [4096], 'previously': [4099], 'characterized': [4100], 'set': [4101], 'AR/DHT-responsive': [4103], 'target': [4104], 'majority': [4107], 'genes': [4110, 4208, 4272], 'oppositely': [4112], 'LNCaP': [4119], 'S2A).': [4122], 'found': [4127], 'regulate': [4129], 'overall': [4140], 'manner': [4148], '2B': [4174], 'h.': [4178], 'total,': [4180], '2011': [4181], 'differentially': [4184, 4206], 'control': [4192], 'cells,': [4195, 4264], 'defining': [4197], 'overlap': [4204], 'HT-sensitive': [4210], 'derived,': [4215], 'overlapping': [4223], 'distinct': [4225], 'changes': [4227], 'elicited': [4228], 'condition': [4231], 'individual': [4235], 'S2B).': [4240], 'Gene': [4241], 'lists': [4242], 'Dataset': [4246], 'EV1.': [4247], 'program': [4258], 'includes': [4266], 'DHT-responsive': [4271], '169),': [4275], 'tra': [4278]}, 'cited_by_api_url': 'https://api.openalex.org/works?filter=cites:W2900491285', 'counts_by_year': [{'year': 2024, 'cited_by_count': 7}, {'year': 2023, 'cited_by_count': 9}, {'year': 2022, 'cited_by_count': 9}, {'year': 2021, 'cited_by_count': 15}, 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